Mass Spectrometry Reviews最新文献_第7页

A Special Issue of Mass Spectrometry Reviews to Honor Professor Renato Zenobi: A Lifetime of Mentorship and Innovation in Mass Spectrometry 《质谱评论》特刊纪念Renato Zenobi教授：在质谱领域的终身指导和创新。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03 Epub Date: 2025-11-04 DOI: 10.1002/mas.70012

Martin Pabst, Pawel L. Urban

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Decoding Sugars: Mass Spectrometric Advances in the Analysis of the Sugar Alphabet 解码糖：质谱法在糖字母表分析中的进展。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03 Epub Date: 2025-02-19 DOI: 10.1002/mas.21927

Jitske M. van Ede, Dinko Soic, Martin Pabst

{"title":"Decoding Sugars: Mass Spectrometric Advances in the Analysis of the Sugar Alphabet","authors":"Jitske M. van Ede, Dinko Soic, Martin Pabst","doi":"10.1002/mas.21927","DOIUrl":"10.1002/mas.21927","url":null,"abstract":"<div>\u0000 \u0000 Monosaccharides play a central role in metabolic networks and in the biosynthesis of glycomolecules, which perform essential functions across all domains of life. Thus, identifying and quantifying these building blocks is crucial in both research and industry. Routine methods have been established to facilitate the analysis of common monosaccharides. However, despite the presence of common metabolites, most organisms utilize distinct sets of monosaccharides and derivatives. These molecules therefore display a large diversity, potentially numbering in the hundreds or thousands, with many still unknown. This complexity presents significant challenges in the study of glycomolecules, particularly in microbes, including pathogens and those with the potential to serve as novel model organisms. This review discusses mass spectrometric techniques for the isomer-sensitive analysis of monosaccharides, their derivatives, and activated forms. Although mass spectrometry allows for untargeted analysis and sensitive detection in complex matrices, the presence of stereoisomers and extensive modifications necessitates the integration of advanced chromatographic, electrophoretic, ion mobility, or ion spectroscopic methods. Furthermore, stable-isotope incorporation studies are critical in elucidating biosynthetic routes in novel organisms.\u0000 </div>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 2","pages":"282-333"},"PeriodicalIF":6.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Mapping protein–protein interactions by mass spectrometry 通过质谱法绘制蛋白质与蛋白质之间的相互作用图。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2025-12-16 Epub Date: 2024-05-14 DOI: 10.1002/mas.21887

Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo

{"title":"Mapping protein–protein interactions by mass spectrometry","authors":"Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo","doi":"10.1002/mas.21887","DOIUrl":"10.1002/mas.21887","url":null,"abstract":"Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious diseases. Recent advances in mass spectrometry (MS)-based protein interactomics have significantly expanded our understanding of the PPIs in cells, with techniques that continue to improve in terms of sensitivity, and specificity providing new opportunities for the study of PPIs in diverse biological systems. These techniques differ depending on the type of interaction being studied, with each approach having its set of advantages, disadvantages, and applicability. This review highlights recent advances in enrichment methodologies for interactomes before MS analysis and compares their unique features and specifications. It emphasizes prospects for further improvement and their potential applications in advancing our knowledge of PPIs in various biological contexts.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 1","pages":"69-106"},"PeriodicalIF":6.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2025-12-16

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Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry 亲水相互作用液相色谱-质谱联用分析甲基化季铵化合物。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2025-12-16 Epub Date: 2025-05-29 DOI: 10.1002/mas.21942

Iman Zarei, Ambrin Farizah Babu, Ville M. Koistinen, Marjo Tuomainen, Anna Kårlund, Retu Haikonen, Marko Lehtonen, Kati Hanhineva

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The Finnish Mass Spectrometry Regional Issue 芬兰质谱区域问题

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2025-12-16 DOI: 10.1002/mas.70018

Hilkka Kenttämaa

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Mass spectrometry in ocular drug research 质谱法在眼科药物研究中的应用

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2025-12-16 Epub Date: 2023-08-02 DOI: 10.1002/mas.21861

Eva M. del Amo, Kati-Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola

{"title":"Mass spectrometry in ocular drug research","authors":"Eva M. del Amo, Kati-Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola","doi":"10.1002/mas.21861","DOIUrl":"10.1002/mas.21861","url":null,"abstract":"Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments. The second part of the review consists of an introduction to ocular proteomics, with special emphasis on targeted absolute quantitation of membrane transporters and metabolizing enzymes. The third part of the review deals with liquid chromatography–MS (LC-MS) and MS imaging (MSI) methods used in the analysis of drugs and metabolites in ocular samples. The sensitivity and speed of LC-MS make simultaneous quantitation of various drugs and metabolites possible in minute tissue samples, even though ocular sample preparation requires careful handling. The MSI methodology is on the verge of becoming as important as LC-MS in ocular pharmacokinetic studies, since the spatial resolution has reached the level, where cell layers can be separated, and quantitation with isotope-labeled standards has come more reliable. MS will remain in the foreseeable future as the main analytical method that will progress our understanding of ocular pharmacokinetics.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 1","pages":"37-68"},"PeriodicalIF":6.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21861","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9975265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Analysis of triacylglycerol and phospholipid sn-positional isomers by liquid chromatographic and mass spectrometric methodologies 用液相色谱和质谱方法分析甘油三酯和磷脂的非位置异构体

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2025-12-16 Epub Date: 2023-06-06 DOI: 10.1002/mas.21853

Mikael Fabritius, Baoru Yang

{"title":"Analysis of triacylglycerol and phospholipid sn-positional isomers by liquid chromatographic and mass spectrometric methodologies","authors":"Mikael Fabritius, Baoru Yang","doi":"10.1002/mas.21853","DOIUrl":"10.1002/mas.21853","url":null,"abstract":"Analysis of triacylglycerol (TG) and phospholipid sn-positional isomers can be divided into two main categories: (a) direct separation by chromatography or other means such as ion mobility mass spectrometry and (b) quantification of regioisomer ratios by structurally informative fragment ions with mass spectrometric methods. Due to long retention times and limited performance, researchers are moving away from direct chromatographic separation of isomers, using mass spectrometry instead. Many established analytical methods are targeting specific isomers of interest instead of untargeted analysis of comprehensive profiles of regioisomers. Challenges remain arising from the large number of isobaric and isomeric lipid species in natural samples, often overlapping chromatographically and sharing structurally informative fragment ions. Further, fragmentation of glycerolipids is influenced by the nature of the attached fatty acids, and the lack of available regiopure standards is still an obstacle for establishing calibration curves required for accurate quantification of regioisomers. Additionally, throughput of many methods is still quite limited. Optimization algorithms and fragmentation models are useful especially for analysis of TG regioisomers, as identification using calibration curves alone without proper separation is difficult with complex samples.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 1","pages":"4-36"},"PeriodicalIF":6.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9576392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Mass Spectrometry-Based Applications in Tannin Analytics: From Qualitative and Quantitative Analyses to Biological Activity 质谱法在单宁分析中的应用：从定性和定量分析到生物活性。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2025-12-16 Epub Date: 2025-11-27 DOI: 10.1002/mas.70013

Marica T. Engström, Maarit Karonen

{"title":"Mass Spectrometry-Based Applications in Tannin Analytics: From Qualitative and Quantitative Analyses to Biological Activity","authors":"Marica T. Engström, Maarit Karonen","doi":"10.1002/mas.70013","DOIUrl":"10.1002/mas.70013","url":null,"abstract":"Tannins are widespread specialized plant metabolites that contribute significantly to the polyphenol content of plant-based diets. Their effects on human and animal health vary depending on their structure, with potential benefits including antioxidative, antimicrobial, anthelmintic, and anticarcinogenic properties. Understanding tannin composition and quantity in plant products is essential, as their bioactivities are influenced by their functional groups. Mass spectrometry-based techniques excel in tannin analysis, offering both qualitative and quantitative insights. Combining ultrahigh-performance liquid chromatography with electrospray ionization and high-resolution and triple quadrupole mass analyzers is optimal for comprehensive tannin profiling. Such an approach enables precise analysis and helps predict tannin bioactivities. This review highlights the mass spectrometric analysis of proanthocyanidins and hydrolysable tannins, addressing ionization techniques, interpretation of multiply charged ions, characteristic fragmentations, and reaction monitoring. Applications related to tannin bioactivities are also briefly discussed, demonstrating the utility of mass spectrometry in tannin analysis in complex sample matrices.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 1","pages":"120-146"},"PeriodicalIF":6.6,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/mas.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2025-12-16

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