Przegla̜d Gastroenterologiczny最新文献

{"title":"SARS-CoV-2 vaccination in inflammatory bowel disease (IBD) patients - does treatment for IBD negatively affect SARS-CoV-2 antibodies? A single-centre, prospective study.","authors":"Katarzyna Karłowicz, Konrad Lewandowski, Edyta Tulewicz-Marti, Katarzyna Maciejewska, Adam Tworek, Beata Stępień-Wrochna, Martyna Głuszek-Osuch, Michał Łodyga, Grażyna Rydzewska","doi":"10.5114/pg.2023.130126","DOIUrl":"10.5114/pg.2023.130126","url":null,"abstract":"<p><strong>Introduction: </strong>Inflammatory bowel disease (IBD) patients use a wide variety of immunosuppressive drugs, including biologics, but their effect on SARS-CoV-2 vaccine antibody levels remains a mystery.</p><p><strong>Aim: </strong>We analysed whether the drugs used in the treatment of IBD patients could affect the concentration of SARS-CoV-2 antibodies.</p><p><strong>Material and methods: </strong>This is a prospective, single-centre evaluation of the persistence of SARS-CoV-2 antibodies after vaccination at various time points: every 2 months throughout the 6^th month after the first dose.</p><p><strong>Results: </strong>We included a total of 346 vaccinated IBD patients in the study. A negative correlation between antibody level and time from full vaccination was confirmed for the following types of therapy: infliximab (rho = -0.32, <i>p</i> < 0.001), adalimumab (rho = -0.35, <i>p</i> = 0.025), and vedolizumab (rho = -0.50, <i>p</i> < 0.001). In the case of other, long-term drug administration, a negative correlation between antibody level and time from full vaccination was confirmed for mesalazine (rho = -0.35, <i>p</i> < 0.001), budesonide (rho = -0.58, <i>p</i> = 0.004), systemic glucocorticoids (rho = -0.58, <i>p</i> < 0.001), and azathioprine (rho = -0.44, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Due to the immunosuppressive and biological treatment, IBD patients are exposed to a shorter persistence of SARS-CoV-2 antibodies and require booster doses. The role of gastroenterologists in educating patients about the need to continue SARS-CoV-2 vaccination remains crucial.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological rhythms of the gut and microbiota.","authors":"Albert Chodowiec, Mirosław Tarasewicz, Anna Łokić, Marcin Kazberuk, Anatol Panasiuk","doi":"10.5114/pg.2023.132437","DOIUrl":"https://doi.org/10.5114/pg.2023.132437","url":null,"abstract":"<p><p>Numerous physiological processes occurring in the digestive system are subject to circadian rhythms, which are regulated by the endogenous biological clock. The motor activity of the small intestine, large intestine, and rectum operates in a 24-hour system, with significant differences between day and night periods. It is primarily correlated with the time of meals, hormone secretion rhythms, and other activities undertaken by the organism. In recent years, numerous scientific reports have emerged about the fundamental role of circadian rhythms in the proper functioning of the gut microbiota. In addition, the microbiota and its metabolites also influence the host's daily cycles, which affects the overall state of their organism. The aim of this review is to outline the mechanisms of action and interactions between biological rhythms, gut motility, and the functioning of the gut microbiota.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of left ventricular assist devices on 30-day readmission and outcomes in non-variceal upper gastrointestinal bleeding: a nationwide analysis.","authors":"Umer Farooq, Zahid Ijaz Tarar, Adnan Malik, Muhammad Kashif Amin, Mustafa Gandhi, Moosa Tarar, Faisal Kamal","doi":"10.5114/pg.2023.134394","DOIUrl":"https://doi.org/10.5114/pg.2023.134394","url":null,"abstract":"<p><strong>Introduction: </strong>Bleeding, especially non-variceal upper gastrointestinal bleeding (NVUGIB), remains the most common cause of readmission in left ventricular assist device (LVAD) patients. Any readmission after NVUGIB carries a worse prognosis.</p><p><strong>Aim: </strong>To compare readmission outcomes in NVUGIB patients with and without LVAD.</p><p><strong>Material and methods: </strong>We identified adult NVUGIB patients using the National Readmission Database 2018 employing International Classification of Diseases, Tenth Revision (ICD-10) codes. The patients were grouped based on LVAD history. Proportions were compared using the Fisher exact test, and multivariate Cox proportional regression analysis was used to compute adjusted <i>p</i>-values. We used Stata version 14.2 to perform analyses considering 2-sided <i>p</i> < 0.05 as statistically significant.</p><p><strong>Results: </strong>The analysis included 322,342 NVUGIB patients, 1403 had a history of LVAD (mean age 64.25 years). The 30-day all-cause readmission rate in NVUGIB with LVAD was higher (24.31% vs. 13.92%, <i>p</i> < 0.001). Gastrointestinal bleeding as a readmission cause was more prevalent in the LVAD group. In patients with LVAD, NVUGIB readmissions required more complex endoscopic procedures, either requiring intervention during endoscopy or enteroscopy. There was no difference in mortality in NVUGIB readmissions (1.51% vs. 4.49%, <i>p</i> = 0.36); however, the length and cost of stay were higher in the LVAD group. Additionally, we identified novel independent predictors of readmission from NVUGIB in patients with LVADs.</p><p><strong>Conclusions: </strong>Readmissions in NVUGIB patients after LVAD require complex haemostatic intervention and are associated with greater resource utilization. To reduce readmissions and associated healthcare costs, it is essential to identify high-risk patients.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of biotechnologies in the treatment of haemorrhoidal disease and optimisation of patient management.","authors":"Dinara Nuspekova, Aidos Doskaliyev, Auyeskhan Dzhumabekov, Khabibulla Akilov, Aina Dossan","doi":"10.5114/pg.2024.139517","DOIUrl":"https://doi.org/10.5114/pg.2024.139517","url":null,"abstract":"<p><strong>Introduction: </strong>Haemorrhoidal disease is one of the most common nowadays. It is often associated with a sedentary lifestyle. The leading cause of its development is also a functional disorder of the intestine and chronic constipation. To date, there is a steady growth rate of this disease, leading to its \"rejuvenation\". The current stage of development indicates the need for further improvement of surgical treatment and optimisation of patient management methods and the creation of uniform standards of care for this contingent of patients.</p><p><strong>Aim: </strong>To evaluate the clinical effectiveness of the use of platelet-rich plasma therapy and the biologically active substance \"ozoyl\" in the treatment of haemorrhoidal disease.</p><p><strong>Material and methods: </strong>The main group included 100 patients with chronic haemorrhoids who were operated on in the period from March 2021 to March 2022. For this group, autoplasma was used during surgery, and an ozoyl-based drug in the postoperative period. The remaining 100 participants of this study, assigned to the control group, underwent a conventional haemorrhoidectomy operation and standard patient management using a hydrophilic ointment based on chloramphenicol.</p><p><strong>Results: </strong>After the conducted clinical studies, it was established that in the main group, the pain syndrome decreased by about 30%, considering the period from the first day of the postoperative period compared to the control group. The postoperative wound healed in the main group in the third week after the operation, unlike the control group, in which this event was noted in the fourth week. The patients did not complain during the examination 3 months later.</p><p><strong>Conclusions: </strong>This study is of practical significance because haemorrhoidal disease today has a high prevalence, and an integrated approach is required for the treatment of such patients. Ozoyl is a powerful cell and tissue repairer.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of an idiopathic adult ileocolic intussusception.","authors":"Platon Dimopoulos, Ioanna Akrida, George-Pappas Gogos, Vasileios Leivaditis, Georgios-Ioannis Verras, Konstantinos Tasios, Andreas Antzoulas, Vasiliki Garantzioti, Nikolas Drakos, Francesk Mulita","doi":"10.5114/pg.2024.138804","DOIUrl":"https://doi.org/10.5114/pg.2024.138804","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of <i>Fecalibacteria prausntzii</i> in Egyptian patients with inflammatory bowel disease.","authors":"Khaled Abd El Atty, Hanan Nouh, Shwikar Abdelsalam, Ahmed Ellakany, Hany Abdaalah, Doaa Header","doi":"10.5114/pg.2024.139427","DOIUrl":"https://doi.org/10.5114/pg.2024.139427","url":null,"abstract":"<p><strong>Introduction: </strong>Inflammatory bowel diseases (IBD) are characterised by chronic inflammation of the gastrointestinal tract. There aetiopathogenesis has not yet been fully elucidated. <i>Faecalibacterium prausnitzii</i> is one of the most abundant in human gut, and it is found in about 5% of the gut microbiota.</p><p><strong>Aim: </strong>To study the role of <i>F. prausnitzii</i> in Egyptian patients with ulcerative colitis (UC) and Crohn's disease (CD) and to assess its relationship with the disease activity.</p><p><strong>Material and methods: </strong>This study includes 80 patients divided as follows: group I: 30 patients with UC; group II: 30 patients with CD; and group III: 20 healthy patients as control. DNA execration was performed using a faecal extraction kit and quantitative SYBR green real time PCR to identify the core of <i>F. prausnitzii</i>.</p><p><strong>Results: </strong>In group 1 of UC patients, the level of bacteria was reduced by a mean of 1.68E-01, and in the control group by a mean of 2.72E-01 (<i>p</i> ₂ = 0.004, significant). Regarding <i>F. prausnitzii</i> in UC patients according to Mayo score, in severe patients the level of bacteria was reduced significantly by a median of 4.80E-02. Regarding <i>F. prausnitzii</i> in group 2 of CD, the level of bacteria was significantly reduced by mean of 1.70E-01, and in the control group by a mean of 2.72E-01 (<i>p</i> ₃ = 0.037, significant).</p><p><strong>Conclusions: </strong>There was a significant difference between CD and UC patients and the control group in <i>F. prausnitzii</i>. There was a significant reduction in the level of <i>F. prausnitzii</i> in severe UC cases.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effect of stinging nettle (<i>Urtica dioica</i> L.) extract on body weight gain in rats on a high-fat diet.","authors":"Kenan Kaçak, Turan Yaman, Ahmet Uyar, Ahmet Ufuk Kömüroğlu","doi":"10.5114/pg.2023.130142","DOIUrl":"10.5114/pg.2023.130142","url":null,"abstract":"<p><strong>Introduction: </strong>The leaves and seeds of <i>Urtica dioica</i> (UD) are used in folk treatments for many diseases. Anticarcinogenic, anti-inflammatory, antioxidant, and antiallergenic properties of UD have been reported.</p><p><strong>Aim: </strong>To uncover the effects of nettle seed (<i>Urtica dioica</i>; UD) extract on body weight gain in rats on a high-fat diet (HFD).</p><p><strong>Material and methods: </strong>Male Wistar albino rats (<i>n</i> = 32) were divided into 4 groups, comprising a control group, a group that received a HFD (HFD group), a group that received UD extracts (UD group), and a group that received a HFD as well as UD extracts (HFD + UD group). UD extracts were given a daily dose of 300 mg/kg of body weight orally for 75 days.</p><p><strong>Results: </strong>The HFD led to weight gain that was partially moderated by the UD extract. Histopathological findings in the HFD + UD group were uniformly significantly lower than those in the HFD group. Serum alanine transaminase, alanine aminotransferase, triglyceride, and low-density lipoprotein levels were significantly higher in the HFD group than in the HFD + UD group, and the HDL levels were lower in the HFD group than in the control group and the HFD + UD group.</p><p><strong>Conclusions: </strong>The cholesterol levels were discovered to be highest in the HFD + UD group. Therefore, it was concluded that the UD extract did not completely protect the rats against body weight gain.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overweight, obesity, and carbohydrate metabolism disorder in workers of an industrial facility in Kazakhstan: early prevention and its management.","authors":"Maxim Tszyan","doi":"10.5114/pg.2023.134368","DOIUrl":"https://doi.org/10.5114/pg.2023.134368","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, the issue of widespread increased body weight in combination with blood glycaemic changes in the able-bodied population of Kazakhstan has become especially acute, which in turn leads to dangerous complications and an increased burden on the country's healthcare structures.</p><p><strong>Aim: </strong>To investigate the effectiveness of early prevention of overweight, obesity, and carbohydrate metabolism disorders in the able-bodied workers at an industrial facility in Kazakhstan.Material and methods: The study was conducted in 2019-2021 using elements of both empirical (observation, comparison, measurement) and theoretical (analysis and synthesis, statistical processing of results with the calculation of the reliability criterion) models of scientific knowledge.</p><p><strong>Results: </strong>The factors that have a correlation with this pathology and the strength of their interaction have been studied. New approaches to primary prevention have been developed, and algorithms have been formulated not only for the early detection of pathologies but also for the most effective and efficient methods of combating the occurrence of such pathologies in the population.</p><p><strong>Conclusions: </strong>To prevent the further spread of the phenomenon of overweight among workers in the industrial sector of Kazakhstan, the following measures are necessary: daily walking (more than 10,000 steps), dosed physical activity in the form of cardio and swimming, and nutrition correction (Mediterranean diet) with alcohol restriction. This prevention significantly reduces body weight and optimizes carbohydrate metabolism.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of Single-Pass Albumin Dialysis (SPAD), Prometheus, and Molecular Adsorbent Recycling System (MARS) liver haemodialysis vs. Standard Medical Therapy (SMT): meta-analysis and systematic review.","authors":"Eyad Gadour, Mohammed Abdullah Kaballo, Khalid Shrwani, Zeinab Hassan, Ahmed Kotb, Ahmed Aljuraysan, Bogdan Miuţescu, Nouf Sherwani, Waleed Mahallawi","doi":"10.5114/pg.2024.139297","DOIUrl":"https://doi.org/10.5114/pg.2024.139297","url":null,"abstract":"<p><strong>Introduction: </strong>Because not all liver dysfunction patients are suitable for transplantations and there is a shortage of grafts, liver support therapies have gained interest. In this regard, extracorporeal albumin dialysis devices such as single-pass albumin dialysis (SPAD), Prometheus, and molecular adsorbent recycling system (MARS) have been valuable in supplementing standard medical therapy (SMT). However, the efficacy and safety of these devices is often questioned.Aim: We performed a systematic review to summarize the efficacy and safety of MARS, SPAD, and Prometheus as supportive treatments for liver dysfunction.</p><p><strong>Material and methods: </strong>PubMed, Medline, Cochrane Library, Web of Science, and Google Scholar electronic databases were extensively searched for all randomized trials published in English. In addition, meta-analytic analyses were performed with Review Manager software, and Cochrane's risk of bias tool embedded in this software was used for bias assessment.</p><p><strong>Results: </strong>Twelve trials including a total of 653 patients were eligible for inclusion. Subgroup analyses of data from these trials revealed that MARS and Prometheus were associated with significant removal of bilirubin (MD = -5.14 mg/dl; 95% CI: -7.26 - -3.02; <i>p</i> < 0.00001 and MD = -8.11 mg/dl; 95% CI: -12.40 - -3.82; <i>p</i> = 0.0002, respectively) but not bile acids and ammonia when compared to SMT. Furthermore, MARS was as effective as Prometheus and SPAD in the reduction of bilirubin (MD = 2.98 mg/dl; 95% CI: -4.26 - 10.22; <i>p</i> = 0.42 and MD = 0.67 mg/dl; 95% CI: -2.22 - 3.56; <i>p</i> = 0.65), bile acids (MD = -17.06 µmol/l; 95% CI: -64.33 - 30.20; <i>p</i> = 0.48 and MD = 16.21 µmol/l; 95% CI: -17.26 - 49.68; <i>p</i> = 0.34), and ammonia (MD = 26 µmol/l; 95% CI: -12.44 - 64.44; <i>p</i> = 0.18). In addition, MARS had a considerable effect in improving hepatic encephalopathy (HE) (RR = 1.54; 95% CI: 1.15-2.05; <i>p</i> = 0.004). However, neither MARS nor Prometheus had a mortality benefit compared to SMTRR (0.86; 95% CI: 0.71-1.03; <i>p</i> = 0.11 and RR = 0.87; 95% CI: 0.66-1.14; <i>p</i> = 0.31, respectively).</p><p><strong>Conclusions: </strong>MARS, SPAD, and Prometheus, as liver support therapies, are equally effective in reducing albumin-bound and water-soluble substances. Moreover, MARS is associated with HE improvement. However, none of the therapies was associated with a significant reduction in mortality or adverse events.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of mental and psychological status with disease activity in patients with inflammatory bowel disease using SCL-90 R Questionnaire.","authors":"Ezzat Ali, Doaa Header, Khaled Abdel Aty, Nada Othman, Moamen Fawzy, Hussein El Amin, Mohamed Elnady","doi":"10.5114/pg.2024.139579","DOIUrl":"https://doi.org/10.5114/pg.2024.139579","url":null,"abstract":"<p><strong>Introduction: </strong>Inflammatory bowel disease (IBD) can affect mental health. There is no evidence that stress is a direct cause of the disease. Most IBD patients describe an emotional impact, mainly feelings of depression and anxiety. Many questionnaires are used to assess anxiety in those patients, including SCL-90.</p><p><strong>Aim: </strong>To investigate the correlation between mental and psychological status to disease activity in patients with inflammatory bowel disease using 90-Item Symptom Checklist (SCL-90 R) questionnaire.</p><p><strong>Material and methods: </strong>The study included 100 patients (50 Crohn's disease (CD) patients - 50 ulcerative colitis (UC) patients). Detailed history taking, systemic physical examination, laboratory investigations, colonoscopy, and the SCL-90-R symptom checklist - a self-report psychometric instrument (questionnaire) for each patient.</p><p><strong>Results: </strong>The mean age of Crohn's disease patients was 24.2 ±3.6 years. In ulcerative colitis the mean age was 28.5 ±7.3 years. No age or gender relation could be detected with the SCL-90 score in both groups. Our study showed a direct correlation of CD disease activity (CDAI) and endoscopic activity (SES) according to the SCL-90 R questionnaire. There was direct correlation of UC disease activity (SCCAI) and endoscopic activity (UCEIS) according to the SCL-90 R questionnaire.</p><p><strong>Conclusions: </strong>There is a direct correlation between disease activity and endoscopic activity in UC and CD according to the SCL-90 R questionnaire.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}