Progress in brain research最新文献_第3页

Stress in specific population: Cognitive decline in aging, occupational challenges, strategies for medical professionals. 特定人群的压力：老年认知能力下降，职业挑战，医疗专业人员的策略。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-10 DOI: 10.1016/bs.pbr.2025.01.017

Gargi Gautam, Nasrollah Moradikor

{"title":"Stress in specific population: Cognitive decline in aging, occupational challenges, strategies for medical professionals.","authors":"Gargi Gautam, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.01.017","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.017","url":null,"abstract":"Understanding cognitive decline and its contributing causes, such as stress, which presents differently in different groups, is crucial given the aging population's rapid growth. This chapter looks at how stress affects older persons' cognitive decline, with a particular emphasis on the difficulties faced by medical professionals in their line of work and how to lessen the consequences. The severity and course of cognitive decline differ from person to person and are impacted by factors such as lifestyle, medical history, and stress at work. The COVID-19 pandemic has made medical practitioners' already high demands even more precarious. Stress in underprivileged areas and among veterans emphasizes the negative effects of work-related stress on mental health even more. Techniques that improve psychological well-being and lessen burnout include resilience training, digital tools, supportive leadership, and mindfulness-based stress reduction (MBSR). Enhancing work-life balance and promoting a healthier work environment can be achieved by combining these interventions with organizational changes. Aging-related cognitive impairment necessitates a multimodal strategy that includes targeted stress reduction methods and organizational adjustments. Setting mental health as a top priority in healthcare settings promotes the wellbeing of staff members, enhances patient care, and improves healthcare results.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"363-379"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to neurobiology and pharmacology of stress. 神经生物学和应激药理学导论。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-03 DOI: 10.1016/bs.pbr.2025.01.006

Saeid Abbasi-Maleki, Babak Nakhaei, Samira Rostami Mehr, Nasrollah Moradikor

{"title":"Introduction to neurobiology and pharmacology of stress.","authors":"Saeid Abbasi-Maleki, Babak Nakhaei, Samira Rostami Mehr, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.01.006","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.006","url":null,"abstract":"In order to improve individual and community health outcomes, stress research is crucial for developing our understanding of human biology, psychology, and social dynamics. It also informs therapeutic practices, public health campaigns, and educational activities. The chapter explores how neurotransmitters, including glutamate, GABA, adrenaline, norepinephrine, serotonin, dopamine, and adrenaline, mediate stress responses, impact mood and behavior, and play a part in a number of stress-related disorders. The relevance of focused research and therapy approaches aimed at reestablishing equilibrium within these systems is highlighted by the fact that dysregulation of these neurotransmitters can exacerbate health problems. Additionally, it is investigated how the amygdala, hippocampus, and prefrontal cortex interact to process emotions, build resilience, and determine an individual's susceptibility to stress. These interactions are regulated by both neuroplasticity and hereditary and epigenetic factors. The chapter discusses the pharmaceutical approach to stress management, which includes a variety of drugs such as beta-blockers, anxiolytics, and antidepressants that work by targeting different neurotransmitter systems to reduce anxiety and mood disorders. Even while these therapies work, they may have negative consequences and side effects that should be carefully considered in clinical settings. The chapter promotes a comprehensive approach to stress management that combines medication, lifestyle changes, psychotherapy, and stress-reduction methods. Healthcare workers can improve patient care and ultimately the health and quality of life for people with stress-related disorders by knowing the complexity of pharmaceutical therapies and how they affect the stress response.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthy happiness: The effect of happiness in promoting brain health. 健康快乐：快乐在促进大脑健康方面的作用。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-25 DOI: 10.1016/bs.pbr.2025.03.004

Matthew-Zane L Broderick, Qadir Khan, Nasrollah Moradikor

{"title":"Healthy happiness: The effect of happiness in promoting brain health.","authors":"Matthew-Zane L Broderick, Qadir Khan, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.03.004","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.03.004","url":null,"abstract":"The Merriam-Webster dictionary defines happiness as \"a state of well-being and contentment\". Psychologically, happiness can be defined as a state of current well-being and positivity resulting from recent stimuli, as well as long-term life satisfaction and peace of mind. This refers to two aspects of happiness discussed in psychology, first coined by Aristotle, pleasurable happiness known as \"hedonia\" and the long-term happiness of living a good life called \"eudaimonia\". These early concepts break down the vaguer and complex idea of happiness into long-term pleasure and positivity. This is where it starts to get more challenging when we try to define happiness in neurobiological terms. Many regions, pathways and circuits in the brain work in tandem to create the conscious and recognized state of happiness we cognitively perceive as humans. However, happiness is a feeling that transcends species boundaries. It is a positive state of emotions that can be expressed in different ways, including contentedness, peace, pleasure, excitement, relief, joy, and more. To do this, happiness must be broken down into constituent parts, localized to specific neuroanatomical regions, and associated with specific projects and structures to really build the anatomical architecture of happiness. Understanding how emotion is quantified and experimentally studied allows the field of neuroscience to build a comprehensive \"neurobiological happiness model\". Here in this chapter, we discuss historical and novel findings into this emotion; we discuss its implication as an evolutionary advantage in the adaptive response, how laughter is associated with happiness, and how a state of positive well-being plays a role in promoting positive brain health.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"293 ","pages":"127-148"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of feelings on the blood-brain barrier (BBB) and drug delivery. 感觉对血脑屏障（BBB）和药物传递的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-31 DOI: 10.1016/bs.pbr.2025.03.006

Omnia Ocab, Hager Adel Saad, Rowan Mashal, Karim Osama, Mahmoud Marzouk, Nabila Hamdi

{"title":"Influence of feelings on the blood-brain barrier (BBB) and drug delivery.","authors":"Omnia Ocab, Hager Adel Saad, Rowan Mashal, Karim Osama, Mahmoud Marzouk, Nabila Hamdi","doi":"10.1016/bs.pbr.2025.03.006","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.03.006","url":null,"abstract":"The blood-brain barrier (BBB) is a critical regulator of cerebral homeostasis, displaying high dynamicity of influx and efflux of substances to and from the central nervous system (CNS). In an exploration of the neurochemical pathways through which positive and negative emotions can influence the physiological characteristics of the BBB, this chapter delves into the multifaceted relationship between emotional states and BBB integrity and permeability. Negative emotions exemplified by stress, chronic anxiety, and depression have shown harmful effects on the BBB, suggesting a state of hyperpermeability that compromises the otherwise conferred protection. Few reports in literature examined the exact molecular mechanisms by which negative emotions exhibit signs of damaged and leaky BBB. Although research deciphering those mechanisms is limited, there is consensus that the disruption of tight junction (TJ) protein integrity and expression, along with neuroinflammatory processes, oxidative Stress, and excitotoxicity, plays a role in the induction of BBB damage. Conversely, positive emotions have been shown to exert protective effects, potentially reversing the increased permeability of the BBB. Compared to the research focused on the neural correlates of negative emotions, the neuroscience literature on positive emotions and well-being is still in its infancy. A deeper understanding of the mechanisms by which positive emotions modulate the BBB remains necessary. Additionally, we discuss the therapeutic implications of these findings, considering how emotional well-being can be leveraged in developing treatments for neurological disorders. By integrating neuroscience, psychology, and pharmacology insights, this chapter aims to comprehensively understand the dynamic interplay between emotions and the BBB and its potential to inform novel therapeutic strategies.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"293 ","pages":"203-242"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of positive feelings and negative feelings on brain cell regeneration and degeneration. 积极感受和消极感受对脑细胞再生和退化的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-28 DOI: 10.1016/bs.pbr.2025.02.009

Al-Hassan Soliman Wadan, Mohamed Abdelsattar Ahmed, Dana Saeed Abd Elmonem El Gemaie, Nasrollah Moradikor

引用次数: 0

Stress and gender differences in brain development. 大脑发育中的压力和性别差异。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-04-02 DOI: 10.1016/bs.pbr.2025.01.013

Abraham Olufemi Asuku, Priscilla Omobonke Adebayo, Gbonjubola Oyinlola Ogungbangbe

{"title":"Stress and gender differences in brain development.","authors":"Abraham Olufemi Asuku, Priscilla Omobonke Adebayo, Gbonjubola Oyinlola Ogungbangbe","doi":"10.1016/bs.pbr.2025.01.013","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.013","url":null,"abstract":"This chapter investigates the ways in which male and female brains are differently affected by stress during early development, which in turn affects how susceptible each group is to stress-related illnesses. When examining the structure and function of the brain, gender differences and stress must be taken into account. Male and female brain development differs in response to the prenatal testis's secretion of androgen. It appears that when it comes to responding to stress, encoding memories, feeling emotions, solving specific issues, and making decisions, men and women use distinct areas of the brain. Findings revealed that stress led to specific changes in brain structure and function, with gender-specific differences observed. The prefrontal cortex, the hippocampus, and the amygdala are among the brain regions connected to the stress response. The stress response has been linked to the presentation of numerous mental and psychosomatic conditions. The way men and women respond to stress varies on a biological and psychological level. To gain more insight into the gender differences seen throughout brain development, these disparities must also be investigated. This chapter implies that gender-specific vulnerabilities should be addressed and healthy brain development should be promoted by stress-related interventions.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"319-337"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neuroscientific basis of post-traumatic stress disorder (PTSD): From brain to treatment. 创伤后应激障碍（PTSD）的神经科学基础：从大脑到治疗。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-03 DOI: 10.1016/bs.pbr.2025.01.009

Lila Agbaria, Foad Mirzaei, Nathalie Omar A'amar, Farah Tawfiq Raba, Garbis Papazian, Khushbu Bhatnagar, Nethmini Sirimanne, Aaqil Ahamed Ayoubkhan, Albankha Gerald Thilagendra, Anushka Gupta

{"title":"The neuroscientific basis of post-traumatic stress disorder (PTSD): From brain to treatment.","authors":"Lila Agbaria, Foad Mirzaei, Nathalie Omar A'amar, Farah Tawfiq Raba, Garbis Papazian, Khushbu Bhatnagar, Nethmini Sirimanne, Aaqil Ahamed Ayoubkhan, Albankha Gerald Thilagendra, Anushka Gupta","doi":"10.1016/bs.pbr.2025.01.009","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.009","url":null,"abstract":"Post-traumatic stress disorder (PTSD) is a debilitating mental health condition resulting from exposure to traumatic events, marked by persistent psychological distress and impairment in daily functioning. Risk factors for PTSD include genetic predispositions, neurobiological factors, as well as psychosocial and environmental influences. Specific demographic groups, such as veterans, first responders, and individuals in high-risk environments, are more susceptible to developing the disorder. Despite growing research, there remain gaps in understanding the full pathophysiology of PTSD, and existing diagnostic methods and treatments are not universally effective, contributing to a significant public health burden. This chapter explores the pathophysiology of PTSD, focusing on its underlying mechanisms, associated risk factors, and high-risk populations. Biological biomarkers such as neuroimaging findings, hormonal imbalances, genetic predispositions, and physiological indicators are discussed in the context of their role in PTSD diagnosis and understanding. Both pharmacological treatments and non-pharmacological interventions, including Cognitive Behavioral Therapy (CBT), Eye Movement Desensitization and Reprocessing (EMDR), and mindfulness-based techniques, are reviewed for their effectiveness in symptom management. Further research is essential to advance individualized diagnostic techniques and optimize treatment strategies, ensuring more personalized care for PTSD patients.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"427-468"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of stress on neuronal cell: Morphological to molecular approach. 应激对神经细胞的影响：形态学到分子学的研究。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.1016/bs.pbr.2025.01.010

Ishita Bhardwaj, Sippy Singh, Atifa Haseeb Ansari, Swayam Prabha Rai, Durgesh Singh

{"title":"Effect of stress on neuronal cell: Morphological to molecular approach.","authors":"Ishita Bhardwaj, Sippy Singh, Atifa Haseeb Ansari, Swayam Prabha Rai, Durgesh Singh","doi":"10.1016/bs.pbr.2025.01.010","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.010","url":null,"abstract":"Stress can be characterized as any perceived or actual threat that necessitates compensatory actions to maintain homeostasis. It can alter an organism's behavior over time by permanently altering the composition and functionality of brain circuitry. The amygdala and prefrontal cortex are two interrelated brain regions that have been the focus of initial research on stress and brain structural and functional plasticity, with the hippocampus serving as the entry point for most of this knowledge. Prolonged stress causes significant morphological alterations in important brain regions such as the hippocampus, amygdala, and prefrontal cortex. Memory, learning, and emotional regulation are among the cognitive functions that are adversely affected by these changes, including neuronal shrinkage, dendritic retraction, and synaptic malfunction. Stress perturbs the equilibrium of neurotransmitters, neuronal plasticity, and mitochondrial function at the molecular level. On the other hand, chronic stress negatively impacts physiology and can result in neuropsychiatric diseases. Recent molecular research has linked various epigenetic processes, such as DNA methylation, histone modifications, and noncoding RNAs, to the dysregulation of genes in the impacted brain circuits responsible for the pathophysiology of chronic stress. Numerous disorders, including neurodegenerative diseases (NDDs) including Alzheimer's, amyotrophic lateral sclerosis, Friedreich's ataxia, Huntington's disease, multiple sclerosis, and Parkinson's disease, have been linked to oxidative stress as a possible cause.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"469-502"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Affect in the dark: Navigating the complex landscape of social cognition in blindness. 黑暗中的情感：在失明中导航社会认知的复杂景观。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-20 DOI: 10.1016/bs.pbr.2025.02.002

Veronica Domenici, Olivier Collignon, Giada Lettieri

引用次数: 0

HABEMO: An innovative haptic tool for investigating the bodily representation of mental states in individuals with visual impairments. HABEMO：一种创新的触觉工具，用于研究有视觉障碍的人的精神状态的身体表征。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-25 DOI: 10.1016/bs.pbr.2025.02.001

Giada Lettieri, Roberta P Calce, Olivier Collignon

{"title":"HABEMO: An innovative haptic tool for investigating the bodily representation of mental states in individuals with visual impairments.","authors":"Giada Lettieri, Roberta P Calce, Olivier Collignon","doi":"10.1016/bs.pbr.2025.02.001","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.02.001","url":null,"abstract":"The embodiment of emotions constitutes a profound aspect of our psychological experience, shaping not only how we express but also how we perceive and understand our feelings. Here, we introduce an innovative haptic tool to explore the relationship between emotional states and bodily reactions, with a focus on its applicability to individuals with visual impairments. Our paradigm is highly intuitive, ensuring accessibility while maintaining accuracy comparable to traditional tasks reliant on visual stimuli. Through motion tracking and a 3D human representation, our system allows to capture in a naturalistic manner where individuals sense affective and cognitive states within their bodies. To validate this method, we conducted two experiments employing both haptic and visual versions of the same task, revealing a compelling alignment between modalities in capturing individuals' internalized manifestations of emotional states. Our novel haptic paradigm allows the mapping of emotions in the body in an intuitive way, offering a more inclusive and versatile method for exploring how people connect their emotions to their physical experiences. More importantly, the haptic version of our task holds particular promise for investigating how individuals with limited or no visual capability maintain representations of emotional and cognitive states within their bodies. In addition to its profound implications for understanding emotions, this innovative tool holds promise for exploring a wide variety of research questions beyond the realm of affective states, thereby broadening its utility as a versatile instrument for investigating various aspects of human perception, cognition, and embodiment particularly within the context of visual impairment.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"292 ","pages":"157-173"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0