Mass Spectrometry Reviews最新文献_第6页

Electrokinetic Manipulations Combined With Direct and Ambient Ionization Mass Spectrometry 电动操作与直接和环境电离质谱相结合。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03 Epub Date: 2024-12-15 DOI: 10.1002/mas.21921

Nicholas E. Manicke, Lahiru Wedasingha, Magnus Rydberg

{"title":"Electrokinetic Manipulations Combined With Direct and Ambient Ionization Mass Spectrometry","authors":"Nicholas E. Manicke, Lahiru Wedasingha, Magnus Rydberg","doi":"10.1002/mas.21921","DOIUrl":"10.1002/mas.21921","url":null,"abstract":"<p>Mass spectrometry (MS) is a powerful analytical technique that typically involves sample preparation and online analytical separation before MS detection. Traditional methods often face bottlenecks in sample preparation and analytical separation, despite the rapid detection capabilities of MS. This review explores the integration of electrokinetic manipulations directly with the ionization step to enhance MS performance, focusing on methods that eliminate or simplify sample preparation and separation processes. Techniques such as paper spray, electrophoresis in nanoelectrospray ionization (nESI) emitters, induced nESI, counterflow gradient electrofocusing, and in-syringe electrokinetics are highlighted for their ability to combine extraction and ionization in a single step, significantly improving throughput. The review delves into the use of electric fields during sample preparation and separations for these methods, demonstrating the efficiency of electrophoretic methods in driving extractions, crude separations, desalting, and enhanced sensitivity. The integration of these methods directly with MS ionization aims to enhance the analytical capabilities of mass spectrometry, while reducing costs and increasing throughput relative to traditional approaches.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 2","pages":"244-259"},"PeriodicalIF":6.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reminiscence on Renato Zenobi by Alfredo Ibáñez Renato Zenobi的回忆Alfredo Ibáñez。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03 Epub Date: 2025-09-27 DOI: 10.1002/mas.70009

Alfredo Ibáñez

引用次数: 0

Mass Spectrometry-Based Proteomics for Next-Generation Precision Oncology 基于质谱的蛋白质组学用于下一代精确肿瘤学。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03 Epub Date: 2025-04-23 DOI: 10.1002/mas.21932

Kuen-Tyng Lin, Gul Muneer, Pei-Rong Huang, Ciao-Syuan Chen, Yu-Ju Chen

{"title":"Mass Spectrometry-Based Proteomics for Next-Generation Precision Oncology","authors":"Kuen-Tyng Lin, Gul Muneer, Pei-Rong Huang, Ciao-Syuan Chen, Yu-Ju Chen","doi":"10.1002/mas.21932","DOIUrl":"10.1002/mas.21932","url":null,"abstract":"<div>\u0000 \u0000 <p>Cancer is the leading cause of death worldwide characterized by patient heterogeneity and complex tumor microenvironment. While the genomics-based testing has transformed modern medicine, the challenge of diverse clinical outcomes highlights unmet needs for precision oncology. As functional molecules regulating cellular processes, proteins hold great promise as biomarkers and drug targets. Mass spectrometry (MS)-based clinical proteomics has illuminated the molecular features of cancers and facilitated discovery of biomarkers or therapeutic targets, paving the way for innovative strategies that enhance the precision of personalized treatment. In this article, we introduced the tools and current achievements of MS-based proteomics, choice of discovery and targeted MS from discovery to validation phases, profiling sensitivity from bulk samples to single-cell level and tissue to liquid biopsy specimens, current regulatory landscape of MS-based protein laboratory-developed tests (LDTs). The challenges, success and future perspectives in translating research MS assay into clinical applications are also discussed. With well-designed validation studies to demonstrate clinical benefits and meet the regulatory requirements for both analytical and clinical performance, the future of MS-based assays is promising with numerous opportunities to improve cancer diagnosis, treatment, and monitoring.</p>\u0000 </div>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 2","pages":"361-391"},"PeriodicalIF":6.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postionization Mass Spectrometry Imaging: Past, Present, and Future 电离质谱成像：过去、现在和未来。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03 Epub Date: 2024-11-18 DOI: 10.1002/mas.21918

Xiaokang Guan, Qiao Lu, Shuxian Liu, Xiaowen Yan

{"title":"Postionization Mass Spectrometry Imaging: Past, Present, and Future","authors":"Xiaokang Guan, Qiao Lu, Shuxian Liu, Xiaowen Yan","doi":"10.1002/mas.21918","DOIUrl":"10.1002/mas.21918","url":null,"abstract":"<div>\u0000 \u0000 <p>Mass spectrometry imaging (MSI) technologies are widely used today to study the in situ spatial distributions for a variety of analytes. As these technologies advance, the pursuit of higher resolution in MSI has intensified. The limitation of direct desorption/ionization is its insufficient ionization, posing a constraint on the advancement of high-resolution MSI technologies. The introduction of postionization process compensates the low ionization efficiency caused by sacrificing the desorption area while pursuing high spatial resolution, resolving the conflict between high spatial resolution and high sensitivity in direct desorption/ionization method. Here, we discuss the sampling and ionization steps of MSI separately, and review the postionization methods in MSI according to three different sampling modes: laser sampling, probe sampling, and ion beam sampling. Postionization technology excels in enhancing ionization efficiency, boosting sensitivity, mitigating discrimination effect, simplifying sample preparation, and expanding the scope of applicability. These advantages position postionization technology as a promising tool for biomedical sciences, materials sciences, forensic analysis and other fields.</p>\u0000 </div>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 2","pages":"231-243"},"PeriodicalIF":6.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03

引用次数: 0

The Evolution of Secondary/Extractive Electrospray Ionization: From Ionization Mechanism to Instrumental Advances 二次/萃取电喷雾电离的演变：从电离机理到仪器的进展。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03 Epub Date: 2025-04-08 DOI: 10.1002/mas.21931

Guoyuan Liao, Bo Yang, Lei Li, Xiaolan Hu, Christian George, Abdelwahid Mellouki, Anthony Wexler, Pablo Sinues, Xue Li

{"title":"The Evolution of Secondary/Extractive Electrospray Ionization: From Ionization Mechanism to Instrumental Advances","authors":"Guoyuan Liao, Bo Yang, Lei Li, Xiaolan Hu, Christian George, Abdelwahid Mellouki, Anthony Wexler, Pablo Sinues, Xue Li","doi":"10.1002/mas.21931","DOIUrl":"10.1002/mas.21931","url":null,"abstract":"<div>\u0000 \u0000 <p>Secondary electrospray ionization (SESI) and extractive electrospray ionization (EESI), as derivative technologies of electrospray ionization (ESI), have empowered the real-time analysis of trace compounds residing in gases and aerosols. Over the past three decades, SESI and EESI have demonstrated remarkable potential in a wide spectrum of applications, spanning disease diagnosis, drug detection, food safety, and environmental surveillance. Concurrently, the strides made in deciphering the ionization mechanisms of SESI and EESI have spurred the creation of diverse ion source configurations that are characterized by enhanced sensitivity and diminished background noise. This comprehensive review encapsulates the ionization mechanisms inherent in SESI and EESI processes, with particular emphasis on the impact of analyte characteristics (such as proton affinity, dipole moment, polarizability, and solubility) and ion source operational parameters (encompassing temperature, humidity, voltage, flow rate and electrospray composition) on ionization efficiency. Additionally, it delves into the progression of SESI and EESI sources, highlights recent breakthroughs, and probes into future trajectories, furnishing novel perspectives for the development of both technologies and the associated instruments.</p></div>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 2","pages":"334-360"},"PeriodicalIF":6.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reminiscence on Renato Zenobi by Pablo Sinues 巴勃罗·西努斯的《雷纳托·芝诺比的回忆》。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03 Epub Date: 2025-09-29 DOI: 10.1002/mas.70008

Pablo Sinues

引用次数: 0

Human Capital Is the Most Valuable 人力资本是最有价值的。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03 Epub Date: 2025-12-15 DOI: 10.1002/mas.70017

Renato Zenobi

引用次数: 0

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03

引用次数: 0

Thermometer Ions, Internal Energies, and In-Source Fragmentation in Ambient Ionization 温度计离子、内能和环境电离中的源内碎裂。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2026-02-03 Epub Date: 2025-01-27 DOI: 10.1002/mas.21924

Emilie Bertrand, Valérie Gabelica

{"title":"Thermometer Ions, Internal Energies, and In-Source Fragmentation in Ambient Ionization","authors":"Emilie Bertrand, Valérie Gabelica","doi":"10.1002/mas.21924","DOIUrl":"10.1002/mas.21924","url":null,"abstract":"<p>Ionization and fragmentation are at the core of mass spectrometry. But they are not necessarily separated in space, as in-source fragmentation can also occur. Here, we survey the literature published since our 2005 review on the internal energy and fragmentation in electrospray ionization sources. We present new thermometer molecules to diagnose and quantify source heating, provide tables of recommended threshold (<i>E</i><sub>0</sub>) and appearance energies (<i>E</i><sub>app</sub>) for the survival yield method, and attempt to compare the softness of a variety of ambient pressure ionization sources. The droplet size distribution and desolvation dynamics play a major role: lower average internal energies are obtained when the ions remain protected by a solvation shell and spend less time nakedly exposed to activating conditions in the transfer interface. Methods based on small droplet formation without charging can thus be softer than electrospray. New dielectric barrier discharge sources can gas-phase ionize small molecules while conferring barely more internal energy than electrospray ionization. However, the tuning of the entire source interface often has an even greater influence on ion internal energies and fragmentation than on the ionization process itself. We hope that this review will facilitate further research to control and standardize in-source ion activation conditions, and to ensure the transferability of data and research results in mass spectrometry.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"45 2","pages":"260-281"},"PeriodicalIF":6.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12866378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0