Przegla̜d Gastroenterologiczny最新文献

{"title":"Transitional care in pediatric inflammatory bowel disease: current strategies and future directions - a narrative review.","authors":"Pawel Rucinski, Katarzyna Akutko, Tomasz Pytrus","doi":"10.5114/pg.2025.156726","DOIUrl":"10.5114/pg.2025.156726","url":null,"abstract":"<p><p>Approximately 25% of inflammatory bowel disease (IBD) cases are diagnosed in childhood, with distinct characteristics compared to adult-onset disease. Transitioning from pediatric to adult care is a critical phase requiring structured planning. A literature review of PubMed, Scopus, and Web of Science articles from the past 6 years highlights that structured transition programs improve adherence, reduce relapse rates, and lower hospitalizations, yet many centers lack formal protocols. Key barriers include inadequate provider training, poor communication between pediatric and adult teams, and limited resources. Digital health tools and tailored education programs show promise in addressing these gaps, while cultural factors influence transition timing across regions. Standardized, evidence-based transition protocols adapted to local contexts are essential. Future research should focus on digital interventions, long-term outcomes, cost-effectiveness, and enhanced provider training. A multidisciplinary, patient-centered approach is crucial for addressing the complex medical and psychosocial needs of young adults with IBD.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 2","pages":"126-134"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of curcumin in achieving clinical remission and reducing disease activity in ulcerative colitis: a randomised, controlled trial.","authors":"Deldar Morad Abdulah, Azad S Mohammed","doi":"10.5114/pg.2026.165031","DOIUrl":"10.5114/pg.2026.165031","url":null,"abstract":"<p><strong>Introduction: </strong>Ulcerative colitis (UC) is a chronic inflammatory condition affecting the inner lining of the colon. For patients with mild to moderate symptoms who do not improve with optimised mesalamine therapy, corticosteroids or immunomodulators may be necessary, although these options carry a risk of significant side effects.</p><p><strong>Aim: </strong>Our study evaluated the efficacy of curcumin in achieving clinical remission and reducing disease severity in UC patients.</p><p><strong>Material and methods: </strong>In this clinical trial, patients diagnosed with mild-to-moderate UC were randomised into a control group (<i>n</i> = 30) or a curcumin therapy group (<i>n</i> = 30). Both groups received standard treatment, but the experimental group additionally received 2 g of curcumin capsules daily for 2 months. Patients were recruited from the Internal Medicine Unit of Azadi Teaching Hospital in the Kurdistan Region between February 2023 and June 2024.</p><p><strong>Results: </strong>Per-protocol analysis revealed significantly greater improvement in the curcumin therapy group compared to controls (-2.76 vs. -0.87; <i>p</i> = 0.0004). Both groups showed significant reductions in SCCAI scores: the curcumin group improved from 6.29 to 5.13 (<i>p</i> = 0.0075), while the control group improved from 5.13 to 3.65 (<i>p</i> < 0.0001). However, no significant difference in remission rates was observed between the groups.</p><p><strong>Conclusions: </strong>We demonstrated that a two-month curcumin therapy regimen of 2 g daily is ineffective in reducing disease severity in patients with mild-to-moderate UC. However, patients in the curcumin therapy group showed greater improvement compared to the control group.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 3","pages":"357-366"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of gastrojejunostomy on carbohydrate metabolism in patients with pancreatic cancer.","authors":"Oliwia Grząsiak-Kraj, Alicja Majos, Adam Durczyński, Piotr Hogendorf, Nela Hejduk, Janusz Strzelczyk","doi":"10.5114/pg.2026.160484","DOIUrl":"10.5114/pg.2026.160484","url":null,"abstract":"<p><strong>Introduction: </strong>Impaired glucose metabolism and diabetes frequently accompany pancreatic cancer. In patients with unresectable disease, palliative gastrojejunostomy is commonly performed to relieve gastrointestinal obstruction; however, its metabolic consequences remain insufficiently understood.</p><p><strong>Aim: </strong>To assess the effect of gastrojejunostomy on carbohydrate metabolism in patients with unresectable pancreatic cancer and normal body mass index (BMI).</p><p><strong>Material and methods: </strong>About 85% of patients with pancreatic cancer have impaired glucose tolerance or type 2 diabetes, with co-occurrence of the two conditions being complex and multifactorial. Patients with unresectable pancreatic cancer commonly develop signs and symptoms of gastrointestinal obstruction; symptomatic treatment involves performing gastroenterostomy. The study enrolled patients hospitalised due to unresectable pancreatic head tumour who underwent palliative gastrojejunostomy. The study included patients with BMI ranging from 17.5 kg/m² to 24.9 kg/m². Blood plasma insulin and glucose concentrations were assessed before the procedure, on the 1^st and 3^rd day, and 4 weeks after the procedure. Furthermore, HOMA-IR and QUICKI insulin resistance measures were analysed. The control group comprised patients hospitalised due to unresectable pancreatic head tumour who underwent exploratory laparotomy without palliative gastrojejunostomy.</p><p><strong>Results: </strong>The mean BMI of all the analysed individuals was 21.5 ±2.1 kg/m². The mean baseline insulin concentration was 7.6 ±5.3 µU/ml, while the mean baseline glucose concentration was 140.2 ±49.9 mg/dl. Statistically significant decreases in both insulin and glucose concentrations were observed as early as on the 1^st day after the procedure; the values gradually decreased. Four weeks after the operation, the mean insulin and glucose concentrations were 3.1 ±2.2 µU/ml and 91.2 ±23.9 mg/dl, respectively, in the study group. Statistically significantly reduced insulin resistance was observed, expressed by decreased HOMA-IR and increased QUICKI. No statistically significant differences between consecutive measurements were noted in the control group.</p><p><strong>Conclusions: </strong>Gastrojejunostomy performed in patients with unresectable pancreatic head tumour and normal BMI had a significant impact on carbohydrate metabolism. The operation resulted in decreased glucose and insulin concentrations, and reduced insulin resistance. The results suggest a beneficial metabolic effect of gastrojejunostomy performed in patients with normal BMI and pancreatic cancer. No significant changes in glucose and insulin concentrations as compared to baseline values were noted in the control group, which excludes pancreatic cancer as the sole cause of observed changes in carbohydrate metabolism.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 1","pages":"88-96"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13085048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric diseases in patients following colorectal operations: a single-centre retrospective study.","authors":"Francesk Mulita, Irida Pano, Ejona Shaska, Elias Liolis, Andreas Antzoulas, Konstantinos Tasios, George Theofanis, Theodora Skoura, Theodore Voudoukis, Nikolas Drakos, Paraskevi Katsakiori, Antonios Katsantonis, Georgios Korovesis, Dimitrios Schizas, Vasileios Leivaditis","doi":"10.5114/pg.2026.164959","DOIUrl":"10.5114/pg.2026.164959","url":null,"abstract":"<p><strong>Introduction: </strong>Colorectal cancer (CRC) is the second most common cause of cancer-related death globally and the third most common type of cancer.</p><p><strong>Aim: </strong>This study aims to evaluate the prevalence of psychiatric morbidities after colorectal surgical procedures, identify associated risk factors for their development, and determine whether improved access to psychological therapies would benefit this patient population.</p><p><strong>Material and methods: </strong>Between January 2019 and December 2023, 603 patients with a diagnosis of colorectal disease underwent elective colorectal operations in our institution and were considered for this retrospective study. Data were collected from medical and operating theatre records as well as from the hospital-coded database. Patient data were primarily analysed for the incidence of colorectal diseases such as colorectal cancer, diverticulitis, and inflammatory bowel disease. Secondary variables include patient characteristics (age at operation, gender), length of hospital stay, and operative parameters (time and type).</p><p><strong>Results: </strong>During the 5-year study period, a total of 603 records of patients operated on for colorectal disease in our institution were retrieved from the computer database. A total of 499 (83%) colectomies were performed using the open method, and 104 (17%) were performed using the laparoscopic technique. Among patients undergoing colorectal operation in our institution 126 (20.1%) had a psychiatric disorder in the one-year postoperative follow-up. The most common type of mental disorder was mood disorder, which appeared in 26 patients.</p><p><strong>Conclusions: </strong>This retrospective study shows that the technique of colectomy does not appear to affect the incidence of psychiatric disorders. However, our study indicates the need for a prospective randomised controlled trial with a larger number of participants.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 3","pages":"380-384"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Crohn's disease unmasked: from elusive skin clues to diagnosis and treatment - a comprehensive review.","authors":"Raman Nitskovich, Konrad Lewandowski, Grażyna Rydzewska, Irena Walecka","doi":"10.5114/pg.2026.165036","DOIUrl":"10.5114/pg.2026.165036","url":null,"abstract":"<p><p>Metastatic Crohn's disease (MCD) is the rarest yet one of the most disabling cutaneous manifestations of inflammatory bowel disease. Granulomatous lesions frequently mimic infections, autoimmune dermatoses, or drug reactions, causing delayed diagnosis and substantial psychosocial burden. Its true incidence is probably underestimated, as lesions may precede, accompany, or follow intestinal Crohn's disease and often arise in intimate locations. This review synthesises current knowledge on epidemiology, pathogenesis, and clinical-histological features, emphasising emerging mechanisms such as dysregulated Th17/IL-23/TNF-α signalling, NOD2 variants, epitope spreading, and aberrant T-cell homing. We present the 2025 Delphi diagnostic criteria for oral and genital/other MCD and concise differential-diagnosis frameworks. Treatment evidence is summarised from topical and systemic therapies to biologics, IL-23 inhibitors, and JAK blockade. Finally, we introduce DUET-MCD, a 24-month stepwise dermatology - gastroenterology management scheme designed to standardise care and reduce diagnostic delay - prompting the question of how many \"refractory\" dermatoses represent unrecognised MCD.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 3","pages":"284-298"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between severity of depression and quality of life in irritable bowel syndrome.","authors":"Magdalena Kopczyńska, Łukasz Durko, Miłosz Caban, Ewa Małecka-Wojciesko","doi":"10.5114/pg.2026.164965","DOIUrl":"10.5114/pg.2026.164965","url":null,"abstract":"<p><strong>Introduction: </strong>While irritable bowel syndrome (IBS) is not life-threatening for most, it has enormous influence on quality of life (QoL) and mental health.</p><p><strong>Aim: </strong>The aim of this study was to analyse QoL in patients with IBS to identify the domains most affected by IBS.</p><p><strong>Material and methods: </strong>A total of 87 patients and 56 healthy subjects were enrolled consecutively. All participants were asked to complete self-administered questionnaires: the 36-Item Short Form Health survey (SF-36) and the Beck Depression Inventory questionnaire (BDI).</p><p><strong>Results: </strong>Based on the SF-36, there was no difference in QoL between the male and female groups in any of the domains. Statistically significant correlations were found between BDI scores and all domains in the SF-36 form, such as physical functioning, role fulfilment limited by physical health problems, bodily pain, general health, vitality, social functioning, role fulfilment limited by emotional problems, and mental health, as well as between age and physical functioning (<i>r</i> = -0.302, <i>p</i> < 0.05) and physical health (<i>r</i> = -0.295, <i>p</i> < 0.05). Statistically significant negative correlations were also found between the duration of the disorder and general health (<i>r</i> = -0.290, <i>p</i> < 0.05), social functioning (<i>r</i> = -0.257, <i>p</i> < 0.05), and physical health (<i>r</i> = -0.258, <i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>IBS is connected with impaired patient QoL and high prevalence of depression, with a high correlation rate of both parameter scores. IBS symptoms may lead to low QoL in those patients, causing depression traits in some of them.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 3","pages":"319-326"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic cholangioscopy with laser lithotripsy of common bile duct stone using flexible ureteroscope: a case report and literature review.","authors":"Samer Al-Rawashdah","doi":"10.5114/pg.2026.164946","DOIUrl":"10.5114/pg.2026.164946","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 3","pages":"394-398"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rescue therapy with upadacitinib in severe Crohn's disease.","authors":"Miłosz Caban, Adam Fabisiak, Patrycja Dudek, Ewa Małecka-Wojciesko","doi":"10.5114/pg.2026.161902","DOIUrl":"10.5114/pg.2026.161902","url":null,"abstract":"","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 2","pages":"222-227"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irritable bowel syndrome clinical trials: getting the IBS Severity Scoring System responder rate right.","authors":"Henning Sommermeyer, Krzysztof Chmielowiec, Paulina Wojtyła-Buciora, Malgorzata Bernatek, Pawel Olszewski, Zygmunt Kopczynski, Jacek Piatek","doi":"10.5114/pg.2025.156735","DOIUrl":"10.5114/pg.2025.156735","url":null,"abstract":"<p><strong>Introduction: </strong>The Irritable Bowel Syndrome Severity Scoring System (IBS-SSS) is frequently used to characterize treatment effects in IBS patients. Calculation of a responder rate using IBS-SSS data commonly uses a cut-off value of -50 points.</p><p><strong>Aim: </strong>To analyze data from a recently published IBS trial to evaluate whether this cut-off value is appropriate or needs to be revised.</p><p><strong>Material and methods: </strong>Data from 201 patients were used to establish a receiver operating characteristic (ROC) curve for IBS-SSS change data using IBS-Adequate Relief scale data as a binary classifier. The area under the curve (AUC) and its 95% CI for the ROC were determined. Curves plotting accuracy rates and Youden's J index values against changes on the IBS-SSS used as cut-off values were employed to determine an optimal cut-off value.</p><p><strong>Results: </strong>The AUC of the ROC curve was 0.9738 (95% CI from 0.9565 to 0.9912). The curve of accuracy rates had two maxima (-122 and -133 points), while that of the Youden's J index values had only one maximum at -122 points, considered to be the optimal cut-off value.</p><p><strong>Conclusions: </strong>The frequently used -50 points cut-off value might not be optimal for determining clinically meaningful responder rates from IBS-SSS measurements. At least for the IBS-SSS data analyzed in the present study, a change of -122 points appears to be more appropriate. Interpretation of IBS-SSS responder rates from past or future clinical trials should carefully check for the cut-off values applied for their calculation.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 1","pages":"49-54"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13085041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between heart rate variability and inflammatory bowel disease activity: a prospective cohort study.","authors":"Aleksandra Filipiuk, Paweł Krzesiński, Robert Wierzbowski, Beata Uziębło-Życzkowska, Michał Zawistowski, Gonciarz Maciej","doi":"10.5114/pg.2026.165027","DOIUrl":"10.5114/pg.2026.165027","url":null,"abstract":"<p><strong>Introduction: </strong>The autonomic nervous system (ANS), particularly its parasympathetic branch, appears to play a role in the regulation of inflammatory pathways in inflammatory bowel diseases (IBD). Heart rate variability (HRV) is one of the methods used to assess ANS activity.</p><p><strong>Aim: </strong>The aim of the study was to determine whether HRV monitoring can be used to assess the activity of inflammatory bowel diseases (IBD) or predict the response to treatment.</p><p><strong>Material and methods: </strong>We evaluated HRV parameters in 26 patients, 19 with Crohn's disease (CD) and 7 with ulcerative colitis (UC). Holter electrocardiogram (Holter ECG) monitoring was performed three times: first at the time of disease exacerbation and study inclusion, second after achieving clinical improvement, and third during clinical remission.</p><p><strong>Results: </strong>The high-frequency spectrum (HF) parameter averaged 29.392 ±8.524 Hz in disease exacerbation, while in remission it decreased to an average of 25.803 ±5.062 Hz. We also observed an association between the percentage change in root mean square of successive differences (RMSSD) and the proportion of successive NN intervals that differ by more than 50 ms (pNN50) between measurements taken during exacerbation and remission with the time to the next disease exacerbation.</p><p><strong>Conclusions: </strong>It was additionally found that higher baseline standard deviation of the NN interval (SDNN) values associated with a longer period of remission. The limitations of our study preclude the formulation of definitive conclusions. However, HRV assessment and vagus nerve stimulation may still represent promising avenues for future research.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"21 3","pages":"385-390"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}