Muhammad Liaquat Raza, Ghulam Kubra, Ali Ammar, Nasrollah Moradikor
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The role of heart-brain connectivity in neurodegeneration: Mechanisms and impacts.
Heart-brain connectivity is an emerging area of research, exploring the bidirectional communication between the cardiovascular and central nervous systems. This connectivity plays a significant role in neurodegenerative diseases, where both the heart and brain contribute to disease progression. This chapter shed light on the autonomic nervous system, neurocardiac interactions, and microvascular changes that are central to understanding how heart dysfunction can affect brain health. Pathophysiological processes such as inflammation, oxidative stress, and altered heart rate variability can exacerbate neurodegeneration, particularly in conditions like Alzheimer's and Parkinson's diseases. Understanding the heart-brain axis provides new avenues for early diagnosis and potential therapeutic strategies for neurodegenerative diseases. Future research should aim to unravel the complex interactions between these systems and explore how modifying cardiac function could influence brain health and disease progression.
期刊介绍：
Progress in Brain Research is the most acclaimed and accomplished series in neuroscience. The serial is well-established as an extensive documentation of contemporary advances in the field. The volumes contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry and the behavioral sciences.
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