Mass Spectrometry Reviews最新文献_第8页

Effects of charge on protein ion structure: Lessons from cation-to-anion, proton-transfer reactions 电荷对蛋白质离子结构的影响：阳离子到阴离子、质子转移反应的启示

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-05-02 DOI: 10.1002/mas.21847

Theresa A. Gozzo, Matthew F. Bush

引用次数: 0

Mass spectrometric approaches in discovering lipid biomarkers for COVID-19 by lipidomics: Future challenges and perspectives 通过脂质组学发现 COVID-19 脂质生物标记物的质谱方法：未来的挑战与展望

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-04-27 DOI: 10.1002/mas.21848

Siddabasave Gowda B. Gowda, Chandra Shekhar, Divyavani Gowda, Yifan Chen, Hitoshi Chiba, Shu-Ping Hui

{"title":"Mass spectrometric approaches in discovering lipid biomarkers for COVID-19 by lipidomics: Future challenges and perspectives","authors":"Siddabasave Gowda B. Gowda, Chandra Shekhar, Divyavani Gowda, Yifan Chen, Hitoshi Chiba, Shu-Ping Hui","doi":"10.1002/mas.21848","DOIUrl":"10.1002/mas.21848","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) has emerged as a global health threat and has rapidly spread worldwide. Significant changes in the lipid profile before and after COVID-19 confirmed the significance of lipid metabolism in regulating the response to viral infection. Therefore, understanding the role of lipid metabolism may facilitate the development of new therapeutics for COVID-19. Owing to their high sensitivity and accuracy, mass spectrometry (MS)-based methods are widely used for rapidly identifying and quantifying of thousands of lipid species present in a small amount of sample. To enhance the capabilities of MS for the qualitative and quantitative analysis of lipids, different platforms have been combined to cover a wide range of lipidomes with high sensitivity, specificity, and accuracy. Currently, MS-based technologies are being established as efficient methods for discovering potential diagnostic biomarkers for COVID-19 and related diseases. As the lipidome of the host cell is drastically affected by the viral replication process, investigating lipid profile alterations in patients with COVID-19 and targeting lipid metabolism pathways are considered to be crucial steps in host-directed drug targeting to develop better therapeutic strategies. This review summarizes various MS-based strategies that have been developed for lipidomic analyzes and biomarker discoveries to combat COVID-19 by integrating various other potential approaches using different human samples. Furthermore, this review discusses the challenges in using MS technologies and future perspectives in terms of drug discovery and diagnosis of COVID-19.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"1041-1065"},"PeriodicalIF":6.9,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9423503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass spectrometry of polymers: A tutorial review 聚合物质谱分析：教程综述

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-04-18 DOI: 10.1002/mas.21844

Chrys Wesdemiotis, Kayla N. Williams-Pavlantos, Addie R. Keating, Andrew S. McGee, Calum Bochenek

{"title":"Mass spectrometry of polymers: A tutorial review","authors":"Chrys Wesdemiotis, Kayla N. Williams-Pavlantos, Addie R. Keating, Andrew S. McGee, Calum Bochenek","doi":"10.1002/mas.21844","DOIUrl":"10.1002/mas.21844","url":null,"abstract":"Ever since the inception of synthetic polymeric materials in the late 19th century, the number of studies on polymers as well as the complexity of their structures have only increased. The development and commercialization of new polymers with properties fine-tuned for specific technological, environmental, consumer, or biomedical applications requires powerful analytical techniques that permit the in-depth characterization of these materials. One such method with the ability to provide chemical composition and structure information with high sensitivity, selectivity, specificity, and speed is mass spectrometry (MS). This tutorial review presents and exemplifies the various MS techniques available for the elucidation of specific structural features in a synthetic polymer, including compositional complexity, primary structure, architecture, topology, and surface properties. Key to every MS analysis is sample conversion to gas-phase ions. This review describes the fundamentals of the most suitable ionization methods for synthetic materials and provides relevant sample preparation protocols. Most importantly, structural characterizations via one-step as well as hyphenated or multidimensional approaches are introduced and demonstrated with specific applications, including surface sensitive and imaging techniques. The aim of this tutorial review is to illustrate the capabilities of MS for the characterization of large, complex polymers and emphasize its potential as a powerful compositional and structural elucidation tool in polymer chemistry.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 3","pages":"427-476"},"PeriodicalIF":6.6,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21844","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive and heart-cutting multidimensional liquid chromatography–mass spectrometry and its applications in food analysis 多维液相色谱-质谱联用技术及其在食品分析中的应用。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-04-13 DOI: 10.1002/mas.21845

Irene Caño-Carrillo, Bienvenida Gilbert-López, Lidia Montero, Ana B. Martínez-Piernas, Juan F. García-Reyes, Antonio Molina-Díaz

{"title":"Comprehensive and heart-cutting multidimensional liquid chromatography–mass spectrometry and its applications in food analysis","authors":"Irene Caño-Carrillo, Bienvenida Gilbert-López, Lidia Montero, Ana B. Martínez-Piernas, Juan F. García-Reyes, Antonio Molina-Díaz","doi":"10.1002/mas.21845","DOIUrl":"10.1002/mas.21845","url":null,"abstract":"In food analysis, conventional one-dimensional liquid chromatography methods sometimes lack sufficient separation power due to the complexity and heterogeneity of the analyzed matrices. Therefore, the use of two-dimensional liquid chromatography (2D-LC) turns out to be a powerful tool to consider, especially when coupled to mass spectrometry (MS). This review presents the most remarkable 2D-LC–MS food applications reported in the last 10 years, including a critical discussion of the multiple approaches, modulation strategies as well as the importance of the optimization of the different analytical aspects that will condition the 2D-LC–MS performance. The presence of contaminants in food (food safety), the food quality, and authenticity or the relationship between the beneficial effects of food and human health are some of the fields in which most of the 2D-LC–MS applications are mainly focused. Both heart-cutting and comprehensive applications are described and discussed in this review, highlighting the potential of 2D-LC–MS for the analysis of such complex samples.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"936-976"},"PeriodicalIF":6.9,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21845","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9648484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomics mining of cancer hallmarks on a single-cell resolution 单细胞分辨率的癌症特征蛋白质组学挖掘。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-04-12 DOI: 10.1002/mas.21842

Maomao Li, Jing Zuo, Kailin Yang, Ping Wang, Shengtao Zhou

{"title":"Proteomics mining of cancer hallmarks on a single-cell resolution","authors":"Maomao Li, Jing Zuo, Kailin Yang, Ping Wang, Shengtao Zhou","doi":"10.1002/mas.21842","DOIUrl":"10.1002/mas.21842","url":null,"abstract":"Dysregulated proteome is an essential contributor in carcinogenesis. Protein fluctuations fuel the progression of malignant transformation, such as uncontrolled proliferation, metastasis, and chemo/radiotherapy resistance, which severely impair therapeutic effectiveness and cause disease recurrence and eventually mortality among cancer patients. Cellular heterogeneity is widely observed in cancer and numerous cell subtypes have been characterized that greatly influence cancer progression. Population-averaged research may not fully reveal the heterogeneity, leading to inaccurate conclusions. Thus, deep mining of the multiplex proteome at the single-cell resolution will provide new insights into cancer biology, to develop prognostic biomarkers and treatments. Considering the recent advances in single-cell proteomics, herein we review several novel technologies with particular focus on single-cell mass spectrometry analysis, and summarize their advantages and practical applications in the diagnosis and treatment for cancer. Technological development in single-cell proteomics will bring a paradigm shift in cancer detection, intervention, and therapy.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"1019-1040"},"PeriodicalIF":6.9,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9659218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probe-based mass spectrometry approaches for single-cell and single-organelle measurements 用于单细胞和单细胞器测量的基于探针的质谱方法。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-04-03 DOI: 10.1002/mas.21841

Daniel C. Castro, Peter Chan-Andersen, Elena V. Romanova, Jonathan V. Sweedler

{"title":"Probe-based mass spectrometry approaches for single-cell and single-organelle measurements","authors":"Daniel C. Castro, Peter Chan-Andersen, Elena V. Romanova, Jonathan V. Sweedler","doi":"10.1002/mas.21841","DOIUrl":"10.1002/mas.21841","url":null,"abstract":"Exploring the chemical content of individual cells not only reveals underlying cell-to-cell chemical heterogeneity but is also a key component in understanding how cells combine to form emergent properties of cellular networks and tissues. Recent technological advances in many analytical techniques including mass spectrometry (MS) have improved instrumental limits of detection and laser/ion probe dimensions, allowing the analysis of micron and submicron sized areas. In the case of MS, these improvements combined with MS's broad analyte detection capabilities have enabled the rise of single-cell and single-organelle chemical characterization. As the chemical coverage and throughput of single-cell measurements increase, more advanced statistical and data analysis methods have aided in data visualization and interpretation. This review focuses on secondary ion MS and matrix-assisted laser desorption/ionization MS approaches for single-cell and single-organelle characterization, which is followed by advances in mass spectral data visualization and analysis.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 4","pages":"888-912"},"PeriodicalIF":6.6,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9323501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive and heart-cutting multidimensional liquid chromatography-mass spectrometry and its applications in food analysis. 全面切心多维液相色谱-质谱法及其在食品分析中的应用。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-04-03 DOI: 10.1002/mas.21843

Irene Caño-Carrillo, Bienvenida Gilbert-López, Lidia Montero, Ana B Martínez-Piernas, Juan F García-Reyes, Antonio Molina-Díaz

{"title":"Comprehensive and heart-cutting multidimensional liquid chromatography-mass spectrometry and its applications in food analysis.","authors":"Irene Caño-Carrillo, Bienvenida Gilbert-López, Lidia Montero, Ana B Martínez-Piernas, Juan F García-Reyes, Antonio Molina-Díaz","doi":"10.1002/mas.21843","DOIUrl":"https://doi.org/10.1002/mas.21843","url":null,"abstract":"In food analysis, conventional one-dimensional liquid chromatography methods sometimes lack sufficient separation power due to the complexity and heterogeneity of the analysed matrices. Therefore, the use of two-dimensional liquid chromatography (2D-LC) turns out to be a powerful tool to consider, especially when coupled to mass spectrometry (MS). This review presents the most remarkable 2D-LC-MS food applications reported in the last 10 years, including a critical discussion of the multiple approaches, modulation strategies as well as the importance of the optimisation of the different analytical aspects that will condition the 2D-LC-MS performance. The presence of contaminants in food (food safety), the food quality and authenticity or the relationship between the beneficial effects of food and human health are some of the fields in which most of the 2D-LC-MS applications are mainly focused. Both heart-cutting and comprehensive applications are described and discussed in this review, highlighting the potential of 2D-LC-MS for the analysis of such complex samples.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9234502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Editorial from Dominic M. Desiderio Dominic M. Desiderio的社论

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-03-17 DOI: 10.1002/mas.21840

Dom Desiderio

引用次数: 0

Innovations in applications of mass spectrometry impact many fields of science 质谱技术应用的创新影响着许多科学领域。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-03-17 DOI: 10.1002/mas.21839

Catherine Fenselau

引用次数: 0

Measurement and utilization of the proteomic reactivity by mass spectrometry 质谱法测定蛋白质组反应性及其应用。