Przegla̜d Gastroenterologiczny最新文献_第9页

Causes of death after liver transplantation among patients with solitary hepatocellular carcinoma in the United State, from 2004 to 2015. 2004年至2015年美国孤立性肝细胞癌患者肝移植后死亡原因

IF 1.3

Przegla̜d Gastroenterologiczny Pub Date : 2023-01-01 DOI: 10.5114/pg.2023.126045

Anas Elgenidy, Ahmed M Afifi

{"title":"Causes of death after liver transplantation among patients with solitary hepatocellular carcinoma in the United State, from 2004 to 2015.","authors":"Anas Elgenidy, Ahmed M Afifi","doi":"10.5114/pg.2023.126045","DOIUrl":"https://doi.org/10.5114/pg.2023.126045","url":null,"abstract":"Liver transplantation has gained broad acceptance as a therapeutic modality for hepatocellular carcinoma (HCC), with better overall survival than liver resection [1]. The United Network for Organ Sharing (UNOS) adopted Milan criteria for liver transplantation in patients with HCC (single lesion, diameter ≤ 50 mm, without vascular invasion, and with no metastasis) to improve survival [2]. Yang et al. reported that the median overall survival is 5.75 years after transplantation for patients meeting UNOS criteria [1]. So, even though choosing these criteria is a focal point, there is another important topic, i.e. knowing the causes of death after selecting these criteria. However, the causes of death are unclear. We used Surveillance, Epidemiology, and End Results (seer)*stat software, latest version 8.3.9.2 in our study to access SEER plus data, 18 registries [3, 4]. We identified the solitary HCC diagnosis with the primary site labelled C22.0, specific ICD-O-3 hist/behave (8170/3 – 8175/3) and concerning UNOS criteria (CS extension 2004–2015). We evaluated causes of death (ICD-10 identifications) and calculated the standardized mortality ratio (SMR), which represents the number of observed deaths from a specific cause to the number that would be expected to die over a given period. Therefore, understanding the distribution of different causes of death after liver transplantation among HCC patients is helpful in counselling patients regarding their care and survivorship. We reviewed 1260 US patients with solitary HCC who had undergone liver transplants during the period 2004–2015 (Figure 1). Most patients were aged between 45 and 79 years (1204; 95.6%), were white (1002; 79.5), male (960; 76%), married (805; 63.9%), and with a localized stage (1227; 97.4%). Of the included patients 400 (31.7%) died during this period, with a mean age","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"18 1","pages":"132-134"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/40/PG-18-50390.PMC10050984.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current perspective and review of literature on robotic gastrectomy and oncological outcomes 机器人胃切除术和肿瘤预后的研究现状及文献综述

IF 1.3

Przegla̜d Gastroenterologiczny Pub Date : 2023-01-01 DOI: 10.5114/pg.2023.124148

D. Coco, S. Leanza

引用次数: 0

Personalized medicine in biomarker identification at their optimal cut-off selection. 在生物标记物最佳临界值选择中进行个性化医疗识别。

IF 1.3

Przegla̜d Gastroenterologiczny Pub Date : 2023-01-01 Epub Date: 2022-10-18 DOI: 10.5114/pg.2022.120441

Tadeusz J Lewandowski

{"title":"Personalized medicine in biomarker identification at their optimal cut-off selection.","authors":"Tadeusz J Lewandowski","doi":"10.5114/pg.2022.120441","DOIUrl":"10.5114/pg.2022.120441","url":null,"abstract":"Introduction: Retrospective exploratory analysis to identify biomarker pairs in the AVAGAST Phase III study.Aim: The main hypothesis of this retrospective exploratory biomarker analysis is the identification of dichotomization levels based on optimal selection driven by the predictive value of single biomarkers. The outcome of interest optimization might unveil additional treatment benefits. Furthermore, testing the biomarker pairs at their optimal cut-off selection might provide the predictive score candidates.Material and methods: 712 plasma 92% and 727 plasma 94% tumor samples of all patients were using Cox model by identifying optimal dichotomization to maximize treatment benefit. A quadrant analysis grouped biomarker pairs into subsets yielded the best clinical benefit. Candidate biomarker score using the nested 2-fold cross-validation method was used to adjust the optimal cut-off selection.Results: Patients with lower VEGF-R1 at optimal cut-off with low IHER2G showed significant improvement in PFS - first line (HR = 0.62; 95% CI: 0.50 to 0.78). The interaction p-value of the biomarker pair was adjusted at 0.0147094.Conclusions: The predictive biomarker is a potential candidate for PFS - first line in patients with advanced gastric cancer treated with Bevacizumab.","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"1 1","pages":"402-408"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effects of the pandemic period on cirrhosis patients. 疫情期间对肝硬化患者影响的评估。

IF 1.3

Przegla̜d Gastroenterologiczny Pub Date : 2023-01-01 Epub Date: 2023-09-22 DOI: 10.5114/pg.2023.131393

Rezan Karaali, Ejder Saylav Bora, Firdevs Topal

{"title":"Evaluation of the effects of the pandemic period on cirrhosis patients.","authors":"Rezan Karaali, Ejder Saylav Bora, Firdevs Topal","doi":"10.5114/pg.2023.131393","DOIUrl":"10.5114/pg.2023.131393","url":null,"abstract":"Introduction: Cirrhosis is a common liver disease, which is characterized by life-limiting complications. In cirrhosis, liver ACE2 mRNA levels were 34-times upregulated, ACE2 protein 97-times upregulated, and ACE2 receptors increased in 80% of hepatocytes. Increased ACE2 receptor sensitizes hepatocytes to COVID-19.Aim: To evaluate the applications of cirrhosis patients to the Emergency Department before and after the pandemic.Material and methods: The study was conducted retrospectively in a single centre on cirrhotic patients who applied to the Emergency Department in a 2-year period. The obtained data were compared with the laboratory values of the patients: the severity of cirrhosis, the reasons for applying to the Emergency Department, hospitalization/discharge status, and pre-pandemic and pandemic period values. The mortality of the patients was recorded.Results: The biochemical values, CTP score, and complications of cirrhosis patients deteriorated during the pandemic period, which contributed to the increase in mortality and that the CTP score and its complications worsened, which contributed to the increase in mortality. COVID-19 positivity contributes to the progression of the CTP score, but it is not directly associated with mortality.Conclusions: We think that new treatment protocols should be included in the guidelines to minimize the effects of this type of viral infection on the liver.","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"18 3","pages":"320-326"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71485288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translation and validation of the Ukrainian version of the visceral sensitivity index for patients with irritable bowel syndrome. 肠易激综合征患者内脏敏感性指数乌克兰版本的翻译和验证。

IF 1.3

Przegla̜d Gastroenterologiczny Pub Date : 2023-01-01 Epub Date: 2023-09-22 DOI: 10.5114/pg.2023.131391

Artem Neverovskyi, Vadym Shypulin, Nataliya Mikhnova

{"title":"Translation and validation of the Ukrainian version of the visceral sensitivity index for patients with irritable bowel syndrome.","authors":"Artem Neverovskyi, Vadym Shypulin, Nataliya Mikhnova","doi":"10.5114/pg.2023.131391","DOIUrl":"10.5114/pg.2023.131391","url":null,"abstract":"Introduction: Gastrointestinal-specific anxiety (GSA) is considered as an important factor in the course of irritable bowel syndrome (IBS). GSA may be evaluated by the visceral sensitivity index (VSI).Aim: To translate original English version of the VSI into Ukrainian language (VSI-UA) and then to test its validity and reliability in patients with IBS.Material and methods: 108 patients of both sexes, aged 18-44 years, with IBS were assessed by the VSI-UA, Patient Health Questionnaire-9 (PHQ-9), Beck's Depression Inventory (BDI), and the Hospital Anxiety and Depression Scale: depression (HADS-Dep) and anxiety (HADS-Anx). Reliability was checked by Cronbach's α and test-retest method with calculation of the intraclass correlation coefficient (ICC). Content validity was assessed by calculation of the content validity ratio (CVR) and content validity index (CVI). The construct validity was assessed by estimating Pearson`s correlation between VSI-UA, PHQ-9, BDI, HADS-Anx, and HADS-Dep.Results: Cronbach's α for VSI-UA was 0.84; the ICC between the first measurement and the one repeated 4 weeks after administration of VSI-UA was 0.92 (95% CI: 0.87-0.95). The calculated CVR for each item of the VSI-UA was higher than the critical value of 0.56, and the CVI was 0.94. A moderate positive correlation was found between VSI-UA and PHQ-9 (r = 0.65), BDI (r = 0.69), HADS-Anx (r = 0.61), and HADS-Dep (r = 0.48); p < 0.05 in all correlations.Conclusions: VSI-UA is a reliable and valid tool for the assessment of GSA in Ukrainian-language patients with IBS, and it could be implemented in routine clinical practice to manage patients with IBS.","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"18 3","pages":"313-319"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71485300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selected parameters of nutritional status in patients with pancreatic head cancer - own experience. 胰头癌症患者营养状况的选择参数——自身经验。

IF 1.3

Przegla̜d Gastroenterologiczny Pub Date : 2023-01-01 Epub Date: 2023-09-22 DOI: 10.5114/pg.2023.131392

Konrad Zaręba, Justyna Dorf, Kerianne Cummings, Zbigniew Kamocki, Bogusław Kędra

{"title":"Selected parameters of nutritional status in patients with pancreatic head cancer - own experience.","authors":"Konrad Zaręba, Justyna Dorf, Kerianne Cummings, Zbigniew Kamocki, Bogusław Kędra","doi":"10.5114/pg.2023.131392","DOIUrl":"10.5114/pg.2023.131392","url":null,"abstract":"Introduction: Around 200,000 new cases of pancreatic cancer are diagnosed yearly worldwide. It is the fourth most common cause of cancer deaths. Pancreatic cancer has a high mortality rate due to unspecific symptoms being responsible for late diagnosis.Aim: In this study, the authors analysed selected nutritional parameters and the severity of anaemia in patients diagnosed with pancreatic head cancer.Material and methods: Data were collected upon admission to the 2nd Clinical Department of General, Gastrointestinal, and Oncological Surgery in the University Clinical Hospital in Bialystok, Poland and retrospectively with the help of correctly collected anamnesis.Results: It has been shown that most patients with pancreatic cancer are malnourished at the time of diagnosis. Body mass index (BMI) is the least valuable parameter primarily. Weight loss has been determined to be the most accurate predictor of the patient's metabolic status, although it should never be the only parameter. Although these factors do not suggest an inflammatory process, serum protein levels and albumin concentration should be considered.Conclusions: When assessing the nutritional status of patients with pancreatic cancer, many predictive factors should be considered. BMI seems to be the least accurate parameter for assessing nutritional status in patients diagnosed with cancer. However, when combined with weight loss and serum albumin levels, it can be quite useful as a prognostic factor.","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"18 3","pages":"308-312"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71485291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eosinophilic gastroenteritis - a manifestation of an allergic disease in the gastrointestinal tract? Part 1. Epidemiology and diagnosis. 嗜酸性胃肠炎-胃肠道变态反应性疾病的表现?第1部分。流行病学和诊断。

IF 1.3

Przegla̜d Gastroenterologiczny Pub Date : 2023-01-01 DOI: 10.5114/pg.2022.118634

Andrzej Kuźmiński, Tomasz Rosada, Justyna Przybyszewska, Natalia Ukleja-Sokołowska, Zbigniew Bartuzi

引用次数: 1

Eosinophilic gastroenteritis - a manifestation of an allergic disease in the gastrointestinal tract? Part 2. Treatment. 嗜酸性胃肠炎-胃肠道变态反应性疾病的表现?第2部分。治疗。

IF 1.3

Przegla̜d Gastroenterologiczny Pub Date : 2023-01-01 DOI: 10.5114/pg.2022.118635

Andrzej Kuźmiński, Tomasz Rosada, Justyna Przybyszewska, Natalia Ukleja-Sokołowska, Zbigniew Bartuzi

{"title":"Eosinophilic gastroenteritis - a manifestation of an allergic disease in the gastrointestinal tract? Part 2. Treatment.","authors":"Andrzej Kuźmiński, Tomasz Rosada, Justyna Przybyszewska, Natalia Ukleja-Sokołowska, Zbigniew Bartuzi","doi":"10.5114/pg.2022.118635","DOIUrl":"https://doi.org/10.5114/pg.2022.118635","url":null,"abstract":"Treatment of eosinophilic gastroenteritis (EGE) is mainly empirical and is based on the assessment of symptom severity and the experience of clinicians. Patients with mild disease can be treated symptomatically, while patients with more severe symptoms or malabsorption symptoms require more aggressive therapy. So far, several therapeutic options have been proposed, including the following: dietary treatment, glucocorticosteroids, inhibitors of leukotriene receptors, mast cell stabilizers, immunomodulating drugs, and biological drugs. Unfortunately, there is still a lack of well-designed, prospective. and randomized clinical trials involving large groups of patients with EGE and assessing the effectiveness of individual treatments. More research is needed to compare the efficacy and safety profiles of the various treatments available, and to select the prognostic factors of relapse, which in turn will be extremely important in making decisions about the initial treatment phase and maintenance therapy.","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"18 2","pages":"135-140"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bd/0c/PG-18-47602.PMC10395056.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9935791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of PCSK9 inhibitors on metabolic-associated fatty liver disease: a short review. PCSK9抑制剂对代谢相关脂肪肝疾病的影响:简要综述

IF 1.3

Przegla̜d Gastroenterologiczny Pub Date : 2023-01-01 DOI: 10.5114/pg.2023.126054

Ewelina Jakielska, Paweł Głuszak, Marta Walczak, Wiesław Bryl

引用次数: 0

Evaluation of nutritional status in patients with liver cirrhosis. Validity and prognostic value of the Patient-Generated Subjective Global Assessment. 肝硬化患者营养状况的评估。患者生成的主观整体评估的有效性和预后价值。

IF 1.3

Przegla̜d Gastroenterologiczny Pub Date : 2023-01-01 Epub Date: 2022-10-01 DOI: 10.5114/pg.2022.119964

Nataliia Pentiuk, Vitalii Motsiuk

{"title":"Evaluation of nutritional status in patients with liver cirrhosis. Validity and prognostic value of the Patient-Generated Subjective Global Assessment.","authors":"Nataliia Pentiuk, Vitalii Motsiuk","doi":"10.5114/pg.2022.119964","DOIUrl":"10.5114/pg.2022.119964","url":null,"abstract":"Introduction: Malnutrition is a common condition in liver cirrhosis (LC), which is associated with poor survival. Despite the wide range of tools, there is no agreement on a standard nutritional assessment method applicable to LC.Aim: To determine the validity and prognostic value of the Patient-Generated Subjective Global Assessment (PG-SGA) as a nutritional assessment tool in LC patients.Material and methods: In 2019-2021, 161 patients with LC (aged 55.2 ±11.6 years) were involved, of whom 23, 57, and 81 patients were classified as Class A, B, and C Child-Turcotte-Pugh (CTP), accordingly. Fifty patients died during follow-up (489 (293-639) days). The PG-SGA, Controlling Nutritional Status (CONUT), handgrip strength, and skeletal muscle index (SMI) were used to assess nutritional status.Results: According to the PG-SGA 29.8% of patients were moderately malnourished and 29.8% were severely malnourished. 50.6% of CTP C patients were severely malnourished. Numerical PG-SGA correlated with CTP, Model for End-Stage Liver Disease, CONUT, SMI, and handgrip strength. Low SMI and handgrip strength were present in 87.5% and 66.7% of severely malnourished patients, respectively. PG-SGA predicted mortality (AUC = 0.775, p < 0.001). Severely malnourished patients had significantly lower survival than moderately malnourished and well-nourished patients in the Kaplan-Meier analysis. Hepatic encephalopathy (HR = 2.29, p = 0.046), hypoalbuminemia (HR = 2.27, p = 0.022), and severe malnutrition according to PG-SGA (HR = 2.39, p = 0.016) were independent predictors of mortality in Cox proportional hazards regression analysis.Conclusions: The PG-SGA is a reliable nutritional assessment tool and can predict mortality in LC patients.","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"18 3","pages":"327-333"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71485287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0