Cardiovascular influence on cognitive decline: The heart's role in neurodegenerative disorders.

4区医学 Q3 Neuroscience

Progress in brain research Pub Date : 2025-01-01 Epub Date: 2025-04-18 DOI:10.1016/bs.pbr.2025.04.006

Gargi Gautam, Nasrollah Moradikor

{"title":"Cardiovascular influence on cognitive decline: The heart's role in neurodegenerative disorders.","authors":"Gargi Gautam, Nasrollah Moradikor","doi":"10.1016/bs.pbr.2025.04.006","DOIUrl":null,"url":null,"abstract":"<p><p>Cognitive performance is greatly influenced by cardiovascular health, as vascular integrity and brain perfusion are directly related to diseases including Parkinson's disease, Alzheimer's disease, and vascular dementia. Examining the intricate relationship between the heart and brain, this chapter highlights how atrial fibrillation, diabetes, hypertension, and dyslipidemia affect neurovascular coupling (NVC). Chronic inflammation, oxidative stress, and endothelial dysfunction are some of the risk factors that lead to neurodegeneration. The cerebral microvasculature is further compromised by atherosclerosis and heart failure, which exacerbates neuronal damage and increases the risk of dementia. Supported by clinical and epidemiological data, the discussion delves into the mechanisms behind vascular dementia and the vascular contributions to Alzheimer's disease. Slowing cognitive deterioration requires early intervention through lipid management, blood pressure control, and anticoagulant medication. Additionally, developments in precision medicine and neurovascular-targeted therapies present encouraging paths toward management and prevention. Through the discussion of modifiable cardiovascular risks, this chapter emphasizes how vital vascular health is to maintaining cognitive function and slowing the progression of neurodegenerative diseases.</p>","PeriodicalId":20598,"journal":{"name":"Progress in brain research","volume":"294 ","pages":"33-46"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in brain research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/bs.pbr.2025.04.006","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/18 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Neuroscience","Score":null,"Total":0}

引用次数: 0

Abstract

Cognitive performance is greatly influenced by cardiovascular health, as vascular integrity and brain perfusion are directly related to diseases including Parkinson's disease, Alzheimer's disease, and vascular dementia. Examining the intricate relationship between the heart and brain, this chapter highlights how atrial fibrillation, diabetes, hypertension, and dyslipidemia affect neurovascular coupling (NVC). Chronic inflammation, oxidative stress, and endothelial dysfunction are some of the risk factors that lead to neurodegeneration. The cerebral microvasculature is further compromised by atherosclerosis and heart failure, which exacerbates neuronal damage and increases the risk of dementia. Supported by clinical and epidemiological data, the discussion delves into the mechanisms behind vascular dementia and the vascular contributions to Alzheimer's disease. Slowing cognitive deterioration requires early intervention through lipid management, blood pressure control, and anticoagulant medication. Additionally, developments in precision medicine and neurovascular-targeted therapies present encouraging paths toward management and prevention. Through the discussion of modifiable cardiovascular risks, this chapter emphasizes how vital vascular health is to maintaining cognitive function and slowing the progression of neurodegenerative diseases.

查看原文本刊更多论文

心血管对认知能力下降的影响：心脏在神经退行性疾病中的作用。

认知表现很大程度上受心血管健康的影响，因为血管完整性和脑灌注与帕金森病、阿尔茨海默病和血管性痴呆等疾病直接相关。本章探讨了心脏和大脑之间复杂的关系，重点介绍了心房颤动、糖尿病、高血压和血脂异常如何影响神经血管耦合（NVC）。慢性炎症、氧化应激和内皮功能障碍是导致神经变性的一些危险因素。动脉粥样硬化和心力衰竭进一步损害了大脑微血管，从而加剧了神经元损伤，增加了患痴呆的风险。在临床和流行病学数据的支持下，讨论深入探讨血管性痴呆背后的机制以及血管对阿尔茨海默病的贡献。减缓认知退化需要通过脂质管理、血压控制和抗凝药物进行早期干预。此外，精准医学和神经血管靶向治疗的发展为管理和预防提供了令人鼓舞的途径。通过对可改变的心血管风险的讨论，本章强调血管健康对于维持认知功能和减缓神经退行性疾病的进展是多么重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Progress in brain research 医学-神经科学

CiteScore

5.20

自引率

0.00%

发文量

174

审稿时长

6-12 weeks

期刊介绍： Progress in Brain Research is the most acclaimed and accomplished series in neuroscience. The serial is well-established as an extensive documentation of contemporary advances in the field. The volumes contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry and the behavioral sciences.