Youssef Razouqi, Hanane El Fatimi, Marouane Mergaoui, Loubna Khalki
{"title":"探索帕金森病的心-脑轴改变。","authors":"Youssef Razouqi, Hanane El Fatimi, Marouane Mergaoui, Loubna Khalki","doi":"10.1016/bs.pbr.2025.04.009","DOIUrl":null,"url":null,"abstract":"<p><p>Neurodegenerative diseases such as Parkinson's disease (PD) are controlled by a sophisticated network known as the heart-brain axis. This chapter delves deep into the pathophysiology of PD, exploring in detail the links between the brain and the heart, covering topics as diverse as autonomic dysfunction, cardiac sympathetic denervation and neuroinflammation. We investigate the potential for genetics, proteomics, and biomarkers to radically alter the course of neurodegenerative and cardiovascular disease diagnosis and treatment. Protective medications, deep brain stimulation, and behavioural modifications are some of the newer and more established methods that have emerged in recent years to maintain the health of the heart and brain, two of the body's most important systems.Ultimately, this chapter argues that to treat Parkinson's disease (PD) effectively, it is essential to opt for a multidisciplinary approach that takes into account both the neurological and cardiovascular aspects of the condition.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"294 ","pages":"135-159"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring heart-brain axis alterations in Parkinson's disease.\",\"authors\":\"Youssef Razouqi, Hanane El Fatimi, Marouane Mergaoui, Loubna Khalki\",\"doi\":\"10.1016/bs.pbr.2025.04.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Neurodegenerative diseases such as Parkinson's disease (PD) are controlled by a sophisticated network known as the heart-brain axis. This chapter delves deep into the pathophysiology of PD, exploring in detail the links between the brain and the heart, covering topics as diverse as autonomic dysfunction, cardiac sympathetic denervation and neuroinflammation. We investigate the potential for genetics, proteomics, and biomarkers to radically alter the course of neurodegenerative and cardiovascular disease diagnosis and treatment. Protective medications, deep brain stimulation, and behavioural modifications are some of the newer and more established methods that have emerged in recent years to maintain the health of the heart and brain, two of the body's most important systems.Ultimately, this chapter argues that to treat Parkinson's disease (PD) effectively, it is essential to opt for a multidisciplinary approach that takes into account both the neurological and cardiovascular aspects of the condition.</p>\",\"PeriodicalId\":20598,\"journal\":{\"name\":\"Progress in brain research\",\"volume\":\"294 \",\"pages\":\"135-159\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in brain research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.pbr.2025.04.009\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"Neuroscience\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in brain research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/bs.pbr.2025.04.009","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/15 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Neuroscience","Score":null,"Total":0}
Exploring heart-brain axis alterations in Parkinson's disease.
Neurodegenerative diseases such as Parkinson's disease (PD) are controlled by a sophisticated network known as the heart-brain axis. This chapter delves deep into the pathophysiology of PD, exploring in detail the links between the brain and the heart, covering topics as diverse as autonomic dysfunction, cardiac sympathetic denervation and neuroinflammation. We investigate the potential for genetics, proteomics, and biomarkers to radically alter the course of neurodegenerative and cardiovascular disease diagnosis and treatment. Protective medications, deep brain stimulation, and behavioural modifications are some of the newer and more established methods that have emerged in recent years to maintain the health of the heart and brain, two of the body's most important systems.Ultimately, this chapter argues that to treat Parkinson's disease (PD) effectively, it is essential to opt for a multidisciplinary approach that takes into account both the neurological and cardiovascular aspects of the condition.
期刊介绍：
Progress in Brain Research is the most acclaimed and accomplished series in neuroscience. The serial is well-established as an extensive documentation of contemporary advances in the field. The volumes contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry and the behavioral sciences.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
