Mass Spectrometry Reviews最新文献_第10页

Gas-phase Förster resonance energy transfer in mass-selected and trapped ions 质量选择离子和捕获离子中的气相福斯特共振能量转移。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-12-13 DOI: 10.1002/mas.21828

Jeppe Langeland, Thomas T. Lindkvist, Christina Kjær, Steen Brøndsted Nielsen

{"title":"Gas-phase Förster resonance energy transfer in mass-selected and trapped ions","authors":"Jeppe Langeland, Thomas T. Lindkvist, Christina Kjær, Steen Brøndsted Nielsen","doi":"10.1002/mas.21828","DOIUrl":"10.1002/mas.21828","url":null,"abstract":"Förster Resonance Energy transfer (FRET) is a nonradiative process that may occur from an electronically excited donor to an acceptor when the emission spectrum of the donor overlaps with the absorption spectrum of the acceptor. FRET experiments have been done in the gas phase based on specially designed mass-spectroscopy setups with the goal to obtain structural information on biomolecular ions labeled with a FRET pair (i.e., donor and acceptor dyes) and to shed light on the energy-transfer process itself. Ions are accumulated in a radio-frequency ion trap or a Penning trap where mass selection of those of interest takes place, followed by photoexcitation. Gas-phase FRET is identified from detection of emitted light either from the donor, the acceptor, or both, or from a fragmentation channel that is specific to the acceptor when electronically excited. The challenge associated with the first approach is the collection and detection of photons emitted from a thin ion cloud that is not easily accessible while the second approach relies both on the photophysical and chemical behavior of the acceptor. In this review, we present the different instrumentation used for gas-phase FRET, including a discussion of advantages and disadvantages, and examples on how the technique has provided important structural information that is not easily obtainable otherwise. Furthermore, we describe how the spectroscopic properties of the dyes are affected by nearby electric fields, which is readily discernable from experiments on simple model systems with alkyl or π-conjugated bridges. Such spectral changes can have a significant effect on the FRET efficiency. Ideas for new directions are presented at the end with special focus on cold-ion spectroscopy.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 3","pages":"477-499"},"PeriodicalIF":6.6,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21828","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10337728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical proteomics towards multiomics in cancer 临床蛋白质组学走向癌症多组学。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2022-12-10 DOI: 10.1002/mas.21827

Chad J. Creighton

引用次数: 0

Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2019–2020 基质辅助激光解吸/电离质谱法分析碳水化合物和糖缀合物:2019-2020年更新

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-12-05 DOI: 10.1002/mas.21806

David J. Harvey

{"title":"Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2019–2020","authors":"David J. Harvey","doi":"10.1002/mas.21806","DOIUrl":"10.1002/mas.21806","url":null,"abstract":"This review is the tenth update of the original article published in 1999 on the application of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2020. Also included are papers that describe methods appropriate to analysis by MALDI, such as sample preparation techniques, even though the ionization method is not MALDI. The review is basically divided into three sections: (1) general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation, quantification and the use of arrays. (2) Applications to various structural types such as oligo- and polysaccharides, glycoproteins, glycolipids, glycosides and biopharmaceuticals, and (3) other areas such as medicine, industrial processes and glycan synthesis where MALDI is extensively used. Much of the material relating to applications is presented in tabular form. The reported work shows increasing use of incorporation of new techniques such as ion mobility and the enormous impact that MALDI imaging is having. MALDI, although invented nearly 40 years ago is still an ideal technique for carbohydrate analysis and advancements in the technique and range of applications show little sign of diminishing.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"42 5","pages":"1984-2206"},"PeriodicalIF":6.6,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21806","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5708031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Chemical compositional analysis of jet fuels: Contributions of mass spectrometry in the 21st century 喷气燃料的化学成分分析：质谱仪在 21 世纪的贡献。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-12-02 DOI: 10.1002/mas.21825

Mark Romanczyk

引用次数: 0

Ion-molecule reactions of mass-selected ions 大量选择离子的离子-分子反应。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-11-29 DOI: 10.1002/mas.21819

Kevin Parker, Nicholas E. Bollis, Victor Ryzhov

{"title":"Ion-molecule reactions of mass-selected ions","authors":"Kevin Parker, Nicholas E. Bollis, Victor Ryzhov","doi":"10.1002/mas.21819","DOIUrl":"10.1002/mas.21819","url":null,"abstract":"Gas-phase reactions of mass-selected ions with neutrals covers a very broad area of fundamental and applied mass spectrometry (MS). Oftentimes, ion-molecule reactions (IMR) can serve as a viable alternative to collision-induced dissociation and other ion dissociation techniques when using tandem MS. This review focuses on the literature pertaining applications of IMR since 2013. During the past decade considerable efforts have been made in analytical applications of IMR, including advances in one of the major techniques for characterization of unsaturated fatty acids and lipids, ozone-induced dissociation, and the development of a new technique for sequencing of large ions, hydrogen atom attachment/abstraction dissociation. Many advances have also been made in identifying gas-phase chemistry specific to a functional group in organic and biological compounds, which are useful in structure elucidation of analytes and differentiation of isomers/isobars. With “soft” ionization techniques like electrospray ionization having become mainstream for quite some time now, the efforts in the area of metal ion catalysis have firmly moved into exploring chemistry of ligated metal complexes in their “natural” oxidation states allowing to model individual steps of mechanisms in homogeneous catalysis, especially in combination with high-level DFT calculations. Finally, IMR continue to contribute to the body of knowledge in the area of chemistry of interstellar processes.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 1","pages":"47-89"},"PeriodicalIF":6.6,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40709543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass spectrometry-based proteomic approaches for salivary protein biomarkers discovery and dental caries diagnosis: A critical review 基于质谱的蛋白质组学方法用于唾液蛋白质生物标记物的发现和龋齿诊断：重要综述。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-11-29 DOI: 10.1002/mas.21822

Paras Ahmad, Ahmed Hussain, Walter L. Siqueira

引用次数: 0

Characterization of the dystrophin-associated protein complex by mass spectrometry 质谱法表征肌营养不良蛋白相关蛋白复合物。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-11-24 DOI: 10.1002/mas.21823

Emily H. Canessa, Rita Spathis, James S. Novak, Aaron Beedle, Kanneboyina Nagaraju, Luca Bello, Elena Pegoraro, Eric P. Hoffman, Yetrib Hathout

{"title":"Characterization of the dystrophin-associated protein complex by mass spectrometry","authors":"Emily H. Canessa, Rita Spathis, James S. Novak, Aaron Beedle, Kanneboyina Nagaraju, Luca Bello, Elena Pegoraro, Eric P. Hoffman, Yetrib Hathout","doi":"10.1002/mas.21823","DOIUrl":"10.1002/mas.21823","url":null,"abstract":"The dystrophin-associated protein complex (DAPC) is a highly organized multiprotein complex that plays a pivotal role in muscle fiber structure integrity and cell signaling. The complex is composed of three distinct interacting subgroups, intracellular peripheral proteins, transmembrane glycoproteins, and extracellular glycoproteins subcomplexes. Dystrophin protein nucleates the DAPC and is important for connecting the intracellular actin cytoskeletal filaments to the sarcolemma glycoprotein complex that is connected to the extracellular matrix via laminin, thus stabilizing the sarcolemma during muscle fiber contraction and relaxation. Genetic mutations that lead to lack of expression or altered expression of any of the DAPC proteins are associated with different types of muscle diseases. Hence characterization of this complex in healthy and dystrophic muscle might bring insights into its role in muscle pathogenesis. This review highlights the role of mass spectrometry in characterizing the DAPC interactome as well as post-translational glycan modifications of some of its components such as α-dystroglycan. Detection and quantification of dystrophin using targeted mass spectrometry are also discussed in the context of healthy versus dystrophic skeletal muscle.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 1","pages":"90-105"},"PeriodicalIF":6.6,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40508538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthetic dyes: A mass spectrometry approach and applications 合成染料：质谱方法及其应用。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-11-10 DOI: 10.1002/mas.21818

Zoe Millbern, Alison Trettin, Rachel Wu, Morgan Demmler, Nelson R. Vinueza

引用次数: 0

Using mass spectrometry-based methods to understand amyloid formation and inhibition of alpha-synuclein and amyloid beta 利用基于质谱的方法了解淀粉样蛋白的形成以及α-突触核蛋白和β-淀粉样蛋白的抑制作用。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-10-12 DOI: 10.1002/mas.21814

Wesley J. Wagner, Michael L. Gross

{"title":"Using mass spectrometry-based methods to understand amyloid formation and inhibition of alpha-synuclein and amyloid beta","authors":"Wesley J. Wagner, Michael L. Gross","doi":"10.1002/mas.21814","DOIUrl":"10.1002/mas.21814","url":null,"abstract":"Amyloid fibrils, insoluble β-sheets structures that arise from protein misfolding, are associated with several neurodegenerative disorders. Many small molecules have been investigated to prevent amyloid fibrils from forming; however, there are currently no therapeutics to combat these diseases. Mass spectrometry (MS) is proving to be effective for studying the high order structure (HOS) of aggregating proteins and for determining structural changes accompanying protein–inhibitor interactions. When combined with native MS (nMS), gas-phase ion mobility, protein footprinting, and chemical cross-linking, MS can afford regional and sometimes amino acid spatial resolution of the aggregating protein. The spatial resolution is greater than typical low-resolution spectroscopic, calorimetric, and the traditional ThT fluorescence methods used in amyloid research today. High-resolution approaches can struggle when investigating protein aggregation, as the proteins exist as complex oligomeric mixtures of many sizes and several conformations or polymorphs. Thus, MS is positioned to complement both high- and low-resolution approaches to studying amyloid fibril formation and protein–inhibitor interactions. This review covers basics in MS paired with ion mobility, continuous hydrogen-deuterium exchange (continuous HDX), pulsed hydrogen-deuterium exchange (pulsed HDX), fast photochemical oxidation of proteins (FPOP) and other irreversible labeling methods, and chemical cross-linking. We then review the applications of these approaches to studying amyloid-prone proteins with a focus on amyloid beta and alpha-synuclein. Another focus is the determination of protein–inhibitor interactions. The expectation is that MS will bring new insights to amyloid formation and thereby play an important role to prevent their formation.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 4","pages":"782-825"},"PeriodicalIF":6.6,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9427217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adventures with peaks 与山峰一起探险向科学家和登山家弗兰蒂塞克-"弗兰克"-图雷切克致敬。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-10-11 DOI: 10.1002/mas.21816

Martin Sadilek, Michael Volny, Victor Ryzhov

引用次数: 0