{"title":"Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?","authors":"Astrid Walrant, Emmanuelle Sachon","doi":"10.1002/mas.21880","DOIUrl":"https://doi.org/10.1002/mas.21880","url":null,"abstract":"Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a purified potential partner, in model systems such as model membranes, and with live cells using both targeted and nontargeted proteomics studies. Different biological partners will be described, among which glycoconjugates, oligonucleotides, peptides, proteins, and lipids, with the photoreactive label inserted either on the peptide of interest or on the potential partner. Particular attention will be paid to the observation and characterization of specific rearrangements following the photolabeling reaction, which can help characterize photoadducts and provide a better understanding of the interacting systems and environment.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"292 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protein glycosylation in lung cancer from a mass spectrometry perspective","authors":"Mirjam Balbisi, Simon Sugár, Lilla Turiák","doi":"10.1002/mas.21882","DOIUrl":"https://doi.org/10.1002/mas.21882","url":null,"abstract":"Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer. Differences in glycosylation patterns have been previously observed between healthy and cancerous samples as well as between different lung cancer subtypes, which suggests untapped diagnostic potential. In addition, understanding the changes mediated by glycosylation may shed light on possible novel therapeutic targets and personalized treatment strategies for lung cancer patients. Mass spectrometry based glycomics and glycoproteomics have emerged as powerful tools for in‐depth characterization of changes in protein glycosylation, providing valuable insights into the molecular basis of lung cancer. This paper reviews the literature on the analysis of protein glycosylation in lung cancer using mass spectrometry, which is dominated by manuscripts published over the past 5 years. Studies analyzing <jats:italic>N</jats:italic>‐glycosylation, <jats:italic>O</jats:italic>‐glycosylation, and glycosaminoglycan patterns in tissue, serum, plasma, and rare biological samples of lung cancer patients are highlighted. The current knowledge on the potential utility of glycan and glycoprotein biomarkers is also discussed.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stanislav I. Pekov, Denis S. Bormotov, Svetlana I. Bocharova, Anatoly A. Sorokin, Maria M. Derkach, Igor A. Popov
{"title":"Mass spectrometry for neurosurgery: Intraoperative support in decision-making","authors":"Stanislav I. Pekov, Denis S. Bormotov, Svetlana I. Bocharova, Anatoly A. Sorokin, Maria M. Derkach, Igor A. Popov","doi":"10.1002/mas.21883","DOIUrl":"10.1002/mas.21883","url":null,"abstract":"<p>Ambient ionization mass spectrometry was proved to be a powerful tool for oncological surgery. Still, it remains a translational technique on the way from laboratory to clinic. Brain surgery is the most sensitive to resection accuracy field since the balance between completeness of resection and minimization of nerve fiber damage determines patient outcome and quality of life. In this review, we summarize efforts made to develop various intraoperative support techniques for oncological neurosurgery and discuss difficulties arising on the way to clinical implementation of mass spectrometry-guided brain surgery.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"44 1","pages":"62-73"},"PeriodicalIF":6.9,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140584061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Young mass spectrometrists special issue","authors":"","doi":"10.1002/mas.21884","DOIUrl":"10.1002/mas.21884","url":null,"abstract":"","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 4","pages":"613"},"PeriodicalIF":6.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140583900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding zwitterionic ring-expansion polymerization through mass spectrometry.","authors":"Mahi Ahmad, Scott M Grayson","doi":"10.1002/mas.21877","DOIUrl":"https://doi.org/10.1002/mas.21877","url":null,"abstract":"<p><p>Zwitterionic ring-expansion polymerization (ZREP) is a polymerization method in which a cyclic monomer is converted into a cyclic polymer through a zwitterionic intermediate. In this review, we explored the ZREP of various cyclic polymers and how mass spectrometry assists in identifying the product architectures and understanding their intricate reaction mechanism. For the majority of polymers (from a few thousand to a few million Da) matrix-assisted laser desorption/ionization time-of-flight mass spectrometry is the most effective mass spectrometry technique to determine the true molecular weight (MW) of the resultant product, but only when the dispersity is low (approximately below 1.2). The key topics covered in this study were the ZREP of cyclic polyesters, cyclic polyamides, and cyclic ethers. In addition, this study also addresses a number of other preliminary topics, including the ZREP of cyclic polycarbonates, cyclic polysiloxanes, and cyclic poly(alkylene phosphates). The purity and efficiency of those syntheses largely depend on the catalyst. Among several catalysts, N-heterocyclic carbenes have exhibited high efficiency in the synthesis of cyclic polyesters and polyamides, whereas tris(pentafluorophenyl)borane [B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>] is the most optimal catalyst for cyclic polyether synthesis.</p>","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"My journey in life and chemistry","authors":"Veronica M. Bierbaum","doi":"10.1002/mas.21879","DOIUrl":"10.1002/mas.21879","url":null,"abstract":"","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"44 2","pages":"93-100"},"PeriodicalIF":6.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Special issue of Dr. Veronica Bierbaum for her contributions to fundamental chemistry in mass spectrometry","authors":"","doi":"10.1002/mas.21878","DOIUrl":"10.1002/mas.21878","url":null,"abstract":"","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"44 2","pages":"91-92"},"PeriodicalIF":6.9,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
McKenna J. Redding, Scott M. Grayson, Laurence Charles
{"title":"Mass spectrometry of dendrimers","authors":"McKenna J. Redding, Scott M. Grayson, Laurence Charles","doi":"10.1002/mas.21876","DOIUrl":"https://doi.org/10.1002/mas.21876","url":null,"abstract":"Mass spectrometry (MS) has become an essential technique to characterize dendrimers as it proved efficient at tackling analytical challenges raised by their peculiar onion-like structure. Owing to their chemical diversity, this review covers benefits of MS methods as a function of dendrimer classes, discussing advantages and limitations of ionization techniques, tandem mass spectrometry (MS/MS) strategies to determine the structure of defective species, as well as most recently demonstrated capabilities of ion mobility spectrometry (IMS) in the field. Complementarily, the well-defined structure of these macromolecules offers major advantages in the development of MS-based method, as reported in a second section reviewing uses of dendrimers as MS and IMS calibration standards and as multifunctional charge inversion reagents in gas phase ion/ion reactions.","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"2014 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140172255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Celebrating the remarkable career of Prof. Catherine Fenselau","authors":"Daniele Fabris","doi":"10.1002/mas.21875","DOIUrl":"10.1002/mas.21875","url":null,"abstract":"","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"43 4","pages":"723-724"},"PeriodicalIF":6.6,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum to “Proteomics-based mass spectrometry profiling of SARS-CoV-2 infection from human nasopharyngeal samples”","authors":"","doi":"10.1002/mas.21874","DOIUrl":"10.1002/mas.21874","url":null,"abstract":"<p>Chatterjee, S. and Zaia, J., 2022. Proteomics-based mass spectrometry profiling of SARS-CoV-2 infection from human nasopharyngeal samples. <i>Mass Spectrometry Reviews</i>, <i>43</i>(1):193–229. [DOI: 10.1002/mas.21813]</p><p>1. Page 2 – In the sentence “…as a disease with ambiguous etiology (Y. Huang et al., 2020)” the correct in-text citation should be “C. Huang et al., 2019” [Huang C, Wang Y, Li X, et al. 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. <i>Lancet</i> (London, England) 395(10223):497–506.]</p><p>2. Page 3 – “, blood (Li, Liu, et al., 2021;” the correct in-text citation should be “L. Li et al., 2021” [Li, L., et al., Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patients. <i>Journal of Translational Medicine</i>, 2021. <b>19</b>(1):30]</p><p>3. Page 3 – “, feces (Li, Liu, et al., 2021; Wang, Xu, et al., 2020)–the in-text citation Wang, Xu, et al., 2020 is changed to “W. Wang et al., 2020” to avoid confusion with another similar in-text citation [Wang W, Xu Y, Gao R, et al. 2020. Detection of SARS-CoV-2 in different types of clinical specimens. <i>Jama</i> 323(18):1843–1844.]</p><p>4. Page 3 – “…glycan shield mechanisms (Bagdonaite & Wandall, 2018; Li, Liu, et al., 2021;” the in-text citation Li, Liu, et al., 2021 should be “L. Li et al., 2021” [Li, L., et al., Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patients. <i>Journal of Translational Medicine</i>, 2021. <b>19</b>(1):30]</p><p>5. Page 17 – “…SARS-CoV-2 interaction with the host cell receptor (Yang, Hughes, et al., 2020)”, the correct citation is “Yang Y, Du Y, Kaltashov IA. 2020. The utility of native MS for understanding the mechanism of action of repurposed therapeutics in COVID-19: heparin as a disruptor of the SARS-CoV-2 interaction with its host cell receptor. <i>Analytical Chemistry</i> 92(16):10930–10934.”</p><p>6. Page 18 – “…of the S-protein (Gstottner et al., 2021; Watanabe, Berndsen, et al., 2020; Yang, Hughes, et al., 2020)” – the citation Yang, Hughes, et al., 2020 should be Yang J, Wang W, Chen Z, et al. 2020. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity. <i>Nature</i> 586(7830):572–577.</p><p>7. Page 18 – “…that allows the first viral entry into the host cells (Gong et al., 2021; Shajahan, Archer-Hartmann, et al., 2021)”—the citation Shajahan, Archer-Hartmann, et al., 2021 should be Shajahan A, Pepi LE, Rouhani DS, Heiss C, Azadi P. 2021. Glycosylation of SARS-CoV-2: structural and functional insights. <i>Analytical and Bioanalytical Chemistry</i> 413(29):7179-7193.</p><p>8. Page 20 – “…reported by Group-based Prediction System 5.0; Wang, Xu, et al., 2020).” The citation should be Wang C, Xu H, Lin S, et al. 2020. GPS 5.0: an update on the prediction of kinase-specific phosphorylation sites in proteins. <i>Genomics, Proteomics & Bioinformatics</i> 18(1):72–80.</p><p>9. Page 20 – ","PeriodicalId":206,"journal":{"name":"Mass Spectrometry Reviews","volume":"44 3","pages":"539-540"},"PeriodicalIF":6.9,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mas.21874","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139929179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}