Increased aortic thromboxane production in experimental atherosclerosis

Peter Henriksson , Monika Stamberger , Ulf Diczfalusy
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引用次数: 24

Abstract

It is of great importance to clarify the role of thromboxane and prostacyclin in the process of atherosclerosis. In order to study this we induced atherosclerosis in rabbits through cholesterol feeding (1% w/w) for three to 12 weeks. After sacrifice the aorta was quickly removed and incubated. The in vitro thromboxane production measured as immunoreactive thromboxane B2 increased by 86 per cent in atherosclerotic vessels compared to control vessels (p<0.0005). The in vitro production of prostacyclin measured as immunoreactive 6-ketoprostaglandin F1 α showed a tendency to higher values in the atherosclerotic vessels compared to the control vessels (31%, p<0.025). This suggests that an increased thromboxane production rather than a decreased prostacyclin production might be important for the progression of atherosclerosis.

实验性动脉粥样硬化中主动脉血栓素产生增加
阐明血栓素和前列环素在动脉粥样硬化过程中的作用具有重要意义。为了研究这一点,我们通过给兔喂胆固醇(1% w/w)诱导动脉粥样硬化3 ~ 12周。献祭后,主动脉被迅速移除并孵育。与对照血管相比,动脉粥样硬化血管中免疫反应性血栓素B2的体外血栓素产量增加了86% (p<0.0005)。体外生成的前列环素(免疫反应性6-酮前列腺素F1 α)在动脉粥样硬化血管中的含量高于对照血管(31%,p<0.025)。这表明血栓素产生的增加而不是前列环素产生的减少可能对动脉粥样硬化的进展很重要。
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