Przegla̜d Gastroenterologiczny最新文献

{"title":"Corticosteroid-induced mood changes in systemic autoimmune diseases: a multicentric study.","authors":"Mohammed Mahmoud Hamouda, Mohammed Abdel-Hassib, Hossam Shabana, Feras Almarshad, Omima Sayed Mohammed, Hazem S Ayoub, Himayat Ullah, Hani Ismail Hamed, Sherein M Alnabawy, Mohamed Abdel-Samiee, Safaa Mahmoud Hammouda","doi":"10.5114/pg.2025.156782","DOIUrl":"10.5114/pg.2025.156782","url":null,"abstract":"<p><strong>Introduction: </strong>Major depressive disorder (MD) is a significant mental health issue projected to become the leading contributor to the global burden of disease by 2030. MD substantially increases between teenage years and early adulthood. In addition, 25% of mood disorders manifest by 18 years old and 50% by age 30. Prior research investigated the relationship between the administration of corticosteroids and the onset of depression, revealing notable depressive symptoms and occurrences of depression in individuals undergoing corticosteroid treatment.</p><p><strong>Aim: </strong>We aimed to determine the prevalence of depression following corticosteroid therapy among a cohort of patients who received corticosteroids.</p><p><strong>Material and methods: </strong>This cross-sectional study was carried out at various centers, including Al-Azhar University Hospitals, involving a cohort of 500 cases.</p><p><strong>Results: </strong>The results of the Beck Depression Inventory showed a significant increase across all questionnaire items following corticosteroid therapy. The mean total score was 6.02 ±2.05 before corticosteroid therapy and 11.28 ±7.94 after therapy, showing a significant increase (<i>p</i> < 0.001). None of the participants exhibited depression before corticosteroid therapy, according to the Beck Depression Inventory. Following corticosteroid therapy, 26% of cases experienced depression, with 10% being mild, 6% moderate, 8% severe, and 2% very severe. Significant changes were observed in body mass index, C-reactive protein, glycated hemoglobin, serum total calcium, and systolic blood pressure (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The presence of depression and severity of depression were significantly higher after corticosteroid therapy compared to before therapy.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 4","pages":"424-429"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12746582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145864901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of physical activity and selected relaxation techniques on the quality of life of female patients with irritable bowel syndrome.","authors":"Ewa Szura, Elżbieta Poniewierka","doi":"10.5114/pg.2025.156888","DOIUrl":"10.5114/pg.2025.156888","url":null,"abstract":"<p><strong>Introduction: </strong>The lack of effective pharmacological methods, at a time of great advances in medicine and pharmacotherapy, to alleviate patients' symptoms drives the search for alternative methods of treatment. Patients often experience mental disorders and symptoms of depression. The difficulty in fully alleviating these symptoms has prompted interest in unconventional interventions that involve close collaboration between doctors, psychologists and coaches.</p><p><strong>Aim: </strong>The purpose of this study was to evaluate the effect of physical exercise and selected relaxation techniques on the quality of life (QOL) of patients with irritable bowel syndrome (IBS).</p><p><strong>Material and methods: </strong>Forty-one women diagnosed with IBS were included in the study. To assess the effectiveness of the method used, the validated IBS-QOL questionnaire was used. The study used an original training program. Twenty-nine women completed the entire 2-month training cycle, in line with the assumptions of the study. The analysis of the results was performed using the program Statistica.</p><p><strong>Results: </strong>The questionnaire contained questions grouped into 9 dimensions. The results demonstrated a 12.5% relationship between physical activity and QOL of IBS patients. Of the QOL dimensions analysed, the largest differences were found in the areas of sexuality, health preoccupation, body image, and dysphoria, and the smallest in the activity interference dimension. There was a statistically significant difference between physical activity and QOL in patients diagnosed with IBS.</p><p><strong>Conclusions: </strong>Appropriate physical activity with selected relaxation techniques improved the QOL of the study subjects.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 4","pages":"439-442"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12746581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The patient at the centre of care: reflections from the XXI Congress of the Polish Society of Gastroenterology.","authors":"Wojciech Marlicz, Grażyna Rydzewska","doi":"10.5114/pg.2025.158049","DOIUrl":"https://doi.org/10.5114/pg.2025.158049","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 4","pages":"469-471"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12905478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring new noninvasive parameters to predict oesophageal varices in patients with NAFLD-associated compensated liver cirrhosis.","authors":"Adnan Agha, Andrea Pasta, Francesco Calabrese, Eram Anwar, Mazin Taha, Virgie G Pedo, Ghada S M Al-Bluwi, Edoardo G Giannini","doi":"10.5114/pg.2024.139210","DOIUrl":"10.5114/pg.2024.139210","url":null,"abstract":"<p><strong>Introduction: </strong>Nonalcoholic fatty liver disease is a leading cause of liver cirrhosis and portal hypertension, which can be complicated by oesophageal varices and variceal bleeding. Screening for oesophageal varices is essential for initiating bleeding prophylaxis. Several noninvasive parameters for predicting oesophageal varices have been suggested (e.g., Baveno VI, expanded Baveno VI, and platelet count/spleen diameter ratio), although with variable efficacy in patients with nonalcoholic fatty liver disease.</p><p><strong>Aim: </strong>This study aimed to compare the non-invasive predictors of oesophageal varices.</p><p><strong>Material and methods: </strong>We retrospectively analyzed the medical records of patients with nonalcoholic fatty liver disease-related compensated liver disease who underwent screening endoscopy at a tertiary care unit in United Arab Emirates. The accuracy of the established (Baveno VI and expanded Baveno VI) and newly devised (platelet count)/(spleen diameter) + liver stiffness × (40 - albumin) noninvasive parameters in predicting oesophageal varices and the presence of large oesophageal varices was assessed in our population.</p><p><strong>Results: </strong>We found that the (platelet count)/(spleen diameter) + liver stiffness × (40 - albumin) formula had a higher accuracy than both Baveno VI (<i>p</i> = 0.030) and expanded Baveno VI criteria (<i>p</i> = 0.050) in predicting the presence of oesophageal varices. The (platelet count)/(spleen diameter) + liver stiffness × (40 - albumin) formula was associated with a higher number of spared endoscopies than Baveno VI (<i>n</i> = 16, 21.9%) and expanded Baveno VI (<i>n</i> = 9, 12.3%) criteria.</p><p><strong>Conclusions: </strong>The new formula could provide superior predictive value than the currently practiced noninvasive predictors of oesophageal varices. However, large-scale studies are warranted to confirm its predictive performance in patients with nonalcoholic fatty liver and other etiologies of chronic liver disease.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"48-54"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low blood orexin concentration as a predictor of increased nutritional risk and all-cause mortality after surgery for colorectal cancer.","authors":"Krzysztof Tojek, Damian Czarnecki, Marcin Ziólkowski, Małgorzata Michalska, Ewa Żekanowska, Natalia Mysiak, Łukasz Wołowiec, Jacek Budzyński","doi":"10.5114/pg.2025.148513","DOIUrl":"10.5114/pg.2025.148513","url":null,"abstract":"<p><strong>Introduction: </strong>Orexin regulates food intake, as well as the development and progression of neoplasms.</p><p><strong>Aim: </strong>The aim of this study was to determine associations between nutritional risk and status and neoplasm stage and prognosis in patients who underwent surgery for colorectal cancer (CRC).</p><p><strong>Material and methods: </strong>In 84 consecutive patients undergoing surgery for CRC, serum orexin, nutritional risk and body composition (assessed by bioelectrical impedance analysis and cross-sectional area determined using abdominal CT) were evaluated before the operation and 3 months after the surgery. The long-term follow-up lasted 1296.0 ±617.7 days.</p><p><strong>Results: </strong>Compared to CRC patients with a serum orexin concentration lower than the cutoff value (197.9 pg/ml) determined in ROC curve analysis in prediction of all-cause mortality during long-term follow-up, those with orexin concentrations equal to or higher than the cutoff value were, at baseline and at the 3-month visit, more likely to have a lower score on the nutritional NRS2002 and a higher score on functional scales, greater handgrip strength, and higher skeletal muscle mass, and were less likely to suffer perioperative complications and all-cause mortality (OR = 0.34; 95% CI: 0.13-0.89; <i>p</i> = 0.026) during the follow-up period. No statistically significant differences in tumor size, histopathological grade or clinical stage were found between CRC patient groups divided according to orexin blood concentration.</p><p><strong>Conclusions: </strong>Serum orexin concentrations were found to be statistically significantly associated with patients' nutritional risk and status before surgery and at a 3-month follow-up visit, and with all-cause mortality during the 3.6-year follow-up.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"62-70"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Toll-like receptors in liver regeneration after partial hepatectomy.","authors":"Spyridon Dritsas, Maximos Frountzas, Dimitrios Schizas, Francesk Mulita, Michalis Katsimpoulas, Paraskevas Gkolfakis, Irene Lidoriki, Ioannis Karavokyros, Elias Liolis, Evangelos Missiakos, Theodore Liakakos, Alkistis Kapelouzou","doi":"10.5114/pg.2025.154724","DOIUrl":"10.5114/pg.2025.154724","url":null,"abstract":"<p><strong>Introduction: </strong>Toll-like receptors (TLRs) play a key role in activating the immune system response after liver injury.</p><p><strong>Aim: </strong>This experimental study aimed to investigate the expression of TLRs and their connecting signaling molecules in liver regeneration.</p><p><strong>Material and methods: </strong>Eighty C57BL/6J mice were divided into eight equal groups: four groups underwent partial hepatectomy (liver resection, LR), and four groups underwent an abdominal incision without hepatectomy (sham, Sh). One group of each type was sacrificed at 12 h (LR12 and Sh12), 24 h (LR24 and Sh24), 36 h (LR36 and Sh36), and 168 h (LR168 and Sh168). Histological and immunohistochemical analyses, blood tests, and quantitative real-time polymerase chain reaction (qRT-PCR) were performed.</p><p><strong>Results: </strong>The qRT-PCR tests indicated significant differences in all immune response proteins (TLR1, TLR2, TLR6, IRAK4, TIRAP, NF-kB, MYD88) between all LR and Sh groups. A progressive increase in the expression of TLRs was observed in the first three pairs, with stabilization of their expression in the last group. Histological examination of liver specimens revealed regeneration of liver tissue in the LR groups. Immunohistochemical analysis revealed increased expression of signaling proteins (TLR1, TLR2, MYD88, IRAK4, TIRAP, NF-kB) in the LR groups as compared to the control groups. White blood, red blood cell count and liver function tests were significantly different between LR and Sh groups.</p><p><strong>Conclusions: </strong>TLR expression was significantly higher in mice that underwent partial hepatectomy than the controls. Further research is required to investigate their potential as therapeutic targets in the management of acute or chronic liver failure after partial hepatectomy.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"294-304"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cell therapy for chronic diffuse liver lesions: main symptoms and causes.","authors":"Yedil Kurakbayev, Samat Saparbayev, Botagoz Turdalieva, Mairash Baimuratova, Bauyrzhan Sarsembayev","doi":"10.5114/pg.2025.154589","DOIUrl":"10.5114/pg.2025.154589","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic liver damage is one of the most important and complex problems in modern gastroenterology. The relevance of studying chronic hepatitis of various aetiologies is associated with its high socio-economic and medical significance due to the steady progressive course, with the development of fibrosis, and then cirrhosis of the liver.</p><p><strong>Aim: </strong>The purpose of this study was to search for and analyse new biotechnological methods for the treatment of diffuse liver diseases to improve patient survival, since the main contingent of patients is typically the able-bodied, socially active part of the population.</p><p><strong>Material and methods: </strong>To achieve this goal, general theoretical methods of scientific knowledge were used, such as analysis, generalization, questioning, and systematization.</p><p><strong>Results: </strong>The article presents a meta-analysis of the results of studies conducted in the field of cellular technologies by leading scientists in the field of the treatment of liver diseases. The issues of transdifferentiation, the mechanisms of action of stem cells in hepatology, as well as the possible risks of this therapy (pro-oncogenic effect, increased fibrosis), are covered.</p><p><strong>Conclusions: </strong>Cell therapy in embryonic, mononuclear, and mesenchymal stromal cells is the most advanced area of modern biotechnology and medicine. Its therapeutic application in chronic liver diseases is base on the possibility of regulating disturbed intercellular interactions in the liver, influencing the mechanisms of cell death (necrosis, apoptosis) and fibrogenesis, which makes this method the most relevant and promising in hepatology.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"318-324"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic use reduces the incidence of antibiotic-associated diarrhea among adult patients: a meta-analysis.","authors":"Henry Wanyama, Tayyab S Akhtar, Sameen Abbas","doi":"10.5114/pg.2025.148486","DOIUrl":"10.5114/pg.2025.148486","url":null,"abstract":"<p><strong>Introduction: </strong>Probiotics potentially mitigate diarrhea incidence and severity, but their effectiveness in antibiotic-associated diarrhea (AAD) remains debated.</p><p><strong>Aim: </strong>This meta-analysis aimed to enhance evidence on probiotic use for AAD.Methods: A systematic search of randomized controlled trials (RCTs) from 2010 to 2023 in PubMed, EMBASE, Scopus, and Google Scholar was conducted. Eligible studies underwent risk assessment with the RoB-2 tool and data extraction using the random effects model. Subgroup analyses evaluated age, sample size, and probiotic strains' influence.</p><p><strong>Results: </strong>Fifteen trials with 7427 participants were included. Overall quality was moderate. Pooled analysis favored probiotics, reducing AAD incidence by 40% (RR = 0.60, 95% CI: 0.43-0.82). This effect was consistent across subgroup analyses. Multistrain probiotics showed superior protection (RR = 0.40 vs. 0.9 or 0.6 for dual or single strains).</p><p><strong>Conclusions: </strong>This review suggests that probiotics, especially multistrain combinations, mitigate AAD incidence. Future large-scale RCTs will address heterogeneity.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"5-16"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric hepatic encephalopathy score (PHES) - when, how, why, and why not: a guide for the unfamiliar.","authors":"Nikola Mumdzhiev, Rumen V Tenev, Mariana P Radicheva","doi":"10.5114/pg.2024.145382","DOIUrl":"10.5114/pg.2024.145382","url":null,"abstract":"<p><p>Psychometric hepatic encephalopathy score (PHES) has established itself as one of the most used tests for detecting minimal hepatic encephalopathy. To use it in a certain population one needs to determine what the norms are, and have a proper set of inclusion and especially exclusion criteria. When performing the test (either for validating or as a search tool) authors may benefit from a little guidance. All the 5 tests - DST (Digital Symbol test), Number Connection Test A (NCT A), Number Connection Test B (NCT B), Serial Dotting Test (SDT), Line Drawing Test (LDT) - have certain parameters to follow. In time, deviations have appeared, and comparability between different samples has become somehow limited. As new tests are emerging, and in order to compare, one must be familiar with the tests' variants, benefits, and limitations.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"31-35"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celiac disease and human gut microbiota - how can we study the composition of microorganisms?","authors":"Wiktor Szczuciński, Dominika Salamon, Anna Sopel, Tomasz Gosiewski","doi":"10.5114/pg.2024.139574","DOIUrl":"10.5114/pg.2024.139574","url":null,"abstract":"<p><p>Celiac disease is an autoimmune disorder induced by consumption of gluten protein present in foods such as wheat and rye. In recent years there has been increasing evidence that changes in composition of gut microbiota may play a significant role in the pathogenesis of celiac disease. Multiple methods of bacterial identification may be used to find microbiota changes characteristic for celiac disease, and the latest methods such as next generation sequencing offer new possibilities of detecting previously unknown bacterial groups that may play a role in the occurrence of celiac disease. This review focuses on multiple methods of identifying bacterial gut microbiome and presents results of recent studies exploring the link between gut microbiota composition and celiac disease.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"17-30"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}