Przegla̜d Gastroenterologiczny最新文献

{"title":"A case report of a forgotten Christmas gift.","authors":"Francesk Mulita, Michail Vailas, Stylianos Kapiris, Elena Mavrodimitraki, Georgios Kyriakopoulos, Dimitrios Schizas, Maria Sotiropoulou","doi":"10.5114/pg.2024.136324","DOIUrl":"https://doi.org/10.5114/pg.2024.136324","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 1","pages":"99-100"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory bowel diseases during the COVID-19 pandemic.","authors":"Edyta Derda, Edyta Szymańska, Magda Sokolek, Jarosław Kierkuś","doi":"10.5114/pg.2024.143143","DOIUrl":"10.5114/pg.2024.143143","url":null,"abstract":"<p><p>Since the beginning of the COVID-19 pandemic in 2020, the safety of those with compromised immune systems and chronic disease has been of particular concern for health care providers. Inflammatory bowel diseases (IBD) are chronic, incurable conditions of digestive system with unknown aetiology, but one of the causes is disordered immune response. Medical therapies most frequently used in IBD are immune suppressing or modifying with the rising use of biologic treatment. All these aspects make patients with Crohn's disease and ulcerative colitis a group of particular risk. Therefore, the aim of this review is to discuss potential mechanisms, risks, and management of patients with IBD during COVID-19 pandemic.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 3","pages":"231-235"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary hydatid cysts of the left thigh.","authors":"Evgenia Mela, Michail Vailas, Francesk Mulita, Konstantinos Laios, Crysovalantis Vergadis, Maria Sotiropoulou, Dimitrios Schizas","doi":"10.5114/pg.2024.143047","DOIUrl":"10.5114/pg.2024.143047","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 3","pages":"333-336"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Von Meyenburg complexes as an incidental finding in a patient with Crohn's disease.","authors":"Weronika Frąk, Danuta Domżał-Magrowska, Ewa Malecka-Wojciesko","doi":"10.5114/pg.2024.145538","DOIUrl":"10.5114/pg.2024.145538","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"16 4","pages":"454-455"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the expression level of methylated septin 9 gene and serological carcinoembryonic antigen to diagnose colorectal cancer. A meta-analysis study.","authors":"Sharifeh Jorboniyan, Haniyeh Bashi Zadeh Fakhar, Mohammad-Esmaiel Akbari, Neda Izadi, Shaghayegh Rangraz","doi":"10.5114/pg.2024.145381","DOIUrl":"10.5114/pg.2024.145381","url":null,"abstract":"<p><strong>Introduction: </strong>Colorectal cancer (CRC) is a rising threat, necessitating accurate early diagnosis.</p><p><strong>Aim: </strong>This meta-analysis scrutinised methylated septin 9 (SEPT9) and carcinoembryonic antigen (CEA) in CRC.</p><p><strong>Methods: </strong>From January 2012 to December 2022, databases including PubMed and Google Scholar were explored for English publications.</p><p><strong>Results: </strong>The meta-analysis revealed SEPT9's superior diagnostic potential, boasting 71% sensitivity and 91% specificity, outshining CEA (49% and 53%). Notably, an 8-study analysis found a positive correlation between tumour grade and elevated CEA and SEPT9 levels, particularly in stages 3 and 4.</p><p><strong>Conclusions: </strong>This meta-analysis supports SEPT9 as a potent CRC marker, urging its integration into diagnostic frameworks for enhanced precision and early intervention. The observed link between tumour grade and biomarker levels enhances clinical relevance. Implementing these findings promises improved CRC diagnosis precision, contributing to enhanced treatment outcomes and patient survival. Advocating for SEPT9's inclusion alongside traditional markers like CEA, this study pioneers more effective colorectal cancer management strategies.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"16 4","pages":"368-379"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of liver transplantation on intestinal and systemic inflammation markers in patients with colitis ulcerosa concomitant with primary sclerosing cholangitis.","authors":"Artur W Uździcki, Marta Wawrzynowicz-Syczewska","doi":"10.5114/pg.2024.145575","DOIUrl":"10.5114/pg.2024.145575","url":null,"abstract":"<p><strong>Introduction: </strong>Primary sclerosing cholangitis (PSC) is an uncommon, chronic liver disease characterised by fibrosis and strictures of a bile ducts, causing cholestasis. In the long term it can lead to complete stenosis leading in turn to liver cirrhosis. In patients with severe form of the disease, the recommended treatment is liver transplantation. Because PSC frequently coexists with ulcerative colitis (UC), it is crucial to determine the effect of liver transplantation on the course of UC.</p><p><strong>Aim: </strong>The aim was to determine the impact of liver transplantation on intestinal and systemic inflammation markers with UC concomitant with PSC (PSC-UC).</p><p><strong>Material and methods: </strong>Sixty-three patients with PSC-UC were enrolled, 25 of whom underwent liver transplantation (OLTx) due to PSC progression. Clinical symptoms, faecal calprotectin levels, C-reactive protein (CRP) serum concentration, erythrocyte sedimentation rate, and white blood cell count (WBC) were obtained.</p><p><strong>Results: </strong>Faecal calprotectin was significantly higher in the post-OLTx group. Mean calprotectin values were 163% higher - 474 ng/ml and 180 ng/ml (<i>p</i> = 0.024) in the post-OLTx group and in the PSC-UC group without the transplantation, respectively. Calprotectin levels exceeded the upper limit of normal (defined as 200 ng/l) in 66% of liver recipients and in 18% of non-transplanted patients (OR = 9.33, <i>p</i> = 0.011). In the post-OLTx group, also CRP concentration (11.01 mg/l vs. 6.54 mg/l, <i>p</i> = 0.30) and WBC (7.58 K/ml vs. 5.72 K/ml, <i>p</i> = 0.006) were higher than in the PSC-UC group without transplantation.</p><p><strong>Conclusions: </strong>We found significantly higher inflammation markers in PSC-UC patients who underwent liver transplantation due to PSC. The effect was strongest in faecal calprotectin levels. In PSC-UC patients after liver transplantation, intensification of UC treatment may be needed, despite the lack of worsening of clinical symptoms.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"16 4","pages":"439-445"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorectal cancer and microbiota: systematic review.","authors":"Nauryzbay Imanbayev, Yerbolat Iztleuov, Yerbol Bekmukhambetov, Ibrahim A Abdelazim, Ainur Donayeva, Ainur Amanzholkyzy, Zhumasheva Aigul, Imanbayeva Aigerim, Yergaliyev Aslan","doi":"10.5114/pg.2024.136228","DOIUrl":"10.5114/pg.2024.136228","url":null,"abstract":"<p><strong>Introduction: </strong>The gut microbiome maintains the mucus membrane barrier's integrity, and it is modulated by the host's immune system.</p><p><strong>Aim: </strong>To detect the effect of microbiota modulation using probiotics, prebiotics, symbiotics, and natural changes on colorectal cancers (CRCs).</p><p><strong>Methods: </strong>A PubMed search was conducted to retrieve the original and <i>in vivo</i> articles published in English language from 2010 until 2021 containing the following keywords: 1) CRCs, 2) CRCs treatment (i.e. surgical, chemotherapy, radiotherapy and/or immunotherapy), and 3) microbiota probiotic(s), prebiotic(s), symbiotic(s), dysbiosis and/or nutritional treatment. A total of 198 PubMed records/articles were initially identified. 108 articles were excluded at the initial screening, and another 29 articles were excluded after reviewing the abstracts, and finally 61 studies were analysed for this systematic review.</p><p><strong>Results: </strong>The gut microbiota metabolites and (SCFAs) short-chain fatty acids (i.e. acetate and butyrate) have a protective effect against CRCs. SCFAs reduce the inflammatory cytokines, inhibit colonocyte proliferation, and promote malignant cell apoptosis. Butyrate maintains the integrity of the mucus membrane barrier and reduces intestinal mucosal inflammation. Reduced butyric acid level and increased inflammatory cytokines were observed after reduced Bacteroides fragilis and Bacteroides vulgatus species in the colon. Akkermansia muciniphila bacterium decreased in patients with CRCs.</p><p><strong>Conclusions: </strong>Prebiotics (i.e. inulin and resistant starch, SCFAs producers) and consumption of unprocessed plant products are useful for developing and maintaining healthy gut microbiota. The pro-, pre- and/or symbiotics may be useful when carefully selected for CRC patients, to restore beneficial gut microbiota and support treatment efficacy.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"16 4","pages":"380-396"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric polyps: a retrospective cohort analysis of 23,668 endoscopies indicates changing epidemiological and phenotypic characteristics.","authors":"Christina Kapizioni, Panagiotis Kourkoulis, Sofia Kartsoli, Georgios Koutoufaris, Panagiotis Giannelis, Aristotelis Mellos, Konstantia Milioni, George Michalopoulos, Spyridon Vrakas, Vasileios Xourgias","doi":"10.5114/pg.2024.136236","DOIUrl":"https://doi.org/10.5114/pg.2024.136236","url":null,"abstract":"<p><strong>Introduction: </strong>Growing adoption of endoscopic procedures in clinical practice has gradually increase the detection rate of gastric polypoid lesions.</p><p><strong>Aim: </strong>To identify the epidemiologic characteristics of gastric polyps as well as changes of these parameters during a 15-year period.</p><p><strong>Material and methods: </strong>We reviewed all the upper endoscopies archived in our database reporting a polypoid lesion from 2003 to 2018. Demographic data, indication for endoscopy, morphological characteristics of polyps, histology, and presence of <i>Helicobacter pylori</i> were collected. We compared the abovementioned data between 2 periods: 2003-2010 and 2010-2018.</p><p><strong>Results: </strong>A total of 989 (4.2%) patients from 23,668 reviewed were identified to harbour a polypoid lesion. Mean patient age was 63.2 years, with 58.8% being female. Most polyps (65.2%) were less than 5 mm in diameter and located in the fundus. Hyperplastic polyps (HPs) were the predominant type (28.6%) while fundic gland polyps (FGPs) were found in 24.1% of patients. Adenomas were the least common type (2.7%). Other pathology was identified in 43.3%. Comparison between the 2 periods revealed a rise of FGPs against HPs with a concomitant shift of location from antrum to fundus and an increase in the number of polyps per patient.</p><p><strong>Conclusions: </strong>FGPs and HPs were the most common polyps found in our cohort, with a change of their pattern during the 15 years. It is imperative to acknowledge the distinct characteristics of gastric polyps so as to properly assess the malignant potential that some of them, or their surrounding gastric mucosa, harbour.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 1","pages":"54-59"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vonoprazan a novel potassium competitive acid blocker; another leap forward.","authors":"Maha Elsabaawy, Ahmed Shaban, Ahmed Ezz Al-Arab, Osama Elbahr, Ahmed Edrees, Sameh Afify","doi":"10.5114/pg.2024.139426","DOIUrl":"https://doi.org/10.5114/pg.2024.139426","url":null,"abstract":"<p><strong>Introduction: </strong>The eradication rate of <i>Helicobacter pylori</i> (<i>H. pylori</i>) has decreased due to antibiotics resistance and inadequate acid suppression. Vonoprazan is a novel potassium-competitive acid blocker (P-CAB), which has a rapid and sustained acid inhibitory effect and may be more effective than conventional proton pump inhibitors (PPIs) in <i>H. pylori</i> eradication.</p><p><strong>Aim: </strong>to study the efficacy and safety of vonoprazan as a component of first-line <i>H. pylori</i> eradication treatment compared with conventional PPI-based therapy.</p><p><strong>Material and methods: </strong>This randomised (one to one) non-blinded study was conducted on 400 consecutive proven <i>H. pylori</i> infected patients, of whom 200 received vonoprazan-based triple therapy, while 200 patients received PPI-based triple therapy for 14 days. The study outcomes were evaluated as eradication rate and adverse events in both patient groups.</p><p><strong>Results: </strong>The eradication rate was 86% in the vonoprazan group and 74.5% in the PPI group. The vonoprazan eradication rate was significantly higher than that of PPIs (<i>p</i> = 0.004). There was no significant difference regarding adverse events between both patient groups.</p><p><strong>Conclusions: </strong>Vonoprazan-based therapy was more effective than PPI-based therapy as a first-line <i>H. pylori</i> eradication treatment. Vonoprazan was generally safe and well tolerated.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"135-142"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role and therapeutic effectiveness of <i>Plantago ovata</i> seed husk (psyllium husk) in the prevention and non-pharmacological treatment of gastrointestinal diseases. Part 1. Clinical use of psyllium husk in the treatment of irritable bowel syndrome, ulcerative colitis, and colorectal cancer.","authors":"Justyna Przybyszewska, Andrzej Kuźmiński, Michał Przybyszewski, Cezary Popławski","doi":"10.5114/pg.2024.139209","DOIUrl":"https://doi.org/10.5114/pg.2024.139209","url":null,"abstract":"<p><p><i>Plantago ovata</i> is a common medicinal plant widely cultivated in tropical regions of the world. The outer seed coat of <i>P. ovata</i>, obtained by cleaning the seeds, contains soluble and insoluble fibre in a ratio of 7:3, making products containing <i>P. ovata</i> husk an ideal source of health-beneficial fibre. The results of clinical trials demonstrate the therapeutic efficacy of psyllium husk for various gastrointestinal disorders. It has also been documented that psyllium ingestion exhibits antioxidant, immunomodulatory, antiproliferative, anticancer, and antiviral effects. Such pleiotropic effects of <i>P. ovata</i> husk are related to the presence in its composition of arabinoxylan, which forms a gel in an aqueous environment, as well as bioactive compounds and their metabolites. This article presents the evidence available in the literature on the therapeutic potential and possible mechanisms of action of psyllium in the treatment of irritable bowel syndrome and ulcerative colitis, and prevention of colorectal cancer.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"121-126"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}