Progress in brain research最新文献

Models developed to explain the effects of stress on brain and behavior. 一些模型用来解释压力对大脑和行为的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.1016/bs.pbr.2025.01.018

Adejoke Elizabeth Memudu, Baliqis Adejoke Olukade, Kenechukwu Emmanuel Nwanama, Gideon S Alex

{"title":"Models developed to explain the effects of stress on brain and behavior.","authors":"Adejoke Elizabeth Memudu, Baliqis Adejoke Olukade, Kenechukwu Emmanuel Nwanama, Gideon S Alex","doi":"10.1016/bs.pbr.2025.01.018","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.018","url":null,"abstract":"There is an integral relationship between stress, brain function and behavior. Over the year's extensive research has led to the development of various models to explain the intricate intersection between brain and stress. This chapter delves into some of the theoretical frameworks that explains the neurobiological and behavioral responses to stress using key models of stress such as the allostatic load model, which is the most common model that describes how chronic stress affect brain structure and function resulting in long-term changes in regions such as the hippocampus, amygdala, and prefrontal cortex which phenotypically express as cognitive impairments, emotional dysfunction seen in various forms of neurological disorder. The neuro-endocrine model, follows the glucocorticoid cascade hypothesis, that associates prolonged stress exposure to hippocampal damage and cognitive decline via alteration in the hypothalamic-pituitary-adrenal (HPA) axis and the overproduction of stress hormones like cortisol which can induce hippocampal atrophy, impair learning and memory, and promote depressive-like behaviors. The neurobiological stress model addresses the role of the hypothalamic-pituitary-adrenal (HPA) axis and stress-related neurotransmitters in shaping behavioral responses, emphasizing alterations in neuroplasticity and synaptic function. These models demonstrate how chronic stress can alter neural plasticity, neurotransmitter systems, and synaptic connectivity, affecting behavior and cognitive function. Hence by integrating molecular, neurobiological, and behavioral perspectives, these models offer a comprehensive understanding of how stress alters brain activity and behavior. The chapter further showcase how these models direct the development of medical interventions, shedding light on potential therapies that target the underlying molecular mechanisms of stress-induced brain changes.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"339-361"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic regulation of stress. 应激的表观遗传调控。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-07 DOI: 10.1016/bs.pbr.2025.01.007

Mariam K Alamoudi, Noura N Alibrahim, Abdulmonem A Alsaleh, Muhammad Liaquat Raza

引用次数: 0

The stress-immune system axis: Exploring the interplay between stress and immunity. 压力-免疫系统轴：探索压力和免疫之间的相互作用。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.1016/bs.pbr.2025.01.003

Muhammad Liaquat Raza

引用次数: 0

Stress and the gut microbiota-brain axis. 压力和肠道微生物群-大脑轴。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-13 DOI: 10.1016/bs.pbr.2025.01.002

Noorulain Hyder, Muhammad Liaquat Raza

引用次数: 0

Early life stress and brain development: Neurobiological and behavioral effects of chronic stress. 早期生活压力与大脑发育：慢性压力对神经生物学和行为的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1016/bs.pbr.2025.01.004

Subia Jamil, Muhammad Liaquat Raza, Nasrollah Moradikor, Motahareh Haghipanah

{"title":"Early life stress and brain development: Neurobiological and behavioral effects of chronic stress.","authors":"Subia Jamil, Muhammad Liaquat Raza, Nasrollah Moradikor, Motahareh Haghipanah","doi":"10.1016/bs.pbr.2025.01.004","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.004","url":null,"abstract":"Early life stress is the term used to describe a variety of traumatic events that a person may have as a kid, such as being subjected to domestic or public violence, being neglected, experiencing parental conflict, being abused physically, emotionally and sexually. These events have the potential to seriously impair the brains normal growth and development, which could have long term psychological and physiological repercussions. Early life stress (ELS) has profound and enduring effects on brain development, contributing to long-term neurological and behavioral changes. Neurologically, ELS can reduce hippocampal volume, impairing memory and emotional regulation, while also sensitizing the amygdala, leading to exaggerated fear and anxiety responses. Additionally, ELS can disrupt the development of the prefrontal cortex (PFC), affecting decision-making, planning, and impulse control. It also alters neurotransmitter systems, such as serotonin and dopamine, influencing mood and motivation, and can trigger chronic neuroinflammation, increasing the risk of neurodegenerative diseases. Behaviorally, ELS heightens the risk of anxiety, depression, and impulsivity, and can contribute to conditions like ADHD and substance abuse Social and emotional difficulties, such as challenges in relationships and empathy, often arise, along with cognitive impairments in learning and memory. Furthermore, ELS increases stress responsiveness, making individuals more vulnerable to future stress. However, these effects can be mitigated by supportive environments and targeted interventions.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"49-79"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping brain neural networks in stress brain connectivity. 绘制压力下的大脑神经网络。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-16 DOI: 10.1016/bs.pbr.2025.01.014

Al-Hassan Soliman Wadan, Mohamed Abdelsattar Ahmed, Nasrollah Moradikor

引用次数: 0

Effects of stress on cognitive performance. 压力对认知表现的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-07 DOI: 10.1016/bs.pbr.2025.01.015

David Chukwuma Nwikwe

{"title":"Effects of stress on cognitive performance.","authors":"David Chukwuma Nwikwe","doi":"10.1016/bs.pbr.2025.01.015","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.015","url":null,"abstract":"Stress remains a pervasive challenge in modern life, exerting significant impacts on cognitive performance and overall well-being by triggering release of stress hormones like adrenaline and cortisol. It has profound implications for education, work performance, and everyday life, impacting cognitive performance, health outcomes, and social relationships. It does this by impacting memory, attention and focus, informed decision-making, developmental and cognitive performance, work and educational performance, genetic and epigenetic influence, and public health. When a stressor is perceived, the hypothalamus in the brain signals the pituitary gland to release adrenocorticotropic hormone, hence adrenaline is quickly released into the bloodstream, causing immediate physiological changes and thus releasing cortisol gradually to help maintain the body's response to stress over a longer period through the hypothalamic-pituitary-adrenal and sympathetic-adrenomedullar axis. The impacts can be short-term or long-term focusing on the working memory, pre-frontal cortex, amygdala, and hippocampus. By recognizing these implications and implementing targeted interventions, we can foster environments that support resilience, optimize performance, and enhance overall well-being across diverse contexts. This chapter also highlighted some mitigation strategies to reduce stress-related activities and improve cognitive performance, such as cognitive-behavioral therapy, mindfulness-based stress reduction, healthy lifestyle adoption, pet therapy, time management and prioritization, and workplace interventions.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"109-135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1016/bs.pbr.2025.01.011

Maryam Azarfarin, Nasrollah Moradikor, Sara Salatin, Mehdi Sarailoo, Masoomeh Dadkhah

{"title":"Stress-related neurodegenerative diseases: Molecular mechanisms implicated in neurodegeneration and therapeutic strategies.","authors":"Maryam Azarfarin, Nasrollah Moradikor, Sara Salatin, Mehdi Sarailoo, Masoomeh Dadkhah","doi":"10.1016/bs.pbr.2025.01.011","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.011","url":null,"abstract":"Chronic stress is a striking cause of major neurodegenerative diseases disorders (NDDs). These diseases share several common mechanisms regarding to disease pathology, in spite of they have various properties and clinical manifestations. NDDs are defined by progressive cognitive decline, and stress contribute to the promotion and progression of disease. In addition, various pathways such as production of reactive oxygen species (ROS), mitochondrial dysfunction, and neurodegeneration are the main crucial hallmarks to develop common NDDs, resulting in neuronal cell death. Although the exact mechanisms of NDDs are underexplored, the potential neuroprotective critical role of such therapies in neuronal loss the treatment of NDDs are not clear. In this regard, researchers investigate the neuroprotective effects of targeting underlying cascade to introduce a promising therapeutic option to NDDs. Herein, we provide an overview of the role of non-pharmacological treatments against oxidative stress, mitochondrial symbiosis, and neuroinflammation in NDDs, mainly discussing the music, diet, and exercise effects of targeting pathways.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"253-288"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addiction and stress: Exploring the reward pathways in brain affected by different drugs. 成瘾与压力：探索不同药物对大脑奖赏通路的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.pbr.2025.01.012

Samira Rostami Mehr, Babak Nakhaei, Hossein Soleimani, Shaahriyar Kouhi Madadlou, Asghar Abbasi Maleky, Saeid Abbasi-Maleki

{"title":"Addiction and stress: Exploring the reward pathways in brain affected by different drugs.","authors":"Samira Rostami Mehr, Babak Nakhaei, Hossein Soleimani, Shaahriyar Kouhi Madadlou, Asghar Abbasi Maleky, Saeid Abbasi-Maleki","doi":"10.1016/bs.pbr.2025.01.012","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.012","url":null,"abstract":"This chapter delves into the complex interplay among addiction, stress, and the reward pathways in the brain, emphasizing the ways in which various drugs affect these systems and exacerbate SUD. Drugs have physiological effects that can be both pleasurable and unpleasant. These effects change behavior through both positive and negative reinforcement. A person's genetic predisposition to addiction is mostly determined by factors such as biological sex, age of first usage, and dopamine receptor density. Drug use behaviors are also greatly influenced by environmental stressors, media exposure, and substance accessibility; nevertheless, protective variables including social support, participation in healthy activities, and preventative programs serve to reduce the dangers associated with drug use. The reinforcement of addictive behaviors is mostly dependent on the brain's reward circuits, which include the nucleus accumbens, ventral tegmental region, and prefrontal cortex, in addition to neurotransmitters such as dopamine, serotonin, and endorphins. Stress makes addiction worse by intensifying cravings and raising the possibility of relapsing. Examined are the impacts of several drug types, such as opioids, stimulants, depressants, and hallucinogens, emphasizing the long-term consequences on brain function and susceptibility to addiction. In order to create individualized interventions that target the environmental and neurological components of addiction and eventually improve treatment results, a thorough understanding of these elements is important.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"381-404"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the connection between stress and sleep: From underlying mechanisms to therapeutic solutions. 理解压力和睡眠之间的联系：从潜在机制到治疗解决方案。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-10 DOI: 10.1016/bs.pbr.2025.01.016

Matthew-Zane L Broderick, Qadir Khan, Nasrollah Moradikor

{"title":"Understanding the connection between stress and sleep: From underlying mechanisms to therapeutic solutions.","authors":"Matthew-Zane L Broderick, Qadir Khan, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.01.016","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.016","url":null,"abstract":"The objective of this chapter is to navigate through the nexus between stress and sleep, highlighting the neurobiological systems that connect them. Starting with an overview of neuroanatomy and physiology of stress and sleep, with a further detailed breakdown of sleep stages and key neuroanatomical centers that are responsible for sleep and wakefulness. Starting with suprachiasmatic nuclei (SCN) in circadian rhythm and sleep regulation overview, with a center point on the molecular systems including the CLOCK/CRY and BMAL1/2/PER1/2 feedback loops. Following this is the neurobiological of stress, specifically the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic-adrenal (SPA) axis and influence on sleep. Vital neural circuits connecting stress and sleep are examined with the attention of the ventral tegmental area (VTA) GABA-somatostatin neurons and the locus coerules in sleep regulation in response to stress. In addition, neuroinflammation's role occurs through the cytokines IL-1β and TNF-α are investigated as a mediator of sleep disturbances caused by stress. It concludes by summarizing the implications of neuroinflammatory modulation in stress-related psychopathologies, emphasizing the opening this provides for interventions that target this inflammation helping to lighten sleep disorder.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"137-159"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0