Progress in brain research最新文献_第2页

Mapping brain neural networks in stress brain connectivity. 绘制压力下的大脑神经网络。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-16 DOI: 10.1016/bs.pbr.2025.01.014

Al-Hassan Soliman Wadan, Mohamed Abdelsattar Ahmed, Nasrollah Moradikor

引用次数: 0

Impact of sexuality on degenerative diseases. 性对退行性疾病的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-28 DOI: 10.1016/bs.pbr.2025.02.007

David Anuoluwapo Oyeniran, Tobiloba Samuel Olajide, Abayomi Oyeyemi Ajagbe, Abdulateef Ayoola Mobolaji

{"title":"Impact of sexuality on degenerative diseases.","authors":"David Anuoluwapo Oyeniran, Tobiloba Samuel Olajide, Abayomi Oyeyemi Ajagbe, Abdulateef Ayoola Mobolaji","doi":"10.1016/bs.pbr.2025.02.007","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.02.007","url":null,"abstract":"Human sexuality is shaped by a complex interplay of biological, psychological, social, and cultural factors, influencing individual identity, behaviors, relationships, and sexual experience. Far from merely reflecting anatomical characteristics, sexuality encompasses emotional and sexual attraction toward individuals across gender spectrums, guided by factors including hormones, genetics, brain processes, and environmental influences. Societal norms and cultural beliefs also mold sexual expression, with diverse sexual identities being either embraced or stigmatized, impacting individual well-being. Sexual health, essential for mental and physical health, connects closely to brain morphology, function, and associated neural mechanisms. The hypothalamus and neurotransmitters like dopamine and oxytocin influence desire, feeling, and pleasure. Additionally, sexuality is linked with the progression and prevalence of degenerative diseases like Alzheimer's and Parkinson's. Sexual dysfunction relating to these diseases often emerges due to neurological changes, cognitive decline, and physical limitations. However, the feeling of sexual satisfaction can mitigate the impact of these diseases by promoting cognitive function, emotional intimacy, and stress reduction. Sexual activity in older adults is linked to better cardiovascular and cognitive health, emphasizing the broader health benefits of sexual well-being. Understanding sexuality across all stages of life, in both health and illness, is essential as it forms an integral part of general well-being and human existence.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"293 ","pages":"57-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1016/bs.pbr.2025.01.011

Maryam Azarfarin, Nasrollah Moradikor, Sara Salatin, Mehdi Sarailoo, Masoomeh Dadkhah

{"title":"Stress-related neurodegenerative diseases: Molecular mechanisms implicated in neurodegeneration and therapeutic strategies.","authors":"Maryam Azarfarin, Nasrollah Moradikor, Sara Salatin, Mehdi Sarailoo, Masoomeh Dadkhah","doi":"10.1016/bs.pbr.2025.01.011","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.011","url":null,"abstract":"Chronic stress is a striking cause of major neurodegenerative diseases disorders (NDDs). These diseases share several common mechanisms regarding to disease pathology, in spite of they have various properties and clinical manifestations. NDDs are defined by progressive cognitive decline, and stress contribute to the promotion and progression of disease. In addition, various pathways such as production of reactive oxygen species (ROS), mitochondrial dysfunction, and neurodegeneration are the main crucial hallmarks to develop common NDDs, resulting in neuronal cell death. Although the exact mechanisms of NDDs are underexplored, the potential neuroprotective critical role of such therapies in neuronal loss the treatment of NDDs are not clear. In this regard, researchers investigate the neuroprotective effects of targeting underlying cascade to introduce a promising therapeutic option to NDDs. Herein, we provide an overview of the role of non-pharmacological treatments against oxidative stress, mitochondrial symbiosis, and neuroinflammation in NDDs, mainly discussing the music, diet, and exercise effects of targeting pathways.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"253-288"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of feelings on decision-making (analytical and rational). 情感对决策的影响（分析性和理性的）。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-25 DOI: 10.1016/bs.pbr.2025.02.008

Gargi Gautam, Jasmine Kaur, Nasrollah Moradikor

引用次数: 0

The roots of happiness: How love and memory shape the core of our brain. 幸福的根源：爱和记忆如何塑造我们大脑的核心。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-04-02 DOI: 10.1016/bs.pbr.2025.03.002

Mohamad Alfateh Abou Haykal

{"title":"The roots of happiness: How love and memory shape the core of our brain.","authors":"Mohamad Alfateh Abou Haykal","doi":"10.1016/bs.pbr.2025.03.002","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.03.002","url":null,"abstract":"This chapter explores the profound impact of love and joyful memories on the brainstem, emphasizing their significance for mental and emotional well-being. It introduces the brainstem's role in essential life functions and its connection to higher emotional processes. Topics delve into the neurobiology of love, detailing how chemicals like oxytocin, dopamine, and serotonin interact with brainstem activity, influencing physical health and emotional resilience. The chapter also examines the role of positive memories, explaining how recalling them activates relaxation responses, reduces stress, and enhances well-being. Practical strategies for cultivating love and creating positive memories are discussed, including mindfulness and intentional relationship-building. The chapter also explores emerging research on love and memory as therapeutic tools for conditions such as PTSD and anxiety. In conclusion, the chapter highlights the interconnectedness of love, memory, and the brainstem, proposing that nurturing these connections can lead to increased joy and emotional fulfillment, making it a valuable resource for both neuroscience and personal development.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"293 ","pages":"41-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of stress on cognitive performance. 压力对认知表现的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-07 DOI: 10.1016/bs.pbr.2025.01.015

David Chukwuma Nwikwe

{"title":"Effects of stress on cognitive performance.","authors":"David Chukwuma Nwikwe","doi":"10.1016/bs.pbr.2025.01.015","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.015","url":null,"abstract":"Stress remains a pervasive challenge in modern life, exerting significant impacts on cognitive performance and overall well-being by triggering release of stress hormones like adrenaline and cortisol. It has profound implications for education, work performance, and everyday life, impacting cognitive performance, health outcomes, and social relationships. It does this by impacting memory, attention and focus, informed decision-making, developmental and cognitive performance, work and educational performance, genetic and epigenetic influence, and public health. When a stressor is perceived, the hypothalamus in the brain signals the pituitary gland to release adrenocorticotropic hormone, hence adrenaline is quickly released into the bloodstream, causing immediate physiological changes and thus releasing cortisol gradually to help maintain the body's response to stress over a longer period through the hypothalamic-pituitary-adrenal and sympathetic-adrenomedullar axis. The impacts can be short-term or long-term focusing on the working memory, pre-frontal cortex, amygdala, and hippocampus. By recognizing these implications and implementing targeted interventions, we can foster environments that support resilience, optimize performance, and enhance overall well-being across diverse contexts. This chapter also highlighted some mitigation strategies to reduce stress-related activities and improve cognitive performance, such as cognitive-behavioral therapy, mindfulness-based stress reduction, healthy lifestyle adoption, pet therapy, time management and prioritization, and workplace interventions.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"109-135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addiction and stress: Exploring the reward pathways in brain affected by different drugs. 成瘾与压力：探索不同药物对大脑奖赏通路的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.pbr.2025.01.012

Samira Rostami Mehr, Babak Nakhaei, Hossein Soleimani, Shaahriyar Kouhi Madadlou, Asghar Abbasi Maleky, Saeid Abbasi-Maleki

{"title":"Addiction and stress: Exploring the reward pathways in brain affected by different drugs.","authors":"Samira Rostami Mehr, Babak Nakhaei, Hossein Soleimani, Shaahriyar Kouhi Madadlou, Asghar Abbasi Maleky, Saeid Abbasi-Maleki","doi":"10.1016/bs.pbr.2025.01.012","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.012","url":null,"abstract":"This chapter delves into the complex interplay among addiction, stress, and the reward pathways in the brain, emphasizing the ways in which various drugs affect these systems and exacerbate SUD. Drugs have physiological effects that can be both pleasurable and unpleasant. These effects change behavior through both positive and negative reinforcement. A person's genetic predisposition to addiction is mostly determined by factors such as biological sex, age of first usage, and dopamine receptor density. Drug use behaviors are also greatly influenced by environmental stressors, media exposure, and substance accessibility; nevertheless, protective variables including social support, participation in healthy activities, and preventative programs serve to reduce the dangers associated with drug use. The reinforcement of addictive behaviors is mostly dependent on the brain's reward circuits, which include the nucleus accumbens, ventral tegmental region, and prefrontal cortex, in addition to neurotransmitters such as dopamine, serotonin, and endorphins. Stress makes addiction worse by intensifying cravings and raising the possibility of relapsing. Examined are the impacts of several drug types, such as opioids, stimulants, depressants, and hallucinogens, emphasizing the long-term consequences on brain function and susceptibility to addiction. In order to create individualized interventions that target the environmental and neurological components of addiction and eventually improve treatment results, a thorough understanding of these elements is important.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"381-404"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the connection between stress and sleep: From underlying mechanisms to therapeutic solutions. 理解压力和睡眠之间的联系：从潜在机制到治疗解决方案。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-10 DOI: 10.1016/bs.pbr.2025.01.016

Matthew-Zane L Broderick, Qadir Khan, Nasrollah Moradikor

{"title":"Understanding the connection between stress and sleep: From underlying mechanisms to therapeutic solutions.","authors":"Matthew-Zane L Broderick, Qadir Khan, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.01.016","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.016","url":null,"abstract":"The objective of this chapter is to navigate through the nexus between stress and sleep, highlighting the neurobiological systems that connect them. Starting with an overview of neuroanatomy and physiology of stress and sleep, with a further detailed breakdown of sleep stages and key neuroanatomical centers that are responsible for sleep and wakefulness. Starting with suprachiasmatic nuclei (SCN) in circadian rhythm and sleep regulation overview, with a center point on the molecular systems including the CLOCK/CRY and BMAL1/2/PER1/2 feedback loops. Following this is the neurobiological of stress, specifically the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic-adrenal (SPA) axis and influence on sleep. Vital neural circuits connecting stress and sleep are examined with the attention of the ventral tegmental area (VTA) GABA-somatostatin neurons and the locus coerules in sleep regulation in response to stress. In addition, neuroinflammation's role occurs through the cytokines IL-1β and TNF-α are investigated as a mediator of sleep disturbances caused by stress. It concludes by summarizing the implications of neuroinflammatory modulation in stress-related psychopathologies, emphasizing the opening this provides for interventions that target this inflammation helping to lighten sleep disorder.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"137-159"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistence of training-induced visual improvements after occipital stroke. 枕脑卒中后训练诱导的视力改善的持续性。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2024-12-31 DOI: 10.1016/bs.pbr.2024.12.001

Hanna E Willis, Berkeley Fahrenthold, Rebecca S Millington-Truby, Rebecca Willis, Lucy Starling, Matthew R Cavanaugh, Marco Tamietto, Krystel Huxlin, Holly Bridge

{"title":"Persistence of training-induced visual improvements after occipital stroke.","authors":"Hanna E Willis, Berkeley Fahrenthold, Rebecca S Millington-Truby, Rebecca Willis, Lucy Starling, Matthew R Cavanaugh, Marco Tamietto, Krystel Huxlin, Holly Bridge","doi":"10.1016/bs.pbr.2024.12.001","DOIUrl":"10.1016/bs.pbr.2024.12.001","url":null,"abstract":"Damage to the primary visual cortex causes homonymous visual impairments that appear to benefit from visual discrimination training. However, whether improvements persist without continued training remains to be determined and was the focus of the present study. After a baseline assessment visit, 20 participants trained twice daily in their blind-field for a minimum of six months (median=155 sessions), using a motion discrimination and integration task. At the end of training, a return study visit was used to assess recovery. Three months later, 14 of the participants returned for a third study visit to assess persistence of recovery. At each study visit, motion discrimination and integration thresholds, Humphrey visual fields, and structural MRI scans were collected. Immediately after training, all but four participants showed improvements in the trained discrimination task, and shrinkage of the perimetrically-defined visual defect. While these gains were sustained in seven out of eleven participants who improved with training, four participants lost their improvement in motion discrimination thresholds at the follow-up visit. Persistence of recovery was not related to age, time since lesion, number of training sessions performed, proportion of V1 damaged, deficit size, or optic tract degeneration measured from structural MRI scans. The present findings underscore the potential of extended visual training to induce long-term improvements in stroke-induced vision loss. However, they also highlight the need for further investigations to better understand the mechanisms driving recovery, its persistence post-training, and especially heterogeneity among participants.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"292 ","pages":"113-142"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of positive emotions on neural pathways and neurotransmitter systems. 积极情绪对神经通路和神经递质系统的治疗作用。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-11 DOI: 10.1016/bs.pbr.2025.02.006

Bilal El-Mansoury, Jawad Laadraoui, Youssef Razouqi, Asmaa Haj-Khlifa, Hanane El Fatimi, Omar El Hiba, Arumugam R Jayakumar

{"title":"Therapeutic effects of positive emotions on neural pathways and neurotransmitter systems.","authors":"Bilal El-Mansoury, Jawad Laadraoui, Youssef Razouqi, Asmaa Haj-Khlifa, Hanane El Fatimi, Omar El Hiba, Arumugam R Jayakumar","doi":"10.1016/bs.pbr.2025.02.006","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.02.006","url":null,"abstract":"Positive emotions have long been recognized for their impact on overall health, yet emerging research highlights the underlying neural mechanisms and neurotransmitter systems that mediate these effects. Several key brain regions such as the prefrontal cortex (PFC), amygdala, anterior cingulate cortex (ACC), and insula, play a role in processing positive emotions and emotional regulation. Several neurotransmitters and neuropeptides, including dopamine, serotonin, and oxytocin are involved emotional resilience and psychological health. Positive emotions can reshape neural circuits, and foster neuroplasticity and neurogenesis. Therefore, positive emotion-based interventions could play an important role in alleviating mood disorders, improve cognitive function, and enhance social and physiological health. This chapter highlights the transformative impact of integrating the science of positive emotions into therapeutic practices, showcasing their potential to improve overall well-being. It delves into the therapeutic effect of positive emotions on neural pathways and neurotransmitter systems, emphasizing their significance in fostering both mental and physical health.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"293 ","pages":"149-178"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0