Przegla̜d Gastroenterologiczny最新文献

{"title":"Study of <i>Fecalibacteria prausntzii</i> in Egyptian patients with inflammatory bowel disease.","authors":"Khaled Abd El Atty, Hanan Nouh, Shwikar Abdelsalam, Ahmed Ellakany, Hany Abdaalah, Doaa Header","doi":"10.5114/pg.2024.139427","DOIUrl":"https://doi.org/10.5114/pg.2024.139427","url":null,"abstract":"<p><strong>Introduction: </strong>Inflammatory bowel diseases (IBD) are characterised by chronic inflammation of the gastrointestinal tract. There aetiopathogenesis has not yet been fully elucidated. <i>Faecalibacterium prausnitzii</i> is one of the most abundant in human gut, and it is found in about 5% of the gut microbiota.</p><p><strong>Aim: </strong>To study the role of <i>F. prausnitzii</i> in Egyptian patients with ulcerative colitis (UC) and Crohn's disease (CD) and to assess its relationship with the disease activity.</p><p><strong>Material and methods: </strong>This study includes 80 patients divided as follows: group I: 30 patients with UC; group II: 30 patients with CD; and group III: 20 healthy patients as control. DNA execration was performed using a faecal extraction kit and quantitative SYBR green real time PCR to identify the core of <i>F. prausnitzii</i>.</p><p><strong>Results: </strong>In group 1 of UC patients, the level of bacteria was reduced by a mean of 1.68E-01, and in the control group by a mean of 2.72E-01 (<i>p</i> ₂ = 0.004, significant). Regarding <i>F. prausnitzii</i> in UC patients according to Mayo score, in severe patients the level of bacteria was reduced significantly by a median of 4.80E-02. Regarding <i>F. prausnitzii</i> in group 2 of CD, the level of bacteria was significantly reduced by mean of 1.70E-01, and in the control group by a mean of 2.72E-01 (<i>p</i> ₃ = 0.037, significant).</p><p><strong>Conclusions: </strong>There was a significant difference between CD and UC patients and the control group in <i>F. prausnitzii</i>. There was a significant reduction in the level of <i>F. prausnitzii</i> in severe UC cases.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"151-158"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The other side of celiac disease - assessment of bone mineral density and body composition in patients with celiac disease.","authors":"Kinga Skoracka, Martyna D Marciniak, Michał Michalak, Agnieszka Zawada, Alicja Ewa Ratajczak-Pawłowska, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak","doi":"10.5114/pg.2024.145481","DOIUrl":"10.5114/pg.2024.145481","url":null,"abstract":"<p><strong>Introduction: </strong>Decreased bone mineral density (BMD) is one of the most frequent extraintestinal symptoms of celiac disease (CD).</p><p><strong>Aim: </strong>The study aimed to investigate BMD, body composition, 25(OH)D, and ionised calcium blood parameters, and to compare them between women with CD and healthy individuals.</p><p><strong>Material and methods: </strong>The study covered 30 adult women with CD and 28 healthy controls. Densitometric measurements of the lumbar spine (L1-L4) and femoral neck (FN) were conducted using dual-energy X-ray absorptiometry (DXA). Body mass was measured with the use of the bioimpedance method. Furthermore, serum 25(OH)D and ionised calcium concentration were determined. All patients completed a questionnaire referring to vitamin D and calcium supplementation.</p><p><strong>Results: </strong>Significant differences were found between the groups for body mass, body mass index (BMI), BMD, <i>T</i>-score, and <i>Z</i>-score of the FN, BMD, and <i>T</i>-score of the L1-L4, and 25(OH)D concentration. Osteopaenia affected 23.33% (<i>n</i> = 7) and 36.67% (<i>n</i> = 11) of patients in the FN and L1-L4, respectively, and osteoporosis in L1-L4 affected 13.33% (<i>n</i> = 4) of patients with CD. There were no cases of osteoporosis in FN. CD patients more often declared vitamin D and calcium supplementation than healthy participants. None of the patients reported a history of fractures.</p><p><strong>Conclusions: </strong>Although patients with CD more often declare supplementing vitamin D and calcium, the prevalence of osteopaenia and osteoporosis is higher in this group compared to healthy controls. At the same time, patients with CD present with lower body mass, BMI, fat tissue, muscle mass, and fat-free mass and higher 25(OH)D concentration.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"16 4","pages":"434-438"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastroesophageal reflux disease in medical students: a cross-sectional study.","authors":"Massad Mu'taz, Nasser Elhammouri, Nour Al-Zoubi, Tayma'a Nawasrah, Sara Abo Fara, Majd Alfuqaha, Sally Hussein, Renad Taqatqa","doi":"10.5114/pg.2024.143155","DOIUrl":"10.5114/pg.2024.143155","url":null,"abstract":"<p><strong>Introduction: </strong>Common clinical problems are frequently seen in medical students. Gastroesophageal reflux disease (GERD) is increasingly seen in clinics and is taken seriously into consideration; from this point, we start discussing this disorder. The most important part is to find out the prevalence of GERD among medical students and determine the most dominant risk factors that affect the prognosis of the disease.</p><p><strong>Aim: </strong>We aim at getting enough information about the best lifestyle modifications to alleviate symptoms.</p><p><strong>Material and methods: </strong>This was a cross-sectional study conducted on medical students in Jordan through a well- structured questionnaire to assess the frequency of symptoms and if there are specific risk factors for medical students.</p><p><strong>Results: </strong>The prevalence of GERD in medical students was found to be 42.3%, and of these 36% also had associated heartburn symptoms. The potential risk factors were psychological stress and bad dietary habits. Personal life stress was found to be the main cause of stress (65%). GERD patients had sleep problems which had a troublesome impact on them.</p><p><strong>Conclusions: </strong>GERD symptoms are frequently encountered among the population, with increased prevalence in medical students. The most common symptom was heartburn. However, most of the students were asymptomatic. Multiple potential risk factors were identified including psychological stress and bad dietary habits.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 3","pages":"303-310"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effect of stinging nettle (<i>Urtica dioica</i> L.) extract on body weight gain in rats on a high-fat diet.","authors":"Kenan Kaçak, Turan Yaman, Ahmet Uyar, Ahmet Ufuk Kömüroğlu","doi":"10.5114/pg.2023.130142","DOIUrl":"10.5114/pg.2023.130142","url":null,"abstract":"<p><strong>Introduction: </strong>The leaves and seeds of <i>Urtica dioica</i> (UD) are used in folk treatments for many diseases. Anticarcinogenic, anti-inflammatory, antioxidant, and antiallergenic properties of UD have been reported.</p><p><strong>Aim: </strong>To uncover the effects of nettle seed (<i>Urtica dioica</i>; UD) extract on body weight gain in rats on a high-fat diet (HFD).</p><p><strong>Material and methods: </strong>Male Wistar albino rats (<i>n</i> = 32) were divided into 4 groups, comprising a control group, a group that received a HFD (HFD group), a group that received UD extracts (UD group), and a group that received a HFD as well as UD extracts (HFD + UD group). UD extracts were given a daily dose of 300 mg/kg of body weight orally for 75 days.</p><p><strong>Results: </strong>The HFD led to weight gain that was partially moderated by the UD extract. Histopathological findings in the HFD + UD group were uniformly significantly lower than those in the HFD group. Serum alanine transaminase, alanine aminotransferase, triglyceride, and low-density lipoprotein levels were significantly higher in the HFD group than in the HFD + UD group, and the HDL levels were lower in the HFD group than in the control group and the HFD + UD group.</p><p><strong>Conclusions: </strong>The cholesterol levels were discovered to be highest in the HFD + UD group. Therefore, it was concluded that the UD extract did not completely protect the rats against body weight gain.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"1 1","pages":"23-32"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmological manifestations in inflammatory bowel disease under the watchful eye of a gastroenterologist from a tertiary centre.","authors":"Konrad Lewandowski, Magdalena Kaniewska, Katarzyna Karłowicz, Martyna Więcek, Edyta Tulewicz-Marti, Piotr Celmer, Małgorzata Frankowska, Joanna Sempińska-Szewczyk, Grażyna Rydzewska","doi":"10.5114/pg.2024.144988","DOIUrl":"10.5114/pg.2024.144988","url":null,"abstract":"<p><strong>Introduction: </strong>Ophthalmological manifestations (O-EIM) are one of the extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD), although their frequency and potential relationship with disease activity and treatment remain underestimated.</p><p><strong>Aim: </strong>The aim of this screening questionnaire was to assess the number of EIM, including O-EIM, among patients with IBD.</p><p><strong>Material and methods: </strong>436 patients with IBD and 102 patients without IBD were included in this single-centre retrospective study. The questionnaire consisted of questions regarding the frequency of EIM, including confirmed O-EIM and ophthalmological symptoms which had not been confirmed by an ophthalmologist.</p><p><strong>Results: </strong>EIM were present in 48.6% of cases; O-EIM were declared by 8.9% (uveitis 3.9% + episcleritis 4.8% + scleritis 0.2%) of the IBD patients. About half (50.7%) of them reported ophthalmological symptoms in the last 3 months, but only 30.5% reported consulting with an ophthalmologist. The multivariable logistic regression indicated some coexisting EIM (anaemia and axial/non-axial spondyloarthropathy), the use of certain medications (steroids, thiopurines, and methotrexate), smoking, family history of glaucoma, and spending more time in front of a computer screen as being linked with ophthalmological involvement among IBD patients.</p><p><strong>Conclusions: </strong>EIM, including O-EIM, are a common problem in patients with IBD. The presence of ophthalmological symptoms and the lack of follow-up with an ophthalmologist make it difficult to correctly estimate the true number of IBD patients experiencing O-EIM. Therefore, patients with IBD should be routinely referred for ophthalmological evaluation.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"16 4","pages":"397-407"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of periampullary diverticulum on endoscopic retrograde cholangiopancreatography: bridging the gap between fiction and reality.","authors":"Sameh Afify, Maha Elsabaawy, Ahmed Ezz Al-Arab, Ahmed Edrees","doi":"10.5114/pg.2024.143148","DOIUrl":"10.5114/pg.2024.143148","url":null,"abstract":"<p><strong>Introduction: </strong>Periampullary diverticulum (PAD) is frequently discovered in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). Studies have yielded conflicting results regarding its impact on the technical success of ERCP and post-ERCP complications.</p><p><strong>Aim: </strong>This study aims to assess the success and safety of ERCP in patients with PAD.</p><p><strong>Material and methods: </strong>This study included 400 patients who underwent ERCP for common bile duct (CBD) stones. Patients were classified into the PAD group (200 patients) and the non-PAD group (200 patients). Within the PAD group, patients were further subclassified into three types based on the location of the papilla. The study compared the two groups in terms of technical success and ERCP complications.</p><p><strong>Results: </strong>The success rate of cannulation using selective techniques, needle-knife precut, or trans-pancreatic sphincterotomy was 88%, 7.5%, and 4.5%, respectively, for the PAD group and 81%, 9.5%, and 9.5%, respectively, for the non-PAD group (<i>p</i> = 0.099). Complete CBD clearance was achieved in 85% of the PAD group and 84% of the non-PAD group (<i>p</i> = 0.782). The rate of post-ERCP complications was similar in both groups (<i>p</i> = 0.371). Periampullary diverticulum type 1 was associated with more challenging cannulation (<i>p</i> < 0.001), a lower rate of complete CBD clearance (<i>p</i> < 0.001), and a higher rate of post-ERCP pancreatitis (<i>p</i> = 0.002) compared to other types.</p><p><strong>Conclusions: </strong>The presence of PAD does not hinder the technical success of ERCP and is not associated with a higher frequency of post-ERCP complications.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"16 4","pages":"446-453"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overweight, obesity, and carbohydrate metabolism disorder in workers of an industrial facility in Kazakhstan: early prevention and its management.","authors":"Maxim Tszyan","doi":"10.5114/pg.2023.134368","DOIUrl":"https://doi.org/10.5114/pg.2023.134368","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, the issue of widespread increased body weight in combination with blood glycaemic changes in the able-bodied population of Kazakhstan has become especially acute, which in turn leads to dangerous complications and an increased burden on the country's healthcare structures.</p><p><strong>Aim: </strong>To investigate the effectiveness of early prevention of overweight, obesity, and carbohydrate metabolism disorders in the able-bodied workers at an industrial facility in Kazakhstan.Material and methods: The study was conducted in 2019-2021 using elements of both empirical (observation, comparison, measurement) and theoretical (analysis and synthesis, statistical processing of results with the calculation of the reliability criterion) models of scientific knowledge.</p><p><strong>Results: </strong>The factors that have a correlation with this pathology and the strength of their interaction have been studied. New approaches to primary prevention have been developed, and algorithms have been formulated not only for the early detection of pathologies but also for the most effective and efficient methods of combating the occurrence of such pathologies in the population.</p><p><strong>Conclusions: </strong>To prevent the further spread of the phenomenon of overweight among workers in the industrial sector of Kazakhstan, the following measures are necessary: daily walking (more than 10,000 steps), dosed physical activity in the form of cardio and swimming, and nutrition correction (Mediterranean diet) with alcohol restriction. This prevention significantly reduces body weight and optimizes carbohydrate metabolism.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"143-150"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between perineural infiltrations and delayed gastric emptying after Whipple procedure for periampullary tumours, and the relationship with other clinicopathological factors and overall survival.","authors":"Konstantinos Bouchagier, Francesk Mulita, Georgios-Ioannis Verras, Steffen Nehr, Ioannis Perdikaris, Konstantinos Tasios, Andreas Antzoulas, Angelos Samaras, Serafeim Klimopoulos, Ioannis Maroulis","doi":"10.5114/pg.2023.129464","DOIUrl":"10.5114/pg.2023.129464","url":null,"abstract":"<p><strong>Introduction: </strong>Pancreaticoduodenectomy is a major procedure. Delayed gastric emptying (DGE) is a frequent postoperative complication that is attributed to several factors.</p><p><strong>Aim: </strong>To investigate the probable association between perineural infiltrations and DGE, and the effects on overall survival.</p><p><strong>Material and methods: </strong>A total of 123 patients who underwent pancreaticoduodenectomy were enrolled in the study. Factors like the presence of perineural infiltrations and post-operative DGE along with age, gender, presence of postoperative fistula, and grade of fistula and postoperative haemorrhage were analysed, and survival analyses were conducted.</p><p><strong>Results: </strong>The presence of perineural infiltrations is statistically associated with DGE occurrence (<i>p</i> = 0.01). Moreover, the occurrence of DGE is statistically associated with male gender (<i>p</i> = 0.001), worse grade of postoperative fistula (<i>p</i> < 0.01), and the presence of postoperative haemorrhage (<i>p</i> = 0.03). There was no statistical association between the presence of perineural infiltrations and the other factors. Cox regression and Kaplan-Meier survival analyses showed that increased overall survival is associated with low age (<i>p</i> = 0.018 and <i>p</i> = 0.028, respectively), absence of perineural infiltrations (<i>p</i> = 0.005 and <i>p</i> = 0.003, respectively), better grade of postoperative fistula (<i>p</i> < 0.001), and absence of postoperative haemorrhage (<i>p</i> < 0.001). Multivariate analysis showed that independent prognostic factors for survival prognosis are perineural infiltrations, age, the presence of postoperative pancreatic fistula, and the presence of postoperative haemorrhage.</p><p><strong>Conclusions: </strong>This is the first study that proves a statistically significant association between the presence of perineural infiltrations and the occurrence of DGE. Moreover, perineural infiltrations are an important independent prognostic factor for overall survival, along with other clinical factors.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"1 1","pages":"89-96"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70474926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrahepatic aneurysm in a branch of the right hepatic artery in a patient with vasculitis due to systemic lupus erythematosus.","authors":"Zoi Nitsa, Francesk Mulita, Maria Sotiropoulou, Andreas Panagakis, Markos Despotidis, Lysandros Karydakis, Dimitrios Schizas, Michail Vailas","doi":"10.5114/pg.2024.136247","DOIUrl":"https://doi.org/10.5114/pg.2024.136247","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"214-216"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of Single-Pass Albumin Dialysis (SPAD), Prometheus, and Molecular Adsorbent Recycling System (MARS) liver haemodialysis vs. Standard Medical Therapy (SMT): meta-analysis and systematic review.","authors":"Eyad Gadour, Mohammed Abdullah Kaballo, Khalid Shrwani, Zeinab Hassan, Ahmed Kotb, Ahmed Aljuraysan, Bogdan Miuţescu, Nouf Sherwani, Waleed Mahallawi","doi":"10.5114/pg.2024.139297","DOIUrl":"https://doi.org/10.5114/pg.2024.139297","url":null,"abstract":"<p><strong>Introduction: </strong>Because not all liver dysfunction patients are suitable for transplantations and there is a shortage of grafts, liver support therapies have gained interest. In this regard, extracorporeal albumin dialysis devices such as single-pass albumin dialysis (SPAD), Prometheus, and molecular adsorbent recycling system (MARS) have been valuable in supplementing standard medical therapy (SMT). However, the efficacy and safety of these devices is often questioned.Aim: We performed a systematic review to summarize the efficacy and safety of MARS, SPAD, and Prometheus as supportive treatments for liver dysfunction.</p><p><strong>Material and methods: </strong>PubMed, Medline, Cochrane Library, Web of Science, and Google Scholar electronic databases were extensively searched for all randomized trials published in English. In addition, meta-analytic analyses were performed with Review Manager software, and Cochrane's risk of bias tool embedded in this software was used for bias assessment.</p><p><strong>Results: </strong>Twelve trials including a total of 653 patients were eligible for inclusion. Subgroup analyses of data from these trials revealed that MARS and Prometheus were associated with significant removal of bilirubin (MD = -5.14 mg/dl; 95% CI: -7.26 - -3.02; <i>p</i> < 0.00001 and MD = -8.11 mg/dl; 95% CI: -12.40 - -3.82; <i>p</i> = 0.0002, respectively) but not bile acids and ammonia when compared to SMT. Furthermore, MARS was as effective as Prometheus and SPAD in the reduction of bilirubin (MD = 2.98 mg/dl; 95% CI: -4.26 - 10.22; <i>p</i> = 0.42 and MD = 0.67 mg/dl; 95% CI: -2.22 - 3.56; <i>p</i> = 0.65), bile acids (MD = -17.06 µmol/l; 95% CI: -64.33 - 30.20; <i>p</i> = 0.48 and MD = 16.21 µmol/l; 95% CI: -17.26 - 49.68; <i>p</i> = 0.34), and ammonia (MD = 26 µmol/l; 95% CI: -12.44 - 64.44; <i>p</i> = 0.18). In addition, MARS had a considerable effect in improving hepatic encephalopathy (HE) (RR = 1.54; 95% CI: 1.15-2.05; <i>p</i> = 0.004). However, neither MARS nor Prometheus had a mortality benefit compared to SMTRR (0.86; 95% CI: 0.71-1.03; <i>p</i> = 0.11 and RR = 0.87; 95% CI: 0.66-1.14; <i>p</i> = 0.31, respectively).</p><p><strong>Conclusions: </strong>MARS, SPAD, and Prometheus, as liver support therapies, are equally effective in reducing albumin-bound and water-soluble substances. Moreover, MARS is associated with HE improvement. However, none of the therapies was associated with a significant reduction in mortality or adverse events.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"101-111"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}