Mass Spectrometry Reviews最新文献_第7页

Mapping protein-protein interactions by mass spectrometry. 通过质谱法绘制蛋白质与蛋白质之间的相互作用图。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2024-05-14 DOI: 10.1002/mas.21887

Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M Cristea, Markku Varjosalo

{"title":"Mapping protein-protein interactions by mass spectrometry.","authors":"Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M Cristea, Markku Varjosalo","doi":"10.1002/mas.21887","DOIUrl":"10.1002/mas.21887","url":null,"abstract":"Protein-protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious diseases. Recent advances in mass spectrometry (MS)-based protein interactomics have significantly expanded our understanding of the PPIs in cells, with techniques that continue to improve in terms of sensitivity, and specificity providing new opportunities for the study of PPIs in diverse biological systems. These techniques differ depending on the type of interaction being studied, with each approach having its set of advantages, disadvantages, and applicability. This review highlights recent advances in enrichment methodologies for interactomes before MS analysis and compares their unique features and specifications. It emphasizes prospects for further improvement and their potential applications in advancing our knowledge of PPIs in various biological contexts.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modern machine-learning applications in ambient ionization mass spectrometry 环境电离质谱中的现代机器学习应用

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2024-04-26 DOI: 10.1002/mas.21886

Anatoly A. Sorokin, Stanislav I. Pekov, Denis S. Zavorotnyuk, Mariya M. Shamraeva, Denis S. Bormotov, Igor A. Popov

引用次数: 0

Editor's note 编者注

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2024-04-25 DOI: 10.1002/mas.21885

引用次数: 0

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse? 光亲和标记与 MS 联用，识别多肽生物伙伴：二次反应，是好是坏？

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2024-04-05 DOI: 10.1002/mas.21880

Astrid Walrant, Emmanuelle Sachon

引用次数: 0

Protein glycosylation in lung cancer from a mass spectrometry perspective 从质谱分析角度看肺癌中的蛋白质糖基化

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2024-04-05 DOI: 10.1002/mas.21882

Mirjam Balbisi, Simon Sugár, Lilla Turiák

{"title":"Protein glycosylation in lung cancer from a mass spectrometry perspective","authors":"Mirjam Balbisi, Simon Sugár, Lilla Turiák","doi":"10.1002/mas.21882","DOIUrl":"https://doi.org/10.1002/mas.21882","url":null,"abstract":"Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer. Differences in glycosylation patterns have been previously observed between healthy and cancerous samples as well as between different lung cancer subtypes, which suggests untapped diagnostic potential. In addition, understanding the changes mediated by glycosylation may shed light on possible novel therapeutic targets and personalized treatment strategies for lung cancer patients. Mass spectrometry based glycomics and glycoproteomics have emerged as powerful tools for in‐depth characterization of changes in protein glycosylation, providing valuable insights into the molecular basis of lung cancer. This paper reviews the literature on the analysis of protein glycosylation in lung cancer using mass spectrometry, which is dominated by manuscripts published over the past 5 years. Studies analyzing N‐glycosylation, O‐glycosylation, and glycosaminoglycan patterns in tissue, serum, plasma, and rare biological samples of lung cancer patients are highlighted. The current knowledge on the potential utility of glycan and glycoprotein biomarkers is also discussed.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass spectrometry for neurosurgery: Intraoperative support in decision-making 神经外科的质谱分析：为决策提供术中支持

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2024-04-04 DOI: 10.1002/mas.21883

Stanislav I. Pekov, Denis S. Bormotov, Svetlana I. Bocharova, Anatoly A. Sorokin, Maria M. Derkach, Igor A. Popov

引用次数: 0

Young mass spectrometrists special issue 青年质谱专家特刊

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2024-04-03 DOI: 10.1002/mas.21884

引用次数: 0

Understanding zwitterionic ring-expansion polymerization through mass spectrometry. 通过质谱法了解齐聚物扩环聚合。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2024-03-31 DOI: 10.1002/mas.21877

Mahi Ahmad, Scott M Grayson

{"title":"Understanding zwitterionic ring-expansion polymerization through mass spectrometry.","authors":"Mahi Ahmad, Scott M Grayson","doi":"10.1002/mas.21877","DOIUrl":"https://doi.org/10.1002/mas.21877","url":null,"abstract":"Zwitterionic ring-expansion polymerization (ZREP) is a polymerization method in which a cyclic monomer is converted into a cyclic polymer through a zwitterionic intermediate. In this review, we explored the ZREP of various cyclic polymers and how mass spectrometry assists in identifying the product architectures and understanding their intricate reaction mechanism. For the majority of polymers (from a few thousand to a few million Da) matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is the most effective mass spectrometry technique to determine the true molecular weight (MW) of the resultant product, but only when the dispersity is low (approximately below 1.2). The key topics covered in this study were the ZREP of cyclic polyesters, cyclic polyamides, and cyclic ethers. In addition, this study also addresses a number of other preliminary topics, including the ZREP of cyclic polycarbonates, cyclic polysiloxanes, and cyclic poly(alkylene phosphates). The purity and efficiency of those syntheses largely depend on the catalyst. Among several catalysts, N-heterocyclic carbenes have exhibited high efficiency in the synthesis of cyclic polyesters and polyamides, whereas tris(pentafluorophenyl)borane [B(C6F5)3] is the most optimal catalyst for cyclic polyether synthesis.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

My journey in life and chemistry 我的人生和化学之旅

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2024-03-27 DOI: 10.1002/mas.21879

Veronica M. Bierbaum

引用次数: 0

Special issue of Dr. Veronica Bierbaum for her contributions to fundamental chemistry in mass spectrometry Veronica Bierbaum 博士特刊，以表彰她对质谱分析基础化学的贡献。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2024-03-21 DOI: 10.1002/mas.21878

引用次数: 0