Przegla̜d Gastroenterologiczny最新文献

{"title":"Artificial intelligence in liver transplantation: current state, future prospects, and challenges - a narrative review.","authors":"Ivan Romic, Juraj Kolak, Vilena Vrbanovic Mijatovic, Karmen Jericevic, Zvonimir Glazar, Josip Basic, Laura Barta, Davor Mijatovic, Hrvoje Silovski","doi":"10.5114/pg.2026.164961","DOIUrl":"10.5114/pg.2026.164961","url":null,"abstract":"<p><p>The use of artificial intelligence (AI) in liver transplantation (LT) presents new opportunities to improve safety, outcomes, and efficiency of LT. This review explores AI's potential applications, including enhanced donor-recipient matching, predictive analytics for post-transplant outcomes, organ viability assessment, and organisational benefits for surgeons. AI's ability to compile and analyse complex datasets can optimise donor liver utilisation and personalise immunosuppressive therapies. Furthermore, AI-driven systems can improve logistical management and postoperative monitoring, enabling early detection of complications. Implementation of various AI systems in everyday practice could result in higher success rates of LT and better patient care. This narrative minireview highlights current advancements, challenges, and future directions for AI in LT.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 3","pages":"278-283"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines for the management of coeliac disease: recommendations of the Intestinal Diseases Section of the Polish Society of Gastroenterology.","authors":"Magdalena Gawron-Kiszka, Michał Kukla, Katarzyna Maciejewska, Wojciech Marlicz, Andrzej Mróz, Paulina Panufnik, Kinga Skoracka, Joanna Wypych, Rafał Filip, Magdalena Kaniewska, Maria Kłopocka, Iwona Krela-Kaźmierczak, Jarosław Reguła, Grażyna Rydzewska, Anna Szaflarska-Popławska, Renata Talar-Wojnarowska, Edyta Zagórowicz, Małgorzata Zwolińska-Wcisło, Piotr Eder","doi":"10.5114/pg.2026.164973","DOIUrl":"10.5114/pg.2026.164973","url":null,"abstract":"<p><p>These guidelines, developed by the Intestinal Diseases Section of the Polish Society of Gastroenterology, aim to improve and standardise the quality of care for patients with coeliac disease. The recommendations are based on the latest scientific evidence and current guidelines published by other recognised international expert societies. The recommendations were created using a methodology adapted from the GRADE system. The final consensus statements were evaluated by a panel of Polish experts using a Likert scale, with a high degree of consensus (greater than 75%) established as the threshold for acceptance. The document was also reviewed in consultation with representatives of coeliac disease patient advocacy groups. For diagnostic algorithms, testing for anti-tissue transglutaminase IgA antibodies combined with the level of total serum IgA is recommended as the first-line screening tool. Gastroduodenoscopy with duodenal biopsy is advised as the subsequent diagnostic step; however, specific criteria for a non-biopsy approach in selected groups of both paediatric and adult patients were also defined. Strict adherence to a gluten-free diet remains the cornerstone of treatment. Furthermore, the guidelines establish principles for disease monitoring, provide detailed differential diagnosis for other gluten-related disorders, and outline management algorithms for non-responsive and refractory coeliac disease. The recommendations of the Polish Society of Gastroenterology provide structured, practical tools for the diagnosis, differentiation, treatment, and monitoring of coeliac disease, thereby optimising clinical decision-making and emphasising an interdisciplinary model of medical care.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 3","pages":"241-277"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Raoultella planticola</i> as a rare cause of liver abscess.","authors":"Estera Zarębska-Biernat, Piotr Piejko, Rafał Sobański, Aneta Zelek","doi":"10.5114/pg.2025.148475","DOIUrl":"10.5114/pg.2025.148475","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"111-113"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal treatment for long-term survival in ampullary adenocarcinoma metastatic to the liver.","authors":"Jakub Ciesielka, Karolina Majewska, Beata Jabłońska, Małgorzata Domagała-Haduch, Łukasz Liszka, Iwona Gisterek-Grocholska, Sławomir Mrowiec","doi":"10.5114/pg.2025.148485","DOIUrl":"10.5114/pg.2025.148485","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"102-106"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural history and progression risk factors of ulcerative proctitis: a retrospective study from a single tertiary centre in Poland.","authors":"Katarzyna Gaweł, Krzysztof Dąbkowski, Iwona Zawada, Magdalena Szczygłowska, Marta Zykowska, Wojciech Marlicz, Teresa Starzyńska","doi":"10.5114/pg.2024.136231","DOIUrl":"10.5114/pg.2024.136231","url":null,"abstract":"<p><strong>Introduction: </strong>Ulcerative proctitis is a chronic disease, characterized by lower risk of complications and less aggressive treatment in comparison to other forms of ulcerative colitis. Therefore, the key issue is to predict the natural course of the disease and protect against proximal spread of inflammatory lesions in the future.</p><p><strong>Aim: </strong>To identify risk factors for progression of ulcerative proctitis and investigate the natural history of the disease.</p><p><strong>Material and methods: </strong>We performed a retrospective study and included patients with ulcerative proctitis, diagnosed between January 2010 and December 2020, who suffered from ulcerative proctitis for at least 1 year. The collected data were then subjected to statistical analysis.</p><p><strong>Results: </strong>We identified 116 cases of ulcerative proctitis in patients aged between 19 and 84 years. Proximal extension of the disease occurred in 65 (56%) people - left sided colitis developed in 55 (85%) and pancolitis in 10 (15%) patients. We detected many progression risk factors of ulcerative proctitis, among which the most meaningful were Mayo Endoscopic Score at levels 2 and 3 at onset (<i>p</i> < 0.05), high stress level (<i>p</i> < 0.05), more than one exacerbation in the first year of the disease (<i>p</i> < 0.05), and the use of systemic glucocorticosteroids during exacerbations in mild-to-moderate activity of the disease (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>According to our study, early identification of progression risk factors in ulcerative proctitis is crucial for the future outcomes of the disease. The proper treatment at onset is relevant in preventing the progression of inflammatory lesions and the development of disease complications.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 1","pages":"78-83"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative oxidative stress as a biomarker of postoperative complications in colorectal cancer patients.","authors":"Konrad Zaręba, Justyna Dorf, Kerianne M Cummings, Mateusz Maciejczyk, Anna Zalewska, Bogusław Kędra","doi":"10.5114/pg.2025.156811","DOIUrl":"10.5114/pg.2025.156811","url":null,"abstract":"<p><strong>Introduction: </strong>Relationships between redox homeostasis, nutritional status, and postoperative complications in patients with colorectal cancer are still unexplained.</p><p><strong>Aim: </strong>This study aimed to evaluate selected parameters of oxidative stress and nutritional status in colorectal cancer patients and their impact on postoperative complications.</p><p><strong>Material and methods: </strong>The study included 50 patients with colorectal cancer. In all patients, body mass index (BMI), body weight loss, and the Nutritional Risk Screening tool (NRS 2002) were assessed. The levels of total protein and albumin, complete blood count (CBC), total antioxidant capacity (TAC), total oxidant status (TOS), and malondialdehyde (MDA) level were measured. Oxidative stress index (OSI) and the TAC/MDA ratio were calculated.</p><p><strong>Results: </strong>We detected a significantly higher TAC level (<i>p</i> = 0.0017) and lower TOS level in patients with normal BMI compared to those with increased BMI. We observed a higher TAC level in patients without weight loss (<i>p</i> = 0.0407), whereas the MDA concentration was higher in patients with weight loss than in those without weight loss (<i>p</i> = 0.0025). TAC was significantly higher whereas TOS, OSI, and TAC/MDA ratio were significantly lower in patients without symptoms of malnutrition (<i>p</i> < 0.05). Patients without postoperative complications had higher levels of TOS and MDA, and a lower level of TAC (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The occurrence of postoperative complications may be associated with increased oxidative stress in patients with colorectal cancer.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 4","pages":"409-423"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12746570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visceral artery aneurysms as an unusual cause of jaundice.","authors":"Hubert Zatorski, Paulina Jakubowska, Karolina Westrych, Michał Rogozik, Włodzimierz Hendiger, Stefańczyk Ludomir, Ewa Małecka-Wojciesko","doi":"10.5114/pg.2025.156732","DOIUrl":"10.5114/pg.2025.156732","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 4","pages":"457-460"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12746571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145865188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disturbances of autonomic nervous system and gastric activity in response to visceral stimulation in functional dyspepsia patients.","authors":"Magdalena Przybylska-Feluś, Agata Furgała, Katarzyna Ciesielczyk, Krzysztof Gil, Małgorzata Zwolińska-Wcisło","doi":"10.5114/pg.2025.154638","DOIUrl":"10.5114/pg.2025.154638","url":null,"abstract":"<p><strong>Introduction: </strong>Functional dyspepsia (FD) is mainly caused by gastric hypersensitivity and impaired gastric motility.</p><p><strong>Aim: </strong>The aim of the study was to evaluate the effect of a meal on autonomic nervous system (ANS) activity and gastric function in patients with dyspepsia.</p><p><strong>Material and methods: </strong>The study included 38 patients with functional dyspepsia (age: 37.8 ±11.2 years) and 38 healthy volunteers (age: 39.8 ±11.1 years). Simultaneous recordings of electrogastrography (EGG) and electrocardiography (ECG) with heart rate variability (HRV) analysis were performed in the fasting state and after administration of a standard meal.</p><p><strong>Results: </strong>EGG. In fasting dyspepsia group, lower normogastria (51.62 ±19.62 vs. 79.13 ±14.12%; <i>p</i> = 0.004) and average percentage of slow wave coupling (APSWC) (51.11 ±13.25 vs. 69.22 ±14.18%; <i>p</i> = 0.001) were observed compared to the control group. After a meal, in FD patients bradygastria increased from 5.6 ±3.1% to 12.2 ±6.3% (<i>p</i> = 0.01); APSWC increased but did not reach the value of the control group (77.3 ±14.1%); and the increase in the amplitude of slow waves after a meal was smaller (by 49%) than that in the control group (by 215%; <i>p</i> = 0.0001). ANS. Preprandially, the parameters of HRV spectral analysis were significantly lower in FD patients than in the control group (LF; <i>p</i> = 0.03; HF; <i>p</i> = 0.01). Postprandially, FD patients showed an increase in LF (<i>p</i> = 0.001) and HF (<i>p</i> = 0.02) indices, similar to the control group, but the parameters values were lower.</p><p><strong>Conclusions: </strong>The postprandial parasympathetic response was reduced in patients with dyspepsia. The decreased reactivity of the ANS in functional disorders contributes to gastric myoelectric dysfunction as manifested by clinical signs of dyspepsia.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"284-293"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of healthcare staff for the prevention of colon cancer.","authors":"Angelis Peteinaris, Francesk Mulita, Eleni Bekou, Dimitra Lakiotaki, Ira-Eirini Kostopoulou, Elias Liolis, Vasileios Tatanis, Konstantinos Tasios, Levan Tchabashvili, Andreas Antzoulas, Vasiliki Garantzioti, Antonios Koutras, Theodoros Spinos, Marina Mylonopoulou, Konstantinos Bouchagier, Dimitrios Schizas","doi":"10.5114/pg.2025.154592","DOIUrl":"10.5114/pg.2025.154592","url":null,"abstract":"<p><p>Malignancies are one of the most important problems of healthcare systems worldwide. Late diagnosis makes the treatment, therapeutic or not, difficult and constitutes an important obstacle to the orderly functioning of the healthcare systems in terms of financial and human resources. The prevention of certain types of cancer offers the general population, through screening tests, the ability to achieve early diagnosis and treatment. The healthcare workforce constitutes a part of the general population that should be aware of the screening tests and the consequences of cancer. Here, we investigated whether healthcare workers in Greek hospitals are well informed about the screening tests used as gold standards for the prevention of colon cancer. Moreover, we studied whether they screen themselves for the prevention of this type of cancer.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"251-260"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of SARS-CoV-2 infection on the liver function tests: a systematic review and meta-analysis of observational studies.","authors":"Katarzyna Kotfis, Piotr Szredzki, Dominika Maciejewska-Markiewicz, Joanna Sołek-Pastuszka, Hanna Wiśniewska, Luis F Lara, Maria Marlicz, Mariusz Kaczmarczyk, Michał Kukla, Anna Belina, George Koulaouzidis, Marta Syczewska, Karolina Jakubczyk, Natalia Ekstedt, Ewa Stachowska, Magdalena Kaniewska, Grażyna Rydzewska, Igor Łoniewski, Anastasios Koulaouzidis, Wojciech Marlicz, Karolina Skonieczna-Żydecka","doi":"10.5114/pg.2025.148899","DOIUrl":"10.5114/pg.2025.148899","url":null,"abstract":"<p><strong>Introduction: </strong>SARS-CoV-2 infection has been associated with respiratory distress syndrome and hepatic injury. The mechanism of liver injury is not fully understood and may be a combined effect of viral hepatitis, systemic inflammation, gut barrier disruption, microbiome alterations or drug toxicity.</p><p><strong>Aim: </strong>We carried out a systematic review and meta-analysis to determine whether SARS-CoV-2 infection affects the level of liver-produced molecules: alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyl transferase (GGTP), bilirubin, total protein, albumin, and prothrombin (with INR).</p><p><strong>Methods: </strong>Ten authors independently searched PubMed and Embase from their inception until 04/03/2021 for observational studies to evaluate whether SARS CoV-2 infection influences the level of liver-produced molecules. This early search aimed to capture changes associated with the initial variants of SARS-CoV-2 before widespread vaccination efforts. Full-text studies in adult humans in which the aim was liver damage were included. Eligible studies included adult populations with more than 30 subjects, and the analysis adhered to PRISMA guidelines. Data extraction involved a thorough process to ensure accuracy, with inconsistencies resolved by senior clinicians. Statistical analysis was conducted using random effects meta-analysis of outcomes for which ≥ 2 studies contributed data, and the risk of bias was assessed using the New Ottawa Scale. The study protocol was registered in the PROSPERO database (CRD42021242958).</p><p><strong>Results: </strong>The initial search yielded 3180 hits. 2644 studies were excluded as duplicates and/or after evaluation on the title/abstract level. No additional articles were identified via hand search. There were 536 full-text articles reviewed. Overall, the search strategy yielded 252 studies that were included in the meta-analysis.</p><p><strong>Conclusions: </strong>The overall mean liver parameter values were not altered compared to physiological values, except for GGTP, lactate dehydrogenase activity, and INR values. In the case of AST, ALT and albumin levels, mean point estimates were close to limit values of standards. SARS-CoV-2 infection triggers gut barrier defects, which results in transient elevation of liver enzymes and clotting times.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"20 3","pages":"261-271"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}