Przegla̜d Gastroenterologiczny最新文献

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Raoultella planticola as a rare cause of liver abscess. Raoultella planticola是肝脓肿的罕见病因。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2025-03-16 DOI: 10.5114/pg.2025.148475
Estera Zarębska-Biernat, Piotr Piejko, Rafał Sobański, Aneta Zelek
{"title":"<i>Raoultella planticola</i> as a rare cause of liver abscess.","authors":"Estera Zarębska-Biernat, Piotr Piejko, Rafał Sobański, Aneta Zelek","doi":"10.5114/pg.2025.148475","DOIUrl":"10.5114/pg.2025.148475","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"111-113"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal treatment for long-term survival in ampullary adenocarcinoma metastatic to the liver. 转移到肝脏的壶腹腺癌的长期生存的多模式治疗。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2025-03-16 DOI: 10.5114/pg.2025.148485
Jakub Ciesielka, Karolina Majewska, Beata Jabłońska, Małgorzata Domagała-Haduch, Łukasz Liszka, Iwona Gisterek-Grocholska, Sławomir Mrowiec
{"title":"Multimodal treatment for long-term survival in ampullary adenocarcinoma metastatic to the liver.","authors":"Jakub Ciesielka, Karolina Majewska, Beata Jabłońska, Małgorzata Domagała-Haduch, Łukasz Liszka, Iwona Gisterek-Grocholska, Sławomir Mrowiec","doi":"10.5114/pg.2025.148485","DOIUrl":"10.5114/pg.2025.148485","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"102-106"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural history and progression risk factors of ulcerative proctitis: a retrospective study from a single tertiary centre in Poland. 溃疡性直肠炎的自然史和进展危险因素:一项来自波兰单一三级中心的回顾性研究。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2024-03-11 DOI: 10.5114/pg.2024.136231
Katarzyna Gaweł, Krzysztof Dąbkowski, Iwona Zawada, Magdalena Szczygłowska, Marta Zykowska, Wojciech Marlicz, Teresa Starzyńska
{"title":"Natural history and progression risk factors of ulcerative proctitis: a retrospective study from a single tertiary centre in Poland.","authors":"Katarzyna Gaweł, Krzysztof Dąbkowski, Iwona Zawada, Magdalena Szczygłowska, Marta Zykowska, Wojciech Marlicz, Teresa Starzyńska","doi":"10.5114/pg.2024.136231","DOIUrl":"10.5114/pg.2024.136231","url":null,"abstract":"<p><strong>Introduction: </strong>Ulcerative proctitis is a chronic disease, characterized by lower risk of complications and less aggressive treatment in comparison to other forms of ulcerative colitis. Therefore, the key issue is to predict the natural course of the disease and protect against proximal spread of inflammatory lesions in the future.</p><p><strong>Aim: </strong>To identify risk factors for progression of ulcerative proctitis and investigate the natural history of the disease.</p><p><strong>Material and methods: </strong>We performed a retrospective study and included patients with ulcerative proctitis, diagnosed between January 2010 and December 2020, who suffered from ulcerative proctitis for at least 1 year. The collected data were then subjected to statistical analysis.</p><p><strong>Results: </strong>We identified 116 cases of ulcerative proctitis in patients aged between 19 and 84 years. Proximal extension of the disease occurred in 65 (56%) people - left sided colitis developed in 55 (85%) and pancolitis in 10 (15%) patients. We detected many progression risk factors of ulcerative proctitis, among which the most meaningful were Mayo Endoscopic Score at levels 2 and 3 at onset (<i>p</i> < 0.05), high stress level (<i>p</i> < 0.05), more than one exacerbation in the first year of the disease (<i>p</i> < 0.05), and the use of systemic glucocorticosteroids during exacerbations in mild-to-moderate activity of the disease (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>According to our study, early identification of progression risk factors in ulcerative proctitis is crucial for the future outcomes of the disease. The proper treatment at onset is relevant in preventing the progression of inflammatory lesions and the development of disease complications.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"78-83"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disturbances of autonomic nervous system and gastric activity in response to visceral stimulation in functional dyspepsia patients. 功能性消化不良患者对内脏刺激的自主神经系统和胃活动紊乱。
IF 2.5
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2025-09-24 DOI: 10.5114/pg.2025.154638
Magdalena Przybylska-Feluś, Agata Furgała, Katarzyna Ciesielczyk, Krzysztof Gil, Małgorzata Zwolińska-Wcisło
{"title":"Disturbances of autonomic nervous system and gastric activity in response to visceral stimulation in functional dyspepsia patients.","authors":"Magdalena Przybylska-Feluś, Agata Furgała, Katarzyna Ciesielczyk, Krzysztof Gil, Małgorzata Zwolińska-Wcisło","doi":"10.5114/pg.2025.154638","DOIUrl":"10.5114/pg.2025.154638","url":null,"abstract":"<p><strong>Introduction: </strong>Functional dyspepsia (FD) is mainly caused by gastric hypersensitivity and impaired gastric motility.</p><p><strong>Aim: </strong>The aim of the study was to evaluate the effect of a meal on autonomic nervous system (ANS) activity and gastric function in patients with dyspepsia.</p><p><strong>Material and methods: </strong>The study included 38 patients with functional dyspepsia (age: 37.8 ±11.2 years) and 38 healthy volunteers (age: 39.8 ±11.1 years). Simultaneous recordings of electrogastrography (EGG) and electrocardiography (ECG) with heart rate variability (HRV) analysis were performed in the fasting state and after administration of a standard meal.</p><p><strong>Results: </strong>EGG. In fasting dyspepsia group, lower normogastria (51.62 ±19.62 vs. 79.13 ±14.12%; <i>p</i> = 0.004) and average percentage of slow wave coupling (APSWC) (51.11 ±13.25 vs. 69.22 ±14.18%; <i>p</i> = 0.001) were observed compared to the control group. After a meal, in FD patients bradygastria increased from 5.6 ±3.1% to 12.2 ±6.3% (<i>p</i> = 0.01); APSWC increased but did not reach the value of the control group (77.3 ±14.1%); and the increase in the amplitude of slow waves after a meal was smaller (by 49%) than that in the control group (by 215%; <i>p</i> = 0.0001). ANS. Preprandially, the parameters of HRV spectral analysis were significantly lower in FD patients than in the control group (LF; <i>p</i> = 0.03; HF; <i>p</i> = 0.01). Postprandially, FD patients showed an increase in LF (<i>p</i> = 0.001) and HF (<i>p</i> = 0.02) indices, similar to the control group, but the parameters values were lower.</p><p><strong>Conclusions: </strong>The postprandial parasympathetic response was reduced in patients with dyspepsia. The decreased reactivity of the ANS in functional disorders contributes to gastric myoelectric dysfunction as manifested by clinical signs of dyspepsia.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"284-293"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of healthcare staff for the prevention of colon cancer. 对医护人员进行预防结肠癌的筛检。
IF 2.5
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2025-09-23 DOI: 10.5114/pg.2025.154592
Angelis Peteinaris, Francesk Mulita, Eleni Bekou, Dimitra Lakiotaki, Ira-Eirini Kostopoulou, Elias Liolis, Vasileios Tatanis, Konstantinos Tasios, Levan Tchabashvili, Andreas Antzoulas, Vasiliki Garantzioti, Antonios Koutras, Theodoros Spinos, Marina Mylonopoulou, Konstantinos Bouchagier, Dimitrios Schizas
{"title":"Screening of healthcare staff for the prevention of colon cancer.","authors":"Angelis Peteinaris, Francesk Mulita, Eleni Bekou, Dimitra Lakiotaki, Ira-Eirini Kostopoulou, Elias Liolis, Vasileios Tatanis, Konstantinos Tasios, Levan Tchabashvili, Andreas Antzoulas, Vasiliki Garantzioti, Antonios Koutras, Theodoros Spinos, Marina Mylonopoulou, Konstantinos Bouchagier, Dimitrios Schizas","doi":"10.5114/pg.2025.154592","DOIUrl":"10.5114/pg.2025.154592","url":null,"abstract":"<p><p>Malignancies are one of the most important problems of healthcare systems worldwide. Late diagnosis makes the treatment, therapeutic or not, difficult and constitutes an important obstacle to the orderly functioning of the healthcare systems in terms of financial and human resources. The prevention of certain types of cancer offers the general population, through screening tests, the ability to achieve early diagnosis and treatment. The healthcare workforce constitutes a part of the general population that should be aware of the screening tests and the consequences of cancer. Here, we investigated whether healthcare workers in Greek hospitals are well informed about the screening tests used as gold standards for the prevention of colon cancer. Moreover, we studied whether they screen themselves for the prevention of this type of cancer.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"251-260"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of SARS-CoV-2 infection on the liver function tests: a systematic review and meta-analysis of observational studies. SARS-CoV-2感染对肝功能检测的影响:观察性研究的系统回顾和荟萃分析
IF 2.5
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2025-03-24 DOI: 10.5114/pg.2025.148899
Katarzyna Kotfis, Piotr Szredzki, Dominika Maciejewska-Markiewicz, Joanna Sołek-Pastuszka, Hanna Wiśniewska, Luis F Lara, Maria Marlicz, Mariusz Kaczmarczyk, Michał Kukla, Anna Belina, George Koulaouzidis, Marta Syczewska, Karolina Jakubczyk, Natalia Ekstedt, Ewa Stachowska, Magdalena Kaniewska, Grażyna Rydzewska, Igor Łoniewski, Anastasios Koulaouzidis, Wojciech Marlicz, Karolina Skonieczna-Żydecka
{"title":"The effect of SARS-CoV-2 infection on the liver function tests: a systematic review and meta-analysis of observational studies.","authors":"Katarzyna Kotfis, Piotr Szredzki, Dominika Maciejewska-Markiewicz, Joanna Sołek-Pastuszka, Hanna Wiśniewska, Luis F Lara, Maria Marlicz, Mariusz Kaczmarczyk, Michał Kukla, Anna Belina, George Koulaouzidis, Marta Syczewska, Karolina Jakubczyk, Natalia Ekstedt, Ewa Stachowska, Magdalena Kaniewska, Grażyna Rydzewska, Igor Łoniewski, Anastasios Koulaouzidis, Wojciech Marlicz, Karolina Skonieczna-Żydecka","doi":"10.5114/pg.2025.148899","DOIUrl":"10.5114/pg.2025.148899","url":null,"abstract":"<p><strong>Introduction: </strong>SARS-CoV-2 infection has been associated with respiratory distress syndrome and hepatic injury. The mechanism of liver injury is not fully understood and may be a combined effect of viral hepatitis, systemic inflammation, gut barrier disruption, microbiome alterations or drug toxicity.</p><p><strong>Aim: </strong>We carried out a systematic review and meta-analysis to determine whether SARS-CoV-2 infection affects the level of liver-produced molecules: alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (GGTP), bilirubin, total protein, albumin, and prothrombin (with INR).</p><p><strong>Methods: </strong>Ten authors independently searched PubMed and Embase from their inception until 04/03/2021 for observational studies to evaluate whether SARS CoV-2 infection influences the level of liver-produced molecules. This early search aimed to capture changes associated with the initial variants of SARS-CoV-2 before widespread vaccination efforts. Full-text studies in adult humans in which the aim was liver damage were included. Eligible studies included adult populations with more than 30 subjects, and the analysis adhered to PRISMA guidelines. Data extraction involved a thorough process to ensure accuracy, with inconsistencies resolved by senior clinicians. Statistical analysis was conducted using random effects meta-analysis of outcomes for which ≥ 2 studies contributed data, and the risk of bias was assessed using the New Ottawa Scale. The study protocol was registered in the PROSPERO database (CRD42021242958).</p><p><strong>Results: </strong>The initial search yielded 3180 hits. 2644 studies were excluded as duplicates and/or after evaluation on the title/abstract level. No additional articles were identified via hand search. There were 536 full-text articles reviewed. Overall, the search strategy yielded 252 studies that were included in the meta-analysis.</p><p><strong>Conclusions: </strong>The overall mean liver parameter values were not altered compared to physiological values, except for GGTP, lactate dehydrogenase activity, and INR values. In the case of AST, ALT and albumin levels, mean point estimates were close to limit values of standards. SARS-CoV-2 infection triggers gut barrier defects, which results in transient elevation of liver enzymes and clotting times.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"261-271"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary habits and salivary cortisol levels as an early predictor of metabolic syndrome in children: a case-control study. 饮食习惯和唾液皮质醇水平作为儿童代谢综合征的早期预测指标:一项病例对照研究。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2024-07-31 DOI: 10.5114/pg.2024.141933
Ahmed ElSayed Wageeh, Ahmed Arafat, Amina AbdelWahab, Amany Mahmoud Elkilany, Maha Mohamed Anani, Zeinab Abdelall Mohammed
{"title":"Dietary habits and salivary cortisol levels as an early predictor of metabolic syndrome in children: a case-control study.","authors":"Ahmed ElSayed Wageeh, Ahmed Arafat, Amina AbdelWahab, Amany Mahmoud Elkilany, Maha Mohamed Anani, Zeinab Abdelall Mohammed","doi":"10.5114/pg.2024.141933","DOIUrl":"10.5114/pg.2024.141933","url":null,"abstract":"<p><strong>Introduction: </strong>Dysregulation of the hypothalamic-pituitary-adrenal axis is an essential factor in developing metabolic syndrome. Dysregulation of the hypothalamic-pituitary-adrenal axis increases cortisol levels, which is associated with increased abdominal body fat accumulation, triglyceride storage in the adipose cell, insulin resistance, and development of hypertension.</p><p><strong>Aim: </strong>To understand the relationship between dietary habits, salivary cortisol levels and metabolic syndrome in children.</p><p><strong>Material and methods: </strong>This case-controlled study included 46 subjects selected from primary schools in Ismailia city, Egypt. The study subjects were divided into two matched age and gender groups: Group 1: Children with metabolic syndrome as a patient group. Group 2: Normal age- and sex-matched children as a control group. All children were subjected to history taking, measurements, and laboratory investigations (total lipid profile, fasting blood sugar, circadian salivary cortisol in the day and at night).</p><p><strong>Results: </strong>There was a statistically significantly lower HDL level in the patient group compared to the control group, while there were statistically significantly higher levels of triglycerides, cholesterol, and fasting blood sugar in the patient group compared to the control group (<i>p</i> < 0.05). There was a statistically significant positive correlation between salivary cortisol level in the day and both systolic and diastolic blood pressure levels in the patient group (<i>r</i> = 0.554, <i>p</i> = 0.006 and <i>r</i> = 0.485, <i>p</i> = 0.019, respectively). Similarly, there was a statistically significant positive correlation between salivary cortisol level in the day and waist circumference in the patient group (<i>r</i> = 0.500, <i>p</i> = 0.018). On the other hand, in the control group there was no statistically significant correlation between salivary cortisol level and triglycerides, low-density lipoprotein, high-density lipoprotein, FBS, body mass index, waist circumference, and blood pressure.</p><p><strong>Conclusions: </strong>Dietary habits, family history, and salivary cortisol levels during the day are more strongly correlated with components of metabolic syndrome, especially central obesity and blood pressure. Dietary habits have a great impact on developing metabolic syndrome; thus a healthy lifestyle is advised. Further studies, with a larger number of participants, are encouraged to confirm our observations.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 2","pages":"148-157"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary squamous cell carcinoma of the liver. 原发性肝鳞状细胞癌。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2025-06-06 DOI: 10.5114/pg.2025.151849
Andreas Antzoulas, Francesk Mulita, Vasileios Leivaditis, Anastasios J Karayiannakis, George Pappas Gogos, Markos Antonopoulos, George S Papadopoulos, Panagiota Goutou, Dimitra Koumoundourou, Nikolaos Benetatos
{"title":"Primary squamous cell carcinoma of the liver.","authors":"Andreas Antzoulas, Francesk Mulita, Vasileios Leivaditis, Anastasios J Karayiannakis, George Pappas Gogos, Markos Antonopoulos, George S Papadopoulos, Panagiota Goutou, Dimitra Koumoundourou, Nikolaos Benetatos","doi":"10.5114/pg.2025.151849","DOIUrl":"10.5114/pg.2025.151849","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 2","pages":"218-222"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solid pancreatic lesions: etiology, morphology and utility of macroscopic on-site evaluation in predicting good yield of endoscopic ultrasound-guided biopsy. 胰腺实性病变:病因学、形态学和预测超声内镜引导下活检良率的宏观现场评估的应用。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2025-06-06 DOI: 10.5114/pg.2025.151850
Abbas Ali Tasneem, Taha Yaseen, Syed Mudassir Laeeq, Zain Majid, Nasir Hassan Luck
{"title":"Solid pancreatic lesions: etiology, morphology and utility of macroscopic on-site evaluation in predicting good yield of endoscopic ultrasound-guided biopsy.","authors":"Abbas Ali Tasneem, Taha Yaseen, Syed Mudassir Laeeq, Zain Majid, Nasir Hassan Luck","doi":"10.5114/pg.2025.151850","DOIUrl":"10.5114/pg.2025.151850","url":null,"abstract":"<p><strong>Introduction: </strong>Solid pancreatic lesions (SPL)s can be due to various etiologies, and their management depends on the histologic diagnosis.</p><p><strong>Aim: </strong>The aim of this study was to document the etiology, morphology, and utility of macroscopic on-site evaluation (MOSE) in predicting good yield of endoscopic ultrasound (EUS)-guided biopsy.</p><p><strong>Material and methods: </strong>All patients with SPLs referred for EUS-guided biopsy were included in the study. Etiology, morphology and results of EUS-guided biopsy were recorded. Rapid on-site evaluation (ROSE) was not available; therefore, MOSE was performed by an endoscopist. Macroscopically, MOSE was considered satisfactory if at least 1 tissue core at least 1 inch long was secured. Histopathologically, a biopsy specimen was considered to have a good yield if it was sufficient to establish a diagnosis. Factors predicting good yield of biopsy (GYB) were identified.</p><p><strong>Results: </strong>Of the total 176 patients included in the study, 111 (63.1%) were male (mean age 53.8 (±12.6) years; range: 14-80 years). Good yield biopsies (GYB) numbered 144 (81.8%); among them, 97 (67.4%) were neoplastic and 47 (32.6%) non-neoplastic SPLs. The commonest neoplastic SPLs were pancreatic ductal adenocarcinoma (PDA) (76; 78.3%), neuroendocrine tumors (NETs) (13; 13.4%), metastasis (5; 5.1%), and others (3; 3.1%), while the commonest non-neoplastic SPLs were mass-forming chronic pancreatitis (MFCP) (33; 70.2%), autoimmune pancreatitis (AIP) (5; 10.6%), and tuberculosis (2; 4.3%). PDAs were more common in older patients (65/76; 85.5%) and in the head region of the pancreas (47; 61.8%), while NETs were more common in younger patients 7/13 (53.8%) and in the body of the pancreas 5/13 (38.5%). Factors predicting GYB were SPL size > 15 mm (<i>p</i> = 0.045), use of fine needle biopsy (FNB) needles (<i>p</i> = 0.001), ≥ 2 passes (<i>p</i> = 0.001), and satisfactory MOSE (<i>p</i> ≤ 0.0001) on univariate analysis; and FNB use (<i>p</i> = 0.049) and satisfactory MOSE (<i>p</i> = 0.001) on multivariate analysis. Our criteria for satisfactory MOSE had high sensitivity (85.4%), positive predictive value (95.35%), and diagnostic accuracy (84.7%).</p><p><strong>Conclusions: </strong>The commonest neoplastic SPLs are PDA and NET, and the commonest non-neoplastic SPLs are MFCP and AIP. PDAs have a predilection for the head region and older age, while NETs have a predilection for younger patients and the body of the pancreas. A good biopsy yield is likely with use of FNB needles and satisfactory MOSE.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 2","pages":"192-198"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the clinical utility of measuring serum infliximab and vedolizumab concentrations during monitoring of biologic therapy in patients with inflammatory bowel disease. 评估在监测炎症性肠病患者生物治疗过程中测量血清英夫利昔单抗和维多单抗浓度的临床效用。
IF 2.5
Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.5114/pg.2025.147747
Beata Kotowicz, Magdalena Chojnacka, Małgorzata Fuksiewicz, Piotr Kucha, Edyta Zagórowicz
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