Przegla̜d Gastroenterologiczny最新文献

{"title":"Intrahepatic aneurysm in a branch of the right hepatic artery in a patient with vasculitis due to systemic lupus erythematosus.","authors":"Zoi Nitsa, Francesk Mulita, Maria Sotiropoulou, Andreas Panagakis, Markos Despotidis, Lysandros Karydakis, Dimitrios Schizas, Michail Vailas","doi":"10.5114/pg.2024.136247","DOIUrl":"https://doi.org/10.5114/pg.2024.136247","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of a forgotten Christmas gift.","authors":"Francesk Mulita, Michail Vailas, Stylianos Kapiris, Elena Mavrodimitraki, Georgios Kyriakopoulos, Dimitrios Schizas, Maria Sotiropoulou","doi":"10.5114/pg.2024.136324","DOIUrl":"https://doi.org/10.5114/pg.2024.136324","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between perineural infiltrations and delayed gastric emptying after Whipple procedure for periampullary tumours, and the relationship with other clinicopathological factors and overall survival.","authors":"Konstantinos Bouchagier, Francesk Mulita, Georgios-Ioannis Verras, Steffen Nehr, Ioannis Perdikaris, Konstantinos Tasios, Andreas Antzoulas, Angelos Samaras, Serafeim Klimopoulos, Ioannis Maroulis","doi":"10.5114/pg.2023.129464","DOIUrl":"10.5114/pg.2023.129464","url":null,"abstract":"<p><strong>Introduction: </strong>Pancreaticoduodenectomy is a major procedure. Delayed gastric emptying (DGE) is a frequent postoperative complication that is attributed to several factors.</p><p><strong>Aim: </strong>To investigate the probable association between perineural infiltrations and DGE, and the effects on overall survival.</p><p><strong>Material and methods: </strong>A total of 123 patients who underwent pancreaticoduodenectomy were enrolled in the study. Factors like the presence of perineural infiltrations and post-operative DGE along with age, gender, presence of postoperative fistula, and grade of fistula and postoperative haemorrhage were analysed, and survival analyses were conducted.</p><p><strong>Results: </strong>The presence of perineural infiltrations is statistically associated with DGE occurrence (<i>p</i> = 0.01). Moreover, the occurrence of DGE is statistically associated with male gender (<i>p</i> = 0.001), worse grade of postoperative fistula (<i>p</i> < 0.01), and the presence of postoperative haemorrhage (<i>p</i> = 0.03). There was no statistical association between the presence of perineural infiltrations and the other factors. Cox regression and Kaplan-Meier survival analyses showed that increased overall survival is associated with low age (<i>p</i> = 0.018 and <i>p</i> = 0.028, respectively), absence of perineural infiltrations (<i>p</i> = 0.005 and <i>p</i> = 0.003, respectively), better grade of postoperative fistula (<i>p</i> < 0.001), and absence of postoperative haemorrhage (<i>p</i> < 0.001). Multivariate analysis showed that independent prognostic factors for survival prognosis are perineural infiltrations, age, the presence of postoperative pancreatic fistula, and the presence of postoperative haemorrhage.</p><p><strong>Conclusions: </strong>This is the first study that proves a statistically significant association between the presence of perineural infiltrations and the occurrence of DGE. Moreover, perineural infiltrations are an important independent prognostic factor for overall survival, along with other clinical factors.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70474926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric polyps: a retrospective cohort analysis of 23,668 endoscopies indicates changing epidemiological and phenotypic characteristics.","authors":"Christina Kapizioni, Panagiotis Kourkoulis, Sofia Kartsoli, Georgios Koutoufaris, Panagiotis Giannelis, Aristotelis Mellos, Konstantia Milioni, George Michalopoulos, Spyridon Vrakas, Vasileios Xourgias","doi":"10.5114/pg.2024.136236","DOIUrl":"https://doi.org/10.5114/pg.2024.136236","url":null,"abstract":"<p><strong>Introduction: </strong>Growing adoption of endoscopic procedures in clinical practice has gradually increase the detection rate of gastric polypoid lesions.</p><p><strong>Aim: </strong>To identify the epidemiologic characteristics of gastric polyps as well as changes of these parameters during a 15-year period.</p><p><strong>Material and methods: </strong>We reviewed all the upper endoscopies archived in our database reporting a polypoid lesion from 2003 to 2018. Demographic data, indication for endoscopy, morphological characteristics of polyps, histology, and presence of <i>Helicobacter pylori</i> were collected. We compared the abovementioned data between 2 periods: 2003-2010 and 2010-2018.</p><p><strong>Results: </strong>A total of 989 (4.2%) patients from 23,668 reviewed were identified to harbour a polypoid lesion. Mean patient age was 63.2 years, with 58.8% being female. Most polyps (65.2%) were less than 5 mm in diameter and located in the fundus. Hyperplastic polyps (HPs) were the predominant type (28.6%) while fundic gland polyps (FGPs) were found in 24.1% of patients. Adenomas were the least common type (2.7%). Other pathology was identified in 43.3%. Comparison between the 2 periods revealed a rise of FGPs against HPs with a concomitant shift of location from antrum to fundus and an increase in the number of polyps per patient.</p><p><strong>Conclusions: </strong>FGPs and HPs were the most common polyps found in our cohort, with a change of their pattern during the 15 years. It is imperative to acknowledge the distinct characteristics of gastric polyps so as to properly assess the malignant potential that some of them, or their surrounding gastric mucosa, harbour.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role and therapeutic effectiveness of <i>Plantago ovata</i> seed husk (psyllium husk) in the prevention and non-pharmacological treatment of gastrointestinal diseases. Part 1. Clinical use of psyllium husk in the treatment of irritable bowel syndrome, ulcerative colitis, and colorectal cancer.","authors":"Justyna Przybyszewska, Andrzej Kuźmiński, Michał Przybyszewski, Cezary Popławski","doi":"10.5114/pg.2024.139209","DOIUrl":"https://doi.org/10.5114/pg.2024.139209","url":null,"abstract":"<p><p><i>Plantago ovata</i> is a common medicinal plant widely cultivated in tropical regions of the world. The outer seed coat of <i>P. ovata</i>, obtained by cleaning the seeds, contains soluble and insoluble fibre in a ratio of 7:3, making products containing <i>P. ovata</i> husk an ideal source of health-beneficial fibre. The results of clinical trials demonstrate the therapeutic efficacy of psyllium husk for various gastrointestinal disorders. It has also been documented that psyllium ingestion exhibits antioxidant, immunomodulatory, antiproliferative, anticancer, and antiviral effects. Such pleiotropic effects of <i>P. ovata</i> husk are related to the presence in its composition of arabinoxylan, which forms a gel in an aqueous environment, as well as bioactive compounds and their metabolites. This article presents the evidence available in the literature on the therapeutic potential and possible mechanisms of action of psyllium in the treatment of irritable bowel syndrome and ulcerative colitis, and prevention of colorectal cancer.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vonoprazan a novel potassium competitive acid blocker; another leap forward.","authors":"Maha Elsabaawy, Ahmed Shaban, Ahmed Ezz Al-Arab, Osama Elbahr, Ahmed Edrees, Sameh Afify","doi":"10.5114/pg.2024.139426","DOIUrl":"https://doi.org/10.5114/pg.2024.139426","url":null,"abstract":"<p><strong>Introduction: </strong>The eradication rate of <i>Helicobacter pylori</i> (<i>H. pylori</i>) has decreased due to antibiotics resistance and inadequate acid suppression. Vonoprazan is a novel potassium-competitive acid blocker (P-CAB), which has a rapid and sustained acid inhibitory effect and may be more effective than conventional proton pump inhibitors (PPIs) in <i>H. pylori</i> eradication.</p><p><strong>Aim: </strong>to study the efficacy and safety of vonoprazan as a component of first-line <i>H. pylori</i> eradication treatment compared with conventional PPI-based therapy.</p><p><strong>Material and methods: </strong>This randomised (one to one) non-blinded study was conducted on 400 consecutive proven <i>H. pylori</i> infected patients, of whom 200 received vonoprazan-based triple therapy, while 200 patients received PPI-based triple therapy for 14 days. The study outcomes were evaluated as eradication rate and adverse events in both patient groups.</p><p><strong>Results: </strong>The eradication rate was 86% in the vonoprazan group and 74.5% in the PPI group. The vonoprazan eradication rate was significantly higher than that of PPIs (<i>p</i> = 0.004). There was no significant difference regarding adverse events between both patient groups.</p><p><strong>Conclusions: </strong>Vonoprazan-based therapy was more effective than PPI-based therapy as a first-line <i>H. pylori</i> eradication treatment. Vonoprazan was generally safe and well tolerated.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forgettable in the care of liver cirrhosis: the unseen culprits of progression from bad to worse.","authors":"Maha Elsabaawy, Omkosoum Alhaddad","doi":"10.5114/pg.2024.136361","DOIUrl":"https://doi.org/10.5114/pg.2024.136361","url":null,"abstract":"<p><p>Patients with liver cirrhosis constitute a critically ill and unique population, and their stability relies on a well-coordinated multidisciplinary team with a carefully structured plan. Overlooking any aspect of this plan can expedite disease progression, leading to severe complications. The lack of disease-specific nutritional guidance, the prevalent sedentary lifestyle among patients, and insufficient screening for hepatocellular carcinoma, oesophageal varices, sarcopaenia, minimal hepatic encephalopathy, and diabetes mellitus, along with fibrosis progression and cirrhosis decompensation, can add further complexities. Additionally, devaluing the impact of obesity in triggering liver cirrhosis can be disadvantageous. Prolonged and inappropriate use of proton pump inhibitors also poses a significant challenge with a wide range of complications. These often-unheeded aspects in the care of liver cirrhosis patients represents the unseen culprits of progression from bad to worse and warrant serious consideration.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 pandemic on the number of patients presenting with appendicitis to the emergency department.","authors":"Ioanna Akrida, Georgios-Ioannis Verras, Konstantinos Bouchagier, Dimitrios Kehagias, Charalampos Kaplanis, Konstantinos Tasios, Andreas Antzoulas, Angelos Samaras, Nikolaos Benetatos, Ioannis Maroulis, Francesk Mulita","doi":"10.5114/pg.2023.129495","DOIUrl":"10.5114/pg.2023.129495","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic has had an influence on the number of patients presenting to the emergency department (ED) with surgical conditions.</p><p><strong>Aim: </strong>To evaluate the number of patients presenting with acute appendicitis (AA) and the percentage of complicated appendicitis before and after the COVID-19 disease outbreak.</p><p><strong>Material and methods: </strong>This is a retrospective study based on the data of all patients presenting with AA to the ED of a tertiary COVID referral university hospital in Greece. We analysed the number of patients treated with AA, patient characteristics, and the proportion of patients with complicated appendicitis, and we compared the 2 groups of patients treated 12 months before and 12 months after COVID-19 onset in Greece.</p><p><strong>Results: </strong>A total of 152 patients were included in this study. There was a significant decrease in the number of patients presenting with AA after COVID-19 onset in Greece. Respectively, 91 and 61 patients were subjected to appendectomy 12 months before and after COVID-19 onset. Comparing the 2 groups of patients, there was a statistically significant increase in the operation time (<i>p</i> = 0.01) after COVID-19 onset, whereas the percentage of complicated appendicitis, the duration of symptoms before presenting to the ED (< 24 h, > 24 h), and the type of operation (laparoscopic, open, converted) did not differ significantly between the 2 groups of patients.</p><p><strong>Conclusions: </strong>The number of patients presenting to the ED with AA decreased after COVID-19 onset, most likely because patients hesitated to seek help in a COVID-19 referral hospital.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the incidence of celiac disease in patients with microscopic colitis? Why are these two diseases related?","authors":"Berat Ebik, Nazım Ekin, Ferhat Bacaksiz, Ali Uzel, Mustafa Zanyar Akkuzu, Feyzullah Ucmak, Muhsin Kaya, Vedat Goral","doi":"10.5114/pg.2023.126855","DOIUrl":"10.5114/pg.2023.126855","url":null,"abstract":"<p><strong>Introduction: </strong>Although there are studies in the literature showing that celiac disease (CD) is more common in patients with microscopic colitis (MC), there are publications to the contrary. The pathophysiologies of both diseases are different from each other.</p><p><strong>Aim: </strong>To investigate the frequency of CD in MC patients, the different features of these 2 diseases, and the relationship between them.</p><p><strong>Material and methods: </strong>In our prospective and cross-sectional analytical study, the presence of CD was investigated in 90 patients diagnosed with MC by colonoscopy and biopsy due to chronic diarrhoea between September 2011 and December 2021.</p><p><strong>Results: </strong>We detected MC in 102 (9.3%) of 1096 patients investigated for chronic diarrhoea. We detected CD in 1 (1.1%) of 90 patients with MC who participated in the study. Only 10% of the patients were positive for AGA IgA, 3.3% for EMA IgA, and 2.2% for Anti-TG2 IgA. There was no difference in autoantibody titre in treatment-responsive and treatment-resistant MC patients. HLA DQ2 was positive in 32.2% (<i>n</i> = 29) of the MC patients, and HLA DQ8 was found in 5.5% (<i>n</i> = 5). Intraepithelial lymphocyte increase was remarkable in the duodenal biopsies of MC patients who did not respond to treatment (40% vs. 11.4%; <i>p</i> = 0.007).</p><p><strong>Conclusions: </strong>We did not reach the conclusion that CD is more common in MC patients. An increase in IEL may also occur in the small intestine in patients with MC who do not respond to treatment.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70474874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of oxidative stress, metabolic disorders in colorectal cancer patients.","authors":"Konrad Zaręba, Justyna Dorf, Kerianne Cummings, Seena Tabibi, Mateusz Maciejczyk, Bogusław Kędra","doi":"10.5114/pg.2024.139995","DOIUrl":"https://doi.org/10.5114/pg.2024.139995","url":null,"abstract":"<p><strong>Introduction: </strong>Colorectal cancer have been one of the most common malignant neoplasm in the world. In most patients with this cancer, we can observe both redox homeostasis and nutritional disorders.</p><p><strong>Aim: </strong>To assess the occurrence of oxidative stress in patients with colorectal cancer and its severity depending on the nutritional status of patients.</p><p><strong>Material and methods: </strong>The study group consisted of 50 patients with colorectal cancer. In the control group, samples were obtained from 40 healthy subjects. Basal metabolic index and nutrition risk screening (NRS) 2002 scale was completed. The total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA) were determined yielding the oxidative stress index (OSI) determined by the TOS/TAC ratio and TAC/MDA ratio.</p><p><strong>Results: </strong>There were statistically significant differences (<i>p</i> < 0.05) in the levels of not only TAC, TOS, OSI, but also MDA and TAC/MDA. In healthy patients, the TAC and TAC/MDA level was significantly higher (<i>p</i> < 0.05) compared to the cancer patients, while the TOS, OSI and MDA level was significantly lower (<i>p</i> < 0.05). In patients with BMI < 24.9 kg/m², the level of TAC was significantly higher and the level of TOS was significantly lower (<i>p</i> < 0.05) compared to patients with BMI > 24.9 kg/m². In patients with features of malnutrition according to the NRS 2002 scale, TOS and OSI were statistically significantly higher (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Neoplastic disease, such as colorectal cancer, precipitates an increase in oxidative stress. Concurrently, the nutritional status of patients, especially malnutrition, further intensifies this process.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}