Progress in brain research最新文献_第2页

Stress in specific population: Cognitive decline in aging, occupational challenges, strategies for medical professionals. 特定人群的压力：老年认知能力下降，职业挑战，医疗专业人员的策略。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-10 DOI: 10.1016/bs.pbr.2025.01.017

Gargi Gautam, Nasrollah Moradikor

{"title":"Stress in specific population: Cognitive decline in aging, occupational challenges, strategies for medical professionals.","authors":"Gargi Gautam, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.01.017","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.017","url":null,"abstract":"Understanding cognitive decline and its contributing causes, such as stress, which presents differently in different groups, is crucial given the aging population's rapid growth. This chapter looks at how stress affects older persons' cognitive decline, with a particular emphasis on the difficulties faced by medical professionals in their line of work and how to lessen the consequences. The severity and course of cognitive decline differ from person to person and are impacted by factors such as lifestyle, medical history, and stress at work. The COVID-19 pandemic has made medical practitioners' already high demands even more precarious. Stress in underprivileged areas and among veterans emphasizes the negative effects of work-related stress on mental health even more. Techniques that improve psychological well-being and lessen burnout include resilience training, digital tools, supportive leadership, and mindfulness-based stress reduction (MBSR). Enhancing work-life balance and promoting a healthier work environment can be achieved by combining these interventions with organizational changes. Aging-related cognitive impairment necessitates a multimodal strategy that includes targeted stress reduction methods and organizational adjustments. Setting mental health as a top priority in healthcare settings promotes the wellbeing of staff members, enhances patient care, and improves healthcare results.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"363-379"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to neurobiology and pharmacology of stress. 神经生物学和应激药理学导论。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-03 DOI: 10.1016/bs.pbr.2025.01.006

Saeid Abbasi-Maleki, Babak Nakhaei, Samira Rostami Mehr, Nasrollah Moradikor

{"title":"Introduction to neurobiology and pharmacology of stress.","authors":"Saeid Abbasi-Maleki, Babak Nakhaei, Samira Rostami Mehr, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.01.006","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.006","url":null,"abstract":"In order to improve individual and community health outcomes, stress research is crucial for developing our understanding of human biology, psychology, and social dynamics. It also informs therapeutic practices, public health campaigns, and educational activities. The chapter explores how neurotransmitters, including glutamate, GABA, adrenaline, norepinephrine, serotonin, dopamine, and adrenaline, mediate stress responses, impact mood and behavior, and play a part in a number of stress-related disorders. The relevance of focused research and therapy approaches aimed at reestablishing equilibrium within these systems is highlighted by the fact that dysregulation of these neurotransmitters can exacerbate health problems. Additionally, it is investigated how the amygdala, hippocampus, and prefrontal cortex interact to process emotions, build resilience, and determine an individual's susceptibility to stress. These interactions are regulated by both neuroplasticity and hereditary and epigenetic factors. The chapter discusses the pharmaceutical approach to stress management, which includes a variety of drugs such as beta-blockers, anxiolytics, and antidepressants that work by targeting different neurotransmitter systems to reduce anxiety and mood disorders. Even while these therapies work, they may have negative consequences and side effects that should be carefully considered in clinical settings. The chapter promotes a comprehensive approach to stress management that combines medication, lifestyle changes, psychotherapy, and stress-reduction methods. Healthcare workers can improve patient care and ultimately the health and quality of life for people with stress-related disorders by knowing the complexity of pharmaceutical therapies and how they affect the stress response.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress and gender differences in brain development. 大脑发育中的压力和性别差异。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-04-02 DOI: 10.1016/bs.pbr.2025.01.013

Abraham Olufemi Asuku, Priscilla Omobonke Adebayo, Gbonjubola Oyinlola Ogungbangbe

{"title":"Stress and gender differences in brain development.","authors":"Abraham Olufemi Asuku, Priscilla Omobonke Adebayo, Gbonjubola Oyinlola Ogungbangbe","doi":"10.1016/bs.pbr.2025.01.013","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.013","url":null,"abstract":"This chapter investigates the ways in which male and female brains are differently affected by stress during early development, which in turn affects how susceptible each group is to stress-related illnesses. When examining the structure and function of the brain, gender differences and stress must be taken into account. Male and female brain development differs in response to the prenatal testis's secretion of androgen. It appears that when it comes to responding to stress, encoding memories, feeling emotions, solving specific issues, and making decisions, men and women use distinct areas of the brain. Findings revealed that stress led to specific changes in brain structure and function, with gender-specific differences observed. The prefrontal cortex, the hippocampus, and the amygdala are among the brain regions connected to the stress response. The stress response has been linked to the presentation of numerous mental and psychosomatic conditions. The way men and women respond to stress varies on a biological and psychological level. To gain more insight into the gender differences seen throughout brain development, these disparities must also be investigated. This chapter implies that gender-specific vulnerabilities should be addressed and healthy brain development should be promoted by stress-related interventions.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"319-337"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neuroscientific basis of post-traumatic stress disorder (PTSD): From brain to treatment. 创伤后应激障碍（PTSD）的神经科学基础：从大脑到治疗。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-03 DOI: 10.1016/bs.pbr.2025.01.009

Lila Agbaria, Foad Mirzaei, Nathalie Omar A'amar, Farah Tawfiq Raba, Garbis Papazian, Khushbu Bhatnagar, Nethmini Sirimanne, Aaqil Ahamed Ayoubkhan, Albankha Gerald Thilagendra, Anushka Gupta

{"title":"The neuroscientific basis of post-traumatic stress disorder (PTSD): From brain to treatment.","authors":"Lila Agbaria, Foad Mirzaei, Nathalie Omar A'amar, Farah Tawfiq Raba, Garbis Papazian, Khushbu Bhatnagar, Nethmini Sirimanne, Aaqil Ahamed Ayoubkhan, Albankha Gerald Thilagendra, Anushka Gupta","doi":"10.1016/bs.pbr.2025.01.009","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.009","url":null,"abstract":"Post-traumatic stress disorder (PTSD) is a debilitating mental health condition resulting from exposure to traumatic events, marked by persistent psychological distress and impairment in daily functioning. Risk factors for PTSD include genetic predispositions, neurobiological factors, as well as psychosocial and environmental influences. Specific demographic groups, such as veterans, first responders, and individuals in high-risk environments, are more susceptible to developing the disorder. Despite growing research, there remain gaps in understanding the full pathophysiology of PTSD, and existing diagnostic methods and treatments are not universally effective, contributing to a significant public health burden. This chapter explores the pathophysiology of PTSD, focusing on its underlying mechanisms, associated risk factors, and high-risk populations. Biological biomarkers such as neuroimaging findings, hormonal imbalances, genetic predispositions, and physiological indicators are discussed in the context of their role in PTSD diagnosis and understanding. Both pharmacological treatments and non-pharmacological interventions, including Cognitive Behavioral Therapy (CBT), Eye Movement Desensitization and Reprocessing (EMDR), and mindfulness-based techniques, are reviewed for their effectiveness in symptom management. Further research is essential to advance individualized diagnostic techniques and optimize treatment strategies, ensuring more personalized care for PTSD patients.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"427-468"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of stress on neuronal cell: Morphological to molecular approach. 应激对神经细胞的影响：形态学到分子学的研究。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.1016/bs.pbr.2025.01.010

Ishita Bhardwaj, Sippy Singh, Atifa Haseeb Ansari, Swayam Prabha Rai, Durgesh Singh

{"title":"Effect of stress on neuronal cell: Morphological to molecular approach.","authors":"Ishita Bhardwaj, Sippy Singh, Atifa Haseeb Ansari, Swayam Prabha Rai, Durgesh Singh","doi":"10.1016/bs.pbr.2025.01.010","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.010","url":null,"abstract":"Stress can be characterized as any perceived or actual threat that necessitates compensatory actions to maintain homeostasis. It can alter an organism's behavior over time by permanently altering the composition and functionality of brain circuitry. The amygdala and prefrontal cortex are two interrelated brain regions that have been the focus of initial research on stress and brain structural and functional plasticity, with the hippocampus serving as the entry point for most of this knowledge. Prolonged stress causes significant morphological alterations in important brain regions such as the hippocampus, amygdala, and prefrontal cortex. Memory, learning, and emotional regulation are among the cognitive functions that are adversely affected by these changes, including neuronal shrinkage, dendritic retraction, and synaptic malfunction. Stress perturbs the equilibrium of neurotransmitters, neuronal plasticity, and mitochondrial function at the molecular level. On the other hand, chronic stress negatively impacts physiology and can result in neuropsychiatric diseases. Recent molecular research has linked various epigenetic processes, such as DNA methylation, histone modifications, and noncoding RNAs, to the dysregulation of genes in the impacted brain circuits responsible for the pathophysiology of chronic stress. Numerous disorders, including neurodegenerative diseases (NDDs) including Alzheimer's, amyotrophic lateral sclerosis, Friedreich's ataxia, Huntington's disease, multiple sclerosis, and Parkinson's disease, have been linked to oxidative stress as a possible cause.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"469-502"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress-related psychiatric disorders. 与压力相关的精神疾病。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-16 DOI: 10.1016/bs.pbr.2025.01.019

Abbas Al Bazzal, Mohammad Ali Mtairek, Mohammad Hadi Awde, Haidar Kanso, Fatima Hajj, Fatima Al Amin, Zeinab Kazan, Nadia A Mohammed, Hiba Hamdar

{"title":"Stress-related psychiatric disorders.","authors":"Abbas Al Bazzal, Mohammad Ali Mtairek, Mohammad Hadi Awde, Haidar Kanso, Fatima Hajj, Fatima Al Amin, Zeinab Kazan, Nadia A Mohammed, Hiba Hamdar","doi":"10.1016/bs.pbr.2025.01.019","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.019","url":null,"abstract":"Stress is a natural human emotion that motivates us to face difficulties and risks. Everyone experiences stress to some extent, but when it becomes chronic or reaches a level that cannot be managed, its effects begin to manifest. It is a common condition that most individuals confront, and its effects on the body and brain have become more obvious in recent years. Social and environmental interactions activate systemic reactions primarily controlled by the brain via immunological, neuroendocrine, and metabolic pathways. Long-term stress disrupts homeostasis, activating stress mediators that attempt to restore balance but frequently cause cumulative damage, particularly to the hippocampus, amygdala, and hypothalamus. Furthermore, persistent stress can have a direct and indirect effect on initiating psychiatric illnesses such as depression, anxiety, ADHD, and schizophrenia. Studies on neuroimaging show anatomical and functional alterations in stress-affected regions such as the prefrontal cortex and the hippocampus, which are linked to emotional dysregulation and cognitive decline. To better understand how stress affects psychiatric disorders and exacerbates their symptoms, this chapter will first discuss the molecular mechanism and neurobiological changes it can cause. It will then demonstrate various neuroimaging techniques for studying the effects of stress and offer potential treatments to mitigate these negative effects.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"161-173"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms underlying stress effects on the brain: Basic concepts and clinical implications. 应激对大脑影响的机制：基本概念和临床意义。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-05 DOI: 10.1016/bs.pbr.2025.01.008

Hager Adel Saad, Mahmoud Marzouk, Hla Abdelrahman, Nasrollah Moradikor

{"title":"Mechanisms underlying stress effects on the brain: Basic concepts and clinical implications.","authors":"Hager Adel Saad, Mahmoud Marzouk, Hla Abdelrahman, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.01.008","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.008","url":null,"abstract":"Chronic stress impacts the brain through complex physiological, neurological, and immunological responses. The stress response involves the activation of the sympathetic-adrenal-medullary (SAM) system and the hypothalamic-pituitary-adrenal (HPA) axis, releasing stress hormones like norepinephrine and cortisol. While these responses are adaptive short-term, chronic stress disrupts homeostasis, increasing the risk of cardiovascular diseases, neurodegenerative disorders, and psychiatric conditions such as depression. This dysregulation is linked to persistent neuroinflammation, oxidative stress, and neurotransmitter imbalances involving dopamine and serotonin, impairing neuroplasticity and leading to structural changes in critical brain areas, such as the hippocampus and prefrontal cortex. Moreover, stress affects gene expression, particularly neuroinflammatory pathways, contributing to long-term cognitive function and emotional regulation alterations. Advancements in neuroimaging and molecular techniques, including MRI, PET, and SPECT, hold promise for identifying biomarkers and better understanding stress-induced brain changes. These insights are critical for developing targeted interventions to mitigate the adverse effects of chronic stress on brain health.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"21-47"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanism underlying stress response and adaptation. 应激反应和适应的分子机制。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-17 DOI: 10.1016/bs.pbr.2025.01.005

Joshua Ayodele Yusuf, Stephen Tunmise Akanbi, Darasimi Racheal Olorunlowu, Elizabeth Kehinde Opoola, Eniola Elizabeth Ogunlade, Emmanuel Adebayo Kayode, Emmanuel Oluwagbenga Adejobi, Yasar Olalekan Sulaiman, Dorcas Ifeoluwa Odemakinde, Esther Opeyemi Aworeni, Nurat Ize Abdulmalik, Dolapo Priscilla Oluyemi, Ayomide Esther Isaac, Oluwaferanmi Israel Aromose, Oyindamola Munirat Adewale, Victor Ogunrinde, Tijesunimi Ayomide Adeleke, Olufunto Omodele Adeleye

{"title":"Molecular mechanism underlying stress response and adaptation.","authors":"Joshua Ayodele Yusuf, Stephen Tunmise Akanbi, Darasimi Racheal Olorunlowu, Elizabeth Kehinde Opoola, Eniola Elizabeth Ogunlade, Emmanuel Adebayo Kayode, Emmanuel Oluwagbenga Adejobi, Yasar Olalekan Sulaiman, Dorcas Ifeoluwa Odemakinde, Esther Opeyemi Aworeni, Nurat Ize Abdulmalik, Dolapo Priscilla Oluyemi, Ayomide Esther Isaac, Oluwaferanmi Israel Aromose, Oyindamola Munirat Adewale, Victor Ogunrinde, Tijesunimi Ayomide Adeleke, Olufunto Omodele Adeleye","doi":"10.1016/bs.pbr.2025.01.005","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.005","url":null,"abstract":"Stress, a common life experience, impacts both mental and physical health, contributing to conditions such as anxiety and cardiovascular disease. It triggers physiological and psychological responses, primarily through the Hypothalamic-Pituitary-Adrenal (HPA) and Sympathetic-Adrenal-Medullary (SAM) axes, which are coordinated by the autonomic nervous system. Dysregulation of the glucocorticoid system, mediated by mineralocorticoid and glucocorticoid receptors, plays a critical role in neurodegenerative disorders like Alzheimer's disease. Cellular pathways like PI3K/Akt, NF-κB, and AP-1 transcription factors maintain homeostasis during stress and are targets for therapeutic research. Epigenetic influences and genomic modifications highlight the long-lasting effects of stress on gene expression. Adaptive responses, such as allostasis, allow the body to maintain stability amid stress. However, excessive stress leads to allostatic load, negatively impacting the immune, endocrine, and nervous systems. Current treatments include pharmacological and lifestyle interventions, with emerging approaches such as psychobiotics and precision medicine offering future potential.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"81-108"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress-induced neurodegeneration and behavioral alterations in Caenorhabditis elegans: Insights into the evolutionary conservation of stress-related pathways and implications for human health. 秀丽隐杆线虫应激诱导的神经退行性变和行为改变：应激相关途径的进化保护及其对人类健康的影响

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-07 DOI: 10.1016/bs.pbr.2025.01.001

Toheeb O Oyerinde, Victor E Anadu, Tobiloba S Olajide, Olayemi K Ijomone, Oritoke M Okeowo, Omamuyovwi M Ijomone

{"title":"Stress-induced neurodegeneration and behavioral alterations in Caenorhabditis elegans: Insights into the evolutionary conservation of stress-related pathways and implications for human health.","authors":"Toheeb O Oyerinde, Victor E Anadu, Tobiloba S Olajide, Olayemi K Ijomone, Oritoke M Okeowo, Omamuyovwi M Ijomone","doi":"10.1016/bs.pbr.2025.01.001","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.001","url":null,"abstract":"Stress is a significant determinant for a range of neurological and psychiatric illnesses, and comprehending its influence on the brain is vital for developing effective interventions. Caenorhabditis elegans (C. elegans), a tiny nematode, has become a potent model system for investigating the impact of stress on neuronal integrity, behavior, and lifespan. This chapter presents a comprehensive summary of the existing understanding of stress-induced neurodegeneration, behavioral abnormalities, and changes in lifespan in C. elegans. We explored the stress response pathways in C. elegans, specifically focusing on the heat shock response and insulin-like signaling (ILS) pathway, targeting how these pathways affect neural integrity and functions. Additionally, this chapter highlighted behavioral modifications such as changes in locomotion, feeding, pharyngeal pumping, defecation, and copulation behaviors that occur in C. elegans following exposure to stressors, and how these findings contribute to our comprehension of stress-related illnesses. Furthermore, the evolutionary preservation of stress responses in both C. elegans and humans, underscoring the significance of C. elegans studies for translational research were highlighted. In conclusion, the possible implications of C. elegans research on human well-being, with a specific emphasis on the discovery of targets for treatment and the creation of innovative approaches to address stress-related conditions are discussed in this chapter.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"405-425"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synaptic modulation by coffee compounds: Insights into neural plasticity. 咖啡化合物对突触的调节：神经可塑性的启示

4区医学

Progress in brain research Pub Date : 2024-01-01 Epub Date: 2024-06-21 DOI: 10.1016/bs.pbr.2024.06.008

Al-Hassan Soliman Wadan, Muhammad Liaquat Raza, Nasrollah Moradikor

{"title":"Synaptic modulation by coffee compounds: Insights into neural plasticity.","authors":"Al-Hassan Soliman Wadan, Muhammad Liaquat Raza, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2024.06.008","DOIUrl":"https://doi.org/10.1016/bs.pbr.2024.06.008","url":null,"abstract":"The physiological structure and functioning of the brain are determined by activity-dependent processes and affected by \"synapse plasticity.\" Because chemical transmitters target and regulate synapses, exogenous chemical stimulants and transmitters can alter their physiological functions by interacting with synaptic surface receptors or chemical modulators. Caffeine, a commonly used pharmacologic substance, can target and alter synapses. It impact various biological, chemical, and metabolic processes related to synaptic function. This chapter investigates how caffeine affects fluctuations in structure and function in the hippocampus formation and neocortical structure, regions known for their high synaptic plasticity profile. Specifically, caffeine modulates various synaptic receptors and channel activities by mobilizing intracellular calcium, inhibiting phosphodiesterase, and blocking adenosine and GABA cellular receptors. These caffeine-induced pathways and functions allow neurons to generate plastic modulations in synaptic actions such as efficient and morphological transmission. Moreover, at a network level, caffeine can stimulate neural oscillators in the cortex, resulting in repetitive signals that strengthen long-range communication between cortical areas reliant on N-methyl-d-aspartate receptors. This suggests that caffeine could facilitate the reorganization of cortical network functions through its effects on synaptic mobilization.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"289 ","pages":"181-191"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0