Inhibitory effect of stinging nettle (Urtica dioica L.) extract on body weight gain in rats on a high-fat diet.

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Przegla̜d Gastroenterologiczny Pub Date : 2024-01-01 Epub Date: 2023-07-31 DOI:10.5114/pg.2023.130142

Kenan Kaçak, Turan Yaman, Ahmet Uyar, Ahmet Ufuk Kömüroğlu

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引用次数: 0

Abstract

Introduction: The leaves and seeds of Urtica dioica (UD) are used in folk treatments for many diseases. Anticarcinogenic, anti-inflammatory, antioxidant, and antiallergenic properties of UD have been reported.

Aim: To uncover the effects of nettle seed (Urtica dioica; UD) extract on body weight gain in rats on a high-fat diet (HFD).

Material and methods: Male Wistar albino rats (n = 32) were divided into 4 groups, comprising a control group, a group that received a HFD (HFD group), a group that received UD extracts (UD group), and a group that received a HFD as well as UD extracts (HFD + UD group). UD extracts were given a daily dose of 300 mg/kg of body weight orally for 75 days.

Results: The HFD led to weight gain that was partially moderated by the UD extract. Histopathological findings in the HFD + UD group were uniformly significantly lower than those in the HFD group. Serum alanine transaminase, alanine aminotransferase, triglyceride, and low-density lipoprotein levels were significantly higher in the HFD group than in the HFD + UD group, and the HDL levels were lower in the HFD group than in the control group and the HFD + UD group.

Conclusions: The cholesterol levels were discovered to be highest in the HFD + UD group. Therefore, it was concluded that the UD extract did not completely protect the rats against body weight gain.

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荨麻提取物对高脂饮食大鼠体重增加的抑制作用

简介：荨麻（Urtica dioica，UD）的叶子和种子在民间被用于治疗多种疾病。目的：揭示荨麻籽（Urtica dioica; UD）提取物对高脂饮食（HFD）大鼠体重增加的影响：雄性 Wistar 白化大鼠（n = 32）分为 4 组，包括对照组、摄入高脂饮食组（HFD 组）、摄入 UD 提取物组（UD 组）以及摄入高脂饮食和 UD 提取物组（HFD + UD 组）。UD提取物的每日口服剂量为300毫克/千克体重，连续75天：结果：高脂饮食导致体重增加，而 UD 提取物在一定程度上减缓了体重增加。HFD+UD组的组织病理学结果均明显低于HFD组。HFD组的血清丙氨酸转氨酶、丙氨酸氨基转移酶、甘油三酯和低密度脂蛋白水平明显高于HFD + UD组，HFD组的高密度脂蛋白水平低于对照组和HFD + UD组：结论：发现高脂低糖+超低脂饮食组的胆固醇水平最高。因此，结论是 UD 提取物并不能完全防止大鼠体重增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Przegla̜d Gastroenterologiczny GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.20

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Gastroenterology Review is a journal published each 2 months, aimed at gastroenterologists and general practitioners. Published under the patronage of Consultant in Gastroenterology and Polish Pancreatic Club.