Progress in brain research最新文献_第3页

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1016/bs.pbr.2025.01.011

Maryam Azarfarin, Nasrollah Moradikor, Sara Salatin, Mehdi Sarailoo, Masoomeh Dadkhah

{"title":"Stress-related neurodegenerative diseases: Molecular mechanisms implicated in neurodegeneration and therapeutic strategies.","authors":"Maryam Azarfarin, Nasrollah Moradikor, Sara Salatin, Mehdi Sarailoo, Masoomeh Dadkhah","doi":"10.1016/bs.pbr.2025.01.011","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.011","url":null,"abstract":"Chronic stress is a striking cause of major neurodegenerative diseases disorders (NDDs). These diseases share several common mechanisms regarding to disease pathology, in spite of they have various properties and clinical manifestations. NDDs are defined by progressive cognitive decline, and stress contribute to the promotion and progression of disease. In addition, various pathways such as production of reactive oxygen species (ROS), mitochondrial dysfunction, and neurodegeneration are the main crucial hallmarks to develop common NDDs, resulting in neuronal cell death. Although the exact mechanisms of NDDs are underexplored, the potential neuroprotective critical role of such therapies in neuronal loss the treatment of NDDs are not clear. In this regard, researchers investigate the neuroprotective effects of targeting underlying cascade to introduce a promising therapeutic option to NDDs. Herein, we provide an overview of the role of non-pharmacological treatments against oxidative stress, mitochondrial symbiosis, and neuroinflammation in NDDs, mainly discussing the music, diet, and exercise effects of targeting pathways.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"253-288"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of feelings on decision-making (analytical and rational). 情感对决策的影响（分析性和理性的）。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-25 DOI: 10.1016/bs.pbr.2025.02.008

Gargi Gautam, Jasmine Kaur, Nasrollah Moradikor

引用次数: 0

The roots of happiness: How love and memory shape the core of our brain. 幸福的根源：爱和记忆如何塑造我们大脑的核心。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-04-02 DOI: 10.1016/bs.pbr.2025.03.002

Mohamad Alfateh Abou Haykal

{"title":"The roots of happiness: How love and memory shape the core of our brain.","authors":"Mohamad Alfateh Abou Haykal","doi":"10.1016/bs.pbr.2025.03.002","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.03.002","url":null,"abstract":"This chapter explores the profound impact of love and joyful memories on the brainstem, emphasizing their significance for mental and emotional well-being. It introduces the brainstem's role in essential life functions and its connection to higher emotional processes. Topics delve into the neurobiology of love, detailing how chemicals like oxytocin, dopamine, and serotonin interact with brainstem activity, influencing physical health and emotional resilience. The chapter also examines the role of positive memories, explaining how recalling them activates relaxation responses, reduces stress, and enhances well-being. Practical strategies for cultivating love and creating positive memories are discussed, including mindfulness and intentional relationship-building. The chapter also explores emerging research on love and memory as therapeutic tools for conditions such as PTSD and anxiety. In conclusion, the chapter highlights the interconnectedness of love, memory, and the brainstem, proposing that nurturing these connections can lead to increased joy and emotional fulfillment, making it a valuable resource for both neuroscience and personal development.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"293 ","pages":"41-55"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of stress on cognitive performance. 压力对认知表现的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-07 DOI: 10.1016/bs.pbr.2025.01.015

David Chukwuma Nwikwe

{"title":"Effects of stress on cognitive performance.","authors":"David Chukwuma Nwikwe","doi":"10.1016/bs.pbr.2025.01.015","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.015","url":null,"abstract":"Stress remains a pervasive challenge in modern life, exerting significant impacts on cognitive performance and overall well-being by triggering release of stress hormones like adrenaline and cortisol. It has profound implications for education, work performance, and everyday life, impacting cognitive performance, health outcomes, and social relationships. It does this by impacting memory, attention and focus, informed decision-making, developmental and cognitive performance, work and educational performance, genetic and epigenetic influence, and public health. When a stressor is perceived, the hypothalamus in the brain signals the pituitary gland to release adrenocorticotropic hormone, hence adrenaline is quickly released into the bloodstream, causing immediate physiological changes and thus releasing cortisol gradually to help maintain the body's response to stress over a longer period through the hypothalamic-pituitary-adrenal and sympathetic-adrenomedullar axis. The impacts can be short-term or long-term focusing on the working memory, pre-frontal cortex, amygdala, and hippocampus. By recognizing these implications and implementing targeted interventions, we can foster environments that support resilience, optimize performance, and enhance overall well-being across diverse contexts. This chapter also highlighted some mitigation strategies to reduce stress-related activities and improve cognitive performance, such as cognitive-behavioral therapy, mindfulness-based stress reduction, healthy lifestyle adoption, pet therapy, time management and prioritization, and workplace interventions.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"109-135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormesis and brain diseases. 刺激和脑部疾病。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-05-28 DOI: 10.1016/bs.pbr.2025.05.003

Vernise J T Lim, Nishat I Tabassum, Jacqueline M Orian, Thiruma V Arumugam, Eddie Feng-Ju Weng

{"title":"Hormesis and brain diseases.","authors":"Vernise J T Lim, Nishat I Tabassum, Jacqueline M Orian, Thiruma V Arumugam, Eddie Feng-Ju Weng","doi":"10.1016/bs.pbr.2025.05.003","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.05.003","url":null,"abstract":"Hormesis, the concept that low doses of potentially harmful stressors can elicit adaptive, beneficial effects, plays a significant role in brain health and aging. Neurohormesis refers to the adaptive response of neurons to mild stress, activating pathways that enhance cellular repair. As the brain ages, it experiences disruptions in energy metabolism, oxidative stress, mitochondrial dysfunction, and chronic inflammation, all of which contribute to neurodegenerative diseases like stroke, Parkinson's, Alzheimer's and multiple sclerosis (MS). However, low-dose stressors such as exercise, fasting, and certain dietary compounds have been shown to activate stress-resilience mechanisms, promoting brain health and delaying neurodegeneration. Dietary interventions, such as calorie restriction (CR) and intermittent fasting (IF), stimulate neuroprotective signaling, involving molecular targets like NF-E2-related factor 2 (NRF2), cAMP response element-binding protein (CREB), and brain-derived neurotrophic factor (BDNF). These factors regulate stress-related chaperones and promote cognitive function. The chapter highlights the role of mitochondrial health, autophagy, and circadian rhythms in aging and neurohormesis by CR and IF. Despite the potential of hormetic interventions, aging impairs the capacity of the brain to respond to stress, making it more vulnerable to neurodegeneration. Understanding neurohormesis offers promising therapeutic avenues for enhancing brain resilience and delaying the onset of age-related cognitive decline and neurodegenerative diseases. The integration of advanced technologies, such as multi-omics and epigenetic studies, could further elucidate the protective effects of hormesis on brain health, paving the way for targeted interventions to combat neurodegeneration.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"295 ","pages":"229-258"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart rate variability as an indicator of brain health in neurodegeneration. 心率变异性作为神经变性患者大脑健康的指标。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-07-10 DOI: 10.1016/bs.pbr.2025.04.007

Ghulam Kubra, Muhammad Liaquat Raza

引用次数: 0

Neurocardiology and neurodegenerative disease: Emerging research on emotional regulation and brain-heart connectivity. 神经心脏病学和神经退行性疾病：情绪调节和脑-心连通性的新兴研究。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-05-22 DOI: 10.1016/bs.pbr.2025.04.011

Obayda M Diraneyya, Muhammad Liaquat Raza, Syed Ali Abbas

引用次数: 0

Philopsychedelia beyond the West: The decolonial reflorescence of psychedelic philosophy. 超越西方的迷幻哲学：迷幻哲学的非殖民化折射。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-12 DOI: 10.1016/bs.pbr.2025.07.001

Jan Clefferson Costa de Freitas, Nathalia Cristina Medeiros Maia, Markone Brandão da Silva Shanenawa, Juan Vásquez Amaringo, René Alvarado Martinez

{"title":"Philopsychedelia beyond the West: The decolonial reflorescence of psychedelic philosophy.","authors":"Jan Clefferson Costa de Freitas, Nathalia Cristina Medeiros Maia, Markone Brandão da Silva Shanenawa, Juan Vásquez Amaringo, René Alvarado Martinez","doi":"10.1016/bs.pbr.2025.07.001","DOIUrl":"10.1016/bs.pbr.2025.07.001","url":null,"abstract":"The main purpose of this work is to identify the intersections between decolonial thought and psychedelic philosophy. By \"psychedelic\" we mean a pharmacological category, the effects of substances that modulates perception, a myriad of consciousness states, a set of ecstatic practices, a variety of countercultural movements, a constellation of artistic avant-gardes, and a plurality of ways of being. We thus intend to demonstrate how visionary aesthetics, liminal phenomenologies, ancestral epistemologies, ethics of resistance, politics of freedom and kaleidoscopic metaphysics are conceptual horizons from which a decolonization of the \"manifestations of the mind\" can come to light. Through an analytical-descriptive methodology, we idealize obtaining, as a result of this research, a philosophical justification of the indispensability of integrating decoloniality into the reflorescence of psychedelia. In a nutshell: we envision to clarify the extent to which psychedelic experiences can be ways of understanding insurgent knowledges, as well as explaining the proportion to which decolonial conceptions can be keys to interpreting psychedelic experiences.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"296 ","pages":"147-173"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Addiction and stress: Exploring the reward pathways in brain affected by different drugs. 成瘾与压力：探索不同药物对大脑奖赏通路的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1016/bs.pbr.2025.01.012

Samira Rostami Mehr, Babak Nakhaei, Hossein Soleimani, Shaahriyar Kouhi Madadlou, Asghar Abbasi Maleky, Saeid Abbasi-Maleki

{"title":"Addiction and stress: Exploring the reward pathways in brain affected by different drugs.","authors":"Samira Rostami Mehr, Babak Nakhaei, Hossein Soleimani, Shaahriyar Kouhi Madadlou, Asghar Abbasi Maleky, Saeid Abbasi-Maleki","doi":"10.1016/bs.pbr.2025.01.012","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.012","url":null,"abstract":"This chapter delves into the complex interplay among addiction, stress, and the reward pathways in the brain, emphasizing the ways in which various drugs affect these systems and exacerbate SUD. Drugs have physiological effects that can be both pleasurable and unpleasant. These effects change behavior through both positive and negative reinforcement. A person's genetic predisposition to addiction is mostly determined by factors such as biological sex, age of first usage, and dopamine receptor density. Drug use behaviors are also greatly influenced by environmental stressors, media exposure, and substance accessibility; nevertheless, protective variables including social support, participation in healthy activities, and preventative programs serve to reduce the dangers associated with drug use. The reinforcement of addictive behaviors is mostly dependent on the brain's reward circuits, which include the nucleus accumbens, ventral tegmental region, and prefrontal cortex, in addition to neurotransmitters such as dopamine, serotonin, and endorphins. Stress makes addiction worse by intensifying cravings and raising the possibility of relapsing. Examined are the impacts of several drug types, such as opioids, stimulants, depressants, and hallucinogens, emphasizing the long-term consequences on brain function and susceptibility to addiction. In order to create individualized interventions that target the environmental and neurological components of addiction and eventually improve treatment results, a thorough understanding of these elements is important.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"381-404"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the connection between stress and sleep: From underlying mechanisms to therapeutic solutions. 理解压力和睡眠之间的联系：从潜在机制到治疗解决方案。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-10 DOI: 10.1016/bs.pbr.2025.01.016

Matthew-Zane L Broderick, Qadir Khan, Nasrollah Moradikor

{"title":"Understanding the connection between stress and sleep: From underlying mechanisms to therapeutic solutions.","authors":"Matthew-Zane L Broderick, Qadir Khan, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.01.016","DOIUrl":"https://doi.org/10.1016/bs.pbr.2025.01.016","url":null,"abstract":"The objective of this chapter is to navigate through the nexus between stress and sleep, highlighting the neurobiological systems that connect them. Starting with an overview of neuroanatomy and physiology of stress and sleep, with a further detailed breakdown of sleep stages and key neuroanatomical centers that are responsible for sleep and wakefulness. Starting with suprachiasmatic nuclei (SCN) in circadian rhythm and sleep regulation overview, with a center point on the molecular systems including the CLOCK/CRY and BMAL1/2/PER1/2 feedback loops. Following this is the neurobiological of stress, specifically the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic-adrenal (SPA) axis and influence on sleep. Vital neural circuits connecting stress and sleep are examined with the attention of the ventral tegmental area (VTA) GABA-somatostatin neurons and the locus coerules in sleep regulation in response to stress. In addition, neuroinflammation's role occurs through the cytokines IL-1β and TNF-α are investigated as a mediator of sleep disturbances caused by stress. It concludes by summarizing the implications of neuroinflammatory modulation in stress-related psychopathologies, emphasizing the opening this provides for interventions that target this inflammation helping to lighten sleep disorder.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"137-159"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0