Progress in brain research最新文献_第6页

Philopsychedelia beyond the West: The decolonial reflorescence of psychedelic philosophy. 超越西方的迷幻哲学：迷幻哲学的非殖民化折射。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-12 DOI: 10.1016/bs.pbr.2025.07.001

Jan Clefferson Costa de Freitas, Nathalia Cristina Medeiros Maia, Markone Brandão da Silva Shanenawa, Juan Vásquez Amaringo, René Alvarado Martinez

{"title":"Philopsychedelia beyond the West: The decolonial reflorescence of psychedelic philosophy.","authors":"Jan Clefferson Costa de Freitas, Nathalia Cristina Medeiros Maia, Markone Brandão da Silva Shanenawa, Juan Vásquez Amaringo, René Alvarado Martinez","doi":"10.1016/bs.pbr.2025.07.001","DOIUrl":"10.1016/bs.pbr.2025.07.001","url":null,"abstract":"The main purpose of this work is to identify the intersections between decolonial thought and psychedelic philosophy. By \"psychedelic\" we mean a pharmacological category, the effects of substances that modulates perception, a myriad of consciousness states, a set of ecstatic practices, a variety of countercultural movements, a constellation of artistic avant-gardes, and a plurality of ways of being. We thus intend to demonstrate how visionary aesthetics, liminal phenomenologies, ancestral epistemologies, ethics of resistance, politics of freedom and kaleidoscopic metaphysics are conceptual horizons from which a decolonization of the \"manifestations of the mind\" can come to light. Through an analytical-descriptive methodology, we idealize obtaining, as a result of this research, a philosophical justification of the indispensability of integrating decoloniality into the reflorescence of psychedelia. In a nutshell: we envision to clarify the extent to which psychedelic experiences can be ways of understanding insurgent knowledges, as well as explaining the proportion to which decolonial conceptions can be keys to interpreting psychedelic experiences.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"296 ","pages":"147-173"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurocardiology and neurodegenerative disease: Emerging research on emotional regulation and brain-heart connectivity. 神经心脏病学和神经退行性疾病：情绪调节和脑-心连通性的新兴研究。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-05-22 DOI: 10.1016/bs.pbr.2025.04.011

Obayda M Diraneyya, Muhammad Liaquat Raza, Syed Ali Abbas

引用次数: 0

Heart rate variability as an indicator of brain health in neurodegeneration. 心率变异性作为神经变性患者大脑健康的指标。

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Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-07-10 DOI: 10.1016/bs.pbr.2025.04.007

Ghulam Kubra, Muhammad Liaquat Raza

引用次数: 0

Hormesis and brain diseases. 刺激和脑部疾病。

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Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-05-28 DOI: 10.1016/bs.pbr.2025.05.003

Vernise J T Lim, Nishat I Tabassum, Jacqueline M Orian, Thiruma V Arumugam, Eddie Feng-Ju Weng

{"title":"Hormesis and brain diseases.","authors":"Vernise J T Lim, Nishat I Tabassum, Jacqueline M Orian, Thiruma V Arumugam, Eddie Feng-Ju Weng","doi":"10.1016/bs.pbr.2025.05.003","DOIUrl":"10.1016/bs.pbr.2025.05.003","url":null,"abstract":"Hormesis, the concept that low doses of potentially harmful stressors can elicit adaptive, beneficial effects, plays a significant role in brain health and aging. Neurohormesis refers to the adaptive response of neurons to mild stress, activating pathways that enhance cellular repair. As the brain ages, it experiences disruptions in energy metabolism, oxidative stress, mitochondrial dysfunction, and chronic inflammation, all of which contribute to neurodegenerative diseases like stroke, Parkinson's, Alzheimer's and multiple sclerosis (MS). However, low-dose stressors such as exercise, fasting, and certain dietary compounds have been shown to activate stress-resilience mechanisms, promoting brain health and delaying neurodegeneration. Dietary interventions, such as calorie restriction (CR) and intermittent fasting (IF), stimulate neuroprotective signaling, involving molecular targets like NF-E2-related factor 2 (NRF2), cAMP response element-binding protein (CREB), and brain-derived neurotrophic factor (BDNF). These factors regulate stress-related chaperones and promote cognitive function. The chapter highlights the role of mitochondrial health, autophagy, and circadian rhythms in aging and neurohormesis by CR and IF. Despite the potential of hormetic interventions, aging impairs the capacity of the brain to respond to stress, making it more vulnerable to neurodegeneration. Understanding neurohormesis offers promising therapeutic avenues for enhancing brain resilience and delaying the onset of age-related cognitive decline and neurodegenerative diseases. The integration of advanced technologies, such as multi-omics and epigenetic studies, could further elucidate the protective effects of hormesis on brain health, paving the way for targeted interventions to combat neurodegeneration.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"295 ","pages":"229-258"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to age-related cognitive-behavioural changes. 介绍与年龄相关的认知行为改变。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-11-17 DOI: 10.1016/bs.pbr.2025.08.019

Matthew-Zane L Broderick, Houd Taji, Fatima Hajj, Biriyankan Balakumar, Omar Al-Achkar, Daniya Tasnim

{"title":"Introduction to age-related cognitive-behavioural changes.","authors":"Matthew-Zane L Broderick, Houd Taji, Fatima Hajj, Biriyankan Balakumar, Omar Al-Achkar, Daniya Tasnim","doi":"10.1016/bs.pbr.2025.08.019","DOIUrl":"10.1016/bs.pbr.2025.08.019","url":null,"abstract":"As individuals age, they undergo both biological and physiological changes that are apparent and expected. Another often overlooked aspect of senescence are the changes in cognition and behaviour. These are often misunderstood or complicated with common neurodegenerative disorders found in the elderly. This chapter acts as an introduction into these cognitive-behavioural changes. There are a variety of methodologies currently employed in the investigation of these changes, such as functional magnetic resonance imaging, electroencephalography, and animal studies. Novel methodologies are being deployed for the analysis of gut-flora interactions with the CNS and how they may impact behavioural changes as our microbiota changes in late-life. Multiple modulatory factors are at play as well, further complicating the multifaceted nature of ageing cognition differences. Sex and genetics are major factors that are associated with age-related behavioural changes. Gross structural and molecular changes in the CNS are also associated with pronounced changes in cognition. Low-grade chronic inflammation, epigenetics and infections also seem to be significant. Neurodegenerative diseases, whilst pathological, work in tandem with natural ageing and present age-related changes in behaviour. The most common changes are summarised and the expression of the previously discussed modulatory factors are presented.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"298 ","pages":"1-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and epigenetic drivers of neurodegenerative disorders. 神经退行性疾病的遗传和表观遗传驱动因素。

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Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-10-07 DOI: 10.1016/bs.pbr.2025.08.002

Kanad Roy, Muskan Syed, Priyanka Narad, Abhishek Sengupta

{"title":"Genetic and epigenetic drivers of neurodegenerative disorders.","authors":"Kanad Roy, Muskan Syed, Priyanka Narad, Abhishek Sengupta","doi":"10.1016/bs.pbr.2025.08.002","DOIUrl":"10.1016/bs.pbr.2025.08.002","url":null,"abstract":"Neurodegenerative illnesses such as Alzheimer's disease, Parkinson's disease, and Huntington's disease present with increasing neurodegeneration and derangement. Genomic mutations and epigenetic changes are known to be part of their causation. This particular chapter discusses the key genetic factors like APP, SNCA, HTT, and C9orf72 mutations that influence the development and course of the disease. Furthermore, we examine epigenetic mechanisms-DNA methylation, histone modification, and non-coding RNAs-that regulate gene expression and contribute to neuronal susceptibility. The discussion also focuses on environmental and behavioral factors that affect the epigenome, highlighting gene-environment interactions. Advancements in omics technology and integrative studies have enhanced comprehension of biological pathways and uncovered novel biomarkers and therapeutic targets. The chapter therefore integrates epigenetic and genetic viewpoints to elucidate the intricate regulatory processes responsible for neurodegeneration and highlights potential avenues for early diagnosis, precision medicine, and therapeutic interventions aimed at remodeling disease pathways.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"297 ","pages":"53-130"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The science behind reminiscence therapy: The healing power of memory. 回忆疗法背后的科学：记忆的治愈力量。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-11 DOI: 10.1016/bs.pbr.2025.08.022

Rashed Iyad Hasan Albustanji, Ammar Akram Taha Alirani, Malak Iyad Albustanji, Mawda Abdelmegid, Mohamed Abdallahi Sidi Mohamed, Nasrollah Moradikor

{"title":"The science behind reminiscence therapy: The healing power of memory.","authors":"Rashed Iyad Hasan Albustanji, Ammar Akram Taha Alirani, Malak Iyad Albustanji, Mawda Abdelmegid, Mohamed Abdallahi Sidi Mohamed, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.08.022","DOIUrl":"10.1016/bs.pbr.2025.08.022","url":null,"abstract":"This chapter aims to explore the theory, types, benefits, and practical applications of Reminiscence Therapy (RT) in elderly care. RT, developed by Robert Butler in the 1960s, uses past memories triggered by photos, music, and familiar objects to improve cognitive, emotional, and social well-being in older adults. The chapter first explains the history and types of RT, including integrative, instrumental, and transmissive forms. It then details the social benefits, highlighting how group RT reduces isolation and strengthens relationships among seniors. Next, the chapter discusses cognitive and emotional improvements such as enhanced memory, reduced depression, and increased self-acceptance. The practical use of RT in care settings is explained, showing how it supports patients with dementia by slowing cognitive decline and preserving identity. Finally, ethical considerations and cultural adaptations are emphasized to ensure effective and respectful therapy. Overall, the chapter presents RT as a valuable, person-centered approach that improves the quality of life for older adults by harnessing the healing power of memory and social connection.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"298 ","pages":"165-186"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive stimulation enhancing memory and mental function. 认知刺激增强记忆和心理功能。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-18 DOI: 10.1016/bs.pbr.2025.08.024

Abdelrahman Albahttiti, Nadithi Bodhiseela, Mohammad Abdelnabi, Methmi Wettasinghe, Naseeb Danaf

{"title":"Cognitive stimulation enhancing memory and mental function.","authors":"Abdelrahman Albahttiti, Nadithi Bodhiseela, Mohammad Abdelnabi, Methmi Wettasinghe, Naseeb Danaf","doi":"10.1016/bs.pbr.2025.08.024","DOIUrl":"10.1016/bs.pbr.2025.08.024","url":null,"abstract":"Cognitive Stimulation Therapy (CST) is one of the best non-drug treatments for dementia patients that is based on evidence and can help them improve their cognitive and emotional performance. CST developed from reality orientation and social interaction models into a prevalent intervention that employs themed activities to stimulate memory, language, and attention functions, thereby improving participant engagement and quality of life. This paper elucidates the theoretical framework, session organisation, and therapeutic methodologies of CST. The research examines the broader implications of CST by assessing its efficacy for patients with Mild Cognitive Impairment (MCI), vascular dementia, and Parkinson's disease. This section assesses the enduring efficacy of CST and examines its correlation with pharmacological interventions, while also exploring contemporary adaptations of CST, including individualised CST (iCST), maintenance CST (MCST), and virtual or technology-enhanced delivery methods. The chapter evaluates global implementation practices, cultural adaptation strategies, and clinical implementation challenges, particularly in resource-limited settings. The chapter illustrates the synergistic benefits of integrating Cognitive Stimulation Therapy (CST) with pharmacological interventions and physical exercise regimens, while emphasising the necessity for research to attain universal and sustainable access for global populations.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"298 ","pages":"73-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Preface. 前言。

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Progress in brain research Pub Date : 2025-01-01 DOI: 10.1016/S0079-6123(25)00171-2

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Preface. 前言。

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Progress in brain research Pub Date : 2025-01-01 DOI: 10.1016/S0079-6123(25)00102-5

Nasrollah Moradikor, Motahareh Haghipanah, Hiba Hamdar

引用次数: 0