Effects of halothane and enflurane on prostanoid concentrations in operation patients

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-09-01 DOI:10.1016/0262-1746(87)90100-4

S. Kaukinen , E. Seppala , L. Kaukinen , R. Ojanen , H. Vapaatalo

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引用次数: 11

Abstract

Prostanoid formation may be stimulated by different events associated with anaesthesia and operation, such as positive pressure ventilation and tissue trauma. We investigated the effects of halothane and enflurane on plasma and serum prostanoid concentrations in 19 patients scheduled for minor operations. In 9 abdominal surgery patients, thromboxane B₂ concentrations were followed up to the fifth postoperative day. Prostanoid determinations were carried out with RIA. In general, the changes in prostanoid concentrations in patients anaesthetised with halothane or enflurane were similar. During spontaneous breathing there was a decrease in plasma PGE₂ and TxB₂ concentrations. During intermittent positive pressure ventilation and operation, PGE₂ and TxB₂ concentrations rose but 6-keto-PGF_1α did not. After operation, TxB₂ concentrations remained elevated but the other prostanoids returned to preoperative values. TxB₂ concentrations decreased to the preoperative level on the first postoperative day. The elevated TxB₂ concentrations during and after surgery can be regarded, in some patients, as a potential risk factor for cardiovascular and thromboembolic complications.

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氟烷和安氟醚对手术患者前列腺素浓度的影响

前列腺素的形成可能受到与麻醉和手术相关的不同事件的刺激，如正压通气和组织创伤。我们研究了氟烷和安氟醚对19例小手术患者血浆和血清前列腺素浓度的影响。9例腹部手术患者随访血栓素B2浓度至术后第5天。前列腺素测定采用放射免疫分析法。总的来说，氟烷或安氟醚麻醉患者前列腺素浓度的变化相似。在自主呼吸时，血浆PGE2和TxB2浓度降低。间歇正压通气和手术时，PGE2和TxB2浓度升高，而6-酮- pgf1 α浓度没有升高。术后TxB2浓度升高，但其他前列腺素恢复到术前水平。TxB2浓度在术后第一天降至术前水平。在一些患者中，手术期间和手术后TxB2浓度升高可被视为心血管和血栓栓塞并发症的潜在危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Prostaglandins, leukotrienes, and medicine

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