{"title":"Impact of emotional trauma on brainstem: Unlocking the effects on neural pathways.","authors":"Darasimi Racheal Olorunlowu, Gladys Deborah Olorunlowu, Precious Motunrayo Owonifa","doi":"10.1016/bs.pbr.2025.03.003","DOIUrl":null,"url":null,"abstract":"<p><p>The brainstem, far from being a simple relay center, emerges as a sophisticated processor of emotional trauma, orchestrating complex neural responses that reshape our understanding of trauma biology. This chapter explores the convoluted relationship between emotional trauma and brainstem function, revealing how traumatic experiences trigger precise quantum-level changes in neural circuits. Through examining chronobiological rhythms and neuroimmune interactions, we uncover the dynamic nature of trauma-induced brainstem adaptations. Our exploration extends to the fascinating brainstem-gut axis, where microbiota communicate with neural circuits to influence emotional processing. Recent discoveries in molecular imaging have identified distinct biomarkers of brainstem dysfunction, opening new avenues for early intervention. We introduce pioneering therapeutic approaches, from targeted optogenetic techniques to artificial intelligence-driven interventions, that promise more effective trauma treatment. By weaving together insights from quantum biology, chronobiology, and systems neuroscience, this chapter presents a fresh perspective on emotional trauma's neural imprint and charts a course toward personalized therapeutic strategies.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"293 ","pages":"99-125"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in brain research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/bs.pbr.2025.03.003","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/2 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Neuroscience","Score":null,"Total":0}
引用次数: 0
Abstract
The brainstem, far from being a simple relay center, emerges as a sophisticated processor of emotional trauma, orchestrating complex neural responses that reshape our understanding of trauma biology. This chapter explores the convoluted relationship between emotional trauma and brainstem function, revealing how traumatic experiences trigger precise quantum-level changes in neural circuits. Through examining chronobiological rhythms and neuroimmune interactions, we uncover the dynamic nature of trauma-induced brainstem adaptations. Our exploration extends to the fascinating brainstem-gut axis, where microbiota communicate with neural circuits to influence emotional processing. Recent discoveries in molecular imaging have identified distinct biomarkers of brainstem dysfunction, opening new avenues for early intervention. We introduce pioneering therapeutic approaches, from targeted optogenetic techniques to artificial intelligence-driven interventions, that promise more effective trauma treatment. By weaving together insights from quantum biology, chronobiology, and systems neuroscience, this chapter presents a fresh perspective on emotional trauma's neural imprint and charts a course toward personalized therapeutic strategies.
期刊介绍:
Progress in Brain Research is the most acclaimed and accomplished series in neuroscience. The serial is well-established as an extensive documentation of contemporary advances in the field. The volumes contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry and the behavioral sciences.