Impact of emotional trauma on brainstem: Unlocking the effects on neural pathways.

4区 医学 Q3 Neuroscience
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-04-02 DOI:10.1016/bs.pbr.2025.03.003
Darasimi Racheal Olorunlowu, Gladys Deborah Olorunlowu, Precious Motunrayo Owonifa
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引用次数: 0

Abstract

The brainstem, far from being a simple relay center, emerges as a sophisticated processor of emotional trauma, orchestrating complex neural responses that reshape our understanding of trauma biology. This chapter explores the convoluted relationship between emotional trauma and brainstem function, revealing how traumatic experiences trigger precise quantum-level changes in neural circuits. Through examining chronobiological rhythms and neuroimmune interactions, we uncover the dynamic nature of trauma-induced brainstem adaptations. Our exploration extends to the fascinating brainstem-gut axis, where microbiota communicate with neural circuits to influence emotional processing. Recent discoveries in molecular imaging have identified distinct biomarkers of brainstem dysfunction, opening new avenues for early intervention. We introduce pioneering therapeutic approaches, from targeted optogenetic techniques to artificial intelligence-driven interventions, that promise more effective trauma treatment. By weaving together insights from quantum biology, chronobiology, and systems neuroscience, this chapter presents a fresh perspective on emotional trauma's neural imprint and charts a course toward personalized therapeutic strategies.

情绪创伤对脑干的影响:解开对神经通路的影响。
脑干远不是一个简单的传递中心,而是一个复杂的情感创伤处理器,精心策划复杂的神经反应,重塑我们对创伤生物学的理解。本章探讨了情感创伤与脑干功能之间的复杂关系,揭示了创伤经历如何触发神经回路中精确的量子级变化。通过检查时间生物节律和神经免疫相互作用,我们揭示了创伤诱导的脑干适应的动态性质。我们的探索延伸到令人着迷的脑干-肠道轴,在那里微生物群与神经回路交流,影响情绪处理。分子成像的最新发现已经确定了脑干功能障碍的不同生物标志物,为早期干预开辟了新的途径。我们介绍了开创性的治疗方法,从靶向光遗传技术到人工智能驱动的干预措施,这些方法有望更有效地治疗创伤。通过将量子生物学、时间生物学和系统神经科学的见解编织在一起,本章展示了情感创伤的神经印记的新视角,并为个性化治疗策略绘制了路线图。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Progress in brain research
Progress in brain research 医学-神经科学
CiteScore
5.20
自引率
0.00%
发文量
174
审稿时长
6-12 weeks
期刊介绍: Progress in Brain Research is the most acclaimed and accomplished series in neuroscience. The serial is well-established as an extensive documentation of contemporary advances in the field. The volumes contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry and the behavioral sciences.
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