Przegla̜d Gastroenterologiczny最新文献

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A case report of an idiopathic adult ileocolic intussusception. 特发性成人回结肠肠套叠病例报告。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2024-04-14 DOI: 10.5114/pg.2024.138804
Platon Dimopoulos, Ioanna Akrida, George-Pappas Gogos, Vasileios Leivaditis, Georgios-Ioannis Verras, Konstantinos Tasios, Andreas Antzoulas, Vasiliki Garantzioti, Nikolas Drakos, Francesk Mulita
{"title":"A case report of an idiopathic adult ileocolic intussusception.","authors":"Platon Dimopoulos, Ioanna Akrida, George-Pappas Gogos, Vasileios Leivaditis, Georgios-Ioannis Verras, Konstantinos Tasios, Andreas Antzoulas, Vasiliki Garantzioti, Nikolas Drakos, Francesk Mulita","doi":"10.5114/pg.2024.138804","DOIUrl":"https://doi.org/10.5114/pg.2024.138804","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"217-219"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of biotechnologies in the treatment of haemorrhoidal disease and optimisation of patient management. 应用生物技术治疗痔疮疾病,优化患者管理。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2024-05-13 DOI: 10.5114/pg.2024.139517
Dinara Nuspekova, Aidos Doskaliyev, Auyeskhan Dzhumabekov, Khabibulla Akilov, Aina Dossan
{"title":"Application of biotechnologies in the treatment of haemorrhoidal disease and optimisation of patient management.","authors":"Dinara Nuspekova, Aidos Doskaliyev, Auyeskhan Dzhumabekov, Khabibulla Akilov, Aina Dossan","doi":"10.5114/pg.2024.139517","DOIUrl":"https://doi.org/10.5114/pg.2024.139517","url":null,"abstract":"<p><strong>Introduction: </strong>Haemorrhoidal disease is one of the most common nowadays. It is often associated with a sedentary lifestyle. The leading cause of its development is also a functional disorder of the intestine and chronic constipation. To date, there is a steady growth rate of this disease, leading to its \"rejuvenation\". The current stage of development indicates the need for further improvement of surgical treatment and optimisation of patient management methods and the creation of uniform standards of care for this contingent of patients.</p><p><strong>Aim: </strong>To evaluate the clinical effectiveness of the use of platelet-rich plasma therapy and the biologically active substance \"ozoyl\" in the treatment of haemorrhoidal disease.</p><p><strong>Material and methods: </strong>The main group included 100 patients with chronic haemorrhoids who were operated on in the period from March 2021 to March 2022. For this group, autoplasma was used during surgery, and an ozoyl-based drug in the postoperative period. The remaining 100 participants of this study, assigned to the control group, underwent a conventional haemorrhoidectomy operation and standard patient management using a hydrophilic ointment based on chloramphenicol.</p><p><strong>Results: </strong>After the conducted clinical studies, it was established that in the main group, the pain syndrome decreased by about 30%, considering the period from the first day of the postoperative period compared to the control group. The postoperative wound healed in the main group in the third week after the operation, unlike the control group, in which this event was noted in the fourth week. The patients did not complain during the examination 3 months later.</p><p><strong>Conclusions: </strong>This study is of practical significance because haemorrhoidal disease today has a high prevalence, and an integrated approach is required for the treatment of such patients. Ozoyl is a powerful cell and tissue repairer.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"127-134"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibitory effect of stinging nettle (Urtica dioica L.) extract on body weight gain in rats on a high-fat diet. 荨麻提取物对高脂饮食大鼠体重增加的抑制作用
IF 1.3
Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2023-07-31 DOI: 10.5114/pg.2023.130142
Kenan Kaçak, Turan Yaman, Ahmet Uyar, Ahmet Ufuk Kömüroğlu
{"title":"Inhibitory effect of stinging nettle (<i>Urtica dioica</i> L.) extract on body weight gain in rats on a high-fat diet.","authors":"Kenan Kaçak, Turan Yaman, Ahmet Uyar, Ahmet Ufuk Kömüroğlu","doi":"10.5114/pg.2023.130142","DOIUrl":"10.5114/pg.2023.130142","url":null,"abstract":"<p><strong>Introduction: </strong>The leaves and seeds of <i>Urtica dioica</i> (UD) are used in folk treatments for many diseases. Anticarcinogenic, anti-inflammatory, antioxidant, and antiallergenic properties of UD have been reported.</p><p><strong>Aim: </strong>To uncover the effects of nettle seed (<i>Urtica dioica</i>; UD) extract on body weight gain in rats on a high-fat diet (HFD).</p><p><strong>Material and methods: </strong>Male Wistar albino rats (<i>n</i> = 32) were divided into 4 groups, comprising a control group, a group that received a HFD (HFD group), a group that received UD extracts (UD group), and a group that received a HFD as well as UD extracts (HFD + UD group). UD extracts were given a daily dose of 300 mg/kg of body weight orally for 75 days.</p><p><strong>Results: </strong>The HFD led to weight gain that was partially moderated by the UD extract. Histopathological findings in the HFD + UD group were uniformly significantly lower than those in the HFD group. Serum alanine transaminase, alanine aminotransferase, triglyceride, and low-density lipoprotein levels were significantly higher in the HFD group than in the HFD + UD group, and the HDL levels were lower in the HFD group than in the control group and the HFD + UD group.</p><p><strong>Conclusions: </strong>The cholesterol levels were discovered to be highest in the HFD + UD group. Therefore, it was concluded that the UD extract did not completely protect the rats against body weight gain.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"1 1","pages":"23-32"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ophthalmological manifestations in inflammatory bowel disease under the watchful eye of a gastroenterologist from a tertiary centre. 一家三级医疗中心的消化内科医生观察炎症性肠病的眼科表现。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2024-11-13 DOI: 10.5114/pg.2024.144988
Konrad Lewandowski, Magdalena Kaniewska, Katarzyna Karłowicz, Martyna Więcek, Edyta Tulewicz-Marti, Piotr Celmer, Małgorzata Frankowska, Joanna Sempińska-Szewczyk, Grażyna Rydzewska
{"title":"Ophthalmological manifestations in inflammatory bowel disease under the watchful eye of a gastroenterologist from a tertiary centre.","authors":"Konrad Lewandowski, Magdalena Kaniewska, Katarzyna Karłowicz, Martyna Więcek, Edyta Tulewicz-Marti, Piotr Celmer, Małgorzata Frankowska, Joanna Sempińska-Szewczyk, Grażyna Rydzewska","doi":"10.5114/pg.2024.144988","DOIUrl":"10.5114/pg.2024.144988","url":null,"abstract":"<p><strong>Introduction: </strong>Ophthalmological manifestations (O-EIM) are one of the extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD), although their frequency and potential relationship with disease activity and treatment remain underestimated.</p><p><strong>Aim: </strong>The aim of this screening questionnaire was to assess the number of EIM, including O-EIM, among patients with IBD.</p><p><strong>Material and methods: </strong>436 patients with IBD and 102 patients without IBD were included in this single-centre retrospective study. The questionnaire consisted of questions regarding the frequency of EIM, including confirmed O-EIM and ophthalmological symptoms which had not been confirmed by an ophthalmologist.</p><p><strong>Results: </strong>EIM were present in 48.6% of cases; O-EIM were declared by 8.9% (uveitis 3.9% + episcleritis 4.8% + scleritis 0.2%) of the IBD patients. About half (50.7%) of them reported ophthalmological symptoms in the last 3 months, but only 30.5% reported consulting with an ophthalmologist. The multivariable logistic regression indicated some coexisting EIM (anaemia and axial/non-axial spondyloarthropathy), the use of certain medications (steroids, thiopurines, and methotrexate), smoking, family history of glaucoma, and spending more time in front of a computer screen as being linked with ophthalmological involvement among IBD patients.</p><p><strong>Conclusions: </strong>EIM, including O-EIM, are a common problem in patients with IBD. The presence of ophthalmological symptoms and the lack of follow-up with an ophthalmologist make it difficult to correctly estimate the true number of IBD patients experiencing O-EIM. Therefore, patients with IBD should be routinely referred for ophthalmological evaluation.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"16 4","pages":"397-407"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of periampullary diverticulum on endoscopic retrograde cholangiopancreatography: bridging the gap between fiction and reality. 壶腹周围憩室对内窥镜逆行胆管造影的影响:弥合虚构与现实之间的差距。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2024-09-23 DOI: 10.5114/pg.2024.143148
Sameh Afify, Maha Elsabaawy, Ahmed Ezz Al-Arab, Ahmed Edrees
{"title":"Impact of periampullary diverticulum on endoscopic retrograde cholangiopancreatography: bridging the gap between fiction and reality.","authors":"Sameh Afify, Maha Elsabaawy, Ahmed Ezz Al-Arab, Ahmed Edrees","doi":"10.5114/pg.2024.143148","DOIUrl":"10.5114/pg.2024.143148","url":null,"abstract":"<p><strong>Introduction: </strong>Periampullary diverticulum (PAD) is frequently discovered in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). Studies have yielded conflicting results regarding its impact on the technical success of ERCP and post-ERCP complications.</p><p><strong>Aim: </strong>This study aims to assess the success and safety of ERCP in patients with PAD.</p><p><strong>Material and methods: </strong>This study included 400 patients who underwent ERCP for common bile duct (CBD) stones. Patients were classified into the PAD group (200 patients) and the non-PAD group (200 patients). Within the PAD group, patients were further subclassified into three types based on the location of the papilla. The study compared the two groups in terms of technical success and ERCP complications.</p><p><strong>Results: </strong>The success rate of cannulation using selective techniques, needle-knife precut, or trans-pancreatic sphincterotomy was 88%, 7.5%, and 4.5%, respectively, for the PAD group and 81%, 9.5%, and 9.5%, respectively, for the non-PAD group (<i>p</i> = 0.099). Complete CBD clearance was achieved in 85% of the PAD group and 84% of the non-PAD group (<i>p</i> = 0.782). The rate of post-ERCP complications was similar in both groups (<i>p</i> = 0.371). Periampullary diverticulum type 1 was associated with more challenging cannulation (<i>p</i> < 0.001), a lower rate of complete CBD clearance (<i>p</i> < 0.001), and a higher rate of post-ERCP pancreatitis (<i>p</i> = 0.002) compared to other types.</p><p><strong>Conclusions: </strong>The presence of PAD does not hinder the technical success of ERCP and is not associated with a higher frequency of post-ERCP complications.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"16 4","pages":"446-453"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overweight, obesity, and carbohydrate metabolism disorder in workers of an industrial facility in Kazakhstan: early prevention and its management. 哈萨克斯坦工业设施工人的超重、肥胖和碳水化合物代谢紊乱:早期预防及其管理。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2024-01-18 DOI: 10.5114/pg.2023.134368
Maxim Tszyan
{"title":"Overweight, obesity, and carbohydrate metabolism disorder in workers of an industrial facility in Kazakhstan: early prevention and its management.","authors":"Maxim Tszyan","doi":"10.5114/pg.2023.134368","DOIUrl":"https://doi.org/10.5114/pg.2023.134368","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, the issue of widespread increased body weight in combination with blood glycaemic changes in the able-bodied population of Kazakhstan has become especially acute, which in turn leads to dangerous complications and an increased burden on the country's healthcare structures.</p><p><strong>Aim: </strong>To investigate the effectiveness of early prevention of overweight, obesity, and carbohydrate metabolism disorders in the able-bodied workers at an industrial facility in Kazakhstan.Material and methods: The study was conducted in 2019-2021 using elements of both empirical (observation, comparison, measurement) and theoretical (analysis and synthesis, statistical processing of results with the calculation of the reliability criterion) models of scientific knowledge.</p><p><strong>Results: </strong>The factors that have a correlation with this pathology and the strength of their interaction have been studied. New approaches to primary prevention have been developed, and algorithms have been formulated not only for the early detection of pathologies but also for the most effective and efficient methods of combating the occurrence of such pathologies in the population.</p><p><strong>Conclusions: </strong>To prevent the further spread of the phenomenon of overweight among workers in the industrial sector of Kazakhstan, the following measures are necessary: daily walking (more than 10,000 steps), dosed physical activity in the form of cardio and swimming, and nutrition correction (Mediterranean diet) with alcohol restriction. This prevention significantly reduces body weight and optimizes carbohydrate metabolism.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"143-150"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between perineural infiltrations and delayed gastric emptying after Whipple procedure for periampullary tumours, and the relationship with other clinicopathological factors and overall survival. 胰周肿瘤Whipple术后神经周围浸润与胃排空延迟之间的关系,以及与其他临床病理因素和总生存期的关系。
IF 1.3
Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2023-07-17 DOI: 10.5114/pg.2023.129464
Konstantinos Bouchagier, Francesk Mulita, Georgios-Ioannis Verras, Steffen Nehr, Ioannis Perdikaris, Konstantinos Tasios, Andreas Antzoulas, Angelos Samaras, Serafeim Klimopoulos, Ioannis Maroulis
{"title":"Association between perineural infiltrations and delayed gastric emptying after Whipple procedure for periampullary tumours, and the relationship with other clinicopathological factors and overall survival.","authors":"Konstantinos Bouchagier, Francesk Mulita, Georgios-Ioannis Verras, Steffen Nehr, Ioannis Perdikaris, Konstantinos Tasios, Andreas Antzoulas, Angelos Samaras, Serafeim Klimopoulos, Ioannis Maroulis","doi":"10.5114/pg.2023.129464","DOIUrl":"10.5114/pg.2023.129464","url":null,"abstract":"<p><strong>Introduction: </strong>Pancreaticoduodenectomy is a major procedure. Delayed gastric emptying (DGE) is a frequent postoperative complication that is attributed to several factors.</p><p><strong>Aim: </strong>To investigate the probable association between perineural infiltrations and DGE, and the effects on overall survival.</p><p><strong>Material and methods: </strong>A total of 123 patients who underwent pancreaticoduodenectomy were enrolled in the study. Factors like the presence of perineural infiltrations and post-operative DGE along with age, gender, presence of postoperative fistula, and grade of fistula and postoperative haemorrhage were analysed, and survival analyses were conducted.</p><p><strong>Results: </strong>The presence of perineural infiltrations is statistically associated with DGE occurrence (<i>p</i> = 0.01). Moreover, the occurrence of DGE is statistically associated with male gender (<i>p</i> = 0.001), worse grade of postoperative fistula (<i>p</i> < 0.01), and the presence of postoperative haemorrhage (<i>p</i> = 0.03). There was no statistical association between the presence of perineural infiltrations and the other factors. Cox regression and Kaplan-Meier survival analyses showed that increased overall survival is associated with low age (<i>p</i> = 0.018 and <i>p</i> = 0.028, respectively), absence of perineural infiltrations (<i>p</i> = 0.005 and <i>p</i> = 0.003, respectively), better grade of postoperative fistula (<i>p</i> < 0.001), and absence of postoperative haemorrhage (<i>p</i> < 0.001). Multivariate analysis showed that independent prognostic factors for survival prognosis are perineural infiltrations, age, the presence of postoperative pancreatic fistula, and the presence of postoperative haemorrhage.</p><p><strong>Conclusions: </strong>This is the first study that proves a statistically significant association between the presence of perineural infiltrations and the occurrence of DGE. Moreover, perineural infiltrations are an important independent prognostic factor for overall survival, along with other clinical factors.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"1 1","pages":"89-96"},"PeriodicalIF":1.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70474926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrahepatic aneurysm in a branch of the right hepatic artery in a patient with vasculitis due to systemic lupus erythematosus. 一名系统性红斑狼疮血管炎患者的右肝动脉分支肝内动脉瘤。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2024-03-14 DOI: 10.5114/pg.2024.136247
Zoi Nitsa, Francesk Mulita, Maria Sotiropoulou, Andreas Panagakis, Markos Despotidis, Lysandros Karydakis, Dimitrios Schizas, Michail Vailas
{"title":"Intrahepatic aneurysm in a branch of the right hepatic artery in a patient with vasculitis due to systemic lupus erythematosus.","authors":"Zoi Nitsa, Francesk Mulita, Maria Sotiropoulou, Andreas Panagakis, Markos Despotidis, Lysandros Karydakis, Dimitrios Schizas, Michail Vailas","doi":"10.5114/pg.2024.136247","DOIUrl":"https://doi.org/10.5114/pg.2024.136247","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"214-216"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and efficacy of Single-Pass Albumin Dialysis (SPAD), Prometheus, and Molecular Adsorbent Recycling System (MARS) liver haemodialysis vs. Standard Medical Therapy (SMT): meta-analysis and systematic review. 单程白蛋白透析(SPAD)、普罗米修斯(Prometheus)和分子吸附剂循环系统(MARS)肝脏血液透析与标准医疗疗法(SMT)的安全性和有效性:荟萃分析和系统综述。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2024-04-29 DOI: 10.5114/pg.2024.139297
Eyad Gadour, Mohammed Abdullah Kaballo, Khalid Shrwani, Zeinab Hassan, Ahmed Kotb, Ahmed Aljuraysan, Bogdan Miuţescu, Nouf Sherwani, Waleed Mahallawi
{"title":"Safety and efficacy of Single-Pass Albumin Dialysis (SPAD), Prometheus, and Molecular Adsorbent Recycling System (MARS) liver haemodialysis vs. Standard Medical Therapy (SMT): meta-analysis and systematic review.","authors":"Eyad Gadour, Mohammed Abdullah Kaballo, Khalid Shrwani, Zeinab Hassan, Ahmed Kotb, Ahmed Aljuraysan, Bogdan Miuţescu, Nouf Sherwani, Waleed Mahallawi","doi":"10.5114/pg.2024.139297","DOIUrl":"https://doi.org/10.5114/pg.2024.139297","url":null,"abstract":"<p><strong>Introduction: </strong>Because not all liver dysfunction patients are suitable for transplantations and there is a shortage of grafts, liver support therapies have gained interest. In this regard, extracorporeal albumin dialysis devices such as single-pass albumin dialysis (SPAD), Prometheus, and molecular adsorbent recycling system (MARS) have been valuable in supplementing standard medical therapy (SMT). However, the efficacy and safety of these devices is often questioned.Aim: We performed a systematic review to summarize the efficacy and safety of MARS, SPAD, and Prometheus as supportive treatments for liver dysfunction.</p><p><strong>Material and methods: </strong>PubMed, Medline, Cochrane Library, Web of Science, and Google Scholar electronic databases were extensively searched for all randomized trials published in English. In addition, meta-analytic analyses were performed with Review Manager software, and Cochrane's risk of bias tool embedded in this software was used for bias assessment.</p><p><strong>Results: </strong>Twelve trials including a total of 653 patients were eligible for inclusion. Subgroup analyses of data from these trials revealed that MARS and Prometheus were associated with significant removal of bilirubin (MD = -5.14 mg/dl; 95% CI: -7.26 - -3.02; <i>p</i> < 0.00001 and MD = -8.11 mg/dl; 95% CI: -12.40 - -3.82; <i>p</i> = 0.0002, respectively) but not bile acids and ammonia when compared to SMT. Furthermore, MARS was as effective as Prometheus and SPAD in the reduction of bilirubin (MD = 2.98 mg/dl; 95% CI: -4.26 - 10.22; <i>p</i> = 0.42 and MD = 0.67 mg/dl; 95% CI: -2.22 - 3.56; <i>p</i> = 0.65), bile acids (MD = -17.06 µmol/l; 95% CI: -64.33 - 30.20; <i>p</i> = 0.48 and MD = 16.21 µmol/l; 95% CI: -17.26 - 49.68; <i>p</i> = 0.34), and ammonia (MD = 26 µmol/l; 95% CI: -12.44 - 64.44; <i>p</i> = 0.18). In addition, MARS had a considerable effect in improving hepatic encephalopathy (HE) (RR = 1.54; 95% CI: 1.15-2.05; <i>p</i> = 0.004). However, neither MARS nor Prometheus had a mortality benefit compared to SMTRR (0.86; 95% CI: 0.71-1.03; <i>p</i> = 0.11 and RR = 0.87; 95% CI: 0.66-1.14; <i>p</i> = 0.31, respectively).</p><p><strong>Conclusions: </strong>MARS, SPAD, and Prometheus, as liver support therapies, are equally effective in reducing albumin-bound and water-soluble substances. Moreover, MARS is associated with HE improvement. However, none of the therapies was associated with a significant reduction in mortality or adverse events.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"19 2","pages":"101-111"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of mental and psychological status with disease activity in patients with inflammatory bowel disease using SCL-90 R Questionnaire. 使用 SCL-90 R 问卷调查炎症性肠病患者的精神和心理状况与疾病活动的相关性。
IF 1.7
Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2024-05-13 DOI: 10.5114/pg.2024.139579
Ezzat Ali, Doaa Header, Khaled Abdel Aty, Nada Othman, Moamen Fawzy, Hussein El Amin, Mohamed Elnady
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