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Unraveling Posttranslational Modification Complexity: Advances in Quantitative Histone Proteoform Mass Spectrometry. 揭示翻译后修饰的复杂性：定量组蛋白蛋白质谱的进展。
IF 6.9 2区 化学
Mass Spectrometry Reviews Pub Date : 2025-06-01 DOI: 10.1002/mas.21941
Karl F Poncha, Alyssa T Paparella, Nicolas L Young
{"title":"Unraveling Posttranslational Modification Complexity: Advances in Quantitative Histone Proteoform Mass Spectrometry.","authors":"Karl F Poncha, Alyssa T Paparella, Nicolas L Young","doi":"10.1002/mas.21941","DOIUrl":"https://doi.org/10.1002/mas.21941","url":null,"abstract":"<p><p>Histone proteins and their posttranslational modifications are central to chromatin structure and function. These modifications often occur in combinations, generating a diverse array of histone proteoforms that contribute to the dynamic regulation of chromatin architecture. Advancements in mass spectrometry-based proteomics, particularly top-down and middle-down approaches, have significantly enhanced our ability to characterize these proteoforms and elucidate PTM crosstalk. This review provides an analysis of the epigenetic machinery involved in the addition, recognition, and removal of histone PTMs, emphasizing the complexity introduced by histone variants and combinatorial PTM patterns. We examine the challenges and limitations of traditional antibody-based methods for PTM analysis and highlight the advantages of mass spectrometry techniques in providing comprehensive and quantitative insights into histone proteoforms. Key considerations in experimental design, sample preparation, chromatographic separation, and data analysis are outlined for the effective application of mass spectrometry for histone proteoform studies. By integrating these technological advancements on the side of sample preparation, instrumentation, and data processing a deeper understanding of chromatin regulation through PTM crosstalk is achieved, paving the way for mass spectrometry-based proteomics to spearhead the discovery of novel therapeutic strategies with proteoform level specificity.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry. 亲水相互作用液相色谱-质谱联用分析甲基化季铵化合物。
IF 6.9 2区 化学
Mass Spectrometry Reviews Pub Date : 2025-05-29 DOI: 10.1002/mas.21942
Iman Zarei, Ambrin Farizah Babu, Ville M Koistinen, Marjo Tuomainen, Anna Kårlund, Retu Haikonen, Marko Lehtonen, Kati Hanhineva
{"title":"Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry.","authors":"Iman Zarei, Ambrin Farizah Babu, Ville M Koistinen, Marjo Tuomainen, Anna Kårlund, Retu Haikonen, Marko Lehtonen, Kati Hanhineva","doi":"10.1002/mas.21942","DOIUrl":"https://doi.org/10.1002/mas.21942","url":null,"abstract":"<p><p>Liquid chromatography-mass spectrometry (LC-MS) is a powerful technique for the detection and quantification of methylated quaternary ammonium compounds (mQACs), such as acylcarnitines and methylated amino-acid-derived (betainized) compounds, in biological matrices. Due to their high polarity and permanent charge, mQACs present analytical challenges, particularly in achieving efficient chromatographic retention and resolution. Here, we focus on the application of hydrophilic interaction liquid chromatography combined with mass spectrometric (HILIC-MS), for the analysis of these compound classes in biological samples. We highlight practical considerations in their analysis, including their MS/MS fragmentation patterns and identification in positive electrospray mode (ESI)<sup>+</sup>, to support researchers working with mQACs in targeted or untargeted metabolomics studies.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflections on an International Career in Chemistry. 对国际化学事业的思考。
IF 6.9 2区 化学
Mass Spectrometry Reviews Pub Date : 2025-05-24 DOI: 10.1002/mas.21939
Richard B Cole
{"title":"Reflections on an International Career in Chemistry.","authors":"Richard B Cole","doi":"10.1002/mas.21939","DOIUrl":"https://doi.org/10.1002/mas.21939","url":null,"abstract":"","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Practical Applications of Secondary/Extractive Electrospray Ionization (SESI): A Versatile Tool for Real-Time Chemical Analysis. 二次/萃取电喷雾电离（SESI）的实际应用：实时化学分析的通用工具。
IF 6.9 2区 化学
Mass Spectrometry Reviews Pub Date : 2025-05-19 DOI: 10.1002/mas.21938
Xin Luo, Huiling Wang, Xiaolan Hu, Sasho Gligorovski, Xue Li, Pablo Sinues
{"title":"Practical Applications of Secondary/Extractive Electrospray Ionization (SESI): A Versatile Tool for Real-Time Chemical Analysis.","authors":"Xin Luo, Huiling Wang, Xiaolan Hu, Sasho Gligorovski, Xue Li, Pablo Sinues","doi":"10.1002/mas.21938","DOIUrl":"https://doi.org/10.1002/mas.21938","url":null,"abstract":"<p><p>In the 1980s, researchers discovered the remarkable ability of electrospray plumes to effectively ionize gas-phase molecules via secondary ionization. Around 20 years later-coinciding with the ambient mass spectrometry revolution-secondary electrospray ionization (SESI) and extractive electrospray ionization (EESI) coupled to mass spectrometry were revisited and further developed to analyze complex mixtures of gas and aerosol samples in real-time yet with high sensitivity. During the past two decades, these mass spectrometric techniques have been applied across a broad range of applications, such as the detection of illicit drugs, environmental aerosol analysis, and a series of metabolomic studies through the analysis of volatiles emitted from living organisms. This review offers a comprehensive overview of the progress of SESI and EESI applications since their emergence. Finally, we discuss the opportunities, challenges, along with future directions of SESI and EESI techniques.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inspired by Chemistry Through Research, Teaching, and Life. 通过研究，教学和生活受到化学的启发。
IF 6.9 2区 化学
Mass Spectrometry Reviews Pub Date : 2025-05-13 DOI: 10.1002/mas.21937
Chrys Wesdemiotis
{"title":"Inspired by Chemistry Through Research, Teaching, and Life.","authors":"Chrys Wesdemiotis","doi":"10.1002/mas.21937","DOIUrl":"https://doi.org/10.1002/mas.21937","url":null,"abstract":"<p><p>A short biography focusing on educational activities and professional career.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Special Issue Dedicated to the Outstanding Scientific Career of Prof. Chrys Wesdemiotis. 一个特别的问题，献给杰出的科学事业教授Chrys wesdemotis。
IF 6.9 2区 化学
Mass Spectrometry Reviews Pub Date : 2025-05-12 DOI: 10.1002/mas.21940
Laurence Charles, Bryan Katzenmeyer
{"title":"A Special Issue Dedicated to the Outstanding Scientific Career of Prof. Chrys Wesdemiotis.","authors":"Laurence Charles, Bryan Katzenmeyer","doi":"10.1002/mas.21940","DOIUrl":"https://doi.org/10.1002/mas.21940","url":null,"abstract":"","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Richard B. Cole-Reminiscences Upon the Occasion of His Retirement From Sorbonne Université. 理查德·b·科尔从索邦大学退休时的回忆。
IF 6.9 2区 化学
Mass Spectrometry Reviews Pub Date : 2025-05-02 DOI: 10.1002/mas.21936
André M Striegel
{"title":"Richard B. Cole-Reminiscences Upon the Occasion of His Retirement From Sorbonne Université.","authors":"André M Striegel","doi":"10.1002/mas.21936","DOIUrl":"https://doi.org/10.1002/mas.21936","url":null,"abstract":"","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in Characterization of Lipopolysaccharides and Lipid A by Mass Spectrometry. 质谱法表征脂多糖和脂质A的研究进展。
IF 6.9 2区 化学
Mass Spectrometry Reviews Pub Date : 2025-04-29 DOI: 10.1002/mas.21934
Amanda Helms, Jennifer S Brodbelt
{"title":"Progress in Characterization of Lipopolysaccharides and Lipid A by Mass Spectrometry.","authors":"Amanda Helms, Jennifer S Brodbelt","doi":"10.1002/mas.21934","DOIUrl":"https://doi.org/10.1002/mas.21934","url":null,"abstract":"<p><p>Lipopolysaccharides (LPS) are complex molecules embedded in the outer membrane of Gram-negative bacteria. LPS are highly heterogeneous across species and strains, posing a significant analytical challenge. This review article explores recent advances in the identification and characterization of LPS, with a particular focus on the role of mass spectrometry (MS) techniques. The review highlights how MS, in conjunction with various separation methods and spanning different ionization techniques and dissociation modes, has enabled more precise and sensitive determination of LPS composition, with a focus on lipid A structure. Finally, emerging trends in MS applications for LPS research are discussed and its potential to provide deeper insights into the development of antibiotic resistance among pathogenic bacteria.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Special Issue of Mass Spectrometry Reviews to Honor Professor Richard B. Cole. 《质谱评论》特刊纪念理查德·b·科尔教授。
IF 6.9 2区 化学
Mass Spectrometry Reviews Pub Date : 2025-04-28 DOI: 10.1002/mas.21935
Laurent Debrauwer, Olivier Laprévote
{"title":"A Special Issue of Mass Spectrometry Reviews to Honor Professor Richard B. Cole.","authors":"Laurent Debrauwer, Olivier Laprévote","doi":"10.1002/mas.21935","DOIUrl":"https://doi.org/10.1002/mas.21935","url":null,"abstract":"","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mass Spectrometry-Based Proteomics for Next-Generation Precision Oncology. 基于质谱的蛋白质组学用于下一代精确肿瘤学。
IF 6.9 2区 化学
Mass Spectrometry Reviews Pub Date : 2025-04-23 DOI: 10.1002/mas.21932
Kuen-Tyng Lin, Gul Muneer, Pei-Rong Huang, Ciao-Syuan Chen, Yu-Ju Chen
{"title":"Mass Spectrometry-Based Proteomics for Next-Generation Precision Oncology.","authors":"Kuen-Tyng Lin, Gul Muneer, Pei-Rong Huang, Ciao-Syuan Chen, Yu-Ju Chen","doi":"10.1002/mas.21932","DOIUrl":"https://doi.org/10.1002/mas.21932","url":null,"abstract":"<p><p>Cancer is the leading cause of death worldwide characterized by patient heterogeneity and complex tumor microenvironment. While the genomics-based testing has transformed modern medicine, the challenge of diverse clinical outcomes highlights unmet needs for precision oncology. As functional molecules regulating cellular processes, proteins hold great promise as biomarkers and drug targets. Mass spectrometry (MS)-based clinical proteomics has illuminated the molecular features of cancers and facilitated discovery of biomarkers or therapeutic targets, paving the way for innovative strategies that enhance the precision of personalized treatment. In this article, we introduced the tools and current achievements of MS-based proteomics, choice of discovery and targeted MS from discovery to validation phases, profiling sensitivity from bulk samples to single-cell level and tissue to liquid biopsy specimens, current regulatory landscape of MS-based protein laboratory-developed tests (LDTs). The challenges, success and future perspectives in translating research MS assay into clinical applications are also discussed. With well-designed validation studies to demonstrate clinical benefits and meet the regulatory requirements for both analytical and clinical performance, the future of MS-based assays is promising with numerous opportunities to improve cancer diagnosis, treatment, and monitoring.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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