Przegla̜d Gastroenterologiczny最新文献

{"title":"Markers of bacterial translocation as a possible indicator of subclinical inflammation in pediatric inflammatory bowel diseases patients.","authors":"Kinga Kowalska-Duplaga, Przemysław Tomasik, Andrzej Wędrychowicz, Krzysztof Fyderek","doi":"10.5114/pg.2025.151888","DOIUrl":"10.5114/pg.2025.151888","url":null,"abstract":"<p><strong>Introduction: </strong>Recently there has been significant progress in research on the pathogenesis of inflammatory bowel diseases (IBD).</p><p><strong>Aim: </strong>Our study aimed to assess selected markers of bacterial translocation in children with IBD in relationship to disease activity.</p><p><strong>Material and methods: </strong>Lipopolysaccharides (LPS) - markers of bacterial translocation - and proinflammatory cytokines - interleukin (IL)-8, IL-12 and tumor necrosis factor (TNF) α - were assessed in the serum of 27 pediatric IBD patients at the outbreak of the illness and then 1 and 3 months after the introduction of the treatment. The analyzed markers were taken once in 6 healthy children in the control group.</p><p><strong>Results: </strong>Serum TNF-α and LPS concentrations were significantly higher in IBD patients than in the control group (1.74 vs. 0.83 ng/ml and 21.83 vs. 10.26 pg/ml, <i>p</i> < 0.05). In the study group, clinical and laboratory activity mediators significantly decreased during 3 months of the treatment. All proinflammatory cytokines decreased, but significant down-regulation was observed only in relation to IL-12 (129.21 vs. 82.98 pg/ml, <i>p</i> < 0.05) in CD and IL-8 (32.72 vs. 20.97 pg/ml, <i>p</i> < 0.05) in UC patients. TNF-α levels decreased but did not reach values as in healthy children, while LPS levels increased in both groups.</p><p><strong>Conclusions: </strong>IL-12 in CD and IL-8 in UC could be non-invasive markers of reduced inflammation during IBD in children. Improvements in clinical status and reductions in systemic inflammatory markers do not necessarily mean complete cessation of the inflammatory cascade. The elevated TNF-α and LPS levels found in patients in early remission may be a marker of subclinical inflammation.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 2","pages":"185-191"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) and endoscopic ultrasound-guided ethanol ablation (EUS-EA) of pancreatic neuroendocrine tumors and adenocarcinoma: a prospective multicenter study.","authors":"Hussein H Okasha, Ahmed Y Altonbary, Khaled Ragab, Elsayed Ghoneem, Mohammed Tag-Adeen, Abeer Abdellatef, Mohammed S Naguib, Bogdan Miutescu, Eyad Gadour","doi":"10.5114/pg.2025.151852","DOIUrl":"10.5114/pg.2025.151852","url":null,"abstract":"<p><strong>Introduction: </strong>Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) and endoscopic ultrasound-guided ethanol ablation (EUS-EA) are emerging novel methods for managing non-functioning and functioning pNET and adenocarcinoma in the pancreas.</p><p><strong>Aim: </strong>To assess the safety profile, feasibility, and outcomes of EUS-RFA and EUS-EA of focal pancreatic masses.</p><p><strong>Material and methods: </strong>This prospective study included 27 patients, 15 males and 12 females, with a mean age of 36.38 years. EUS-RFA was carried out in 13 patients; 11 had pancreatic insulinoma, and 2 had advanced pancreatic adenocarcinoma. The mean size of the masses was 20.6 mm, while that of the insulinomas was 17.4 mm. The median number of needle passes was 3, with a range of 1 to 6. RFA was conducted using 19G EUSRA needles from Taewoong Co., Ltd., South Korea. No minor or major complications were observed. EUS-EA was carried out in 14 patients, all of whom had pancreatic insulinoma. The mean size of the masses was 15.3 mm. The median number of needle passes was 2, with a range of 1 to 3. We used 19G and 22G echo tip FNA needles from Cook Company, USA. The mean duration of follow-up was 12.4 months. There was mild to moderate acute pancreatitis in 4 patients in the EUS-EA group; all were relieved by conservative therapy, and no hospital admission was required. No early or late significant complications were reported in the EUS-RFA group.</p><p><strong>Results: </strong>There was a complete clinical cure of 10 out of 11 (91%) patients with pancreatic insulinoma who underwent EUS-RFA. However, 1 patient required three sessions, and 2 patients required two sessions of EUS-RFA. The 11^th patient with insulinoma showed a poor response after the first session, then a partial response after the second session of EUS-RFA. The size of the two masses with advanced adenocarcinoma was decreased, but no downstaging of the masses was achieved. There was a complete clinical cure of 8 out of 14 (57%) patients with pancreatic insulinoma who underwent EUS-EA. No clinical cure was observed in 4 patients; 3 underwent major surgery, and the 4^th one underwent EUS-RFA. The last 2 patients showed a partial clinical response with decreased frequency, duration, and severity of hypoglycemic attacks. They were managed by diet regulation; no major surgery was needed.</p><p><strong>Conclusions: </strong>EUS-RFA and EUS-EA can potentially treat lesions and control symptoms. EUS-RFA is a more promising and safer technique for managing functioning insulinomas. However, it cannot downstage pancreatic ductal adenocarcinoma patients. EUS-EA seems less efficient, with more adverse events than EUS-RFA.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 2","pages":"158-164"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of early and long-term clinical outcomes in obstructed proximal and distal colon cancers undergoing emergent surgery.","authors":"Ulaş Aday, Abdulkadir Akbaş, Hikmet Özesmer, Hasan Akkoç","doi":"10.5114/pg.2024.145475","DOIUrl":"10.5114/pg.2024.145475","url":null,"abstract":"<p><strong>Introduction: </strong>Studies comparing proximal and distal colon tumours undergoing emergent surgery for obstruction are limited.</p><p><strong>Aim: </strong>The purpose of our study was to compare the clinical and oncological outcomes of patients with proximal and distal colon cancer, who underwent emergent surgery for obstruction.</p><p><strong>Material and methods: </strong>From January 2012 to June 2022, patients with colon cancer presenting with obstruction and undergoing emergent surgery were analysed. The 2 groups were defined as proximal and distal according to the tumour location with respect to the splenic flexure. Postoperative early and long-term clinical and oncological outcomes were analysed.</p><p><strong>Results: </strong>Of the 118 patients included in the study, there were 46 patients (38.9%) in the proximal group and 72 patients (61.1%) in the distal group. Single-session surgery including resection and anastomosis was performed on 31 (67.4%) and 29 (40.3%) patients in the proximal and distal groups, respectively (<i>p</i> = 0.007). The global mortality rate was 11%, and there was no difference between the groups. Five-year survival was similar in the proximal and distal groups, being 80.4% and 68.1%, respectively. In the analysis of patients who did not develop early mortality and underwent R0 resection, 3-year disease-free survival was 89.5% in the proximal group and 81.5% in the distal group; the difference was not significant (<i>p</i> = 0.165).</p><p><strong>Conclusions: </strong>Mortality is high in emergent surgeries for obstructed proximal and distal colon cancers. If curative resection is achieved, oncological results are good and tumour localisation does not affect survival.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"71-77"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connection of vitamin D levels in blood serum with <i>Helicobacter pylori</i> infection in paediatric patients.","authors":"Kairat Rysbekov, Sagira Abdrakhmanova, Rashida Satybaeva, Dmitry Babenko, Zhanat Abdikadyr","doi":"10.5114/pg.2024.146213","DOIUrl":"10.5114/pg.2024.146213","url":null,"abstract":"<p><strong>Introduction: </strong><i>Helicobacter pylori</i> is a globally prevalent infection, particularly in developing countries, with significant implications for gastrointestinal health in children. Recent studies suggest a potential link between vitamin D and its metabolites in enhancing the effectiveness of <i>H. pylori</i> eradication therapies through their bactericidal properties.</p><p><strong>Aim: </strong>To investigate the correlation between the vitamin D levels and their influence on clinical management and treatment results of children patients, tested for <i>H. pylori</i>.</p><p><strong>Material and methods: </strong>The study was conducted on a cohort of 128 paediatric patients. They were divided into 2 groups, depending on whether positive (first group - A) or negative (second group - B) for <i>H. pylori</i>. To determine vitamin D levels, venous blood was taken from all participants from both groups. Group 1 included patients whose indexes were up to 10 ng/ml; Group 2 included patients whose indexes were from 10 ng/ml to 20 ng/ml; Group 3 levels were from 20 ng/ml to 30 ng/ml; and Group 4 indexes were over 30 ng/ml. The efficiency of the <i>H. pylori</i> eradication scheme in participants of these groups was evaluated.</p><p><strong>Results: </strong>The mean values in Group A were higher than those in Group B: 17.1 and 14.9, respectively, <i>p</i>-value 0.03. <i>Helicobacter pylori</i> prevalence was higher in participants with vitamin D levels below 30 ng/ml. As a result of the study, it was established that vitamin D levels below 30 ng/ml in blood serum could be a predisposing factor in the spread of <i>H. pylori</i> in paediatric patients. At the same time, different levels of deficiency below 30 ng/ml did not affect the frequency of <i>H. pylori</i> infection.</p><p><strong>Conclusions: </strong>The obtained data can be used in developing guidelines for clinical management of children patients who are primarily diagnosed with <i>H. pylori</i> and require eradication therapy.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"84-91"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consumption patterns of the frequently used drugs and their impact on the gastric cancer epidemiological indices in Ukraine, 2014-2021.","authors":"Yevgen O Protas, Valeriia Haysanovska, Olha V Makarenko","doi":"10.5114/pg.2025.149964","DOIUrl":"10.5114/pg.2025.149964","url":null,"abstract":"<p><strong>Introduction: </strong>Gastric cancer remains one of the leading causes of cancer-related death. Many frequently used drugs (proton pump inhibitors (PPI), statins, metformin, and non-steroidal anti-inflammatory drugs (NSAID)) can play a role in the development of gastric cancer or attenuate <i>Helicobacter pylori</i>'s adhesion (cysteine derivatives).</p><p><strong>Aim: </strong>To analyse the patterns and dynamics of consumption of PPIs, statins, metformin, NSAIDs and cysteine derivatives in Ukraine in comparison with global trends, and to explore their potential impact on the gastric cancer morbidity in Ukraine.</p><p><strong>Material and methods: </strong>The consumption of PPIs, statins, metformin, NSAIDs, and cysteine derivatives (by mean of daily defined doses (DDDs)/100 000 habitants per year, 2014-2020) and gastric cancer epidemiological indices, such as the incidence rate (per 100 000 habitants per year, 2014-2021), main forms, and age prevalence, were estimated in Ukraine.</p><p><strong>Results: </strong>Levels of PPI, statins, metformin, NSAID, and cysteine derivative consumption increased by 98.61% (<i>p</i> < 0.0001), 199.15% (<i>p</i> < 0.0001), 141.29% (<i>p</i> < 0.0001), 23.51% (<i>p</i> < 0.0001), and 42.06% (<i>p</i> < 0.0001), respectively, in 2020 compared to 2014 whereas the gastric cancer incidence rate decreased by 26.56% (<i>p</i> < 0.0001) in 2021 compared to 2014 in Ukraine.</p><p><strong>Discussion: </strong>The gastric cancer incidence rate decreased, and its epidemiological structure was stable, in Ukraine between 2014 and 2021. The consumption of PPIs, statins, metformin, NSAIDs, and cysteine derivatives might play a complex role in the development of gastric cancer.</p><p><strong>Conclusions: </strong>The trends of the gastric cancer incidence rate, its epidemiological structure, and the increased consumption of PPIs, statins, metformin, NSAIDs, and cysteine derivatives in Ukraine between 2014 and 2021 correspond to global trends. Statins, metformin, NSAIDs, and cysteine derivatives might lead to a decline in gastric cancer in the population despite the increased consumption of PPIs.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"305-310"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of faecal microbiota transplantation (FMT) in recurrent <i>Clostridioides difficile</i> infection: results of a single-centre retrospective study.","authors":"Marcin Bzdyra, Edyta M Tulewicz-Marti, Anna Przepióra, Konrad Lewandowski, Grażyna Rydzewska","doi":"10.5114/pg.2025.154701","DOIUrl":"10.5114/pg.2025.154701","url":null,"abstract":"<p><strong>Introduction: </strong>Studies have indicated the high effectiveness of faecal microbiota transplantation (FMT) in the treatment of recurrent <i>Clostridioides difficile</i> infection (rCDI). However, there is still a lack of data from different subpopulations regarding FMT and the factors related to it.</p><p><strong>Aim: </strong>The aim of the study was to retrospectively evaluate the efficacy and safety of FMT in rCDI.</p><p><strong>Material and methods: </strong>In all cases, FMT was performed using a nasoenteric tube. A good response following a single FMT was considered an improvement, whereas requiring more than one FMT was considered a suboptimal response.</p><p><strong>Results: </strong>In the analysed period, FMT was performed on a total of 98 patients, including 74 with rCDI (of whom 23 received 2 FMTs, 6 received 3 FMTs, and 1 received 5 FMTs). The average age of the patients was 68 years. 42 (56%) patients were women, 41 (55.4%) had previously used antibiotics, 2 (2.7%) had used steroids, and 4 (5.4%) had used proton pump inhibitors (PPI). Following the first FMT procedure, clinical improvement was observed in 44 (59.4%) patients. The odds of a suboptimal effect of the therapy (needing more than 1 FMT) were associated with prior use of metronidazole. Among all analysed factors, cardiovascular risk factors (such as hypertension and hyperlipidaemia) were associated with a threefold increased likelihood of requiring more than 1 FMT (<i>p</i> = 0.038).</p><p><strong>Conclusions: </strong>In our study, FMT was found to be an effective and safe treatment of recurrent CDI. Use of metronidazole was identified as a risk factor for a suboptimal response to FMT in the studied cohort.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"330-334"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of gastroscopy quality indicators applicable in clinical practice.","authors":"Mikołaj Machaj, Krzysztof Budzyń, Gustaw Błaszczyński, Tomasz Romańczyk","doi":"10.5114/pg.2025.154599","DOIUrl":"10.5114/pg.2025.154599","url":null,"abstract":"<p><p>Despite advances in medicine, upper gastrointestinal cancers remain a significant global concern. In Poland, regardless of the increase in performed esophagogastroduodenoscopies, the rate of missed cancers is around 6%. This is related to the insufficient quality measures during the performed examinations. Our paper discusses key endoscopy quality indicators that can enhance the detection of precancerous lesions and cancers. We categorized the indicators into three sections: pre-procedural (fasting time, premedication), intra-procedural (sedation, photodocumentation, virtual chromoendoscopy, quality metrics, biopsy sampling) and post-procedural (coordinated care, training). Some of them, such as chromoendoscopy and premedication in the upper segment, have been widely studied and popularized in recent years. For several years, we have had strict protocols on how to take specimens depending on the condition. Most of the assumptions presented can be easily implemented into daily routine practice, which can improve health care. These are successfully, routinely used in Japan and Korea. We believe that a collective improvement in the quality of esophagogastroduodenoscopies performed will increase the detection rates of precancerous lesions and early cancers. However, further research in this area is still needed.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"241-250"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concordance of the rapid urease test and the histopathology report in detecting <i>Helicobacter pylori</i> infection in a bariatric population. A retrospective cohort study.","authors":"Piotr Panek, Justyna Rymarowicz, Miłosz Czeliński, Jakub Pośpiech, Marcin Dembiński, Marek Winiarski, Piotr Major, Michał Kukla","doi":"10.5114/pg.2025.156847","DOIUrl":"10.5114/pg.2025.156847","url":null,"abstract":"<p><strong>Introduction: </strong>Bariatric surgery has become one of the most prominent treatment modalities for obesity. Esophagogastroscopy (EGD) with <i>Helicobacter pylori</i> testing is a part of the preoperative work-up. There are no guidelines defining the preferred method of detecting <i>H. pylori</i>.</p><p><strong>Aim: </strong>The study aimed to establish the prevalence of <i>H. pylori</i> infection among bariatric patients and compare the two commonly used invasive diagnostic tests: the rapid urease test (RUT) and histopathology. The secondary aim was to evaluate the usefulness of EGD and histology in diagnosing gastritis.</p><p><strong>Material and methods: </strong>A retrospective analysis was performed among patients with obesity undergoing bariatric surgery. As part of the preoperative work-up, EGD was performed with RUT using the Lencomm GOLD Hp dry CLO test and a histopathology sample taken from the gastric antrum and body. The Cohen's kappa inter-rated reliability test was used for concordance calculation.</p><p><strong>Results: </strong>280 patients were analyzed, of whom 98 (35.00%) were diagnosed with <i>H. pylori</i> infection with at least one method. The Cohen's kappa inter-rated agreement between the RUT and histology sampling was 0.80. Macroscopic gastritis was present in 76 (77.56%) of infected patients. Histology showed microscopic gastritis in 99 (99%) of those patients. 161 (57.50%) of the study group were diagnosed with macroscopic gastritis; among these, histology confirmed inflammation in 119 (73.91%).</p><p><strong>Conclusions: </strong>There is a good concordance between RUT and histopathology diagnosis of <i>H. pylori</i> among the bariatric population. Additionally, there is a low accuracy rate in EGD assessments of gastric mucosa changes.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 4","pages":"395-399"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12746576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145864820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of glutamate dehydrogenase (GLDH) as a diagnostic and prognostic marker in drug-induced liver injury.","authors":"Omkolsoum Alhaddad, Maha Elsabaawy, Amany Salah, Olfat Hendy, Dalia Elsabaawy, Mohamed Mazaly, Aliaa Sabry","doi":"10.5114/pg.2024.143153","DOIUrl":"10.5114/pg.2024.143153","url":null,"abstract":"<p><strong>Introduction: </strong>Drug-induced liver injury (DILI) is a significant clinical event, associated with notable morbidity and mortality. The paucity of DILI diagnostic and/or prognostic biomarkers still represents an unmet need.</p><p><strong>Aim: </strong>We aimed to evaluate the role of glutamate dehydrogenase (GLDH) as a diagnostic and prognostic marker in patients with DILI.</p><p><strong>Material and methods: </strong>A case-control study was conducted on 40 acute DILI patients and 40 acute viral hepatitis patients, in addition to a healthy control group (20). Clinical and laboratory characteristics were evaluated including ELISA assay of GLDH, along with RUCAM score and liver biopsy whenever feasible. All cases were followed up for 6 months.</p><p><strong>Results: </strong>Diclofenac was the most incriminated drug in DILI (40%). GLDH was higher in the DILI than control and acute viral hepatitis patients (18.5 ±10.4, 0.89 ±0.6, 1.5 ±1.2 U/l) respectively (<i>p</i> < 0.001). Moreover, it was strongly correlated with aminotransferases, alkaline phosphatase, prothrombin concentration (PC), and bilirubin. The GLDH level in hepatocellular injury was 24.5 ±4.4 U/l, while it was 1.5.5 ±0.6 U/l in mixed and 3.5 ±1.1 U/l in cholestatic injury (<i>p</i> < 0.001). The AUC for GLDH level was 0.936 (<i>p</i> < 0.001) at a cutoff of 2.1 U/l, where the sensitivity was 90%, specificity 85%, positive predictive value 91.08% and negative predictive value 83.31% in prediction of DILI. GLDH was higher in patients who died than those who survived (32.36 ±1.1 vs. 15.36 ±10.1 U/l, respectively) (<i>p</i> = 0.000). Multivariate analysis defined age, bilirubin, and GLDH as independent predictors of poor outcomes in DILI.</p><p><strong>Conclusions: </strong>GLDH is a highly specific, simple, real-time, and inexpensive diagnostic and prognostic marker of DILI and shows potential to address this unmet need.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 2","pages":"165-172"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New challenges in the management of inflammatory bowel disease: a case study.","authors":"Grazyna Piotrowicz, Agata Rudnik, Mariusz Śmigielski, Adam Piotrowicz, Magdalena Rzeszutek, Agnieszka Klufczyńska","doi":"10.5114/pg.2024.139242","DOIUrl":"10.5114/pg.2024.139242","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"107-110"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}