Psychiatric Quarterly最新文献

Protective Role of Regular Physical Activity on Mental Health During the COVID-19 Pandemic. COVID-19大流行期间规律身体活动对心理健康的保护作用

IF 2.9 4区医学

Psychiatric Quarterly Pub Date : 2026-03-01 Epub Date: 2025-05-13 DOI: 10.1007/s11126-025-10148-4

Vitor Rabelo de Sá, Fernando Eduardo Padovan-Neto

{"title":"Protective Role of Regular Physical Activity on Mental Health During the COVID-19 Pandemic.","authors":"Vitor Rabelo de Sá, Fernando Eduardo Padovan-Neto","doi":"10.1007/s11126-025-10148-4","DOIUrl":"10.1007/s11126-025-10148-4","url":null,"abstract":"Understanding the impacts of lifestyle on mental health has become crucial. This study analyzed whether regular physical activity influences mental health indicators related to major depressive disorder, generalized anxiety, and COVID-19-related anxiety and obsession among Brazilian adults during the pandemic. Additionally, social adjustment and health and disability were assessed to measure broader impacts of physical activity on daily functioning and quality of life during the COVID-19 pandemic, an anxiogenic period. Participants completed sociodemographic, physical activity, and clinical surveys, along with standardized mental health scales: the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), the Brazilian version of the Coronavirus Anxiety Scale (CAS-BR), the COVID-19 Obsession Scale (PB-OCS), the Work and Social Adjustment Scale (WSAS), and the WHO Disability Assessment Schedule (WHODAS 2.0). Descriptive analysis characterized the sample, while univariate, bivariate, and multivariate analyses of variance were conducted to explore the influence of physical activity and sex on mental health outcomes. The results indicated that women exhibited poorer mental health outcomes than men across most measures. Engaging in regular physical activity significantly reduced the risk of major depressive disorder in both women and men. Additionally, physically active women-but not men-had a lower likelihood of generalized anxiety and social adjustment impairments. Furthermore, individuals with longer engagement in physical activity (> 5 years) experienced greater mental health benefits compared to those with shorter engagement (< 5 years), particularly for depressive symptoms and generalized anxiety. This study highlights the protective effects of regular physical activity on mental health, with sex-specific differences in its impact. Long-term engagement in physical activity provides greater mental health benefits, reinforcing the importance of promoting sustained participation rather than short-term engagement.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"105-123"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative Life Events and Negative Emotions among Chinese College Students: The Chain Mediating Roles of Social Phobia and Insomnia. 中国大学生负性生活事件与负性情绪：社交恐惧症与失眠的连锁中介作用

IF 2.9 4区医学

Psychiatric Quarterly Pub Date : 2026-03-01 Epub Date: 2025-05-08 DOI: 10.1007/s11126-025-10155-5

Mingjie Xuan, Xianmiao Cao, Yu Liu, Tongyan Deng, Shuqin Li, Yuhui Wan

{"title":"Negative Life Events and Negative Emotions among Chinese College Students: The Chain Mediating Roles of Social Phobia and Insomnia.","authors":"Mingjie Xuan, Xianmiao Cao, Yu Liu, Tongyan Deng, Shuqin Li, Yuhui Wan","doi":"10.1007/s11126-025-10155-5","DOIUrl":"10.1007/s11126-025-10155-5","url":null,"abstract":"Negative life events have been associated with the development of negative emotions, few studies have examined the chain mediating effect between negative life events and negative emotions among college students. The purpose of this study was to explore the relationship between negative life events and negative emotions in college students, as well as the chain mediating roles of social phobia and insomnia. A total of 8050 college students in three colleges in Anhui Province were selected through stratified cluster sampling method. Baseline data were collected in 2021 and followed up 6 months later. Spearman correlation analysis was used to analyze the relationship between the two. Bootstrapping procedure was used to test for mediating effects. Spearman correlation analysis showed that negative life events were significantly positively correlated with social phobia, insomnia, stress, depression and anxiety (r = 0.388, 0.319, 0.448, 0.449, 0.441). Among college students, the mediating effects of social phobia between negative life events and stress, depression, anxiety were 35.36%, 36.81%, and 37.27%, respectively. Meanwhile, the mediating effects of insomnia between negative life events and stress, depression, anxiety were 10.50%, 9.82% and 9.94%, respectively. The chain mediating effects of social phobia and insomnia between negative life events and stress, depression, anxiety were 3.31%, 3.07%, and 3.11%, in college students, respectively. These results indicate that negative life events can indirectly predict negative emotions, not only through the single mediating effect of social phobia and insomnia but also through the chain mediating effect of social phobia and insomnia.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"91-103"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Trauma-based Intrusive Memory Characteristics Associated with Repetitive Transcranial Magnetic Stimulation (rTMS) for Depression: A Daily Diary Study. 重复性经颅磁刺激（rTMS）对抑郁症创伤性侵入性记忆特征的改变：一项每日日记研究。

IF 2.9 4区医学

Psychiatric Quarterly Pub Date : 2026-03-01 Epub Date: 2025-05-06 DOI: 10.1007/s11126-025-10156-4

Amalia Badawi, Zachary Steel, Kris Rogers, Nalin Wijesinghe, David Berle

{"title":"Changes in Trauma-based Intrusive Memory Characteristics Associated with Repetitive Transcranial Magnetic Stimulation (rTMS) for Depression: A Daily Diary Study.","authors":"Amalia Badawi, Zachary Steel, Kris Rogers, Nalin Wijesinghe, David Berle","doi":"10.1007/s11126-025-10156-4","DOIUrl":"10.1007/s11126-025-10156-4","url":null,"abstract":"The present study investigated whether repetitive transcranial magnetic stimulation (rTMS) for depression reduced trauma-based intrusive memory frequency and associated pathological characteristics such as intensity and distress. Traumatic stress symptoms and general psychopathology outcomes were also investigated. Inpatients at a psychiatric hospital (N = 25) referred for 20-sessions of rTMS for depression completed daily ratings of trauma-related intrusive memory frequency and characteristics. Linear mixed models and repeated measures t-tests were used to analyze the course of change for intrusive memories. Effect sizes and reliable change were also analyzed. Non-linear decreases for intrusive memory frequency and associated characteristics were reported over the course of treatment, with the changes from Days 0 to 7 being sustained at Day 20. Large effect sizes were reported for measures of traumatic stress, and re-experiencing, depression, and stress symptoms. Reliable change was most commonly indicated for measures of traumatic stress and general mental health. Limitations of the study include the lack of a control group and small sample size. To the best of our knowledge, this study is the first to use a within-subject daily-sampling design to monitor intrusive memories, in an inpatient setting, within the context of rTMS treatment. Routine rTMS for depression appears beneficial for reducing trauma-based intrusive memories as well as PTSD symptoms more generally. The present study demonstrates clinical viability of extending routine rTMS protocols used for depression to trauma-based intrusive memories and associated symptomatology.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"75-90"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13032974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognition Mediates the Association Between Meaning in Life and Depression: Sex-Differentiated Analysis in Europeans Aged 50 and Over. 认知在生活意义与抑郁之间起中介作用：50岁及以上欧洲人的性别差异分析。

IF 2.9 4区医学

Psychiatric Quarterly Pub Date : 2025-12-01 Epub Date: 2025-04-24 DOI: 10.1007/s11126-025-10147-5

Marcelo de Maio Nascimento, Adilson Marques, Élvio Rúbio Gouveia, Gerson Ferrari, Andreas Ihle

{"title":"Cognition Mediates the Association Between Meaning in Life and Depression: Sex-Differentiated Analysis in Europeans Aged 50 and Over.","authors":"Marcelo de Maio Nascimento, Adilson Marques, Élvio Rúbio Gouveia, Gerson Ferrari, Andreas Ihle","doi":"10.1007/s11126-025-10147-5","DOIUrl":"10.1007/s11126-025-10147-5","url":null,"abstract":"This study aimed to explore whether immediate recall, delayed recall, and verbal fluency mediated the relationship between meaning in life and depression in a large sample of older adults from 17 European countries. The study also sought to investigate potential differences in mediation trajectories by sex. The data used were from the eighth wave of the SHARE project (year 2019), involving 24,277 individuals (13,874 women). The variables analyzed were: meaning in life extracted from the CASP-19 scale, tests for immediate recall, delayed recall and verbal fluency, and depression (12-item EURO-D scale). Depression was more prevalent among women. For both sexes, meaning in life was positively associated with immediate recall, delayed recall, and verbal fluency, while meaning in life was negatively associated with depression, indicating its potential to alleviate depressive feelings. The three cognitive domains significantly mediated the relationship between meaning in life and depression. Differences in indirect mediation effects between men and women were identified in the pathways: meaning in life → delayed recall → depression and meaning in life → verbal fluency → depression. The total indirect models for men and women differed significantly.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"887-905"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mental Health Help-Seeking Among Young Internal Migrants in China: Shame as a Double-Edged Sword. 中国年轻流动人口的心理健康求助：羞耻感是一把双刃剑

IF 2.9 4区医学

Psychiatric Quarterly Pub Date : 2025-12-01 Epub Date: 2025-04-15 DOI: 10.1007/s11126-025-10127-9

Xuhong Li, Kin-Kit Li

{"title":"Mental Health Help-Seeking Among Young Internal Migrants in China: Shame as a Double-Edged Sword.","authors":"Xuhong Li, Kin-Kit Li","doi":"10.1007/s11126-025-10127-9","DOIUrl":"10.1007/s11126-025-10127-9","url":null,"abstract":"Young migrants in mainland China are vulnerable to mental health issues and are reluctant to seek help from professional sources. Shame is considered an important culture-specific emotion affecting professional help-seeking. The current study aimed to investigate the moderating role of shame in the association between psychological stress and help-seeking in young internal migrants in China. 415 internal migrants (mean age = 29.20; SD = 4.81) were recruited to participate in the survey study with oversampling of those who sought help before. Multiple linear regression and Zero-inflated Poisson regression models were used to examine the moderating effects of shame on the stress-intention and stress-behavior relations, respectively. Among the 65.0% of participants with high psychological stress, 62.6% of them never sought professional help for their mental health issues. The results demonstrate that shame significantly reduced the positive association between psychological stress and professional help-seeking behavior. Conversely, shame also played a protective role, mitigating the negative association between psychological stress and professional help-seeking intention. The findings underline the importance of addressing shame-related issue prior to therapy and developing promotion strategies to improve young migrants' mental health.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"829-845"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12647222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Network Analysis of Personality Traits in Adults with and Without Specific Learning Disorders. 有和没有特殊学习障碍的成人人格特征的网络分析。

IF 2.9 4区医学

Psychiatric Quarterly Pub Date : 2025-12-01 Epub Date: 2025-04-28 DOI: 10.1007/s11126-025-10146-6

Mohamad Ahmad Saleem Khasawneh

{"title":"A Network Analysis of Personality Traits in Adults with and Without Specific Learning Disorders.","authors":"Mohamad Ahmad Saleem Khasawneh","doi":"10.1007/s11126-025-10146-6","DOIUrl":"10.1007/s11126-025-10146-6","url":null,"abstract":"The primary aim of this study was to examine the personality profile of adults with Specific Learning Disorders (SLDs) using the Personality Inventory for DSM-5 (PID-5) to assess maladaptive traits and explore the underlying network structure of these traits in comparison to healthy individuals. The sample included 181 adults with SLDs (mean age = 27.37 ± 6.82; 39.21% female) and 227 healthy adults (mean age = 30.08 ± 7.49; 35.36% female). All participants completed the PID-5 and a socio-demographic checklist. Group differences in PID-5 scores were analyzed using independent-sample t-tests. Network analysis, including the Network Comparison Test (NCT) and centrality assessments, was conducted to examine overall network organization and identify key traits within the maladaptive trait networks. The results showed that adults with SLDs had significantly higher scores in detachment (43.99 ± 22.70 vs. 32.27 ± 17.53, p < 0.05) and negative affectivity (111.97 ± 35.06 vs. 87.26 ± 40.58, p < 0.05) compared to healthy controls. Their personality trait network was more densely connected, with a global strength of 44.95, compared to 36.22 in the control group (p < 0.01). Key traits in the SLD network included suspiciousness (betweenness = 2.116, closeness = 2.286, strength = 1.266), anhedonia (betweenness = 2.240), and eccentricity (strength = 2.146, betweenness = 1.498), indicating stronger interactions among maladaptive traits. A particularly strong connection (edge weight = 0.4059) was observed between withdrawal and anhedonia. In contrast, the control group's network was more balanced, with the most dominant node (N5) exhibiting a strength of 2.1859 and betweenness of 3.5000. These findings highlight distinct personality patterns in individuals with SLDs, underscoring the need for tailored clinical interventions.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"907-925"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Psychological Outcomes of Direct and Indirect Exposure to Trauma: The Lebanese Experience. 直接和间接暴露于创伤的心理结果：黎巴嫩的经验。

IF 2.9 4区医学

Psychiatric Quarterly Pub Date : 2025-12-01 Epub Date: 2025-04-30 DOI: 10.1007/s11126-025-10149-3

Rudy Abi-Habib, Wissam Kheir, Nour Yaktine, Mohamad El Maouch, Pia Tohme

{"title":"The Psychological Outcomes of Direct and Indirect Exposure to Trauma: The Lebanese Experience.","authors":"Rudy Abi-Habib, Wissam Kheir, Nour Yaktine, Mohamad El Maouch, Pia Tohme","doi":"10.1007/s11126-025-10149-3","DOIUrl":"10.1007/s11126-025-10149-3","url":null,"abstract":"Studies have consistently highlighted a high prevalence of mental health difficulties following exposure to trauma. These symptoms can become even more prevalent if one experiences several traumatic events. This study is the first to explore the interaction effect of age and gender on the prevalence of psychological outcomes, including anxiety, depression, stress, and PTSD, investigating whether the impact of age on psychological health is different across genders. Our sample included 546 Lebanese adults who were exposed to both the 2020 Beirut Port explosion and the 2023 earthquakes. Participants completed the PCL-5, the DASS-21, and a series of demographic questions. Results showed that, in the context of direct exposure, the findings for male and female participants indicate that older age is associated with lower mental health symptomatology. Analyzing indirect exposure, age was not significantly correlated with psychological outcomes for males; however, significant negative relationships were observed for all outcomes for females. Findings are discussed from a cultural perspective, emphasizing recommendations for interventions targeting people affected by traumatic events, namely the importance of focusing on the young generation, namely females, who scored the highest on psychological difficulties following indirect exposure to trauma.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"927-942"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive Behavioral Therapy Alone or in Combination with Eszopiclone in Comorbid Insomnia and Obstructive Sleep Apnea in Veterans with Posttraumatic Stress Disorder: A Randomized Trial. 认知行为疗法单独或联合艾司佐匹克隆治疗创伤后应激障碍退伍军人共病性失眠和阻塞性睡眠呼吸暂停：一项随机试验

IF 2.9 4区医学

Psychiatric Quarterly Pub Date : 2025-12-01 Epub Date: 2025-04-09 DOI: 10.1007/s11126-025-10143-9

Ali A El-Solh, Yolanda Lawson, Amber Martinson, Gregory Wilding

{"title":"Cognitive Behavioral Therapy Alone or in Combination with Eszopiclone in Comorbid Insomnia and Obstructive Sleep Apnea in Veterans with Posttraumatic Stress Disorder: A Randomized Trial.","authors":"Ali A El-Solh, Yolanda Lawson, Amber Martinson, Gregory Wilding","doi":"10.1007/s11126-025-10143-9","DOIUrl":"10.1007/s11126-025-10143-9","url":null,"abstract":"We sought to assess the augmentation of brief behavioral therapy for insomnia (BBTI) with eszopiclone (ESZ) over BBTI alone for the treatment of chronic insomnia on sleep quality, sleep indices, and continuous positive airway pressure (CPAP) adherence in PTSD veterans with COMISA. The pilot trial involved 53 PTSD patients (46 males and 7 females, mean age 48.2±8.3 years) with COMISA randomized to combination therapy of BBTI plus 2 weeks of eszopiclone (2 mg/d) or BBTI alone with follow-up visits conducted at 6 and 24 weeks. The main outcome measure was sleep quality assessed by the Pittsburgh Sleep Quality Index (PSQI). A significant decrease in PSQI scores was observed between baseline and 24 weeks for BBTI plus ESZ (-5.24 [95% CI, -6.55 to -3.94]; p < 0.001) and BBTI-only (-5.45 [95%CI, -6.75 to -4.14]; p < 0.001). No significant group allocation effects x time interactions were detected. Similar improvements were recorded for ISI between baseline and 24 weeks (BBTI plus ESZ (-8.32 [95%CI, -10.51 to -6.14]; p < 0.001) and BBTI-only (-8.64 [95%CI, -10.88 to -6.41]; p < 0.001)) with no interaction effect between treatment groups x time. Combination therapy produced a higher remission rate of insomnia at 6 weeks, with both interventions achieving comparable rates at 24 weeks. Results of the mixed effect models for CPAP use revealed no group x time interaction effects. In patients with COMISA, the combination of eszopiclone with BBTI resulted in comparable improvement in sleep quality of life to that achieved with BBTI-only therapy. Although the addition of eszopiclone to BBTI conferred an early benefit in remission rate of insomnia relative to BBTI, both modalities achieved similar outcomes at long-term follow-up.Clinical Trial Registration This study was registered with ClinicalTrials.gov (Identifier NCT03937713).","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"787-802"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12647318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Lifestyle Behaviors with Anxiety and Depression in Type 2 Diabetes Mellitus Patients with Hypertension: A Cross-Sectional Study. 生活方式行为与2型糖尿病合并高血压患者焦虑和抑郁的关系：一项横断面研究

IF 2.9 4区医学

Psychiatric Quarterly Pub Date : 2025-12-01 Epub Date: 2025-04-04 DOI: 10.1007/s11126-025-10136-8

Ziling Feng, Hongying Liu, Wenyan Zhang, Yamin Liu, Ni Xiong, Wenhang Chen, Jianzhou Yang, Xinyin Wu, Wenjie Dai

{"title":"Associations of Lifestyle Behaviors with Anxiety and Depression in Type 2 Diabetes Mellitus Patients with Hypertension: A Cross-Sectional Study.","authors":"Ziling Feng, Hongying Liu, Wenyan Zhang, Yamin Liu, Ni Xiong, Wenhang Chen, Jianzhou Yang, Xinyin Wu, Wenjie Dai","doi":"10.1007/s11126-025-10136-8","DOIUrl":"10.1007/s11126-025-10136-8","url":null,"abstract":"This study aimed to identify the prevalence of anxiety and depression, as well as the associations of lifestyle behaviors with anxiety and depression in type 2 diabetes mellitus (T2DM) patients with hypertension. This cross-sectional study was conducted in Hunan Province of China, with 475 participants included. Data on sociodemographic, lifestyle behaviors, and disease-related characteristics were collected. Anxiety and depression were assessed using self-report questionnaires. This study indicated that the prevalence of anxiety and depression was 37.47% (95% confidence interval [95% CI]: 33.37-42.07%) and 40.63% (95% CI: 36.43-45.26%), respectively. Multivariable logistic regression analyses showed that playing cards or mahjong (adjusted odds ratio [aOR] = 0.46 [95% CI: 0.28-0.76] and aOR = 0.57 [95% CI: 0.34-0.94] for anxiety and depression, respectively) and performing physical activity for > 30 min per day (aOR = 0.32 [95% CI: 0.19-0.52] and aOR = 0.23 [95% CI: 0.14-0.38] for anxiety and depression, respectively) were associated with lower odds of both anxiety and depression, while reading books or newspapers (aOR = 0.34, 95% CI: 0.12-0.93) were associated with lower odds of anxiety alone. Therefore, regular reading, social activities and physical activities can be considered as intervention targets for the prevention and management of anxiety and depression in T2DM patients with hypertension.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"721-733"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semaglutide Plus Metformin Versus Metformin Alone For Antipsychotic-Induced Weight Gain In Patients With Type 2 Diabetes Mellitus. 西马鲁肽联合二甲双胍与单用二甲双胍治疗抗精神病药诱导的2型糖尿病患者体重增加的比较

IF 2.9 4区医学

Psychiatric Quarterly Pub Date : 2025-12-01 Epub Date: 2025-04-14 DOI: 10.1007/s11126-025-10137-7

Catherine Vu, Raymond Thai, Dozie Dike, Bria Sydner

{"title":"Semaglutide Plus Metformin Versus Metformin Alone For Antipsychotic-Induced Weight Gain In Patients With Type 2 Diabetes Mellitus.","authors":"Catherine Vu, Raymond Thai, Dozie Dike, Bria Sydner","doi":"10.1007/s11126-025-10137-7","DOIUrl":"10.1007/s11126-025-10137-7","url":null,"abstract":"To determine whether combination therapy (semaglutide + metformin) is more efficacious than monotherapy (metformin alone) in reducing the risk of antipsychotic-induced weight gain (AIWG) in patients with Type 2 Diabetes Mellitus (T2DM). This was a single-center, retrospective study evaluating patients ≥ 18 years of age receiving care at Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC) from January 2021 to December 2022. Subjects were identified by use of antipsychotic (quetiapine, risperidone, paliperidone, olanzapine, clozapine) with concomitant use of monotherapy or combination therapy. Key exclusion criteria included other medications impacting weight, unstable medical illness, active substance use disorder, and dual antipsychotic use. The primary endpoint was defined as weight loss ≥ 5% from baseline. Secondary outcomes included BMI % difference and HbA1c difference from baseline. Data was analyzed using descriptive statistics. 31 patients were evaluated in each group for the final analysis. 38.7% (12/31) of patients in the monotherapy group achieved the primary outcome of weight loss ≥ 5% from baseline vs. 61.29% (19/31) in the combination group (p = 0.04). For secondary outcomes, the BMI % difference from baseline in the monotherapy group was -3.88% vs. -5.58% in the combination group (p = 0.129). The monotherapy group had a difference in HbA1c % from baseline of 0.14% vs -0.9% in the combination group (p = 0.007). Among T2DM patients on antipsychotics, more patients in the combination group achieved weight loss ≥ 5% within the study period compared to metformin monotherapy. Future research should account for non-diabetic patients, assess lifestyle factors, and exclude other psychotropic medications that may affect weight.","PeriodicalId":20658,"journal":{"name":"Psychiatric Quarterly","volume":" ","pages":"819-827"},"PeriodicalIF":2.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0