Psychiatric Quarterly最新文献_第5页

Treatment Preferences in Acute Psychosis: A Comparison of Patient and Staff Perspectives on Symptom Prioritization and Biopsychosocial Interventions. 急性精神病的治疗偏好：患者和医护人员对症状优先级和生物心理社会干预的观点比较。

IF 2.7 4区医学

Psychiatric Quarterly Pub Date : 2025-03-01 Epub Date: 2024-10-29 DOI: 10.1007/s11126-024-10099-2

Rabea Fischer, Steffen Moritz, Jakob Scheunemann, Matthias Nagel, Charlotte Osthues, Daniel Schöttle, Daniel Luedecke

{"title":"Treatment Preferences in Acute Psychosis: A Comparison of Patient and Staff Perspectives on Symptom Prioritization and Biopsychosocial Interventions.","authors":"Rabea Fischer, Steffen Moritz, Jakob Scheunemann, Matthias Nagel, Charlotte Osthues, Daniel Schöttle, Daniel Luedecke","doi":"10.1007/s11126-024-10099-2","DOIUrl":"10.1007/s11126-024-10099-2","url":null,"abstract":"Patients with acute psychosis are often confronted with the prejudice that they refuse all treatment due to lack of insight. This study examined and compared the aims and preferences for treatment of patients with acute psychosis and of psychiatric inpatient staff. A total of 142 inpatients being treated for a psychotic disorder on either a locked or an open ward indicated which of a range of symptoms they want to be treated and which of various biopsychosocial treatment options they would like to receive. Staff members from the same wards reported which psychiatric symptoms they deemed relevant in the treatment of psychosis and which treatment options should be offered. Patients assigned the highest treatment need to neurocognitive symptoms, followed by affective and positive symptoms. In contrast, staff assigned the highest treatment need to positive symptoms, followed by neurocognitive and affective symptoms. Patients and staff on open wards expressed more treatment needs overall than did patients and staff on locked wards. Patients' desire for treatment differed across treatment types. In comparing patients on locked versus open wards, patients on open wards expressed higher approval of medication than patients on locked wards. Even patients with highly acute psychosis being treated on locked psychiatric wards endorsed treatment. Treatment preferences of this group deviated markedly in some instances from staffs' preferences. Considering their specific needs may contribute to increasing patient self-efficacy, and improving adherence to treatment.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"1-16"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Treatment Preferences in Acute Psychosis: A Comparison of Patient and Staff Perspectives on Symptom Prioritization and Biopsychosocial Interventions. 更正：急性精神病的治疗偏好：比较患者和工作人员对症状优先级和生物心理社会干预的看法。

IF 2.7 4区医学

Psychiatric Quarterly Pub Date : 2025-03-01 DOI: 10.1007/s11126-024-10107-5

Rabea Fischer, Steffen Moritz, Jakob Scheunemann, Matthias Nagel, Charlotte Osthues, Daniel Schöttle, Daniel Luedecke

引用次数: 0

The Mediating Role of Difficulties in Emotion Regulation and Earthquake Stress Coping in the Relationship Between Posttraumatic Cognitive Attribution and Posttraumatic Stress Disorder in Türkiye 2023 Earthquake Survivors. 情绪调节困难和地震应激应对在创伤后认知归因与创伤后应激障碍关系中的中介作用[j] [j][23]。

IF 2.7 4区医学

Psychiatric Quarterly Pub Date : 2025-03-01 Epub Date: 2025-01-29 DOI: 10.1007/s11126-025-10118-w

Azmi Çağlar

{"title":"The Mediating Role of Difficulties in Emotion Regulation and Earthquake Stress Coping in the Relationship Between Posttraumatic Cognitive Attribution and Posttraumatic Stress Disorder in Türkiye 2023 Earthquake Survivors.","authors":"Azmi Çağlar","doi":"10.1007/s11126-025-10118-w","DOIUrl":"10.1007/s11126-025-10118-w","url":null,"abstract":"Natural disasters such as earthquakes leave deep psychological effects on individuals that can lead to posttraumatic stress disorder, and understanding these effects is vital to support psychological recovery processes after trauma. In this context, the aim of this study was to examine the mediating role of emotion regulation difficulties, religious coping, positive reappraisal and seeking social support in the relationship between posttraumatic cognitive attributions and posttraumatic stress disorder in 2023 Kahramanmaraş Pazarcık, Elbistan and Hatay Yayladağı earthquake survivors (N = 408). The findings from the multiple mediation analysis showed the indirect effect of posttraumatic cognitive attribution on PTSD through difficulties in emotion regulation, religious coping, positive reappraisal, and seeking social support. Therefore, difficulties in emotion regulation may be a risk factor for PTSD, while religious coping, positive reappraisal and seeking social support may be protective factors. Strategies to reduce difficulties in emotion regulation and to improve religious coping, positive reappraisal and social support seeking in earthquake survivors may be necessary to reduce PTSD that may be caused by the earthquake.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"201-212"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychometric Properties and Network Analysis of the Arabic Version of Reinforcement Sensitivity Theory of Personality Scale-Short Version in Patients with Anxiety Disorders. 焦虑障碍患者强化敏感性人格量表阿拉伯版-短版的心理测量特征及网络分析。

IF 2.7 4区医学

Psychiatric Quarterly Pub Date : 2025-03-01 Epub Date: 2025-01-17 DOI: 10.1007/s11126-024-10109-3

Rasha Mohamed Abdelrahman, Abdulnaser Fakhrou, Mahmoud Ali Moussa, Mohaddeseh Roshan

{"title":"Psychometric Properties and Network Analysis of the Arabic Version of Reinforcement Sensitivity Theory of Personality Scale-Short Version in Patients with Anxiety Disorders.","authors":"Rasha Mohamed Abdelrahman, Abdulnaser Fakhrou, Mahmoud Ali Moussa, Mohaddeseh Roshan","doi":"10.1007/s11126-024-10109-3","DOIUrl":"10.1007/s11126-024-10109-3","url":null,"abstract":"This study aimed to examine the psychometric properties of the Arabic version of a short version of the Reinforcement Sensitivity Theory of Personality Questionnaire (RST-PQ-S) among a sample of 700 patients with anxiety disorders (53.1% were female). Participants completed the RST-PQ-S, NEO-FFI, Positive Mental Health (PMH), and Kessler Psychological Distress scale. Both Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were employed to test the construct validity of the scale. This study also utilized a network perspective, incorporating Exploratory Graph Analysis (EGA) and centrality measures. As a result of the EFA and CFA, it was determined that the scale consists of 22 items and six subdimensions. These subdimensions were named as follows: \"Flight Fight-Freeze System\", \"Behavioral Inhibition System\", \"Reward Interest\", \"Reward Reactivity\", \"Goal-Drive Persistence\", and \"Impulsivity\". Additionally, the network analysis's findings confirmed the six-factor structure derived from the construct validity assessment. The results of this study demonstrated that the Arabic version of the personality scale is a valid and reliable tool for assessing personality in Arabic-speaking individuals with anxiety disorders. It has the potential to serve as an important diagnostic instrument in clinical and research settings. These findings may assist psychologists and clinicians in Arabic-speaking countries to better understand how the personality traits and anxiety disorders are related.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"145-167"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barriers to Treatment of Mental Disorders in Saudi Arabia. 沙特阿拉伯精神障碍治疗的障碍。

IF 2.7 4区医学

Psychiatric Quarterly Pub Date : 2025-03-01 Epub Date: 2024-11-30 DOI: 10.1007/s11126-024-10104-8

Sumayah Aljhani, Sultan Aldughayim, Ziyad Alsweed, Sulaiman Alherbish, Faris Alhumaid, Rayan Alismail, Saleh Alkhalaf, Ibrahim AlBahouth

{"title":"Barriers to Treatment of Mental Disorders in Saudi Arabia.","authors":"Sumayah Aljhani, Sultan Aldughayim, Ziyad Alsweed, Sulaiman Alherbish, Faris Alhumaid, Rayan Alismail, Saleh Alkhalaf, Ibrahim AlBahouth","doi":"10.1007/s11126-024-10104-8","DOIUrl":"10.1007/s11126-024-10104-8","url":null,"abstract":"Mental disorders are a global health issue affecting millions of individuals. People with mental disorders often face barriers to treatment, including stigma and discrimination, social, religious, and familial barriers, and a lack of knowledge about available treatment options. These barriers can lead to delayed or untreated mental illnesses, with serious consequences for the individuals, their families, and communities. This cross-sectional study explores the treatment barriers for different mental disorders as they significantly impact people's lives. It includes patients diagnosed with mental disorders. The data were collected from the patients or their companions attending Qassim Mental Health Hospital's outpatient clinic. We used a self-administered online questionnaire, sociodemographic variables, and the barrier to access to care evaluation (BACE) scale. Our sample included 332 adult patients with mental disorders (men, 63.9%; women, 36.1%). The mean percentage scores for stigma-, attitude-, and instrument-related barriers were 26.7%, 33.0%, and 18.7%, respectively. Younger age was associated with higher scores in all three BACE domains. Patients with psychotic disorders faced stigma- and attitude-related barriers, but not instrument-related barriers. Patients with multiple mental conditions faced increased stigma- and instrument-related barriers but not attitude-related barriers. Further longitudinal studies are required to better understand these barriers to help patients with mental conditions.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"75-89"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Changes in Usage of Mental Health Services for Rhode Island Children and Youth Before, During, and After Onset of the COVID-19 Pandemic. 在COVID-19大流行发生之前、期间和之后，罗德岛州儿童和青少年心理健康服务使用的患病率和变化

IF 2.7 4区医学

Psychiatric Quarterly Pub Date : 2025-03-01 Epub Date: 2024-12-04 DOI: 10.1007/s11126-024-10103-9

Sharon Zanti, Chenyi Ma

{"title":"Prevalence and Changes in Usage of Mental Health Services for Rhode Island Children and Youth Before, During, and After Onset of the COVID-19 Pandemic.","authors":"Sharon Zanti, Chenyi Ma","doi":"10.1007/s11126-024-10103-9","DOIUrl":"10.1007/s11126-024-10103-9","url":null,"abstract":"This study reports the prevalence of inpatient, emergency department (ED), and outpatient mental health service usage of children/youth before, during, and after onset of the COVID-19 pandemic in Rhode Island. Additionally, we identify significant changes in usage across these time periods and the prevalence of each service type contingent upon various demographic profiles. This retrospective observational analysis used Rhode Island Medicaid claims to identify the unique children and youth who used inpatient, ED, and outpatient mental health services across three key time periods: pre-onset (March 2019-February 2020); onset (March 2020-February 2021); and post-onset (March 2021-February 2022). We used z-tests to analyze changes in the proportion of children/youth who accessed these services in each period. We examined relationships between demographic characteristics and time period with chi-square tests. Significant decreases in inpatient and ED usage were identified from pre-onset to onset (p < .05). While inpatient nearly returned to pre-pandemic usage in post-onset, ED usage remained lower. Outpatient usage increased significantly leading up to the pandemic but remained at similar levels between pre-onset and post-onset. From pre-onset to post-onset, females grew as a percentage of all inpatient, ED, and outpatient users. Over this same period, the proportion of inpatient users aged 12-18 increased and the proportion of ED and outpatient users aged 19-24 increased. Female usage of mental health services increased significantly, and older children/youth seemed to drive any significant increases. Future public health and disaster preparedness policies should focus on the unique mental health needs of these socially vulnerable groups.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"91-116"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network Analysis of Internalizing and Externalizing Symptoms in Arab Gifted Children: A Cross-Sectional Study. 阿拉伯资优儿童内化和外化症状的网络分析：横断面研究

IF 2.7 4区医学

Psychiatric Quarterly Pub Date : 2025-03-01 Epub Date: 2025-01-14 DOI: 10.1007/s11126-025-10112-2

Ayoub Hamdan Al-Rousan, Mohammad Nayef Ayasrah, Mohamad Ahmad Saleem Khasawneh

{"title":"Network Analysis of Internalizing and Externalizing Symptoms in Arab Gifted Children: A Cross-Sectional Study.","authors":"Ayoub Hamdan Al-Rousan, Mohammad Nayef Ayasrah, Mohamad Ahmad Saleem Khasawneh","doi":"10.1007/s11126-025-10112-2","DOIUrl":"10.1007/s11126-025-10112-2","url":null,"abstract":"The current paper aimed to estimate the network structure of general psychopathology (internalizing and externalizing symptoms/disorders) among 239 gifted children in Jordan. This cross-sectional study with a convenience sampling method was conducted between September 2023 and October 2024 among gifted children aged 7-12. The Child Behavior Checklist (CBCL) was employed to assess six symptom clusters: conduct problems, attention-deficit/hyperactivity disorder (ADHD), and oppositional defiant problems as externalizing symptoms, and affective problems, anxiety issues, and somatic complaints as internalizing symptoms. We used the network analysis perspective by graphical least absolute shrinkage and selection operator (gLASSO) and the Extended Bayesian Information Criterion (EBIC). These methods were used to determine network structure and important nodes in the estimated network. \"Sleeps less\" (centrality strength = 2.04, edge weight = 0.33) was the central symptom in the affective cluster. In contrast, \"worries\" (centrality strength = 1.89, edge weight = 0.28) and \"headaches\" (centrality strength = 2.35, edge weight = 0.41) were pivotal in the anxiety and somatic clusters, respectively. The findings suggested that these symptoms had critical roles in the context of the general psychopathology among gifted children. Accordingly, the mentioned symptoms should be assessed and targeted among gifted children. Future studies could evaluate the results of targeting these symptoms on gifted children's well-being and daily functions.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"117-132"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Exploratory Study about Factors and Outcomes Associated with the Experience of Coercive Measures in Mental Health Settings. 精神卫生机构强制措施经历相关因素和结果的探索性研究。

IF 2.7 4区医学

Psychiatric Quarterly Pub Date : 2025-03-01 Epub Date: 2025-01-16 DOI: 10.1007/s11126-024-10110-w

Jesús Herrera-Imbroda, Vera Carbonel-Aranda, Yaiza García-Illanes, Carlos Aguilera-Serrano, Antonio Bordallo-Aragón, Edgar García-Spínola, Daniel Torres-Campos, José María Villagrán, Juan Antonio García-Sanchez, Fermín Mayoral-Cleries, José Guzmán-Parra

{"title":"An Exploratory Study about Factors and Outcomes Associated with the Experience of Coercive Measures in Mental Health Settings.","authors":"Jesús Herrera-Imbroda, Vera Carbonel-Aranda, Yaiza García-Illanes, Carlos Aguilera-Serrano, Antonio Bordallo-Aragón, Edgar García-Spínola, Daniel Torres-Campos, José María Villagrán, Juan Antonio García-Sanchez, Fermín Mayoral-Cleries, José Guzmán-Parra","doi":"10.1007/s11126-024-10110-w","DOIUrl":"10.1007/s11126-024-10110-w","url":null,"abstract":"Coercive measures are commonly used in mental health settings despite their negative effects. The subjective experience of coercion varies widely, and its short- and long-term health impacts are not well understood. This study aimed to analyze the association between different types of coercive measures experienced during psychiatric hospitalization, the subjective experience of coercion, and both short- and long-term health outcomes. The study included 111 patients from two mental health units who experienced coercive measures (mechanical restraint, involuntary medication, or both). Perceived coercion was assessed during hospitalization. Short-term outcomes (post-traumatic stress and treatment satisfaction) were evaluated before discharge, while long-term outcomes (functionality improvement, risk of readmission, and suicidal behavior) were assessed at five-year follow-up. Perceived coercion was associated with higher post-traumatic stress (p < 0.001) and lower satisfaction with treatment (p < 0.001) in the short term. In the long term, perceived coercion showed no association with functionality, readmission risk, or suicidal behavior. However, combined coercive measures were linked to lower functionality improvement (p = 0.028) and higher readmission risk (p = 0.028) compared to involuntary medication alone. The findings suggest that efforts to reduce negative subjective experiences associated with coercive measures may improve patient satisfaction and reduce trauma risk during hospitalization. Combined coercive measures may be a risk factor for poorer long-term outcomes and should be carefully considered.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"133-144"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conscientiousness, Public Service Motivation, Resilience, and Work Engagement among Volunteers in Lebanon. 黎巴嫩志愿者的责任心、公共服务动机、弹性和工作投入。

IF 2.7 4区医学

Psychiatric Quarterly Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1007/s11126-025-10115-z

Hussein Mreydem, Issa Kamal Eddine, Moussa Hojeij, Han Sung Lee, Pascale Salameh, Seockhoon Chung

{"title":"Conscientiousness, Public Service Motivation, Resilience, and Work Engagement among Volunteers in Lebanon.","authors":"Hussein Mreydem, Issa Kamal Eddine, Moussa Hojeij, Han Sung Lee, Pascale Salameh, Seockhoon Chung","doi":"10.1007/s11126-025-10115-z","DOIUrl":"10.1007/s11126-025-10115-z","url":null,"abstract":"We conducted a descriptive-analytical cross-sectional study using an online survey to explore the personality traits of volunteers in Lebanon and examine their relationship with work engagement, psychological status, resilience, and public service motivation. A total of 270 volunteers were recruited through social media platforms. The survey included general questions about volunteering, Utrecht Work Engagement Scale-9 items (UWES-9), the Big Five Personality Inventory-10 (BFPI-10), the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Public Service Motivation (PSM), and the Connor-Davidson Resilience Scale-2 (CD-RISC2). The results revealed that agreeableness and conscientiousness levels were significantly lower among volunteers with low work engagement compared to those with high work engagement. Work engagement was positively correlated with agreeableness and conscientiousness and negatively correlated with neuroticism. Logistic regression showed that being single with a low level of conscientiousness, public service motivation, and resilience predicted low work engagement. Mediation analysis showed that conscientiousness, public service motivation, and resilience directly influenced work engagement, and depression mediated the relationship of conscientiousness and resilience with work engagement. This study highlights the importance of personality traits, mental health, and motivation in understanding work engagement among volunteers, which can help in designing strategies to enhance volunteers' experiences, well-being, and productivity.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"227-240"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are S100B and VILIP-1 Involved in a Common Mechanism of Neuroinflammation in Major Depressive Disorder? S100B 和 VILIP-1 是否参与了重度抑郁症神经炎症的共同机制？

IF 2.7 4区医学

Psychiatric Quarterly Pub Date : 2025-03-01 Epub Date: 2024-11-08 DOI: 10.1007/s11126-024-10102-w

Nagihan Ayaz Naycı, Aybeniz Civan Kahve, Hasan Kaya, Andaç Uzdoğan, Yağmur Darben Azarsız, Süreyya Barun, Erol Göka

{"title":"Are S100B and VILIP-1 Involved in a Common Mechanism of Neuroinflammation in Major Depressive Disorder?","authors":"Nagihan Ayaz Naycı, Aybeniz Civan Kahve, Hasan Kaya, Andaç Uzdoğan, Yağmur Darben Azarsız, Süreyya Barun, Erol Göka","doi":"10.1007/s11126-024-10102-w","DOIUrl":"10.1007/s11126-024-10102-w","url":null,"abstract":"This study aimed to evaluate the role of neuroinflammation in neuronal and glial cells in the pathophysiology of Major Depressive Disorder (MDD) through different biomarkers.S100-B and VILIP-1 levels of patients diagnosed with MDD were evaluated before and after antidepressant treatment. A total of 65 patients diagnosed with MDD and 69 healthy controls were included. Serum levels of S100B and VILIP-1 were measured at the time of diagnosis and after eight weeks antidepressant treatment and compared with healthy controls. Hamilton Depression Rating Scale (HDRS) and the Clinical Global Impression Scale (CGI) were applied to assess the severity of depression. In our study, although serum S100B levels were higher in patients before treatment compared to healthy controls, this difference was not statistically significant. Regarding VILIP-1 levels, there was no statistically significant difference between patients and healthy controls. A positive and statistically significant correlation was found between S100B and VILIP-1 levels in MDD group before the treatment. At the eighth week of treatment, a statistically significant positive correlation was also found between S100B and VILIP-1 levels. Our research is the first study to evaluate MDD through two separate biomarkers specific to glial and neuronal cells.The fact that S100B and VILIP-1 levels showed significant correlations in patients diagnosed with MDD both before and after treatment suggests that they may play a shared role in the pathophysiology of the disorder. The correlation between S100B and VILIP-1 may serve as a guide in understanding the pathophysiology of the disorder and in identifying new drug development targets.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"19-37"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0