Progress in brain research最新文献

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Exploring heart-brain axis alterations in Parkinson's disease. 探索帕金森病的心-脑轴改变。
4区 医学
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-05-15 DOI: 10.1016/bs.pbr.2025.04.009
Youssef Razouqi, Hanane El Fatimi, Marouane Mergaoui, Loubna Khalki
{"title":"Exploring heart-brain axis alterations in Parkinson's disease.","authors":"Youssef Razouqi, Hanane El Fatimi, Marouane Mergaoui, Loubna Khalki","doi":"10.1016/bs.pbr.2025.04.009","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.04.009","url":null,"abstract":"<p><p>Neurodegenerative diseases such as Parkinson's disease (PD) are controlled by a sophisticated network known as the heart-brain axis. This chapter delves deep into the pathophysiology of PD, exploring in detail the links between the brain and the heart, covering topics as diverse as autonomic dysfunction, cardiac sympathetic denervation and neuroinflammation. We investigate the potential for genetics, proteomics, and biomarkers to radically alter the course of neurodegenerative and cardiovascular disease diagnosis and treatment. Protective medications, deep brain stimulation, and behavioural modifications are some of the newer and more established methods that have emerged in recent years to maintain the health of the heart and brain, two of the body's most important systems.Ultimately, this chapter argues that to treat Parkinson's disease (PD) effectively, it is essential to opt for a multidisciplinary approach that takes into account both the neurological and cardiovascular aspects of the condition.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"294 ","pages":"135-159"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormesis and cancer therapy. 激效和癌症治疗。
4区 医学
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-07-25 DOI: 10.1016/bs.pbr.2025.05.010
Glaucia Maria Machado-Santelli, Julyane Batista Chaves
{"title":"Hormesis and cancer therapy.","authors":"Glaucia Maria Machado-Santelli, Julyane Batista Chaves","doi":"10.1016/bs.pbr.2025.05.010","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.05.010","url":null,"abstract":"<p><p>Hormesis, the processes in which small doses of a stressor show stimulatory effects or protective responses on target cells, and high doses show the opposite effects, was described as associated with cancer therapy. Although the introduction of new techniques in cancer therapy improved the success rate and patients' survival, it is important to mainly focus on chemo and radiotherapy. Some examples illustrating the hormetic relationships with cancer therapy are described. The hormetic response in cancer therapy presents considerable complexity due to the wide variability in biological responses observed between different systems and conditions. This variability poses significant challenges for the practical implementation of hormesis in oncological settings. Nevertheless, its potential to optimize existing therapies positions this phenomenon as an area of great interest and relevance for future scientific investigations.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"295 ","pages":"333-350"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emergence of the National Articulation of Marijuana Marches (ANMM) in Brazil: A social movement in the context of the COVID-19 pandemic. 巴西全国大麻游行(ANMM)的出现:COVID-19大流行背景下的社会运动
4区 医学
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-12 DOI: 10.1016/bs.pbr.2025.07.003
Diego Castro
{"title":"The emergence of the National Articulation of Marijuana Marches (ANMM) in Brazil: A social movement in the context of the COVID-19 pandemic.","authors":"Diego Castro","doi":"10.1016/bs.pbr.2025.07.003","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.07.003","url":null,"abstract":"<p><p>His chapter explores the emergence and strengthening of the Articulação Nacional de Marchas da Maconha (ANMM)-the National Articulation of Marijuana Marches-in Brazil during the COVID-19 pandemic. The ANMM, a network of activists and collectives advocating for the legalization of marijuana and the reform of drug policies, represents a significant shift in the anti-prohibitionist movement in Brazil. The pandemic, which forced social movements to adapt to virtual spaces, accelerated the integration of digital technologies into activism, reshaping the strategies and organizational dynamics of the ANMM. Using Bruno Latour's Sociology of Associations (2012), this chapter analyzes the complex interplay between human and non-human actors-such as the internet, social media platforms, and the pandemic itself-in the formation and evolution of the ANMM. The chapter argues that the pandemic not only transformed the way social movements operate but also provided a unique opportunity for the ANMM to consolidate its national presence and amplify its advocacy efforts.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"296 ","pages":"95-106"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An overview of quality of life and visual outcomes in AMD. AMD患者的生活质量和视觉结果综述。
4区 医学
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-05-15 DOI: 10.1016/bs.pbr.2025.03.007
Deanna J Taylor, Jamie Enoch, Lee Jones, Bethany Higgins, Alison Binns, David P Crabb
{"title":"An overview of quality of life and visual outcomes in AMD.","authors":"Deanna J Taylor, Jamie Enoch, Lee Jones, Bethany Higgins, Alison Binns, David P Crabb","doi":"10.1016/bs.pbr.2025.03.007","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.03.007","url":null,"abstract":"<p><p>Age-related macular degeneration (AMD) is the leading cause of blindness in high income countries and third most common cause of blindness worldwide. This chapter provides an overview of existing literature pertaining to the ways in which AMD impacts clinical measures of visual function, quality of life, and performance of everyday tasks. As well as being used in clinics, some of the tests described in this chapter have the potential to be piloted in patients' homes as self-monitoring tools, or as patient-centred outcome measures in clinical trials for new treatments in AMD. Moreover, the research findings reported in this literature review should help clinicians with patient management and expectations, and should to inform future patient, public and professional education on AMD.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"292 ","pages":"203-229"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autonomic nervous system dysregulation in neurodegenerative diseases: Bridging brain and heart. 神经退行性疾病中的自主神经系统失调:连接大脑和心脏。
4区 医学
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-07-04 DOI: 10.1016/bs.pbr.2025.04.010
Sandeep Singh, Durgesh Singh, Atifa Haseeb Ansari, Sippy Singh
{"title":"Autonomic nervous system dysregulation in neurodegenerative diseases: Bridging brain and heart.","authors":"Sandeep Singh, Durgesh Singh, Atifa Haseeb Ansari, Sippy Singh","doi":"10.1016/bs.pbr.2025.04.010","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.04.010","url":null,"abstract":"<p><p>Autonomic nervous system (ANS) dysregulation is commonly observed in a class of neurodegenerative disorders known as α-synucleinopathies including Parkinson's disease (PD), Dementia with Lewy Bodies, Multiple System Atrophy (MSA), and Pure Autonomic Failure. The ANS controls involuntary functions such as heart rate, blood pressure, digestion, and respiratory rate, and its disruption can significantly impact patients' quality of life. In neurodegenerative disorders, damage to brain regions that regulate the ANS, such as the brainstem and hypothalamus, leads to impaired autonomic functions. The autonomic nervous system regulates heart function by balancing sympathetic and parasympathetic activity. The sympathetic branch increases heart rate and contractility during stress, while the parasympathetic branch slows heart rate during rest. This dynamic control ensures optimal heart function, adjusting to physiological demands and maintaining cardiovascular stability. In Parkinson's disease and Dementia with Lewy Bodies disorder, degeneration of dopaminergic neurons affects the sympathetic and parasympathetic branches of the ANS, contributing to cardiovascular dysfunction symptoms like orthostatic hypotension, postprandial hypotension, nondipping, and supine hypertension. In Multiple System Atrophy (MSA), autonomic nervous system dysfunction disrupts heart regulation, leading to severe cardiovascular issues such as orthostatic hypotension, abnormal heart rate, and impaired blood pressure control. These autonomic disturbances increase the risk of fainting, cardiovascular instability and contribute to significant morbidity in MSA patients. The cardiac autonomic function is assessed through some tests like heart rate variability (HRV), isometric handgrip test, orthostatic test, deep breathing tests, baroreflex sensitivity test, and Valsalva manoeuvre which evaluate the balance between sympathetic and parasympathetic nervous system activity. These assessments help identify autonomic dysfunction, which can indicate underlying conditions such as neurodegenerative diseases or cardiovascular disorders.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"294 ","pages":"47-73"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cannabinoid treatment impacts adaptive behavior in autism patients and caregivers' mental health: A prospective real-life cohort study. 大麻素治疗影响自闭症患者和照顾者心理健康的适应行为:一项前瞻性现实队列研究
4区 医学
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-12 DOI: 10.1016/bs.pbr.2025.08.014
Kelly Álvares Guimarães, Letícia Perígolo Jorge, Ana Luiza de Oliveira Resende, Estácio Amaro da Silva Junior, Arthur Melo E Kummer, Wilson da Silva Lessa Júnior, Guilherme Nogueira M de Oliveira
{"title":"Cannabinoid treatment impacts adaptive behavior in autism patients and caregivers' mental health: A prospective real-life cohort study.","authors":"Kelly Álvares Guimarães, Letícia Perígolo Jorge, Ana Luiza de Oliveira Resende, Estácio Amaro da Silva Junior, Arthur Melo E Kummer, Wilson da Silva Lessa Júnior, Guilherme Nogueira M de Oliveira","doi":"10.1016/bs.pbr.2025.08.014","DOIUrl":"10.1016/bs.pbr.2025.08.014","url":null,"abstract":"<p><strong>Introduction: </strong>Pharmacological interventions for behavioral symptoms of Autism Spectrum Disorder (ASD) are limited and recent studies point out benefits with the use of cannabinoids.</p><p><strong>Method: </strong>This longitudinal observational study investigates ASD symptoms after 3 months of starting cannabidiol (CBD)-rich extract therapy and it's impact on the mental health of caregivers. Assessment was based on clinical and socioeconomic questionnaire, Autism Treatment Evaluation Checklist (ATEC), Childhood Autism Rating Scale (CARS) and Vineland 3 Scale. The Brief Symptom Inventory (BSI) was applied to evaluate caregiver's health.</p><p><strong>Results: </strong>Sixteen patients with ASD who received cannabinoid treatment (CBD group) and seventeen patients with ASD without cannabinoid treatment (control group). CBD group was characterized as severe autism, ATEC total (SD) 85.5 ± 34.00, while controls as moderate, ATEC total (SD) 58.6 ± 25.53 (p = 0.047). After 3 months of treatment, CBD group showed a reduction in maladaptive behavior - internalizing (Vineland 3) (p = 0.008), and their caregivers a reduction in symptoms of Interpersonal Sensitivity (BSI) (p = 0.038), Global Severity Index (BSI) (p = 0.025) and Positive Symptom Distress Index (BSI) (p = 0.007), indicating reduction on mental health symptoms. For the control group, after 3 months there was a significant increase in scores for Daily Living Activities (Vineland 3) (p = 0.031) and Socialization (ATEC) (p = 0.037).</p><p><strong>Conclusion: </strong>This study suggests that therapy with cannabidiol (CBD)-rich extract in severe ASD may have positive effects on anxious and depressive symptoms, potentially positively impacting on the mental health of their caregivers.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"296 ","pages":"29-53"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac biomarkers as predictors of cognitive decline in neurodegenerative conditions. 心脏生物标志物作为神经退行性疾病认知能力下降的预测因子。
4区 医学
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-04-19 DOI: 10.1016/bs.pbr.2025.04.005
Ali Haider Bangash, Nasrollah Moradikor
{"title":"Cardiac biomarkers as predictors of cognitive decline in neurodegenerative conditions.","authors":"Ali Haider Bangash, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.04.005","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.04.005","url":null,"abstract":"<p><p>The intricate relationship between cardiovascular health and cognitive function has emerged as a critical area of research in neurodegenerative diseases. This review explored the role of cardiac biomarkers as predictors of cognitive decline, elucidating the types, mechanisms, and clinical implications of these molecular indicators. We examined established biomarkers such as troponins, natriuretic peptides, and C-reactive protein, as well as emerging soluble biomarkers and microRNAs. The mechanisms linking cardiac dysfunction to cognitive decline were discussed, including vascular damage, neuroinflammation, and neurohormonal imbalances. Evidence from clinical studies demonstrated associations between elevated cardiac biomarkers and structural brain changes, as well as a decline in memory and executive function. Despite promising findings, current research faces limitations, including population-specific biases, limited biomarker diversity, and incomplete understanding of pathophysiological mechanisms. We highlighted the clinical implications of incorporating cardiac biomarkers into cognitive health assessments, emphasizing their potential for early detection, risk stratification, and personalized management strategies. The integration of cardiac biomarkers with neuroimaging, genetic data, and neuropsychological assessments is recognized to offer a comprehensive approach to managing high-risk populations. Looking ahead, we identified key areas for future research, including the need for large-scale, longitudinal studies across diverse populations, the exploration of novel biomarkers, and the application of artificial intelligence to enhance predictive models. The potential of cardiac biomarkers in public health initiatives and preventive screening programs was also discussed. Cardiac biomarkers represent a vital link between heart and brain health, offering valuable insights into the complex pathways of cognitive deterioration in neurodegenerative diseases. Their integration into clinical practice holds promise for improving outcomes and quality of life for individuals at risk of, or suffering from, cognitive decline worldwide.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"294 ","pages":"161-173"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of sexuality on degenerative diseases. 性对退行性疾病的影响。
4区 医学
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-28 DOI: 10.1016/bs.pbr.2025.02.007
David Anuoluwapo Oyeniran, Tobiloba Samuel Olajide, Abayomi Oyeyemi Ajagbe, Abdulateef Ayoola Mobolaji
{"title":"Impact of sexuality on degenerative diseases.","authors":"David Anuoluwapo Oyeniran, Tobiloba Samuel Olajide, Abayomi Oyeyemi Ajagbe, Abdulateef Ayoola Mobolaji","doi":"10.1016/bs.pbr.2025.02.007","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.02.007","url":null,"abstract":"<p><p>Human sexuality is shaped by a complex interplay of biological, psychological, social, and cultural factors, influencing individual identity, behaviors, relationships, and sexual experience. Far from merely reflecting anatomical characteristics, sexuality encompasses emotional and sexual attraction toward individuals across gender spectrums, guided by factors including hormones, genetics, brain processes, and environmental influences. Societal norms and cultural beliefs also mold sexual expression, with diverse sexual identities being either embraced or stigmatized, impacting individual well-being. Sexual health, essential for mental and physical health, connects closely to brain morphology, function, and associated neural mechanisms. The hypothalamus and neurotransmitters like dopamine and oxytocin influence desire, feeling, and pleasure. Additionally, sexuality is linked with the progression and prevalence of degenerative diseases like Alzheimer's and Parkinson's. Sexual dysfunction relating to these diseases often emerges due to neurological changes, cognitive decline, and physical limitations. However, the feeling of sexual satisfaction can mitigate the impact of these diseases by promoting cognitive function, emotional intimacy, and stress reduction. Sexual activity in older adults is linked to better cardiovascular and cognitive health, emphasizing the broader health benefits of sexual well-being. Understanding sexuality across all stages of life, in both health and illness, is essential as it forms an integral part of general well-being and human existence.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"293 ","pages":"57-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early life stress and brain development: Neurobiological and behavioral effects of chronic stress. 早期生活压力与大脑发育:慢性压力对神经生物学和行为的影响。
4区 医学
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1016/bs.pbr.2025.01.004
Subia Jamil, Muhammad Liaquat Raza, Nasrollah Moradikor, Motahareh Haghipanah
{"title":"Early life stress and brain development: Neurobiological and behavioral effects of chronic stress.","authors":"Subia Jamil, Muhammad Liaquat Raza, Nasrollah Moradikor, Motahareh Haghipanah","doi":"10.1016/bs.pbr.2025.01.004","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.004","url":null,"abstract":"<p><p>Early life stress is the term used to describe a variety of traumatic events that a person may have as a kid, such as being subjected to domestic or public violence, being neglected, experiencing parental conflict, being abused physically, emotionally and sexually. These events have the potential to seriously impair the brains normal growth and development, which could have long term psychological and physiological repercussions. Early life stress (ELS) has profound and enduring effects on brain development, contributing to long-term neurological and behavioral changes. Neurologically, ELS can reduce hippocampal volume, impairing memory and emotional regulation, while also sensitizing the amygdala, leading to exaggerated fear and anxiety responses. Additionally, ELS can disrupt the development of the prefrontal cortex (PFC), affecting decision-making, planning, and impulse control. It also alters neurotransmitter systems, such as serotonin and dopamine, influencing mood and motivation, and can trigger chronic neuroinflammation, increasing the risk of neurodegenerative diseases. Behaviorally, ELS heightens the risk of anxiety, depression, and impulsivity, and can contribute to conditions like ADHD and substance abuse Social and emotional difficulties, such as challenges in relationships and empathy, often arise, along with cognitive impairments in learning and memory. Furthermore, ELS increases stress responsiveness, making individuals more vulnerable to future stress. However, these effects can be mitigated by supportive environments and targeted interventions.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"49-79"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping brain neural networks in stress brain connectivity. 绘制压力下的大脑神经网络。
4区 医学
Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-16 DOI: 10.1016/bs.pbr.2025.01.014
Al-Hassan Soliman Wadan, Mohamed Abdelsattar Ahmed, Nasrollah Moradikor
{"title":"Mapping brain neural networks in stress brain connectivity.","authors":"Al-Hassan Soliman Wadan, Mohamed Abdelsattar Ahmed, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.01.014","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.014","url":null,"abstract":"<p><p>Stress can cause severe damage to the CNS and contribute to an increased risk of neurological and psychiatric disorders. Gaining more insight into the neurobiology of stress is essential to treating neurological disorders associated with stress, which account for a high percentage of the world's disease burden. However, because of complicated variations in stressor types, stress perception, and preceding exposure to stressors, studying the impacts of stress is challenging. Gender, age, and timing are other crucial variables that can influence the stress response. Behavioral, physiological, genetic, and cellular/molecular neuroscience methodologies have all been widely applied in various research contexts to examine the neurobiological impacts of stress. Furthermore, because these approaches are invasive and hence undesirable or impractical for use in humans, they are frequently challenging to adapt to a therapeutic context. As an alternative to invasive procedures, functional neuroimaging approaches are starting to be developed. We discuss in this chapter brain neural networks under stress brain connection.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"239-251"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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