Photodermatology, photoimmunology & photomedicine最新文献

{"title":"Carcinogenic risk in patients treated with UVA-1 phototherapy: A 5-year retrospective study.","authors":"Davide Cosetti, Vittoria Cioppa, Pietro Rubegni, Emanuele Trovato","doi":"10.1111/phpp.12975","DOIUrl":"https://doi.org/10.1111/phpp.12975","url":null,"abstract":"<p><strong>Background: </strong>UVA-1 phototherapy was first used to treat atopic dermatitis and afterwards to several other skin diseases. The contribution of UVA-1 in human photocarcinogenesis, skin photoaging, immune suppression, and hyperpigmentation is now well established. The actual contribution of UVA-1 radiation to the development of malignant melanoma (MM) in humans cannot be excluded.</p><p><strong>Purpose: </strong>The aim of the study is to evaluate the risk of developing skin cancers (non-melanoma skin cancers (NMSCs) and MM) in patients treated with UVA-1 phototherapy with a 5-year dermatological follow-up.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study with 31 patients with morphea and atopic dermatitis treated with medium dose UVA-1 phototherapy (34 J/cm²). All enrolled patients underwent an oncologic prevention visit annually with a 5-year follow-up with clinical evaluation of the entire skin surface.</p><p><strong>Results: </strong>During the 5-year follow-up, we recorded a case of basal cell carcinoma (BCC) in the cervical region and one case of MM on the back (pT1a). In both cases, the patients were female and affected by morphea. The Glogau 3 group is prevalent (42%), which is consistent with moderate to severe aging; the data appear to be compatible with the age.</p><p><strong>Conclusions: </strong>This study attests that medium-dose UVA-1 phototherapy does not increase the risk of developing skin tumors and that UVA-1 phototherapy is not a worsening factor of facial photoaging. The main limitation of the study is the small sample size, avoiding to obtain statistically significant values. It was not possible to analyze individually the actual daily sun exposure during the 5-year observation period and to correlate it in terms of time and tumor development. Further studies with large sample sizes will be needed to confirm our data. Our study reaffirms how the dermatological examination performed annually is essential in the follow-up of patients undergoing this type of therapy.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"40 3","pages":"e12975"},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the efficacy of 308-nm light-emitting diode and 308-nm excimer lamp for treating vitiligo: A randomized controlled trial.","authors":"Yu Hu, Lihao Liu, Zhuohong Xu, Dan Huang, Hongying Chen, Jiaan Zhang, Lihao Chen, Xiaoxi Dai, Liangliang Zhang, Chao Luan, Mei Ju, Kun Chen","doi":"10.1111/phpp.12972","DOIUrl":"10.1111/phpp.12972","url":null,"abstract":"<p><strong>Background: </strong>In previous studies, the 308-nm light-emitting diode (LED) has been proven safe and effective for treating vitiligo. However, direct comparisons between the 308-nm LED and 308-nm excimer lamp (308-nm MEL) for the treatment of vitiligo are lacking.</p><p><strong>Objective: </strong>To compare the efficacy of the 308-nm LED and 308-nm MEL for treating nonsegmental stable vitiligo.</p><p><strong>Patients and methods: </strong>This randomized controlled trial was conducted between January 2018 and August 2023. Enrolled patients were randomly assigned to either the 308-nm LED or the 308-nm MEL groups, both receiving 16 treatment sessions. Adverse events that occurred during the treatment were documented.</p><p><strong>Results: </strong>In total, 269 stable vitiligo patches from 174 patients completed the study. A total of 131 lesions were included in the 308-nm LED group, and 138 lesions were included in the 308-nm MEL group. After 16 treatment sessions, 38.17% of the vitiligo patches in the 308-nm LED group achieved repigmentation of at least 50% versus 38.41% in the 308-nm MEL group. The two devices exhibited similar results in terms of efficacy for a repigmentation of at least 50% (p = .968). The incidence of adverse effects with the two phototherapy devices was comparable (p = .522).</p><p><strong>Conclusions: </strong>Treatment of vitiligo with the 308-nm LED had a similar efficacy rate to the 308-nm MEL, and the incidence of adverse effects was comparable between the two devices.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"40 3","pages":"e12972"},"PeriodicalIF":2.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of 308‐nm excimer laser and piperine promotes melanocyte proliferation, migration, and melanin content production via the miR‐328/SFRP1 axis","authors":"Yifei Wu, Jiayu Zhang, Sha Du, Xiaochuan Wang, Jinrong Li, Yi Chen, Hongying Zhou, Su Gao, Yongrong Li, Xiuhong Liu","doi":"10.1111/phpp.12970","DOIUrl":"https://doi.org/10.1111/phpp.12970","url":null,"abstract":"ObjectiveBoth piperine and a 308‐nm excimer laser have significant curative effects on vitiligo. This study mainly explored the molecular mechanism of a 308‐nm excimer combined with piperine in regulating melanocyte proliferation.MethodsEpidermal melanocytes were cultured in piperine solution, and the cells were irradiated by an XTRAC excimer laser treatment system at 308‐nm output monochromatic light. Quantitative real‐time polymerase chain reaction (qRT–PCR) and Western blot were for detecting the expression levels of genes or proteins. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) and Transwell method was for assessing cell viability and migration capacity. The content of melanin was also detected.ResultsThe combination of the 308‐nm excimer laser and piperine enhanced the cell proliferation, migration, and melanin production of melanocytes and upregulated the level of miR‐328, and restraint of miR‐328 reversed the influence of the 308‐nm excimer laser and piperine. Secreted frizzled‐related protein 1 (SFRP1) is a direct target gene of miR‐328, and miR‐328 can inhibit the expression of SFRP1 and elevate the protein level of the Wnt/β‐catenin signaling pathway.ConclusionThe 308‐nm excimer laser combined with piperine may be more efficient than piperine alone in the remedy of vitiligo, and the miR‐328/SFRP1 and Wnt/β‐catenin pathways are participated in the proliferation, migration, and melanin synthesis of melanocytes.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"44 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140837122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of dermatology practices accepting Medicaid for phototherapy in the United States: A comprehensive nationwide cross‐sectional analysis","authors":"Seda Sahin, Eric J. Beltrami, Hao Feng","doi":"10.1111/phpp.12973","DOIUrl":"https://doi.org/10.1111/phpp.12973","url":null,"abstract":"","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"11 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140837121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of UVB radiation‐induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene","authors":"Verena Isak, Shayan Azizi, Xi K. Zhou, Devina Mehta, Wanhong Ding, Zakir Bulmer, Daniella S. Aivazi, Ryan W. Dellinger, Richard D. Granstein","doi":"10.1111/phpp.12961","DOIUrl":"https://doi.org/10.1111/phpp.12961","url":null,"abstract":"BackgroundEnvironmental ultraviolet radiation has deleterious effects on humans, including sunburn and immune perturbations. These immune changes are involved in skin carcinogenesis.ObjectivesTo determine whether nicotinamide riboside and/or pterostilbene administered systemically inhibits inflammatory and immune effects of exposure to mid‐range ultraviolet radiation.MethodsTo examine UVB radiation‐induced inflammatory effects, mice were fed standard chow/water, 0.04% pterostilbene in chow and 0.2% nicotinamide riboside in drinking water, diet with nicotinamide riboside alone, or diet with pterostilbene alone. After 4 weeks, mice were exposed to UVB radiation (3500 J/m<jats:sup>2</jats:sup>), and 24‐/48‐h ear swelling was assessed. We also asked if each agent or the combination inhibits UVB radiation suppression of contact hypersensitivity in two models. Mice were fed standard diet/water or chow containing 0.08% pterostilbene, water with 0.4% nicotinamide riboside, or both for 4 weeks. Low‐dose: Half the mice in each group were exposed on the depilated dorsum to UVB radiation (1700 J/m<jats:sup>2</jats:sup>) daily for 4 days, whereas half were mock‐irradiated. Mice were immunized on the exposed dorsum to dinitrofluorobenzene 4 h after the last irradiation, challenged 7 days later on the ears with dinitrofluorobenzene, and 24‐h ear swelling assessed. High dose: Mice were treated similarly except that a single dose of 10,000 J/m<jats:sup>2</jats:sup> of radiation was administered and immunization was performed on the unirradiated shaved abdomen 3 days later.ResultsNicotinamide riboside and pterostilbene together inhibited UVB‐induced skin swelling more than either alone. Pterostilbene alone and both given together could inhibit UVB‐induced immune suppression in both the low‐dose and high‐dose models while nicotinamide riboside alone was more effective in the low‐dose model than the high‐dose model.ConclusionNicotinamide riboside and pterostilbene have protective effects against UVB radiation‐induced tissue swelling and immune suppression.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"81 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140812794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phototherapy for vitiligo: A narrative review on the clinical and molecular aspects, and recent literature","authors":"Anuradha Bishnoi, Davinder Parsad","doi":"10.1111/phpp.12968","DOIUrl":"https://doi.org/10.1111/phpp.12968","url":null,"abstract":"BackgroundVitiligo is characterized by depigmented patches resulting from loss of melanocytes. Phototherapy has emerged as a prominent treatment option for vitiligo, utilizing various light modalities to induce disease stability and repigmentation.Aims and MethodsThis narrative review aims to explore the clinical applications and molecular mechanisms of phototherapy in vitiligo.Results and DiscussionThe review evaluates existing literature on phototherapy for vitiligo, analyzing studies on hospital‐based and home‐based phototherapy, as well as outcomes related to stabilization and repigmentation. Narrowband ultra‐violet B, that is, NBUVB remains the most commonly employed, studied and effective phototherapy modality for vitiligo. Special attention is given to assessing different types of lamps, dosimetry, published guidelines, and the utilization of targeted phototherapy modalities. Additionally, the integration of phototherapy with other treatment modalities, including its use as a depigmenting therapy in generalized/universal vitiligo, is discussed. Screening for anti‐nuclear antibodies and tailoring approaches for non‐photo‐adapters are also examined.ConclusionIn conclusion, this review provides a comprehensive overview of phototherapy for vitiligo treatment. It underscores the evolving landscape of phototherapy and offers insights into optimizing therapeutic outcomes and addressing the challenges ahead. By integrating clinical evidence with molecular understanding, phototherapy emerges as a valuable therapeutic option for managing vitiligo, with potential for further advancements in the field.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"9 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140629092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of education on sun‐safe behaviour in kidney transplant recipients","authors":"Vanessza Tári, Eszter Anna Janka, Gabriella Emri, Balázs Nemes, Éva Remenyik, Emese Gellén","doi":"10.1111/phpp.12966","DOIUrl":"https://doi.org/10.1111/phpp.12966","url":null,"abstract":"BackgroundOrgan transplant recipients (OTR) are more likely to develop skin cancer than the general population. One of the main components of the exposome that triggers the development of skin tumours is solar ultraviolet (UV) radiation. To reduce the incidence of harmful consequences of sun exposure, sun protection education is needed for patients taking long‐term immunosuppressive drugs.MethodsIn a previous study, we assessed the sun‐safe behaviour of 221 OTR using a questionnaire before and after transplantation and personally educated the patients about proper sun protection. After the education, there were no further reminder presentations. Presently, the sun protection and sun seeking habits of the available 176 of these patients were questioned to assess the long‐term effect of the previous sun protection education.ResultsTwo‐four years after the education, more patients wore hats and protected their skin with long‐sleeved clothing than before the education. In terms of sun seeking habits, both occupational and recreational sun exposure decreased significantly. Significantly fewer people went on holiday after transplantation, but those who went on holiday spent significantly less time in the sun.ConclusionThe long‐term positive effects of education can be seen both in the patients' sun protection and in their sun seeking habits. However, the long‐term goal is to maintain these results and thereby reduce the likelihood of skin tumours and consequently the associated tumour death.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"61 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140575485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New trends on personalized sunscreens","authors":"Tamara Gracia‐Cazaña, José Aguilera, Alba Navarro‐Bielsa, Salvador González, Henry W. Lim, Yolanda Gilaberte","doi":"10.1111/phpp.12967","DOIUrl":"https://doi.org/10.1111/phpp.12967","url":null,"abstract":"Background/PurposeNowadays, there are emerging trends in customized and personalized photoprotection, focusing on the innovative approaches to enhance sun protection efficacy tailored to individual needs.MethodsWe conducted an electronic search of the following databases: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Skin Group Specialised Skin Register, and TESEO. Specific search terms related to personalized photoprotection and the variables of age, genetic predisposition, skin phototype, photodermatosis, and physiological conditions such as pregnancy, as well as lifestyle habits were used.Results/ConclusionThe article highlights the challenges and opportunities in adopting personalized photoprotection strategies, aiming to promote skin health and prevent the harmful effects of UV radiation in the era of precision medicine.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"130 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140575633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phototherapy for pigmentary disorders","authors":"Hee Young Kang","doi":"10.1111/phpp.12963","DOIUrl":"https://doi.org/10.1111/phpp.12963","url":null,"abstract":"<h2> CONFLICT OF INTEREST STATEMENT</h2>\u0000<p>The author declares no conflicts of interest.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of excimer light (308 nm) in the treatment of pityriasis lichenoides chronica","authors":"Eman Mohamed Salah, Nermeen Ibrahim Bedair, Sarah Khalil Abd El‐Rahim, Mohammed Ahmed El‐Khalawany","doi":"10.1111/phpp.12964","DOIUrl":"https://doi.org/10.1111/phpp.12964","url":null,"abstract":"IntroductionPityriasis lichenoides chronica is the chronic end of the spectrum of pityriasis lichenoides which have several forms of papulosuamous conditions. Several treatments obtained complete clearance of the condition including phototherapy and specifically narrow band ultraviolet B. The Excimer light 308 is a monochromatic light that acts within the ultraviolet B wavelength and used as a targeted phototherapy in several skin conditions.MethodsThirty‐four patients with histopathologically diagnosed pityriasis lichenoides chronica underwent treatment with biweekly sessions of excimer light 308 nm. Treatment continued until complete clearance was obtained or to a maximum of 48 sessions (24 weeks).ResultsThirty‐one patients obtained complete clearance with no recurrence till the end of the study period, two patients had partial response and only one patient showed poor response to treatment.ConclusionExcimer light can be a safe and effective treatment of pityriasis lichinoides chronica in different ages and genders.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"8 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}