Progress in brain research最新文献_第6页

Affect in the dark: Navigating the complex landscape of social cognition in blindness. 黑暗中的情感：在失明中导航社会认知的复杂景观。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-20 DOI: 10.1016/bs.pbr.2025.02.002

Veronica Domenici, Olivier Collignon, Giada Lettieri

引用次数: 0

HABEMO: An innovative haptic tool for investigating the bodily representation of mental states in individuals with visual impairments. HABEMO：一种创新的触觉工具，用于研究有视觉障碍的人的精神状态的身体表征。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-25 DOI: 10.1016/bs.pbr.2025.02.001

Giada Lettieri, Roberta P Calce, Olivier Collignon

{"title":"HABEMO: An innovative haptic tool for investigating the bodily representation of mental states in individuals with visual impairments.","authors":"Giada Lettieri, Roberta P Calce, Olivier Collignon","doi":"10.1016/bs.pbr.2025.02.001","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.02.001","url":null,"abstract":"The embodiment of emotions constitutes a profound aspect of our psychological experience, shaping not only how we express but also how we perceive and understand our feelings. Here, we introduce an innovative haptic tool to explore the relationship between emotional states and bodily reactions, with a focus on its applicability to individuals with visual impairments. Our paradigm is highly intuitive, ensuring accessibility while maintaining accuracy comparable to traditional tasks reliant on visual stimuli. Through motion tracking and a 3D human representation, our system allows to capture in a naturalistic manner where individuals sense affective and cognitive states within their bodies. To validate this method, we conducted two experiments employing both haptic and visual versions of the same task, revealing a compelling alignment between modalities in capturing individuals' internalized manifestations of emotional states. Our novel haptic paradigm allows the mapping of emotions in the body in an intuitive way, offering a more inclusive and versatile method for exploring how people connect their emotions to their physical experiences. More importantly, the haptic version of our task holds particular promise for investigating how individuals with limited or no visual capability maintain representations of emotional and cognitive states within their bodies. In addition to its profound implications for understanding emotions, this innovative tool holds promise for exploring a wide variety of research questions beyond the realm of affective states, thereby broadening its utility as a versatile instrument for investigating various aspects of human perception, cognition, and embodiment particularly within the context of visual impairment.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"292 ","pages":"157-173"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of heart-brain connectivity in neurodegeneration: Mechanisms and impacts. 心脑连通性在神经变性中的作用：机制和影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-06-25 DOI: 10.1016/bs.pbr.2025.04.008

Muhammad Liaquat Raza, Ghulam Kubra, Ali Ammar, Nasrollah Moradikor

引用次数: 0

Contributions of the endocannabinoid system to the neurobiology of emotions: Advances and perspectives. 内源性大麻素系统对情绪神经生物学的贡献：进展和观点。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-11 DOI: 10.1016/bs.pbr.2025.08.001

Lauro Rodriguez de Pontes, Sidarta Ribeiro

{"title":"Contributions of the endocannabinoid system to the neurobiology of emotions: Advances and perspectives.","authors":"Lauro Rodriguez de Pontes, Sidarta Ribeiro","doi":"10.1016/bs.pbr.2025.08.001","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.08.001","url":null,"abstract":"The endocannabinoid system (ECS) has emerged as a central and multifaceted modulator of emotional physiology, playing a pivotal role in neurotransmission, neuroplasticity, and stress response regulation. This article provides an original and comprehensive review of the neurobiological mechanisms by which the ECS influences emotional activity, highlighting not only its involvement in psychiatric disorders such as depression, anxiety, and post-traumatic stress disorder, but also offering new perspectives on ECS dysregulation as a common pathophysiological factor in these conditions. The originality of this work lies in its critical integration of recent evidence regarding alterations in receptors, enzymes, and endocannabinoid levels, as well as in its analysis of emerging therapeutic approaches targeting ECS pharmacological modulation, including enzyme inhibitors, selective agonists, and phytocannabinoids. The article emphasizes advances in personalized medicine and the identification of predictive biomarkers for therapeutic response, while also discussing ongoing regulatory and clinical challenges. By critically synthesizing available data, this review makes an innovative contribution to the field, consolidating the ECS as a promising and strategic target for the development of new interventions in mental health.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"296 ","pages":"65-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotional stress and cardiovascular health: Impacts on neurodegenerative disease progression. 情绪压力和心血管健康：对神经退行性疾病进展的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-04-23 DOI: 10.1016/bs.pbr.2025.04.004

Mostafa K Abd El-Aziz, Al-Hassan Soliman Wadan, Abdelrahman T I Albahttiti, Nasrollah Moradikor

引用次数: 0

Mechanisms underlying stress effects on the brain: Basic concepts and clinical implications. 应激对大脑影响的机制：基本概念和临床意义。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-05 DOI: 10.1016/bs.pbr.2025.01.008

Hager Adel Saad, Mahmoud Marzouk, Hla Abdelrahman, Nasrollah Moradikor

{"title":"Mechanisms underlying stress effects on the brain: Basic concepts and clinical implications.","authors":"Hager Adel Saad, Mahmoud Marzouk, Hla Abdelrahman, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.01.008","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.008","url":null,"abstract":"Chronic stress impacts the brain through complex physiological, neurological, and immunological responses. The stress response involves the activation of the sympathetic-adrenal-medullary (SAM) system and the hypothalamic-pituitary-adrenal (HPA) axis, releasing stress hormones like norepinephrine and cortisol. While these responses are adaptive short-term, chronic stress disrupts homeostasis, increasing the risk of cardiovascular diseases, neurodegenerative disorders, and psychiatric conditions such as depression. This dysregulation is linked to persistent neuroinflammation, oxidative stress, and neurotransmitter imbalances involving dopamine and serotonin, impairing neuroplasticity and leading to structural changes in critical brain areas, such as the hippocampus and prefrontal cortex. Moreover, stress affects gene expression, particularly neuroinflammatory pathways, contributing to long-term cognitive function and emotional regulation alterations. Advancements in neuroimaging and molecular techniques, including MRI, PET, and SPECT, hold promise for identifying biomarkers and better understanding stress-induced brain changes. These insights are critical for developing targeted interventions to mitigate the adverse effects of chronic stress on brain health.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"21-47"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of positive thinking on synapses. 积极思考对突触的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-29 DOI: 10.1016/bs.pbr.2025.03.005

Suhail Ahmad Dar, Krithika Ramakrishna, Yuvraj Singh Shekhawat

{"title":"Impact of positive thinking on synapses.","authors":"Suhail Ahmad Dar, Krithika Ramakrishna, Yuvraj Singh Shekhawat","doi":"10.1016/bs.pbr.2025.03.005","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.03.005","url":null,"abstract":"This study explores the impact of positive thinking on synaptic function and connectivity. Positive thinking, characterized by optimism, constructive self-talk, and a proactive mindset, enhances resilience and supports healthy habits crucial for neuroplasticity and synaptic development. Research underscores its significant role in hormonal regulation, benefiting both physical and mental well-being. This cognitive approach amplifies positive emotions and is integral to cognitive-behavioral modification. Synaptic plasticity, essential for learning and memory, involves activity-dependent strengthening or weakening of synapses, categorized into short-term (e.g., working memory and decision-making) and long-term (e.g., learning and retention). These processes are regulated by long-term potentiation (LTP) and long-term depression (LTD), influenced by factors such as brain-derived neurotrophic factor (BDNF), astrocytes, medications, and non-invasive interventions. Positive thinking boosts serotonin production, activates dopamine neurons, and lowers cortisol levels, facilitating adaptive learning through interactions between the limbic system and prefrontal cortex. Dopamine promotes neurogenesis by maintaining neural precursor cells, while reduced cortisol levels improve hippocampal synaptic plasticity, enhancing adaptability, learning, and memory retention. Ultimately, positive thinking plays a critical role in advancing education, improving mental health treatment, and serving as the foundation for cognitive training.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"293 ","pages":"17-40"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart-brain synchrony: Therapeutic implications for neurodegenerative disease. 心脑同步：神经退行性疾病的治疗意义。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-05-19 DOI: 10.1016/bs.pbr.2025.04.012

Vahid Kazemizadeh, Samira Rostami Mehr, Farnaz Khazeifard, Reza Hossein Gholizadeh Salmani, Saeid Abbasi-Maleki

{"title":"Heart-brain synchrony: Therapeutic implications for neurodegenerative disease.","authors":"Vahid Kazemizadeh, Samira Rostami Mehr, Farnaz Khazeifard, Reza Hossein Gholizadeh Salmani, Saeid Abbasi-Maleki","doi":"10.1016/bs.pbr.2025.04.012","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.04.012","url":null,"abstract":"Heart and brain functions are intricately connected. Previous research has explored the mechanisms behind the brain- heart axis and its clinical implications. Nonetheless, there is limited studies on the impact of heart disease on brain performance (heart-brain axis). In this context, hypoperfusion resulting from heart failure (HF) is considered a significant risk factor for cognitive impairment. Oxidative stress, immune responses, and blood perfusion contribute to cognitive dysfunction, playing a key role in this process. As such, it is important for healthcare professionals and researchers to consider the cognitive function of heart patients, particularly those having HF, to prevent the activation of this signaling pathway. Additionally, further investigation into the underlying mechanisms results in identifying new therapeutic targets for the treatment of cognitive dysfunction following heart disease. The current review aims to examine cognitive impairment in heart disease as well as its potential mechanisms, offering valuable insights for future research in related areas.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"294 ","pages":"175-190"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress-related psychiatric disorders. 与压力相关的精神疾病。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-16 DOI: 10.1016/bs.pbr.2025.01.019

Abbas Al Bazzal, Mohammad Ali Mtairek, Mohammad Hadi Awde, Haidar Kanso, Fatima Hajj, Fatima Al Amin, Zeinab Kazan, Nadia A Mohammed, Hiba Hamdar

{"title":"Stress-related psychiatric disorders.","authors":"Abbas Al Bazzal, Mohammad Ali Mtairek, Mohammad Hadi Awde, Haidar Kanso, Fatima Hajj, Fatima Al Amin, Zeinab Kazan, Nadia A Mohammed, Hiba Hamdar","doi":"10.1016/bs.pbr.2025.01.019","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.019","url":null,"abstract":"Stress is a natural human emotion that motivates us to face difficulties and risks. Everyone experiences stress to some extent, but when it becomes chronic or reaches a level that cannot be managed, its effects begin to manifest. It is a common condition that most individuals confront, and its effects on the body and brain have become more obvious in recent years. Social and environmental interactions activate systemic reactions primarily controlled by the brain via immunological, neuroendocrine, and metabolic pathways. Long-term stress disrupts homeostasis, activating stress mediators that attempt to restore balance but frequently cause cumulative damage, particularly to the hippocampus, amygdala, and hypothalamus. Furthermore, persistent stress can have a direct and indirect effect on initiating psychiatric illnesses such as depression, anxiety, ADHD, and schizophrenia. Studies on neuroimaging show anatomical and functional alterations in stress-affected regions such as the prefrontal cortex and the hippocampus, which are linked to emotional dysregulation and cognitive decline. To better understand how stress affects psychiatric disorders and exacerbates their symptoms, this chapter will first discuss the molecular mechanism and neurobiological changes it can cause. It will then demonstrate various neuroimaging techniques for studying the effects of stress and offer potential treatments to mitigate these negative effects.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"161-173"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual experience affects neural correlates of audio-haptic integration: A case study of non-sighted individuals. 视觉经验影响听觉-触觉整合的相关神经：非视障个体的个案研究。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-04-19 DOI: 10.1016/bs.pbr.2025.04.002

Meike Scheller, Michael J Proulx, Michelle de Haan, Annegret Dahlmann-Noor, Karin Petrini

{"title":"Visual experience affects neural correlates of audio-haptic integration: A case study of non-sighted individuals.","authors":"Meike Scheller, Michael J Proulx, Michelle de Haan, Annegret Dahlmann-Noor, Karin Petrini","doi":"10.1016/bs.pbr.2025.04.002","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.04.002","url":null,"abstract":"The ability to reduce sensory uncertainty by integrating information across different senses develops late in humans and depends on cross-modal, sensory experience during childhood and adolescence. While the dependence of audio-haptic integration on vision suggests cross-modal neural reorganization, evidence for such changes is lacking. Furthermore, little is known about the neural processes underlying audio-haptic integration even in sighted adults. Here, we examined electrophysiological correlates of audio-haptic integration in sighted adults (n = 29), non-sighted adults (n = 7), and sighted adolescents (n = 12) using a data-driven electrical neuroimaging approach. In sighted adults, optimal integration performance was predicted by topographical and super-additive strength modulations around 205-285 ms. Data from four individuals who went blind before the age of 8-9 years suggests that they achieved optimal integration via different, sub-additive mechanisms at earlier processing stages. Sighted adolescents showed no robust multisensory modulations. Late-blind adults, who did not show behavioral benefits of integration, demonstrated modulations at early latencies. Our findings suggest a critical period for the development of optimal audio-haptic integration dependent on visual experience around the late childhood and early adolescence.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"292 ","pages":"25-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0