Mass Spectrometry Reviews最新文献

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Editorial: Frank Turecek Laudation 社论弗兰克-图雷切克奖
IF 6.6 2区 化学
Mass Spectrometry Reviews Pub Date : 2023-07-14 DOI: 10.1002/mas.21859
Karel Lemr, Vladimír Havlíček
{"title":"Editorial: Frank Turecek Laudation","authors":"Karel Lemr, Vladimír Havlíček","doi":"10.1002/mas.21859","DOIUrl":"10.1002/mas.21859","url":null,"abstract":"","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 3","pages":"411-412"},"PeriodicalIF":6.6,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9781150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in mass spectrometry techniques for atmospheric chemistry research on molecular-level 用于分子水平大气化学研究的质谱技术的最新进展。
IF 6.6 2区 化学
Mass Spectrometry Reviews Pub Date : 2023-07-13 DOI: 10.1002/mas.21857
Wen Zhang, Lu Xu, Haofei Zhang
{"title":"Recent advances in mass spectrometry techniques for atmospheric chemistry research on molecular-level","authors":"Wen Zhang,&nbsp;Lu Xu,&nbsp;Haofei Zhang","doi":"10.1002/mas.21857","DOIUrl":"10.1002/mas.21857","url":null,"abstract":"<p>The Earth's atmosphere is composed of an enormous variety of chemical species associated with trace gases and aerosol particles whose composition and chemistry have critical impacts on the Earth's climate, air quality, and human health. Mass spectrometry analysis as a powerful and popular analytical technique has been widely developed and applied in atmospheric chemistry for decades. Mass spectrometry allows for effective detection, identification, and quantification of a broad range of organic and inorganic chemical species with high sensitivity and resolution. In this review, we summarize recently developed mass spectrometry techniques, methods, and applications in atmospheric chemistry research in the past several years on molecular-level. Specifically, new developments of ion-molecule reactors, various soft ionization methods, and unique coupling with separation techniques are highlighted. The new mass spectrometry applications in laboratory studies and field measurements focused on improving the detection limits for traditional and emerging volatile organic compounds, characterizing multiphase highly oxygenated molecules, and monitoring particle bulk and surface compositions.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"1091-1134"},"PeriodicalIF":6.6,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9770749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of mRNA therapeutics mRNA 疗法的特征。
IF 6.6 2区 化学
Mass Spectrometry Reviews Pub Date : 2023-07-04 DOI: 10.1002/mas.21856
Guilherme J. Guimaraes, Jaeah Kim, Michael G. Bartlett
{"title":"Characterization of mRNA therapeutics","authors":"Guilherme J. Guimaraes,&nbsp;Jaeah Kim,&nbsp;Michael G. Bartlett","doi":"10.1002/mas.21856","DOIUrl":"10.1002/mas.21856","url":null,"abstract":"<p>Therapeutic messenger RNAs (mRNAs) have emerged as powerful tools in the treatment of complex diseases, especially for conditions that lack efficacious treatment. The successful application of this modality can be attributed to its ability to encode entire proteins. While the large nature of these molecules has supported their success as therapeutics, its extended size creates several analytical challenges. To further support therapeutic mRNA development and its deployment in clinical trials, appropriate methods to support their characterization must be developed. In this review, we describe current analytical methods that have been used in the characterization of RNA quality, identity, and integrity. Advantages and limitations from several analytical techniques ranging from gel electrophoresis to liquid chromatography–mass spectrometry and from shotgun sequencing to intact mass measurements are discussed. We comprehensively describe the application of analytical methods in the measurements of capping efficiency, poly A tail analysis, as well as their applicability in stability studies.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"1066-1090"},"PeriodicalIF":6.6,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9738173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ion-molecule studies of energetic oxygen allotropes in flow tubes: O 2 ( v ) , O 2 ( a Δ g 1 ) , O 3 , and O 流管内含能氧同素异形体的离子分子研究o2 (v),o2 (a Δ g1) o2和o2
IF 6.6 2区 化学
Mass Spectrometry Reviews Pub Date : 2023-07-02 DOI: 10.1002/mas.21846
Nicole Eyet, Shaun G. Ard, Nicholas S. Shuman, Albert A. Viggiano
{"title":"Ion-molecule studies of energetic oxygen allotropes in flow tubes: \u0000 \u0000 \u0000 \u0000 \u0000 O\u0000 2\u0000 \u0000 (\u0000 v\u0000 )\u0000 ,\u0000 \u0000 O\u0000 2\u0000 \u0000 (\u0000 a\u0000 \u0000 Δ\u0000 g\u0000 \u0000 \u0000 \u0000 1\u0000 \u0000 )\u0000 ,\u0000 \u0000 O\u0000 3\u0000 \u0000 ,\u0000 and\u0000 \u0000 O","authors":"Nicole Eyet,&nbsp;Shaun G. Ard,&nbsp;Nicholas S. Shuman,&nbsp;Albert A. Viggiano","doi":"10.1002/mas.21846","DOIUrl":"10.1002/mas.21846","url":null,"abstract":"<p>Starting in the 1960s, flow tube apparatuses have played a central role in the study of ion-molecule kinetics, allowing for immense chemical diversity of cationic, anionic, and neutral reactants. Here, we review studies of oxygen allotropes, excluding ground state O<sub>2</sub> (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 \u0000 <mrow>\u0000 <msup>\u0000 <mi>X</mi>\u0000 \u0000 <mn>3</mn>\u0000 </msup>\u0000 \u0000 <msubsup>\u0000 <mo>∑</mo>\u0000 \u0000 <mi>g</mi>\u0000 \u0000 <mo>−</mo>\u0000 </msubsup>\u0000 </mrow>\u0000 </mrow>\u0000 </semantics></math>), and focusing instead on reactions of cations, anions, and metal chemi-ionization reactions with ground state atomic oxygen (O <sup>3</sup>P), vibrationally excited molecular oxygen (O<sub>2</sub>(v)), electronically excited molecular oxygen (O<sub>2</sub> (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 \u0000 <mrow>\u0000 <msup>\u0000 <mi>a</mi>\u0000 \u0000 <mn>1</mn>\u0000 </msup>\u0000 \u0000 <msub>\u0000 <mi>Δ</mi>\u0000 \u0000 <mi>g</mi>\u0000 </msub>\u0000 </mrow>\u0000 </mrow>\u0000 </semantics></math>)), and ozone (O<sub>3</sub>). Historical outlines of work over several decades are given along with a focus on more recent work by our group at the Air Force Research Laboratory.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"44 2","pages":"185-209"},"PeriodicalIF":6.6,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9739192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptides as “better biomarkers”? Value, challenges, and potential solutions to facilitate implementation 肽作为 "更好的生物标记物"?价值、挑战以及促进实施的潜在解决方案。
IF 6.6 2区 化学
Mass Spectrometry Reviews Pub Date : 2023-06-26 DOI: 10.1002/mas.21854
Agnieszka Latosinska, Maria Frantzi, Justyna Siwy
{"title":"Peptides as “better biomarkers”? Value, challenges, and potential solutions to facilitate implementation","authors":"Agnieszka Latosinska,&nbsp;Maria Frantzi,&nbsp;Justyna Siwy","doi":"10.1002/mas.21854","DOIUrl":"10.1002/mas.21854","url":null,"abstract":"<p>Peptides carry important functions in normal physiological and pathophysiological processes and can serve as clinically useful biomarkers. Given the ability to diffuse passively across endothelial barriers, endogenous peptides can be examined in several body fluids, including among others urine, blood, and cerebrospinal fluid. This review article provides an update on the recently published literature that reports on investigating native peptides in body fluids using mass spectrometry-based platforms, specifically those studies that focus on the application of peptides as biomarkers to improve clinical management. We emphasize on the critical evaluation of their clinical value, how close they are to implementation, and the associated challenges and potential solutions to facilitate clinical implementation. During the last 5 years, numerous studies have been published, demonstrating the increased interest in mass spectrometry for the assessment of endogenous peptides as potential biomarkers. Importantly, the presence of few successful examples of implementation in patients' management and/or in the context of clinical trials indicates that the peptide biomarker field is evolving. Nevertheless, most studies still report evidence based on small sample size, while validation phases are frequently missing. Therefore, a gap between discovery and implementation still exists.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 6","pages":"1195-1236"},"PeriodicalIF":6.6,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10042296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of triacylglycerol and phospholipid sn-positional isomers by liquid chromatographic and mass spectrometric methodologies. 用液相色谱和质谱方法分析甘油三酯和磷脂的非位置异构体。
IF 6.6 2区 化学
Mass Spectrometry Reviews Pub Date : 2023-06-06 DOI: 10.1002/mas.21853
Mikael Fabritius, Baoru Yang
{"title":"Analysis of triacylglycerol and phospholipid sn-positional isomers by liquid chromatographic and mass spectrometric methodologies.","authors":"Mikael Fabritius,&nbsp;Baoru Yang","doi":"10.1002/mas.21853","DOIUrl":"https://doi.org/10.1002/mas.21853","url":null,"abstract":"<p><p>Analysis of triacylglycerol (TG) and phospholipid sn-positional isomers can be divided into two main categories: (a) direct separation by chromatography or other means such as ion mobility mass spectrometry and (b) quantification of regioisomer ratios by structurally informative fragment ions with mass spectrometric methods. Due to long retention times and limited performance, researchers are moving away from direct chromatographic separation of isomers, using mass spectrometry instead. Many established analytical methods are targeting specific isomers of interest instead of untargeted analysis of comprehensive profiles of regioisomers. Challenges remain arising from the large number of isobaric and isomeric lipid species in natural samples, often overlapping chromatographically and sharing structurally informative fragment ions. Further, fragmentation of glycerolipids is influenced by the nature of the attached fatty acids, and the lack of available regiopure standards is still an obstacle for establishing calibration curves required for accurate quantification of regioisomers. Additionally, throughput of many methods is still quite limited. Optimization algorithms and fragmentation models are useful especially for analysis of TG regioisomers, as identification using calibration curves alone without proper separation is difficult with complex samples.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9576392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Structural studies of supramolecular complexes and assemblies by ion mobility mass spectrometry 利用离子迁移质谱对超分子复合物和组装体进行结构研究
IF 6.6 2区 化学
Mass Spectrometry Reviews Pub Date : 2023-06-01 DOI: 10.1002/mas.21851
Magdalena M. Zimnicka
{"title":"Structural studies of supramolecular complexes and assemblies by ion mobility mass spectrometry","authors":"Magdalena M. Zimnicka","doi":"10.1002/mas.21851","DOIUrl":"10.1002/mas.21851","url":null,"abstract":"<p>Recent advances in instrumentation and development of computational strategies for ion mobility mass spectrometry (IM-MS) studies have contributed to an extensive growth in the application of this analytical technique to comprehensive structural description of supramolecular systems. Apart from the benefits of IM-MS for interrogation of intrinsic properties of noncovalent aggregates in the experimental gas-phase environment, its merits for the description of native structural aspects, under the premises of having maintained the noncovalent interactions innate upon the ionization process, have attracted even more attention and gained increasing interest in the scientific community. Thus, various types of supramolecular complexes and assemblies relevant for biological, medical, material, and environmental sciences have been characterized so far by IM-MS supported by computational chemistry. This review covers the state-of-the-art in this field and discusses experimental methods and accompanying computational approaches for assessing the reliable three-dimensional structural elucidation of supramolecular complexes and assemblies by IM-MS.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 3","pages":"526-559"},"PeriodicalIF":6.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statistical approaches applicable in managing OMICS data: Urinary proteomics as exemplary case 适用于管理 OMICS 数据的统计方法:以尿液蛋白质组学为例
IF 6.6 2区 化学
Mass Spectrometry Reviews Pub Date : 2023-05-04 DOI: 10.1002/mas.21849
De-Wei An, Yu-Ling Yu, Dries S. Martens, Agnieszka Latosinska, Zhen-Yu Zhang, Harald Mischak, Tim S. Nawrot, Jan A. Staessen
{"title":"Statistical approaches applicable in managing OMICS data: Urinary proteomics as exemplary case","authors":"De-Wei An,&nbsp;Yu-Ling Yu,&nbsp;Dries S. Martens,&nbsp;Agnieszka Latosinska,&nbsp;Zhen-Yu Zhang,&nbsp;Harald Mischak,&nbsp;Tim S. Nawrot,&nbsp;Jan A. Staessen","doi":"10.1002/mas.21849","DOIUrl":"10.1002/mas.21849","url":null,"abstract":"<p>With urinary proteomics profiling (UPP) as exemplary omics technology, this review describes a workflow for the analysis of omics data in large study populations. The proposed workflow includes: (i) planning omics studies and sample size considerations; (ii) preparing the data for analysis; (iii) preprocessing the UPP data; (iv) the basic statistical steps required for data curation; (v) the selection of covariables; (vi) relating continuously distributed or categorical outcomes to a series of single markers (e.g., sequenced urinary peptide fragments identifying the parental proteins); (vii) showing the added diagnostic or prognostic value of the UPP markers over and beyond classical risk factors, and (viii) pathway analysis to identify targets for personalized intervention in disease prevention or treatment. Additionally, two short sections respectively address multiomics studies and machine learning. In conclusion, the analysis of adverse health outcomes in relation to omics biomarkers rests on the same statistical principle as any other data collected in large population or patient cohorts. The large number of biomarkers, which have to be considered simultaneously requires planning ahead how the study database will be structured and curated, imported in statistical software packages, analysis results will be triaged for clinical relevance, and presented.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 6","pages":"1237-1254"},"PeriodicalIF":6.6,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21849","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9466843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of charge on protein ion structure: Lessons from cation-to-anion, proton-transfer reactions 电荷对蛋白质离子结构的影响:阳离子到阴离子、质子转移反应的启示
IF 6.6 2区 化学
Mass Spectrometry Reviews Pub Date : 2023-05-02 DOI: 10.1002/mas.21847
Theresa A. Gozzo, Matthew F. Bush
{"title":"Effects of charge on protein ion structure: Lessons from cation-to-anion, proton-transfer reactions","authors":"Theresa A. Gozzo,&nbsp;Matthew F. Bush","doi":"10.1002/mas.21847","DOIUrl":"10.1002/mas.21847","url":null,"abstract":"<p>Collision cross-section values, which can be determined using ion mobility experiments, are sensitive to the structures of protein ions and useful for applications to structural biology and biophysics. Protein ions with different charge states can exhibit very different collision cross-section values, but a comprehensive understanding of this relationship remains elusive. Here, we review cation-to-anion, proton-transfer reactions (CAPTR), a method for generating a series of charge-reduced protein cations by reacting quadrupole-selected cations with even-electron monoanions. The resulting CAPTR products are analyzed using a combination of ion mobility, mass spectrometry, and collisional activation. We compare CAPTR to other charge-manipulation strategies and review the results of various CAPTR-based experiments, exploring their contribution to a deeper understanding of the relationship between protein ion structure and charge state.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 3","pages":"500-525"},"PeriodicalIF":6.6,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9394055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mass spectrometry of polymers: A tutorial review 聚合物质谱分析:教程综述
IF 6.6 2区 化学
Mass Spectrometry Reviews Pub Date : 2023-04-18 DOI: 10.1002/mas.21844
Chrys Wesdemiotis, Kayla N. Williams-Pavlantos, Addie R. Keating, Andrew S. McGee, Calum Bochenek
{"title":"Mass spectrometry of polymers: A tutorial review","authors":"Chrys Wesdemiotis,&nbsp;Kayla N. Williams-Pavlantos,&nbsp;Addie R. Keating,&nbsp;Andrew S. McGee,&nbsp;Calum Bochenek","doi":"10.1002/mas.21844","DOIUrl":"10.1002/mas.21844","url":null,"abstract":"<p>Ever since the inception of synthetic polymeric materials in the late 19th century, the number of studies on polymers as well as the complexity of their structures have only increased. The development and commercialization of new polymers with properties fine-tuned for specific technological, environmental, consumer, or biomedical applications requires powerful analytical techniques that permit the in-depth characterization of these materials. One such method with the ability to provide chemical composition and structure information with high sensitivity, selectivity, specificity, and speed is mass spectrometry (MS). This tutorial review presents and exemplifies the various MS techniques available for the elucidation of specific structural features in a synthetic polymer, including compositional complexity, primary structure, architecture, topology, and surface properties. Key to every MS analysis is sample conversion to gas-phase ions. This review describes the fundamentals of the most suitable ionization methods for synthetic materials and provides relevant sample preparation protocols. Most importantly, structural characterizations via one-step as well as hyphenated or multidimensional approaches are introduced and demonstrated with specific applications, including surface sensitive and imaging techniques. The aim of this tutorial review is to illustrate the capabilities of MS for the characterization of large, complex polymers and emphasize its potential as a powerful compositional and structural elucidation tool in polymer chemistry.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 3","pages":"427-476"},"PeriodicalIF":6.6,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21844","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9682165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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