Mass Spectrometry Reviews最新文献_第7页

Comprehensive and heart-cutting multidimensional liquid chromatography–mass spectrometry and its applications in food analysis 多维液相色谱-质谱联用技术及其在食品分析中的应用。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-04-13 DOI: 10.1002/mas.21845

Irene Caño-Carrillo, Bienvenida Gilbert-López, Lidia Montero, Ana B. Martínez-Piernas, Juan F. García-Reyes, Antonio Molina-Díaz

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引用次数: 0

Proteomics mining of cancer hallmarks on a single-cell resolution 单细胞分辨率的癌症特征蛋白质组学挖掘。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-04-12 DOI: 10.1002/mas.21842

Maomao Li, Jing Zuo, Kailin Yang, Ping Wang, Shengtao Zhou

{"title":"Proteomics mining of cancer hallmarks on a single-cell resolution","authors":"Maomao Li, Jing Zuo, Kailin Yang, Ping Wang, Shengtao Zhou","doi":"10.1002/mas.21842","DOIUrl":"10.1002/mas.21842","url":null,"abstract":"Dysregulated proteome is an essential contributor in carcinogenesis. Protein fluctuations fuel the progression of malignant transformation, such as uncontrolled proliferation, metastasis, and chemo/radiotherapy resistance, which severely impair therapeutic effectiveness and cause disease recurrence and eventually mortality among cancer patients. Cellular heterogeneity is widely observed in cancer and numerous cell subtypes have been characterized that greatly influence cancer progression. Population-averaged research may not fully reveal the heterogeneity, leading to inaccurate conclusions. Thus, deep mining of the multiplex proteome at the single-cell resolution will provide new insights into cancer biology, to develop prognostic biomarkers and treatments. Considering the recent advances in single-cell proteomics, herein we review several novel technologies with particular focus on single-cell mass spectrometry analysis, and summarize their advantages and practical applications in the diagnosis and treatment for cancer. Technological development in single-cell proteomics will bring a paradigm shift in cancer detection, intervention, and therapy.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"1019-1040"},"PeriodicalIF":6.9,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9659218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probe-based mass spectrometry approaches for single-cell and single-organelle measurements 用于单细胞和单细胞器测量的基于探针的质谱方法。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-04-03 DOI: 10.1002/mas.21841

Daniel C. Castro, Peter Chan-Andersen, Elena V. Romanova, Jonathan V. Sweedler

{"title":"Probe-based mass spectrometry approaches for single-cell and single-organelle measurements","authors":"Daniel C. Castro, Peter Chan-Andersen, Elena V. Romanova, Jonathan V. Sweedler","doi":"10.1002/mas.21841","DOIUrl":"10.1002/mas.21841","url":null,"abstract":"Exploring the chemical content of individual cells not only reveals underlying cell-to-cell chemical heterogeneity but is also a key component in understanding how cells combine to form emergent properties of cellular networks and tissues. Recent technological advances in many analytical techniques including mass spectrometry (MS) have improved instrumental limits of detection and laser/ion probe dimensions, allowing the analysis of micron and submicron sized areas. In the case of MS, these improvements combined with MS's broad analyte detection capabilities have enabled the rise of single-cell and single-organelle chemical characterization. As the chemical coverage and throughput of single-cell measurements increase, more advanced statistical and data analysis methods have aided in data visualization and interpretation. This review focuses on secondary ion MS and matrix-assisted laser desorption/ionization MS approaches for single-cell and single-organelle characterization, which is followed by advances in mass spectral data visualization and analysis.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 4","pages":"888-912"},"PeriodicalIF":6.6,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9323501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive and heart-cutting multidimensional liquid chromatography-mass spectrometry and its applications in food analysis. 全面切心多维液相色谱-质谱法及其在食品分析中的应用。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-04-03 DOI: 10.1002/mas.21843

Irene Caño-Carrillo, Bienvenida Gilbert-López, Lidia Montero, Ana B Martínez-Piernas, Juan F García-Reyes, Antonio Molina-Díaz

{"title":"Comprehensive and heart-cutting multidimensional liquid chromatography-mass spectrometry and its applications in food analysis.","authors":"Irene Caño-Carrillo, Bienvenida Gilbert-López, Lidia Montero, Ana B Martínez-Piernas, Juan F García-Reyes, Antonio Molina-Díaz","doi":"10.1002/mas.21843","DOIUrl":"https://doi.org/10.1002/mas.21843","url":null,"abstract":"In food analysis, conventional one-dimensional liquid chromatography methods sometimes lack sufficient separation power due to the complexity and heterogeneity of the analysed matrices. Therefore, the use of two-dimensional liquid chromatography (2D-LC) turns out to be a powerful tool to consider, especially when coupled to mass spectrometry (MS). This review presents the most remarkable 2D-LC-MS food applications reported in the last 10 years, including a critical discussion of the multiple approaches, modulation strategies as well as the importance of the optimisation of the different analytical aspects that will condition the 2D-LC-MS performance. The presence of contaminants in food (food safety), the food quality and authenticity or the relationship between the beneficial effects of food and human health are some of the fields in which most of the 2D-LC-MS applications are mainly focused. Both heart-cutting and comprehensive applications are described and discussed in this review, highlighting the potential of 2D-LC-MS for the analysis of such complex samples.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9234502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Editorial from Dominic M. Desiderio Dominic M. Desiderio的社论

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-03-17 DOI: 10.1002/mas.21840

Dom Desiderio

引用次数: 0

Innovations in applications of mass spectrometry impact many fields of science 质谱技术应用的创新影响着许多科学领域。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-03-17 DOI: 10.1002/mas.21839

Catherine Fenselau

引用次数: 0

Measurement and utilization of the proteomic reactivity by mass spectrometry 质谱法测定蛋白质组反应性及其应用。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-03-16 DOI: 10.1002/mas.21837

Clodette Punzalan, Lei Wang, Bekim Bajrami, Xudong Yao

引用次数: 0

Mass spectrometry analysis of phosphotyrosine-containing proteins 含磷酪氨酸蛋白质的质谱分析。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-02-14 DOI: 10.1002/mas.21836

Jiajia Li, Xianquan Zhan

引用次数: 0

Recent developments and applications of selected ion flow tube mass spectrometry (SIFT-MS). 选择离子流管质谱（SIFT-MS）的最新发展和应用。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-02-12 DOI: 10.1002/mas.21835

David Smith, Patrik Španěl, Nicholas Demarais, Vaughan S Langford, Murray J McEwan

{"title":"Recent developments and applications of selected ion flow tube mass spectrometry (SIFT-MS).","authors":"David Smith, Patrik Španěl, Nicholas Demarais, Vaughan S Langford, Murray J McEwan","doi":"10.1002/mas.21835","DOIUrl":"10.1002/mas.21835","url":null,"abstract":"Selected ion flow tube mass spectrometry (SIFT-MS) is now recognized as the most versatile analytical technique for the identification and quantification of trace gases down to the parts-per-trillion by volume, pptv, range. This statement is supported by the wide reach of its applications, from real-time analysis, obviating sample collection of very humid exhaled breath, to its adoption in industrial scenarios for air quality monitoring. This review touches on the recent extensions to the underpinning ion chemistry kinetics library and the alternative challenge of using nitrogen carrier gas instead of helium. The addition of reagent anions in the Voice200 series of SIFT-MS instruments has enhanced the analytical capability, thus allowing analyses of volatile trace compounds in humid air that cannot be analyzed using reagent cations alone, as clarified by outlining the anion chemistry involved. Case studies are reviewed of breath analysis and bacterial culture volatile organic compound (VOC), emissions, environmental applications such as air, water, and soil analysis, workplace safety such as transport container fumigants, airborne contamination in semiconductor fabrication, food flavor and spoilage, drugs contamination and VOC emissions from packaging to demonstrate the stated qualities and uniqueness of the new generation SIFT-MS instrumentation. Finally, some advancements that can be made to improve the analytical capability and reach of SIFT-MS are mentioned.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":"e21835"},"PeriodicalIF":6.6,"publicationDate":"2023-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10774108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The isotope distribution: A rose with thorns. 同位素分布：带刺的玫瑰

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-02-06 DOI: 10.1002/mas.21820

Jürgen Claesen, Alan Rockwood, Mikhail Gorshkov, Dirk Valkenborg

{"title":"The isotope distribution: A rose with thorns.","authors":"Jürgen Claesen, Alan Rockwood, Mikhail Gorshkov, Dirk Valkenborg","doi":"10.1002/mas.21820","DOIUrl":"10.1002/mas.21820","url":null,"abstract":"The isotope distribution, which reflects the number and probabilities of occurrence of different isotopologues of a molecule, can be theoretically calculated. With the current generation of (ultra)-high-resolution mass spectrometers, the isotope distribution of molecules can be measured with high sensitivity, resolution, and mass accuracy. However, the observed isotope distribution can differ substantially from the expected isotope distribution. Although differences between the observed and expected isotope distribution can complicate the analysis and interpretation of mass spectral data, they can be helpful in a number of specific applications. These applications include, yet are not limited to, the identification of peptides in proteomics, elucidation of the elemental composition of small organic molecules and metabolites, as well as wading through peaks in mass spectra of complex bioorganic mixtures such as petroleum and humus. In this review, we give a nonexhaustive overview of factors that have an impact on the observed isotope distribution, such as elemental isotope deviations, ion sampling, ion interactions, electronic noise and dephasing, centroiding, and apodization. These factors occur at different stages of obtaining the isotope distribution: during the collection of the sample, during the ionization and intake of a molecule in a mass spectrometer, during the mass separation and detection of ionized molecules, and during signal processing.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10644535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0