Mass Spectrometry Reviews最新文献

{"title":"Mass spectrometry of dendrimers","authors":"McKenna J. Redding,&nbsp;Scott M. Grayson,&nbsp;Laurence Charles","doi":"10.1002/mas.21876","DOIUrl":"10.1002/mas.21876","url":null,"abstract":"<p>Mass spectrometry (MS) has become an essential technique to characterize dendrimers as it proved efficient at tackling analytical challenges raised by their peculiar onion-like structure. Owing to their chemical diversity, this review covers benefits of MS methods as a function of dendrimer classes, discussing advantages and limitations of ionization techniques, tandem mass spectrometry (MS/MS) strategies to determine the structure of defective species, as well as most recently demonstrated capabilities of ion mobility spectrometry (IMS) in the field. Complementarily, the well-defined structure of these macromolecules offers major advantages in the development of MS-based method, as reported in a second section reviewing uses of dendrimers as MS and IMS calibration standards and as multifunctional charge inversion reagents in gas phase ion/ion reactions.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"44 5","pages":"682-714"},"PeriodicalIF":6.6,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21876","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140172255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celebrating the remarkable career of Prof. Catherine Fenselau","authors":"Daniele Fabris","doi":"10.1002/mas.21875","DOIUrl":"10.1002/mas.21875","url":null,"abstract":"","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 4","pages":"723-724"},"PeriodicalIF":6.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Proteomics-based mass spectrometry profiling of SARS-CoV-2 infection from human nasopharyngeal samples”","authors":"","doi":"10.1002/mas.21874","DOIUrl":"10.1002/mas.21874","url":null,"abstract":"&lt;p&gt;Chatterjee, S. and Zaia, J., 2022. Proteomics-based mass spectrometry profiling of SARS-CoV-2 infection from human nasopharyngeal samples. &lt;i&gt;Mass Spectrometry Reviews&lt;/i&gt;, &lt;i&gt;43&lt;/i&gt;(1):193–229. [DOI: 10.1002/mas.21813]&lt;/p&gt;&lt;p&gt;1. Page 2 – In the sentence “…as a disease with ambiguous etiology (Y. Huang et al., 2020)” the correct in-text citation should be “C. Huang et al., 2019” [Huang C, Wang Y, Li X, et al. 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. &lt;i&gt;Lancet&lt;/i&gt; (London, England) 395(10223):497–506.]&lt;/p&gt;&lt;p&gt;2. Page 3 – “, blood (Li, Liu, et al., 2021;” the correct in-text citation should be “L. Li et al., 2021” [Li, L., et al., Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patients. &lt;i&gt;Journal of Translational Medicine&lt;/i&gt;, 2021. &lt;b&gt;19&lt;/b&gt;(1):30]&lt;/p&gt;&lt;p&gt;3. Page 3 – “, feces (Li, Liu, et al., 2021; Wang, Xu, et al., 2020)–the in-text citation Wang, Xu, et al., 2020 is changed to “W. Wang et al., 2020” to avoid confusion with another similar in-text citation [Wang W, Xu Y, Gao R, et al. 2020. Detection of SARS-CoV-2 in different types of clinical specimens. &lt;i&gt;Jama&lt;/i&gt; 323(18):1843–1844.]&lt;/p&gt;&lt;p&gt;4. Page 3 – “…glycan shield mechanisms (Bagdonaite &amp; Wandall, 2018; Li, Liu, et al., 2021;” the in-text citation Li, Liu, et al., 2021 should be “L. Li et al., 2021” [Li, L., et al., Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patients. &lt;i&gt;Journal of Translational Medicine&lt;/i&gt;, 2021. &lt;b&gt;19&lt;/b&gt;(1):30]&lt;/p&gt;&lt;p&gt;5. Page 17 – “…SARS-CoV-2 interaction with the host cell receptor (Yang, Hughes, et al., 2020)”, the correct citation is “Yang Y, Du Y, Kaltashov IA. 2020. The utility of native MS for understanding the mechanism of action of repurposed therapeutics in COVID-19: heparin as a disruptor of the SARS-CoV-2 interaction with its host cell receptor. &lt;i&gt;Analytical Chemistry&lt;/i&gt; 92(16):10930–10934.”&lt;/p&gt;&lt;p&gt;6. Page 18 – “…of the S-protein (Gstottner et al., 2021; Watanabe, Berndsen, et al., 2020; Yang, Hughes, et al., 2020)” – the citation Yang, Hughes, et al., 2020 should be Yang J, Wang W, Chen Z, et al. 2020. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity. &lt;i&gt;Nature&lt;/i&gt; 586(7830):572–577.&lt;/p&gt;&lt;p&gt;7. Page 18 – “…that allows the first viral entry into the host cells (Gong et al., 2021; Shajahan, Archer-Hartmann, et al., 2021)”—the citation Shajahan, Archer-Hartmann, et al., 2021 should be Shajahan A, Pepi LE, Rouhani DS, Heiss C, Azadi P. 2021. Glycosylation of SARS-CoV-2: structural and functional insights. &lt;i&gt;Analytical and Bioanalytical Chemistry&lt;/i&gt; 413(29):7179-7193.&lt;/p&gt;&lt;p&gt;8. Page 20 – “…reported by Group-based Prediction System 5.0; Wang, Xu, et al., 2020).” The citation should be Wang C, Xu H, Lin S, et al. 2020. GPS 5.0: an update on the prediction of kinase-specific phosphorylation sites in proteins. &lt;i&gt;Genomics, Proteomics &amp; Bioinformatics&lt;/i&gt; 18(1):72–80.&lt;/p&gt;&lt;p&gt;9. Page 20 – ","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"44 3","pages":"539-540"},"PeriodicalIF":6.6,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21874","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139929179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in proteomics methods for the analysis of exhaled breath condensate","authors":"Edwin J. Yoo,&nbsp;Julie S. Kim,&nbsp;Stephanie Stransky,&nbsp;Simon Spivack,&nbsp;Simone Sidoli","doi":"10.1002/mas.21871","DOIUrl":"10.1002/mas.21871","url":null,"abstract":"<p>The analysis of exhaled breath condensate (EBC) demonstrates a promising avenue of minimally invasive biopsies for diagnostics. EBC is obtained by cooling exhaled air and collecting the condensation to be utilized for downstream analysis using various analytical methods. The aqueous phase of breath contains a large variety of miscible small compounds including polar electrolytes, amino acids, cytokines, chemokines, peptides, small proteins, metabolites, nucleic acids, and lipids/eicosanoids—however, these analytes are typically present at minuscule levels in EBC, posing a considerable technical challenge. Along with recent improvements in devices for breath collection, the sensitivity and resolution of liquid chromatography coupled to online mass spectrometry-based proteomics has attained subfemtomole sensitivity, vastly enhancing the quality of EBC sample analysis. As a result, proteomics analysis of EBC has been expanding the field of breath biomarker research. We present an au courant overview of the achievements in proteomics of EBC, the advancement of EBC collection devices, and the current and future applications for EBC biomarker analysis.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 4","pages":"713-722"},"PeriodicalIF":6.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139039261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry","authors":"Paola Rizzarelli,&nbsp;Melania Leanza,&nbsp;Marco Rapisarda","doi":"10.1002/mas.21869","DOIUrl":"10.1002/mas.21869","url":null,"abstract":"<p>Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market. Therefore, additional research efforts are required to improve their performance. Mass spectrometry (MS) affords a relevant contribution to optimize biodegradable polymer synthesis, to confirm macromolecular structures, to examine along the time the progress of degradation processes and highlight advantages and drawbacks in the extensive applications. This review aims to provide an overview of the MS investigations carried out to support the synthesis of biodegradable polymers, with helpful information on undesirable products or polymerization mechanism, to understand deterioration pathways by the structure of degradation products and to follow drug release and pharmacokinetic. Additionally, it summarizes MS studies addressed on environmental and health issues related to the extensive use of plastic materials, that is, potential migration of additives or microplastics identification and quantification. The paper is focused on the most significant studies relating to synthetic and microbial biodegradable polymers published in the last 15 years, not including agro-polymers such as proteins and polysaccharides.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"44 6","pages":"947-988"},"PeriodicalIF":6.6,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miniature mass spectrometers and their potential for clinical point-of-care analysis","authors":"Yanbing Zhai,&nbsp;Xinyan Fu,&nbsp;Wei Xu","doi":"10.1002/mas.21867","DOIUrl":"10.1002/mas.21867","url":null,"abstract":"<p>Mass spectrometry (MS) has become a powerful technique for clinical applications with high sensitivity and specificity. Different from conventional MS diagnosis in laboratory, point-of-care (POC) analyses in clinics require mass spectrometers and analytical procedures to be friendly for novice users and applicable for on-site clinical diagnosis. The recent decades have seen the progress in the development of miniature mass spectrometers, providing a promising solution for clinical POC applications. In this review, we report recent advances of miniature mass spectrometers and their exploration in clinical applications, mainly including the rapid analysis of illegal drugs, on-site monitoring of therapeutic drugs, and detection of biomarkers. With improved analytical performance, miniature mass spectrometers are also expected to apply to more and more clinical applications. Some promising POC analyses that can be performed by miniature mass spectrometers in the future are discussed. Lastly, we also provide our perspectives on the challenges in technical development of miniature mass spectrometers for clinical POC analysis.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"1172-1191"},"PeriodicalIF":6.6,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10408290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent application of direct analysis in real time mass spectrometry in plant materials analysis with emphasis on traditional Chinese herbal medicine","authors":"Yang Wang,&nbsp;Shuying Liu","doi":"10.1002/mas.21866","DOIUrl":"10.1002/mas.21866","url":null,"abstract":"<p>Direct analysis in real time (DART) represents a new generation of ionization techniques that are used to rapidly ionize small molecules under ambient environments. The combination of DART with various mass spectrometry (MS) instruments allows analyzing multiple plant materials, including traditional Chinese herbal medicines (TCHMs), under simple or no sample treatment conditions. This review discussed the DART principles, including devices, ionization mechanisms, and operation parameters. Typical spectra detected by DART-MS were exhibited and discussed. Numerous applications of DART-MS in the fields of plant material and TCHM analysis were reviewed, including compound identification, biomarker discovery, fingerprinting analysis, and quantification analysis. Besides, modifications and improvements of DART-MS, such as hyphenated application with other separation methods, laser-based desorption techniques, and online sampling configuration, were summarized as well.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"1150-1171"},"PeriodicalIF":6.6,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of modified nucleotides and nucleosides by isotope dilution mass spectrometry","authors":"Juan M. Marchante-Gayón,&nbsp;Jesús Nicolás Carcelén,&nbsp;Helí Potes Rodríguez,&nbsp;Daniela Pineda-Cevallos,&nbsp;Laura Rodas Sánchez,&nbsp;Adriana González-Gago,&nbsp;Pablo Rodríguez-González,&nbsp;Jose I. García Alonso","doi":"10.1002/mas.21865","DOIUrl":"10.1002/mas.21865","url":null,"abstract":"<p>Epigenetic modifications are closely related to certain disorders of the organism, including the development of tumors. One of the main epigenetic modifications is the methylation of DNA cytosines, 5-methyl-2′-deoxycycytidine. Furthermore, 5-mdC can be oxidized to form three new modifications, 5-(hydroxymethyl)-2′-deoxycytidine, 5-formyl-2′-deoxycytidine, and 5-carboxy-2′-deoxycytidine. The coupling of liquid chromatography with tandem mass spectrometry has been widely used for the total determination of methylated DNA cytosines in samples of biological and clinical interest. These methods are based on the measurement of the free compounds (e.g., urine) or after complete hydrolysis of the DNA (e.g., tissues) followed by a preconcentration, derivatization, and/or clean-up step. This review highlights the main advances in the quantification of modified nucleotides and nucleosides by isotope dilution using isotopically labeled analogs combined with liquid or gas chromatography coupled to mass spectrometry reported in the last 20 years. The different possible sources of labeled compounds are indicated. Special emphasis has been placed on the different types of chromatography commonly used (reverse phase and hydrophilic interaction liquid chromatography) and the derivatization methods developed to enhance chromatographic resolution and ionization efficiency. We have also revised the application of bidimensional chromatography and indicated significant biological and clinical applications of these determinations.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"998-1018"},"PeriodicalIF":6.6,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21865","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10027099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An update on multiplexed mass spectrometry-based lysosomal storage disease diagnosis","authors":"Laura Darie-Ion,&nbsp;Brînduşa Alina Petre","doi":"10.1002/mas.21864","DOIUrl":"10.1002/mas.21864","url":null,"abstract":"<p>Lysosomal storage disorders (LSDs) are a type of inherited metabolic disorders in which biomolecules, accumulate as a specific substrate in lysosomes due to specific individual enzyme deficiencies. Despite the fact that LSDs are incurable, various approaches, including enzyme replacement therapy, hematopoietic stem cell transplantation, or gene therapy are now available. Therefore, a timely diagnosis is a critical initial step in patient treatment. The-<i>state-of-the-art</i> in LSD diagnostic uses, in the first stage, enzymatic activity determination by fluorimetry or by mass spectrometry (MS) with the aid of dry blood spots, based on different enzymatic substrate structures. Due to its sensitivity, high precision, and ability to screen for an unprecedented number of diseases in a single assay, multiplexed tandem MS-based enzyme activity assays for the screening of LSDs in newborns have recently received a lot of attention. Here, (i) we review the current approaches used for simultaneous enzymatic activity determination of LSDs in dried blood spots using multiplex—LC-MS/MS; (ii) we explore the need for designing novel enzymatic substrates that generate different enzymatic products with distinct molecular masses in multiplexed-MS studies; and (iii) we give examples of the relevance of affinity-MS technique as a basis for reversing undesirable immune-reactivity in enzyme replacement therapy.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"1135-1149"},"PeriodicalIF":6.6,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10061603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct mass spectrometry analysis of exhaled human breath in real-time","authors":"Xiaoping Zhang,&nbsp;Vladimir Frankevich,&nbsp;Jianhua Ding,&nbsp;Yuanyuan Ma,&nbsp;Konstantin Chingin,&nbsp;Huanwen Chen","doi":"10.1002/mas.21855","DOIUrl":"10.1002/mas.21855","url":null,"abstract":"<p>The molecular composition of exhaled human breath can reflect various physiological and pathological conditions. Considerable progress has been achieved over the past decade in real-time analysis of exhaled human breath using direct mass spectrometry methods, including selected ion flow tube mass spectrometry, proton transfer reaction mass spectrometry, extractive electrospray ionization mass spectrometry, secondary electrospray ionization mass spectrometry, acetone-assisted negative photoionization mass spectrometry, atmospheric pressure photoionization mass spectrometry, and low-pressure photoionization mass spectrometry. Here, recent developments in direct mass spectrometry analysis of exhaled human breath are reviewed with regard to analytical performance (chemical sensitivity, selectivity, quantitative capabilities) and applications of the developed methods in disease diagnosis, targeted molecular detection, and real-time metabolic monitoring.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"44 1","pages":"43-61"},"PeriodicalIF":6.6,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9974393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}