{"title":"Identification of ASF1B as a prognostic marker for liver cancer by meta-analysis and its immune value revealed by a comprehensive pan-cancer analysis of 33 human cancersrevealed by a comprehensive pan-cancer analysis of 33 human cancers","authors":"Yiyang Chen, Wanbang Zhou, Yiju Gong, Xi Ou","doi":"10.5114/pg.2023.124423","DOIUrl":"https://doi.org/10.5114/pg.2023.124423","url":null,"abstract":"Introduction As one of the most common malignant tumours, liver cancer is difficult to detect in the early stage, with strong metastasis and poor prognosis. Anti-silencing function protein 1 was originally discovered in yeast as a histone H3-H4 chaperone, and studies have shown that ASF1B may be a target for inhibiting the growth of hepatocellular carcinoma cells. Aim To evaluate the diagnostic and prognostic significance of ASF1B expression in human LIHC on the basis of TCGA data. Material and methods A meta-analysis revealed that high ASF1B expression was strongly associated with better overall survival. A comprehensive pan-cancer analysis of 33 human cancers revealed the immunotherapeutic value of ASF1B. Results In this study, we observed a significant upregulation of ASF1B expression in LIHC samples compared to non-cancer samples. Clinical analysis showed that high expression of ASF1B was associated with age, tumour status, and clinical stage. Survival analysis showed that patients with high ASF1B expression had worse overall survival and progression-free survival than patients with low ASF1B expression. The AUCs of the 1-year, 3-year, and 5-year survival-related ROC curves were 0.672, 0.590, and 0.591, respectively. Conclusions Our study shows that ASF1B may provide new ideas for the diagnosis and prognosis of liver cancer patients, as well as providing a new direction for the application of ASF1B in tumour immunotherapy.","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Héctor Adrián Díaz Hernández, José Elihú Cuevas Castillejos, Godolfino Miranda Zazueta, Adriana Fabiola Romano Munive, Francisco Valdovinos Andraca
{"title":"Characteristics of the endoscopic procedures performed in a hybrid tertiary-level hospital during the first year of the COVID-19 pandemic.","authors":"Héctor Adrián Díaz Hernández, José Elihú Cuevas Castillejos, Godolfino Miranda Zazueta, Adriana Fabiola Romano Munive, Francisco Valdovinos Andraca","doi":"10.5114/pg.2022.118136","DOIUrl":"https://doi.org/10.5114/pg.2022.118136","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic caused many changes in gastrointestinal endoscopy units.</p><p><strong>Aim: </strong>To describe the changes that occurred in a gastrointestinal endoscopy unit of a hybrid hospital during the COVID-19 pandemic.</p><p><strong>Material and methods: </strong>We performed a retrospective study of endoscopies performed in the first year of the COVID-19 pandemic. We collected and described the data of interest to the study, which is presented with numbers and percentages or measures of central tendency and dispersion as appropriate. Fisher's exact test or the χ<sup>2</sup> test were used as appropriate.</p><p><strong>Results: </strong>A total of 507 procedures were performed. There was a 92.5% reduction in the performance of endoscopic procedures. In all, 77 (15%) procedures were performed on patients with COVID-19. The most frequent procedures were esophagogastroduodenoscopy (EGD), colonoscopy, and endoscopic retrograde cholangiopancreatography (ERCP). The main indications were gastrointestinal bleeding, placement of enteral accesses, and alterations in the biliary and pancreatic ducts. Of these, 37 (48%) were therapeutic. Patients with COVID-19 were more susceptible to the development of complications.</p><p><strong>Conclusions: </strong>During the first year of the COVID-19 pandemic, the number of endoscopic procedures performed decreased significantly. The procedures most often required were EGD, colonoscopy, and ERCP, mainly indicated by gastrointestinal bleeding, placement of enteral accesses, and alterations of the bile and pancreatic ducts.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/09/PG-18-47490.PMC10395057.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9935790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of deep learning in diagnosing colorectal cancer.","authors":"Dimitrios Bousis, Georgios-Ioannis Verras, Konstantinos Bouchagier, Andreas Antzoulas, Ioannis Panagiotopoulos, Anastasia Katinioti, Dimitrios Kehagias, Charalampos Kaplanis, Konstantinos Kotis, Christos-Nikolaos Anagnostopoulos, Francesk Mulita","doi":"10.5114/pg.2023.129494","DOIUrl":"10.5114/pg.2023.129494","url":null,"abstract":"<p><p>Colon cancer is a major public health issue, affecting a growing number of individuals worldwide. Proper and early diagnosis of colon cancer is the necessary first step toward effective treatment and/or prevention of future disease relapse. Artificial intelligence and its subtypes, deep learning in particular, tend nowadays to have an expanding role in all fields of medicine, and diagnosing colon cancer is no exception. This report aims to summarize the entire application spectrum of deep learning in all diagnostic tests regarding colon cancer, from endoscopy and histologic examination to medical imaging and screening serologic tests.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Appleby technique: review of the state of the art","authors":"D. Coco, S. Leanza","doi":"10.5114/pg.2023.129502","DOIUrl":"https://doi.org/10.5114/pg.2023.129502","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Causes of death after liver transplantation among patients with solitary hepatocellular carcinoma in the United State, from 2004 to 2015.","authors":"Anas Elgenidy, Ahmed M Afifi","doi":"10.5114/pg.2023.126045","DOIUrl":"https://doi.org/10.5114/pg.2023.126045","url":null,"abstract":"Liver transplantation has gained broad acceptance as a therapeutic modality for hepatocellular carcinoma (HCC), with better overall survival than liver resection [1]. The United Network for Organ Sharing (UNOS) adopted Milan criteria for liver transplantation in patients with HCC (single lesion, diameter ≤ 50 mm, without vascular invasion, and with no metastasis) to improve survival [2]. Yang et al. reported that the median overall survival is 5.75 years after transplantation for patients meeting UNOS criteria [1]. So, even though choosing these criteria is a focal point, there is another important topic, i.e. knowing the causes of death after selecting these criteria. However, the causes of death are unclear. We used Surveillance, Epidemiology, and End Results (seer)*stat software, latest version 8.3.9.2 in our study to access SEER plus data, 18 registries [3, 4]. We identified the solitary HCC diagnosis with the primary site labelled C22.0, specific ICD-O-3 hist/behave (8170/3 – 8175/3) and concerning UNOS criteria (CS extension 2004–2015). We evaluated causes of death (ICD-10 identifications) and calculated the standardized mortality ratio (SMR), which represents the number of observed deaths from a specific cause to the number that would be expected to die over a given period. Therefore, understanding the distribution of different causes of death after liver transplantation among HCC patients is helpful in counselling patients regarding their care and survivorship. We reviewed 1260 US patients with solitary HCC who had undergone liver transplants during the period 2004–2015 (Figure 1). Most patients were aged between 45 and 79 years (1204; 95.6%), were white (1002; 79.5), male (960; 76%), married (805; 63.9%), and with a localized stage (1227; 97.4%). Of the included patients 400 (31.7%) died during this period, with a mean age","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/40/PG-18-50390.PMC10050984.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9595483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Splenic artery embolization for the treatment of pancreatic portal hypertension complicated by gastric variceal haemorrhage.","authors":"Min Ai, DaZhi Gao, GuangMing Lu, Jian Xu","doi":"10.5114/pg.2022.121829","DOIUrl":"https://doi.org/10.5114/pg.2022.121829","url":null,"abstract":"Pancreatic sinistral portal hypertension (PSPH) is caused by splenic venous outflow tract obstruction, and it accounts for 5% of all cases of portal hypertension [1–3]. When the splenic vein is blocked, the splenic collateral circulation opens, including the short gastric veins (SGVs) and left gastroepiploic vein (LGEV) as the 2 main pathways. The SGVs return to the portal vein through the gastric coronary vein and the LGEV flows through the right gastroepiploic vein to the superior mesenteric vein. Continuous high pressure in the SGVs increases pressure in the gastric mucosal veins, which changes venous structure and results in mucosal varices in the gastric fundus [4, 5]. Gastric variceal bleeding (GVB) is a life-threatening complication of PSPH that requires rapid intervention [6]. Traditional splenectomy is considered the preferred treatment for this condition; however, severe inflammation, adhesions","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/05/PG-18-48411.PMC10050974.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9610066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edyta Szymanska, Sylwia Szymanska, Maciej Dadalski, Jaroslaw Kierkus
{"title":"Biological markers of disease activity in inflammatory bowel diseases.","authors":"Edyta Szymanska, Sylwia Szymanska, Maciej Dadalski, Jaroslaw Kierkus","doi":"10.5114/pg.2023.129412","DOIUrl":"https://doi.org/10.5114/pg.2023.129412","url":null,"abstract":"<p><p>Inflammatory bowel diseases (IBD) are chronic intestinal conditions of multifactorial aetiology including genetic susceptibility, immunological impairment, dysbiosis, and environmental factors. The diagnosis is based on both clinical and endoscopic features, wherein histopathological evaluation remains a gold diagnostic standard. However, fast, reliable, and non-invasive biological markers have been used for years for diagnosis as well as for disease activity monitoring. Currently, commonly used faecal calprotectin is the only biomarker approved and recommended by the European Crohn's and Colitis Organization (ECCO). Nonetheless, other biological markers discriminating between functional and organic bowel conditions have been widely studied. Therefore, the aim of this manuscript was to review new potential biomarkers of inflammation in IBD. The aim of this study was to review currently available biomarkers of intestinal inflammation and increased gut permeability in IBD.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/5e/PG-18-51066.PMC10395055.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9929721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Type B aortic dissection atypically presenting as chronic abdominal pain.","authors":"Rafał Filip, Wiesław Guz","doi":"10.5114/pg.2023.129417","DOIUrl":"https://doi.org/10.5114/pg.2023.129417","url":null,"abstract":"1 Department of Gastroenterology with IBD Unit, St. Jadwiga Queen Hospital No. 2 affiliated to the Medical College, University of Rzeszow, Rzeszow, Poland 2Department of Internal Medicine, Medical College, University of Rzeszow, Rzeszow, Poland 3Department of Electroradiology, Medical College, University of Rzeszow, Rzeszow, Poland 4Department of Radiology, St. Jadwiga Queen Hospital No. 2, Rzeszow, Poland","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/52/c1/PG-18-51071.PMC10395067.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9941882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current perspective and review of literature on robotic gastrectomy and oncological outcomes","authors":"D. Coco, S. Leanza","doi":"10.5114/pg.2023.124148","DOIUrl":"https://doi.org/10.5114/pg.2023.124148","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70474707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed Ali El-Nady, M. Wahba, O. Ebada, M. Gabr, K. Essam, Abeer Abdellatef, Mohammed Ewid, Hyam Fathy, Mazen Naga, A. Altonbary
{"title":"Endoscopic management of bleeding ectopic varices: multicentric retrospective case series","authors":"Mohamed Ali El-Nady, M. Wahba, O. Ebada, M. Gabr, K. Essam, Abeer Abdellatef, Mohammed Ewid, Hyam Fathy, Mazen Naga, A. Altonbary","doi":"10.5114/pg.2023.130201","DOIUrl":"https://doi.org/10.5114/pg.2023.130201","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}