Mass Spectrometry Reviews最新文献_第6页

Advances in proteomics methods for the analysis of exhaled breath condensate 用于分析呼出气体冷凝物的蛋白质组学方法的进展。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-12-27 DOI: 10.1002/mas.21871

Edwin J. Yoo, Julie S. Kim, Stephanie Stransky, Simon Spivack, Simone Sidoli

{"title":"Advances in proteomics methods for the analysis of exhaled breath condensate","authors":"Edwin J. Yoo, Julie S. Kim, Stephanie Stransky, Simon Spivack, Simone Sidoli","doi":"10.1002/mas.21871","DOIUrl":"10.1002/mas.21871","url":null,"abstract":"The analysis of exhaled breath condensate (EBC) demonstrates a promising avenue of minimally invasive biopsies for diagnostics. EBC is obtained by cooling exhaled air and collecting the condensation to be utilized for downstream analysis using various analytical methods. The aqueous phase of breath contains a large variety of miscible small compounds including polar electrolytes, amino acids, cytokines, chemokines, peptides, small proteins, metabolites, nucleic acids, and lipids/eicosanoids—however, these analytes are typically present at minuscule levels in EBC, posing a considerable technical challenge. Along with recent improvements in devices for breath collection, the sensitivity and resolution of liquid chromatography coupled to online mass spectrometry-based proteomics has attained subfemtomole sensitivity, vastly enhancing the quality of EBC sample analysis. As a result, proteomics analysis of EBC has been expanding the field of breath biomarker research. We present an au courant overview of the achievements in proteomics of EBC, the advancement of EBC collection devices, and the current and future applications for EBC biomarker analysis.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 4","pages":"713-722"},"PeriodicalIF":6.6,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139039261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry. 质谱法研究生物可降解聚合物的表征、降解及应用。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-11-28 DOI: 10.1002/mas.21869

Paola Rizzarelli, Melania Leanza, Marco Rapisarda

{"title":"Investigations into the characterization, degradation, and applications of biodegradable polymers by mass spectrometry.","authors":"Paola Rizzarelli, Melania Leanza, Marco Rapisarda","doi":"10.1002/mas.21869","DOIUrl":"https://doi.org/10.1002/mas.21869","url":null,"abstract":"Biodegradable polymers have been getting more and more attention because of their contribution to the plastic pollution environmental issues and to move towards a circular economy. Nevertheless, biodegradable materials still exhibit various disadvantages restraining a widespread use in the market. Therefore, additional research efforts are required to improve their performance. Mass spectrometry (MS) affords a relevant contribution to optimize biodegradable polymer synthesis, to confirm macromolecular structures, to examine along the time the progress of degradation processes and highlight advantages and drawbacks in the extensive applications. This review aims to provide an overview of the MS investigations carried out to support the synthesis of biodegradable polymers, with helpful information on undesirable products or polymerization mechanism, to understand deterioration pathways by the structure of degradation products and to follow drug release and pharmacokinetic. Additionally, it summarizes MS studies addressed on environmental and health issues related to the extensive use of plastic materials, that is, potential migration of additives or microplastics identification and quantification. The paper is focused on the most significant studies relating to synthetic and microbial biodegradable polymers published in the last 15 years, not including agro-polymers such as proteins and polysaccharides.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Miniature mass spectrometers and their potential for clinical point-of-care analysis 微型质谱仪及其用于临床护理点分析的潜力。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-08-23 DOI: 10.1002/mas.21867

Yanbing Zhai, Xinyan Fu, Wei Xu

引用次数: 0

Recent application of direct analysis in real time mass spectrometry in plant materials analysis with emphasis on traditional Chinese herbal medicine 实时质谱直接分析法在植物材料分析中的最新应用，重点是传统中草药。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-08-20 DOI: 10.1002/mas.21866

Yang Wang, Shuying Liu

引用次数: 0

Quantification of modified nucleotides and nucleosides by isotope dilution mass spectrometry 利用同位素稀释质谱法对修饰的核苷酸和核苷进行定量。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-08-19 DOI: 10.1002/mas.21865

Juan M. Marchante-Gayón, Jesús Nicolás Carcelén, Helí Potes Rodríguez, Daniela Pineda-Cevallos, Laura Rodas Sánchez, Adriana González-Gago, Pablo Rodríguez-González, Jose I. García Alonso

{"title":"Quantification of modified nucleotides and nucleosides by isotope dilution mass spectrometry","authors":"Juan M. Marchante-Gayón, Jesús Nicolás Carcelén, Helí Potes Rodríguez, Daniela Pineda-Cevallos, Laura Rodas Sánchez, Adriana González-Gago, Pablo Rodríguez-González, Jose I. García Alonso","doi":"10.1002/mas.21865","DOIUrl":"10.1002/mas.21865","url":null,"abstract":"Epigenetic modifications are closely related to certain disorders of the organism, including the development of tumors. One of the main epigenetic modifications is the methylation of DNA cytosines, 5-methyl-2′-deoxycycytidine. Furthermore, 5-mdC can be oxidized to form three new modifications, 5-(hydroxymethyl)-2′-deoxycytidine, 5-formyl-2′-deoxycytidine, and 5-carboxy-2′-deoxycytidine. The coupling of liquid chromatography with tandem mass spectrometry has been widely used for the total determination of methylated DNA cytosines in samples of biological and clinical interest. These methods are based on the measurement of the free compounds (e.g., urine) or after complete hydrolysis of the DNA (e.g., tissues) followed by a preconcentration, derivatization, and/or clean-up step. This review highlights the main advances in the quantification of modified nucleotides and nucleosides by isotope dilution using isotopically labeled analogs combined with liquid or gas chromatography coupled to mass spectrometry reported in the last 20 years. The different possible sources of labeled compounds are indicated. Special emphasis has been placed on the different types of chromatography commonly used (reverse phase and hydrophilic interaction liquid chromatography) and the derivatization methods developed to enhance chromatographic resolution and ionization efficiency. We have also revised the application of bidimensional chromatography and indicated significant biological and clinical applications of these determinations.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"998-1018"},"PeriodicalIF":6.9,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21865","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10027099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on multiplexed mass spectrometry-based lysosomal storage disease diagnosis 基于多重质谱技术的溶酶体贮积症诊断的最新进展。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-08-16 DOI: 10.1002/mas.21864

Laura Darie-Ion, Brînduşa Alina Petre

{"title":"An update on multiplexed mass spectrometry-based lysosomal storage disease diagnosis","authors":"Laura Darie-Ion, Brînduşa Alina Petre","doi":"10.1002/mas.21864","DOIUrl":"10.1002/mas.21864","url":null,"abstract":"Lysosomal storage disorders (LSDs) are a type of inherited metabolic disorders in which biomolecules, accumulate as a specific substrate in lysosomes due to specific individual enzyme deficiencies. Despite the fact that LSDs are incurable, various approaches, including enzyme replacement therapy, hematopoietic stem cell transplantation, or gene therapy are now available. Therefore, a timely diagnosis is a critical initial step in patient treatment. The-state-of-the-art in LSD diagnostic uses, in the first stage, enzymatic activity determination by fluorimetry or by mass spectrometry (MS) with the aid of dry blood spots, based on different enzymatic substrate structures. Due to its sensitivity, high precision, and ability to screen for an unprecedented number of diseases in a single assay, multiplexed tandem MS-based enzyme activity assays for the screening of LSDs in newborns have recently received a lot of attention. Here, (i) we review the current approaches used for simultaneous enzymatic activity determination of LSDs in dried blood spots using multiplex—LC-MS/MS; (ii) we explore the need for designing novel enzymatic substrates that generate different enzymatic products with distinct molecular masses in multiplexed-MS studies; and (iii) we give examples of the relevance of affinity-MS technique as a basis for reversing undesirable immune-reactivity in enzyme replacement therapy.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 5","pages":"1135-1149"},"PeriodicalIF":6.9,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10061603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct mass spectrometry analysis of exhaled human breath in real-time 实时直接质谱分析呼出的人的呼吸。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-08-10 DOI: 10.1002/mas.21855

Xiaoping Zhang, Vladimir Frankevich, Jianhua Ding, Yuanyuan Ma, Konstantin Chingin, Huanwen Chen

引用次数: 0

Tissue proteomics repositories for data reanalysis 用于数据再分析的组织蛋白质组学资料库。

IF 6.9 2区化学

Mass Spectrometry Reviews Pub Date : 2023-08-03 DOI: 10.1002/mas.21860

Rafael Stroggilos, Aggeliki Tserga, Jerome Zoidakis, Antonia Vlahou, Manousos Makridakis

{"title":"Tissue proteomics repositories for data reanalysis","authors":"Rafael Stroggilos, Aggeliki Tserga, Jerome Zoidakis, Antonia Vlahou, Manousos Makridakis","doi":"10.1002/mas.21860","DOIUrl":"10.1002/mas.21860","url":null,"abstract":"We are approaching the third decade since the establishment of the very first proteomics repositories back in the mid-'00s. New experimental approaches and technologies continuously enrich the field while producing vast amounts of mass spectrometry data. Together with initiatives to establish standard terminology and file formats, proteomics is rapidly transforming into a mature component of systems biology. Here we describe the ProteomeXchange consortium repositories. We specifically search, collect and evaluate public human tissue datasets (categorized as “complete” by the repository) submitted in 2015–2022, to both map the existing information and assess the data set reusability. Human tissue data are variably represented in the repositories reviewed, ranging between 10% and 25% of the total data submitted, with cancers being the most represented, followed by neuronal and cardiovascular diseases. About half of the retrieved data sets were found to lack annotations or metadata necessary to directly replicate the analysis. This poses a rough challenge to data reusability and highlights the need to increase awareness of the mage-tab file format for metadata in the community. Overall, proteomics repositories have evolved greatly over the past 7 years, as they have grown in size and become equipped with various powerful applications and tools that enable data searching and analytical tasks. However, to make the most of this potential, priority must be given to finding ways to secure detailed metadata for each submission, which is likely the next major milestone for proteomics repositories.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 6","pages":"1270-1284"},"PeriodicalIF":6.9,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21860","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9929896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstructure characterization and mechanistic insight into polyether polyols and their associated polyurethanes. 聚醚多元醇及其相关聚氨酯的微观结构表征和机理研究。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-08-03 DOI: 10.1002/mas.21862

Anthony P Gies, David M Hercules, Arjun Raghuraman, Alex J Kosanovich, Matthew A Baker, Sukrit Mukhopadhyay, Ilia Kobylianskii, Manjiri Paradkar

{"title":"Microstructure characterization and mechanistic insight into polyether polyols and their associated polyurethanes.","authors":"Anthony P Gies, David M Hercules, Arjun Raghuraman, Alex J Kosanovich, Matthew A Baker, Sukrit Mukhopadhyay, Ilia Kobylianskii, Manjiri Paradkar","doi":"10.1002/mas.21862","DOIUrl":"https://doi.org/10.1002/mas.21862","url":null,"abstract":"This article reviews the analytical tool chest used for characterizing alkoxylates and their associated copolymer mixtures. Specific emphasis will be placed upon the use of mass spectrometry-based techniques as rapid characterization tools for optimizing reaction processes in an industrial R&D setting. An initial tutorial will cover the use of matrix-assisted laser desorption/ionization-mass spectrometry and tandem mass spectrometry fragmentation for detailed component analysis (e.g., polyol and isocyanate) of a model polyurethane-based foam. Next, this critical feedback information will be used with the guidance of mass spectrometry to initiate the development of a new, more efficient, tris(pentafluorophenyl)borane (FAB) catalyst-based alkoxylation process for generating the next generation of glycerin-initiated poly(propylene oxide)-co-poly(ethylene oxide) copolymers. Examples will be provided for each step in the FAB-based optimization process that were required to generate the final product. Following this example, two-dimensional liquid chromatography, supercritical fluid chromatography, and ion mobility separations, along with their coupling to mass spectrometry, will be reviewed for their efficiency in characterizing and quantitating the components within these complex polyether polyol mixtures.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9927030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mass spectrometry in ocular drug research. 质谱法在眼科药物研究中的应用。

IF 6.6 2区化学

Mass Spectrometry Reviews Pub Date : 2023-08-02 DOI: 10.1002/mas.21861

Eva M Del Amo, Kati-Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola

{"title":"Mass spectrometry in ocular drug research.","authors":"Eva M Del Amo, Kati-Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola","doi":"10.1002/mas.21861","DOIUrl":"https://doi.org/10.1002/mas.21861","url":null,"abstract":"Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments. The second part of the review consists of an introduction to ocular proteomics, with special emphasis on targeted absolute quantitation of membrane transporters and metabolizing enzymes. The third part of the review deals with liquid chromatography-MS (LC-MS) and MS imaging (MSI) methods used in the analysis of drugs and metabolites in ocular samples. The sensitivity and speed of LC-MS make simultaneous quantitation of various drugs and metabolites possible in minute tissue samples, even though ocular sample preparation requires careful handling. The MSI methodology is on the verge of becoming as important as LC-MS in ocular pharmacokinetic studies, since the spatial resolution has reached the level, where cell layers can be separated, and quantitation with isotope-labeled standards has come more reliable. MS will remain in the foreseeable future as the main analytical method that will progress our understanding of ocular pharmacokinetics.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9975265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0