Mass Spectrometry Reviews最新文献_第9页

Chemical compositional analysis of jet fuels: Contributions of mass spectrometry in the 21st century 喷气燃料的化学成分分析：质谱仪在 21 世纪的贡献。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-12-02 DOI: 10.1002/mas.21825

Mark Romanczyk

引用次数: 0

Ion-molecule reactions of mass-selected ions 大量选择离子的离子-分子反应。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-11-29 DOI: 10.1002/mas.21819

Kevin Parker, Nicholas E. Bollis, Victor Ryzhov

{"title":"Ion-molecule reactions of mass-selected ions","authors":"Kevin Parker, Nicholas E. Bollis, Victor Ryzhov","doi":"10.1002/mas.21819","DOIUrl":"10.1002/mas.21819","url":null,"abstract":"Gas-phase reactions of mass-selected ions with neutrals covers a very broad area of fundamental and applied mass spectrometry (MS). Oftentimes, ion-molecule reactions (IMR) can serve as a viable alternative to collision-induced dissociation and other ion dissociation techniques when using tandem MS. This review focuses on the literature pertaining applications of IMR since 2013. During the past decade considerable efforts have been made in analytical applications of IMR, including advances in one of the major techniques for characterization of unsaturated fatty acids and lipids, ozone-induced dissociation, and the development of a new technique for sequencing of large ions, hydrogen atom attachment/abstraction dissociation. Many advances have also been made in identifying gas-phase chemistry specific to a functional group in organic and biological compounds, which are useful in structure elucidation of analytes and differentiation of isomers/isobars. With “soft” ionization techniques like electrospray ionization having become mainstream for quite some time now, the efforts in the area of metal ion catalysis have firmly moved into exploring chemistry of ligated metal complexes in their “natural” oxidation states allowing to model individual steps of mechanisms in homogeneous catalysis, especially in combination with high-level DFT calculations. Finally, IMR continue to contribute to the body of knowledge in the area of chemistry of interstellar processes.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 1","pages":"47-89"},"PeriodicalIF":6.6,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40709543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass spectrometry-based proteomic approaches for salivary protein biomarkers discovery and dental caries diagnosis: A critical review 基于质谱的蛋白质组学方法用于唾液蛋白质生物标记物的发现和龋齿诊断：重要综述。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-11-29 DOI: 10.1002/mas.21822

Paras Ahmad, Ahmed Hussain, Walter L. Siqueira

引用次数: 0

Characterization of the dystrophin-associated protein complex by mass spectrometry 质谱法表征肌营养不良蛋白相关蛋白复合物。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-11-24 DOI: 10.1002/mas.21823

Emily H. Canessa, Rita Spathis, James S. Novak, Aaron Beedle, Kanneboyina Nagaraju, Luca Bello, Elena Pegoraro, Eric P. Hoffman, Yetrib Hathout

{"title":"Characterization of the dystrophin-associated protein complex by mass spectrometry","authors":"Emily H. Canessa, Rita Spathis, James S. Novak, Aaron Beedle, Kanneboyina Nagaraju, Luca Bello, Elena Pegoraro, Eric P. Hoffman, Yetrib Hathout","doi":"10.1002/mas.21823","DOIUrl":"10.1002/mas.21823","url":null,"abstract":"The dystrophin-associated protein complex (DAPC) is a highly organized multiprotein complex that plays a pivotal role in muscle fiber structure integrity and cell signaling. The complex is composed of three distinct interacting subgroups, intracellular peripheral proteins, transmembrane glycoproteins, and extracellular glycoproteins subcomplexes. Dystrophin protein nucleates the DAPC and is important for connecting the intracellular actin cytoskeletal filaments to the sarcolemma glycoprotein complex that is connected to the extracellular matrix via laminin, thus stabilizing the sarcolemma during muscle fiber contraction and relaxation. Genetic mutations that lead to lack of expression or altered expression of any of the DAPC proteins are associated with different types of muscle diseases. Hence characterization of this complex in healthy and dystrophic muscle might bring insights into its role in muscle pathogenesis. This review highlights the role of mass spectrometry in characterizing the DAPC interactome as well as post-translational glycan modifications of some of its components such as α-dystroglycan. Detection and quantification of dystrophin using targeted mass spectrometry are also discussed in the context of healthy versus dystrophic skeletal muscle.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 1","pages":"90-105"},"PeriodicalIF":6.6,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40508538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthetic dyes: A mass spectrometry approach and applications 合成染料：质谱方法及其应用。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-11-10 DOI: 10.1002/mas.21818

Zoe Millbern, Alison Trettin, Rachel Wu, Morgan Demmler, Nelson R. Vinueza

引用次数: 0

Using mass spectrometry-based methods to understand amyloid formation and inhibition of alpha-synuclein and amyloid beta 利用基于质谱的方法了解淀粉样蛋白的形成以及α-突触核蛋白和β-淀粉样蛋白的抑制作用。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-10-12 DOI: 10.1002/mas.21814

Wesley J. Wagner, Michael L. Gross

{"title":"Using mass spectrometry-based methods to understand amyloid formation and inhibition of alpha-synuclein and amyloid beta","authors":"Wesley J. Wagner, Michael L. Gross","doi":"10.1002/mas.21814","DOIUrl":"10.1002/mas.21814","url":null,"abstract":"Amyloid fibrils, insoluble β-sheets structures that arise from protein misfolding, are associated with several neurodegenerative disorders. Many small molecules have been investigated to prevent amyloid fibrils from forming; however, there are currently no therapeutics to combat these diseases. Mass spectrometry (MS) is proving to be effective for studying the high order structure (HOS) of aggregating proteins and for determining structural changes accompanying protein–inhibitor interactions. When combined with native MS (nMS), gas-phase ion mobility, protein footprinting, and chemical cross-linking, MS can afford regional and sometimes amino acid spatial resolution of the aggregating protein. The spatial resolution is greater than typical low-resolution spectroscopic, calorimetric, and the traditional ThT fluorescence methods used in amyloid research today. High-resolution approaches can struggle when investigating protein aggregation, as the proteins exist as complex oligomeric mixtures of many sizes and several conformations or polymorphs. Thus, MS is positioned to complement both high- and low-resolution approaches to studying amyloid fibril formation and protein–inhibitor interactions. This review covers basics in MS paired with ion mobility, continuous hydrogen-deuterium exchange (continuous HDX), pulsed hydrogen-deuterium exchange (pulsed HDX), fast photochemical oxidation of proteins (FPOP) and other irreversible labeling methods, and chemical cross-linking. We then review the applications of these approaches to studying amyloid-prone proteins with a focus on amyloid beta and alpha-synuclein. Another focus is the determination of protein–inhibitor interactions. The expectation is that MS will bring new insights to amyloid formation and thereby play an important role to prevent their formation.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 4","pages":"782-825"},"PeriodicalIF":6.6,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9427217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adventures with peaks 与山峰一起探险向科学家和登山家弗兰蒂塞克-"弗兰克"-图雷切克致敬。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-10-11 DOI: 10.1002/mas.21816

Martin Sadilek, Michael Volny, Victor Ryzhov

引用次数: 0

How I have learnt to ignore bibliometrics 我是如何学会忽视文献计量学的？

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-10-11 DOI: 10.1002/mas.21815

František Tureček

引用次数: 0

Reminiscence on Frantisek Tureček Frantisek Tureček的回忆。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-10-11 DOI: 10.1002/mas.21817

Ivan K. Chu

引用次数: 0

Proteomics-based mass spectrometry profiling of SARS-CoV-2 infection from human nasopharyngeal samples 基于蛋白质组学的人鼻咽样本SARS-CoV-2感染的质谱分析

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2022-09-29 DOI: 10.1002/mas.21813

Sayantani Chatterjee, Joseph Zaia

{"title":"Proteomics-based mass spectrometry profiling of SARS-CoV-2 infection from human nasopharyngeal samples","authors":"Sayantani Chatterjee, Joseph Zaia","doi":"10.1002/mas.21813","DOIUrl":"10.1002/mas.21813","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the on-going global pandemic of coronavirus disease 2019 (COVID-19) that continues to pose a significant threat to public health worldwide. SARS-CoV-2 encodes four structural proteins namely membrane, nucleocapsid, spike, and envelope proteins that play essential roles in viral entry, fusion, and attachment to the host cell. Extensively glycosylated spike protein efficiently binds to the host angiotensin-converting enzyme 2 initiating viral entry and pathogenesis. Reverse transcriptase polymerase chain reaction on nasopharyngeal swab is the preferred method of sample collection and viral detection because it is a rapid, specific, and high-throughput technique. Alternate strategies such as proteomics and glycoproteomics-based mass spectrometry enable a more detailed and holistic view of the viral proteins and host–pathogen interactions and help in detection of potential disease markers. In this review, we highlight the use of mass spectrometry methods to profile the SARS-CoV-2 proteome from clinical nasopharyngeal swab samples. We also highlight the necessity for a comprehensive glycoproteomics mapping of SARS-CoV-2 from biological complex matrices to identify potential COVID-19 markers.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 1","pages":"193-229"},"PeriodicalIF":6.6,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10112611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1