Mass Spectrometry Reviews最新文献

Recent Advances (2023-2025) of Capillary Electrophoresis-Mass Spectrometry (CE-MS) for Top-Down Proteomics. 毛细管电泳-质谱（CE-MS）用于自上而下蛋白质组学的最新进展（2023-2025）。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-05-07 DOI: 10.1002/mas.70028

Guijie Zhu, David A Alvarez Rodriguez, Noah Gould, Alexander R Ivanov, Kevin Jooß, Liangliang Sun

引用次数: 0

Editorial for the Special Honor Issue Honoring Dr. Carlito B. Lebrilla. 专为纪念卡里托·b·勒布里拉博士而写的社论。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-04-17 DOI: 10.1002/mas.70027

Benjamin A Garcia

引用次数: 0

Personal Reflection on Dr. Carlito Lebrilla. Carlito Lebrilla博士的个人反思。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-04-17 DOI: 10.1002/mas.70026

Benjamin A Garcia

引用次数: 0

A Perspective of Multi-Reflecting TOF MS 透视多反射 TOF MS。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-04-08 Epub Date: 2024-11-12 DOI: 10.1002/mas.21915

A. N. Verenchikov, V. V. Makarov, A. V. Vorobyev, S. N. Kirillov

{"title":"A Perspective of Multi-Reflecting TOF MS","authors":"A. N. Verenchikov, V. V. Makarov, A. V. Vorobyev, S. N. Kirillov","doi":"10.1002/mas.21915","DOIUrl":"10.1002/mas.21915","url":null,"abstract":"Time-of-flight mass spectrometry (TOF MS) excels in rapid and high-sensitivity analysis, making it a cornerstone of analytical chemistry. But as sample complexity explodes in omics studies, so does the need for higher resolving power to ensure accurate results. Traditional TOF instruments face a challenge: achieving high resolution often requires a very large instrument. To overcome this limitation, scientists developed alternative designs for TOF analyzers called multi-pass TOF analyzers (MPT). These MPT analyzers come in two main configurations: multi-turn (MTT) and multi-reflecting (MRT). Drawing on the authors’ extensive experience, this review describes two decades of MPT advancements. It highlights the critical development of optimized analyzer designs, tracing the evolution towards mirror-based MRT instruments, generally providing superior resolution and spatial acceptance compared to MTT. While the manuscript attempts to overview MTT advances, it primarily focuses on MRT technology. Additionally, the review explores the role of orthogonal accelerators and trap pulse converters, comparing their efficiency and the dynamic range limits imposed by space charge effects. By comparing various MRT configurations and commercially available instruments, the review sets out to inform and empower researchers so they can make informed decisions about MRT mass spectrometers.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 3","pages":"476-506"},"PeriodicalIF":6.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold EI—The Way to Improve GC-MS and Increase Its Range of Applications 改进气相色谱-质谱法并扩大其应用范围的途径。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-04-08 Epub Date: 2025-03-05 DOI: 10.1002/mas.21928

Aviv Amirav, Benny Neumark, Oneg Elkabets, Alex Yakovchuk

{"title":"Cold EI—The Way to Improve GC-MS and Increase Its Range of Applications","authors":"Aviv Amirav, Benny Neumark, Oneg Elkabets, Alex Yakovchuk","doi":"10.1002/mas.21928","DOIUrl":"10.1002/mas.21928","url":null,"abstract":"Gas chromatography-mass spectrometry (GC-MS) with Cold electron ionization (EI) is based on interfacing the GC and MS with a supersonic molecular beam (SMB) along with electron ionization of vibrationally cold sample compounds in the SMB in a contact-free fly-through ion source (hence the name Cold EI). Cold EI improves all the central performance aspects of GC-MS, including: a significantly extended range of compounds that are amenable for analysis, enhanced molecular ions, highly improved sample identification, faster analysis (much faster), uniform response to all analytes, greater selectivity and higher signal to noise ratios and lower limits of detection, particularly for compounds that are difficult to analyze. GC-MS with Cold EI executes the analysis of the full range of standard EI applications and most with major improvements of various metrics. Furthermore, it significantly extends the range of compounds and applications amenable for GC-MS analysis. Accordingly, it is a highly superior replacement ion source. In this review article, we describe Cold EI and its main features, discuss its benefits, and demonstrate several of its unique applications including cannabinoids analysis, synthetic organic compounds analysis, whole blood analysis for medical diagnostics, isomer distribution analysis for improved fuels and oils, and explosives analysis.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 3","pages":"548-582"},"PeriodicalIF":6.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Learning Methods for De Novo Peptide Sequencing 全新肽段测序的深度学习方法。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-04-08 Epub Date: 2024-11-29 DOI: 10.1002/mas.21919

Wout Bittremieux, Varun Ananth, William E. Fondrie, Carlo Melendez, Marina Pominova, Justin Sanders, Bo Wen, Melih Yilmaz, William S. Noble

引用次数: 0

Protein glycosylation in lung cancer from a mass spectrometry perspective 从质谱分析角度看肺癌中的蛋白质糖基化

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-04-08 Epub Date: 2024-04-04 DOI: 10.1002/mas.21882

Mirjam Balbisi, Simon Sugár, Lilla Turiák

{"title":"Protein glycosylation in lung cancer from a mass spectrometry perspective","authors":"Mirjam Balbisi, Simon Sugár, Lilla Turiák","doi":"10.1002/mas.21882","DOIUrl":"10.1002/mas.21882","url":null,"abstract":"Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer. Differences in glycosylation patterns have been previously observed between healthy and cancerous samples as well as between different lung cancer subtypes, which suggests untapped diagnostic potential. In addition, understanding the changes mediated by glycosylation may shed light on possible novel therapeutic targets and personalized treatment strategies for lung cancer patients. Mass spectrometry based glycomics and glycoproteomics have emerged as powerful tools for in-depth characterization of changes in protein glycosylation, providing valuable insights into the molecular basis of lung cancer. This paper reviews the literature on the analysis of protein glycosylation in lung cancer using mass spectrometry, which is dominated by manuscripts published over the past 5 years. Studies analyzing N-glycosylation, O-glycosylation, and glycosaminoglycan patterns in tissue, serum, plasma, and rare biological samples of lung cancer patients are highlighted. The current knowledge on the potential utility of glycan and glycoprotein biomarkers is also discussed.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 3","pages":"455-475"},"PeriodicalIF":6.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21882","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in Tandem Mass Spectrometry Data Analysis for Nucleic Acids 核酸串联质谱数据分析研究进展。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-04-08 Epub Date: 2025-01-10 DOI: 10.1002/mas.21923

Michael B. Lanzillotti, Jennifer S. Brodbelt

{"title":"Progress in Tandem Mass Spectrometry Data Analysis for Nucleic Acids","authors":"Michael B. Lanzillotti, Jennifer S. Brodbelt","doi":"10.1002/mas.21923","DOIUrl":"10.1002/mas.21923","url":null,"abstract":"<div>\u0000 \u0000 Mass spectrometry (MS) has become a critical tool in the characterization of covalently modified nucleic acids. Well-developed bottom-up approaches, where nucleic acids are digested with an endonuclease and the resulting oligonucleotides are separated before MS and MS/MS analysis, provide substantial insight into modified nucleotides in biological and synthetic nucleic. Top-down MS presents an alternative approach where the entire nucleic acid molecule is introduced to the mass spectrometer intact and then fragmented by MS/MS. Current top-down MS workflows have incorporated automated, on-line HPLC workflows to enable rapid desalting of nucleic acid samples for facile mass analysis without complication from adduction. Furthermore, optimization of MS/MS parameters utilizing collision, electron, or photon-based activation methods have enabled effective bond cleavage throughout the phosphodiester backbone while limiting secondary fragmentation, allowing characterization of progressively larger (~100 nt) nucleic acids and localization of covalent modifications. Development of software applications to perform automated identification of fragment ions has accelerated the broader adoption of mass spectrometry for analysis of nucleic acids. This review focuses on progress in tandem mass spectrometry for characterization of nucleic acids with particular emphasis on the software tools that have proven critical for advancing the field.\u0000 </div>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 3","pages":"527-547"},"PeriodicalIF":6.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique. 轨道阱质谱法作为主流分析技术的前20年。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-04-08 DOI: 10.1002/mas.70024

Alexander Makarov

引用次数: 0

Ion Activation Methods for Top-Down Proteomics. 自顶向下蛋白质组学的离子激活方法。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-03-31 DOI: 10.1002/mas.70023

Jada N Walker, Jennifer S Brodbelt

引用次数: 0