Exploring new noninvasive parameters to predict oesophageal varices in patients with NAFLD-associated compensated liver cirrhosis.

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Przegla̜d Gastroenterologiczny Pub Date : 2025-01-01 Epub Date: 2024-04-26 DOI:10.5114/pg.2024.139210

Adnan Agha, Andrea Pasta, Francesco Calabrese, Eram Anwar, Mazin Taha, Virgie G Pedo, Ghada S M Al-Bluwi, Edoardo G Giannini

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引用次数: 0

Abstract

Introduction: Nonalcoholic fatty liver disease is a leading cause of liver cirrhosis and portal hypertension, which can be complicated by oesophageal varices and variceal bleeding. Screening for oesophageal varices is essential for initiating bleeding prophylaxis. Several noninvasive parameters for predicting oesophageal varices have been suggested (e.g., Baveno VI, expanded Baveno VI, and platelet count/spleen diameter ratio), although with variable efficacy in patients with nonalcoholic fatty liver disease.

Aim: This study aimed to compare the non-invasive predictors of oesophageal varices.

Material and methods: We retrospectively analyzed the medical records of patients with nonalcoholic fatty liver disease-related compensated liver disease who underwent screening endoscopy at a tertiary care unit in United Arab Emirates. The accuracy of the established (Baveno VI and expanded Baveno VI) and newly devised (platelet count)/(spleen diameter) + liver stiffness × (40 - albumin) noninvasive parameters in predicting oesophageal varices and the presence of large oesophageal varices was assessed in our population.

Results: We found that the (platelet count)/(spleen diameter) + liver stiffness × (40 - albumin) formula had a higher accuracy than both Baveno VI (p = 0.030) and expanded Baveno VI criteria (p = 0.050) in predicting the presence of oesophageal varices. The (platelet count)/(spleen diameter) + liver stiffness × (40 - albumin) formula was associated with a higher number of spared endoscopies than Baveno VI (n = 16, 21.9%) and expanded Baveno VI (n = 9, 12.3%) criteria.

Conclusions: The new formula could provide superior predictive value than the currently practiced noninvasive predictors of oesophageal varices. However, large-scale studies are warranted to confirm its predictive performance in patients with nonalcoholic fatty liver and other etiologies of chronic liver disease.

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来源期刊

Przegla̜d Gastroenterologiczny GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.20

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastroenterology Review is a journal published each 2 months, aimed at gastroenterologists and general practitioners. Published under the patronage of Consultant in Gastroenterology and Polish Pancreatic Club.