Progress in brain research最新文献_第4页

The emergence of the National Articulation of Marijuana Marches (ANMM) in Brazil: A social movement in the context of the COVID-19 pandemic. 巴西全国大麻游行（ANMM）的出现：COVID-19大流行背景下的社会运动

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-12 DOI: 10.1016/bs.pbr.2025.07.003

Diego Castro

引用次数: 0

Exploring heart-brain axis alterations in Parkinson's disease. 探索帕金森病的心-脑轴改变。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-05-15 DOI: 10.1016/bs.pbr.2025.04.009

Youssef Razouqi, Hanane El Fatimi, Marouane Mergaoui, Loubna Khalki

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Hormesis and cancer therapy. 激效和癌症治疗。

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Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-07-25 DOI: 10.1016/bs.pbr.2025.05.010

Glaucia Maria Machado-Santelli, Julyane Batista Chaves

引用次数: 0

AI and emerging technologies for diagnosis. 人工智能和新兴诊断技术。

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Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-10-17 DOI: 10.1016/bs.pbr.2025.08.004

Sowmiya Soundararajan, Jasmine Selvakumar, Vijayalakshmi Selvakumar, Nivetha Baskaran

{"title":"AI and emerging technologies for diagnosis.","authors":"Sowmiya Soundararajan, Jasmine Selvakumar, Vijayalakshmi Selvakumar, Nivetha Baskaran","doi":"10.1016/bs.pbr.2025.08.004","DOIUrl":"10.1016/bs.pbr.2025.08.004","url":null,"abstract":"Healthcare is undergoing a transformation owing to artificial intelligence in medical diagnostics, which is providing unprecedented levels of efficiency and precision. AI is revolutionizing the detection, analysis, and treatment of diseases, especially in the field of medical diagnostics. AI can process enormous volumes of data quickly and effectively by utilizing machine learning and deep learning algorithms, giving healthcare professionals important insights. In addition to improving diagnosis accuracy, these developments are opening the door to early identification and individualized treatment regimens. AI transforms the interpretation of MRIs, computed tomography scans, and X-rays with extreme precision, outperforming humans in the identification of cancerous and vision-related ailments. Early disease identification has been greatly enhanced by the application of AI to identify anomalies associated with neurological and cardiac disorders. By facilitating the rapid identification of cardiac conditions and cancer, predictive analytics helps to significantly lower the number of false positives and negatives. AI reduces errors and human exhaustion and bias, resulting in more equitable and reliable provision of healthcare. With an emphasis on its uses, advantages, and the difficulties associated with incorporating these state-of-the-art technologies into clinical practice, this chapter examines the different ways artificial intelligence is changing medical diagnostics.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"297 ","pages":"191-220"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personalized management of Parkinson's disease. 帕金森病的个性化管理。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-08-29 DOI: 10.1016/bs.pbr.2025.08.007

Dipesh Chakraborty, Pradyot Kumar Roy, Ria Das, Chittabrata Mal

{"title":"Personalized management of Parkinson's disease.","authors":"Dipesh Chakraborty, Pradyot Kumar Roy, Ria Das, Chittabrata Mal","doi":"10.1016/bs.pbr.2025.08.007","DOIUrl":"10.1016/bs.pbr.2025.08.007","url":null,"abstract":"Parkinson's disease is a progressive neurodegenerative disorder characterized by dopaminergic neuron loss, α-synuclein aggregation, and oxidative stress-induced mitochondrial dysfunction. These contribute to motor symptoms like bradykinesia, tremor, rigidity, and postural instability, alongside non-motor issues such as cognitive decline and autonomic dysfunction. With rising global prevalence, especially in aging populations, understanding PD's complex pathophysiology is essential for advancing effective therapeutic strategies. This chapter offers a comprehensive overview of Parkinson's disease, covering its demographic trends, molecular mechanisms, symptoms, and current pharmacological treatments, including their mechanisms, classifications, benefits, and side effects. The central focus is on the emerging shift from standard symptomatic care to personalized, precision-based treatment strategies. These include gene-targeted therapies like RNA interference and CRISPR-Cas9, mitochondrial-based approaches, and stem cell innovations such as induced pluripotent stem cells (iPSCs). Pharmacogenetic profiling and biomarker-based interventions further support individualized therapeutic plans by predicting drug responses and tracking disease progression. This chapter explores patient-centric models like personalized neurorehabilitation, DBS, and cognitive-behavioral therapy, alongside advanced technologies such as AI, VR, AR, and wearable devices that enhance treatment, symptom monitoring, and real-time feedback through mobile applications. Lifestyle adaptations, including precision nutrition and customized exercise regimens, are highlighted as key components of comprehensive care. This chapter highlights a personalized, multi-dimensional approach to Parkinson's disease management, integrating molecular, technological, and lifestyle strategies to both ease symptoms and modify disease progression.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"297 ","pages":"277-318"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision medicine in neurodegenerative diseases: From research to clinical practice. 神经退行性疾病的精准医学：从研究到临床实践。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-11-14 DOI: 10.1016/bs.pbr.2025.08.006

Baskaran Gunasekaran, Amar Harris Arifin, Wong Hong Yu, Saema Hanafi, Kirtana Devi Kumara Rao, Shamala Salvamani

{"title":"Precision medicine in neurodegenerative diseases: From research to clinical practice.","authors":"Baskaran Gunasekaran, Amar Harris Arifin, Wong Hong Yu, Saema Hanafi, Kirtana Devi Kumara Rao, Shamala Salvamani","doi":"10.1016/bs.pbr.2025.08.006","DOIUrl":"10.1016/bs.pbr.2025.08.006","url":null,"abstract":"The chapter outlines how precision medicine is reshaping the way neurodegenerative diseases (NDs) which includes Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD) are understood, diagnosed, and treated. It discusses the limitations of current therapies, which mainly address symptoms without altering disease progression. Genetic and molecular factors that influence disease development are described, including distinctions between familial and sporadic forms. The chapter also covers the roles of epigenetic changes, gene expression, protein dysfunction, mitochondrial DNA, and non-coding RNAs in NDs. Biomarkers in blood and cerebrospinal fluid, along with imaging techniques and digital tools, are presented as key elements in early diagnosis and disease monitoring. Patient stratification based on clinical features, molecular profiles, and biomarkers helps guide treatment decisions and improve outcomes. The chapter reviews ongoing developments in genotype-based drug design, gene therapy, pharmacogenomics, and personalized lifestyle strategies. Clinical case studies show how these approaches are being used in practice. The chapter also discusses challenges in applying precision medicine, such as trial design, data integration, unequal access, and regulatory hurdles. Finally, it highlights the future tools like single-cell transcriptomics, digital twins, and global research collaborations that aim to bring precision approaches into everyday care.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"297 ","pages":"1-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technology-assisted interventions for neuropsychiatric disorders. 神经精神疾病的技术辅助干预。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-09-05 DOI: 10.1016/bs.pbr.2025.08.017

Tala Fliti, Aline Shhaytli, Aya Serhal, Zahraa Takesh, Mariam Chokor

{"title":"Technology-assisted interventions for neuropsychiatric disorders.","authors":"Tala Fliti, Aline Shhaytli, Aya Serhal, Zahraa Takesh, Mariam Chokor","doi":"10.1016/bs.pbr.2025.08.017","DOIUrl":"10.1016/bs.pbr.2025.08.017","url":null,"abstract":"Neuropsychiatric disorders are chronic diseases present in the community and cause both personal and community burdens. Though therapeutically useful and beneficial, standard treatments and managements face some challenges such as social discrimination, concerns about treatments' side effects, and delay in the delivery of the healthcare services. To overcome these barriers, technology-assisted interventions have emerged and are nowadays increasingly used due to their potentials to offer accessible, personalized, and cost-efficient care in neuropsychiatric field. It is believed that these new advancements provide many advantages, such as accessibility, the direct follow-up of the patients, and the development of neuropsychiatric care in the low-income countries. In contrast, technology-assisted interventions in neuropsychiatric disorders encounter certain limitations, especially those related to ethical considerations such as patient privacy, equal access, and data security. This article reviews the role of digital health tools, neurostimulation techniques, and brain-computer interface in neuropsychiatric field. Also, it discusses the advantages and limitations of each technology.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"298 ","pages":"241-269"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early life stress and brain development: Neurobiological and behavioral effects of chronic stress. 早期生活压力与大脑发育：慢性压力对神经生物学和行为的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1016/bs.pbr.2025.01.004

Subia Jamil, Muhammad Liaquat Raza, Nasrollah Moradikor, Motahareh Haghipanah

{"title":"Early life stress and brain development: Neurobiological and behavioral effects of chronic stress.","authors":"Subia Jamil, Muhammad Liaquat Raza, Nasrollah Moradikor, Motahareh Haghipanah","doi":"10.1016/bs.pbr.2025.01.004","DOIUrl":"10.1016/bs.pbr.2025.01.004","url":null,"abstract":"Early life stress is the term used to describe a variety of traumatic events that a person may have as a kid, such as being subjected to domestic or public violence, being neglected, experiencing parental conflict, being abused physically, emotionally and sexually. These events have the potential to seriously impair the brains normal growth and development, which could have long term psychological and physiological repercussions. Early life stress (ELS) has profound and enduring effects on brain development, contributing to long-term neurological and behavioral changes. Neurologically, ELS can reduce hippocampal volume, impairing memory and emotional regulation, while also sensitizing the amygdala, leading to exaggerated fear and anxiety responses. Additionally, ELS can disrupt the development of the prefrontal cortex (PFC), affecting decision-making, planning, and impulse control. It also alters neurotransmitter systems, such as serotonin and dopamine, influencing mood and motivation, and can trigger chronic neuroinflammation, increasing the risk of neurodegenerative diseases. Behaviorally, ELS heightens the risk of anxiety, depression, and impulsivity, and can contribute to conditions like ADHD and substance abuse Social and emotional difficulties, such as challenges in relationships and empathy, often arise, along with cognitive impairments in learning and memory. Furthermore, ELS increases stress responsiveness, making individuals more vulnerable to future stress. However, these effects can be mitigated by supportive environments and targeted interventions.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"291 ","pages":"49-79"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping brain neural networks in stress brain connectivity. 绘制压力下的大脑神经网络。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-16 DOI: 10.1016/bs.pbr.2025.01.014

Al-Hassan Soliman Wadan, Mohamed Abdelsattar Ahmed, Nasrollah Moradikor

引用次数: 0

Impact of sexuality on degenerative diseases. 性对退行性疾病的影响。

4区医学

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-02-28 DOI: 10.1016/bs.pbr.2025.02.007

David Anuoluwapo Oyeniran, Tobiloba Samuel Olajide, Abayomi Oyeyemi Ajagbe, Abdulateef Ayoola Mobolaji

{"title":"Impact of sexuality on degenerative diseases.","authors":"David Anuoluwapo Oyeniran, Tobiloba Samuel Olajide, Abayomi Oyeyemi Ajagbe, Abdulateef Ayoola Mobolaji","doi":"10.1016/bs.pbr.2025.02.007","DOIUrl":"10.1016/bs.pbr.2025.02.007","url":null,"abstract":"Human sexuality is shaped by a complex interplay of biological, psychological, social, and cultural factors, influencing individual identity, behaviors, relationships, and sexual experience. Far from merely reflecting anatomical characteristics, sexuality encompasses emotional and sexual attraction toward individuals across gender spectrums, guided by factors including hormones, genetics, brain processes, and environmental influences. Societal norms and cultural beliefs also mold sexual expression, with diverse sexual identities being either embraced or stigmatized, impacting individual well-being. Sexual health, essential for mental and physical health, connects closely to brain morphology, function, and associated neural mechanisms. The hypothalamus and neurotransmitters like dopamine and oxytocin influence desire, feeling, and pleasure. Additionally, sexuality is linked with the progression and prevalence of degenerative diseases like Alzheimer's and Parkinson's. Sexual dysfunction relating to these diseases often emerges due to neurological changes, cognitive decline, and physical limitations. However, the feeling of sexual satisfaction can mitigate the impact of these diseases by promoting cognitive function, emotional intimacy, and stress reduction. Sexual activity in older adults is linked to better cardiovascular and cognitive health, emphasizing the broader health benefits of sexual well-being. Understanding sexuality across all stages of life, in both health and illness, is essential as it forms an integral part of general well-being and human existence.","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"293 ","pages":"57-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0