Photodermatology, photoimmunology & photomedicine最新文献

{"title":"A case of pediatric indolent systemic mastocytosis: The role of UVB-NB phototherapy in the treatment of cutaneous lesions.","authors":"Valeria Brazzelli, Grazia Bossi, Alice Bonelli, Eugenio Isoletta, Martina Volontè, Stefania Barruscotti, Mara De Amici, Elisa Bono, Jacqueline Ferrari, Emanuela Boveri","doi":"10.1111/phpp.12894","DOIUrl":"10.1111/phpp.12894","url":null,"abstract":"Dear editor, Mastocytosis encompasses a heterogeneous group of disorders characterized by pathological expansion and accumulation of clonal mast cells within one or more organs.1 According to the latest classification, three subtypes of the disease have been recognized based on the site and extent of organ involvement and dysfunction: cutaneous mastocytosis (CM), systemic mastocytosis (SM), and mast cell sarcoma (MCS).2,3 SM has been differentiated into nonadvanced and advanced forms, while the CM is divided into maculopapular CM (MPCM), diffuse CM (DCM), and mastocytoma subtypes.2,3 In pediatric age, mastocytosis is often limited to the skin (CM) and is considered to be a myeloproliferative clonal disease with benign course, outcome, and tendency to spontaneous resolution before puberty.4 Extracutaneous involvement in pediatric mastocytosis is relatively rare, most often presenting in the form of indolent systemic mastocytosis (ISM). Virtually all children with SM present with skin lesions, usually MPCM, accompanied by increased serum tryptase levels.4 Currently, the treatment of SM in pediatric patients lacks of standard guidelines: its primary aim is to limit the release of mediators of mast cell degranulation, by avoiding potential triggering factors. The mainstay of systemic therapy is secondgeneration H1 and H2 antihistamines, useful in decreasing flushing, pruritus, and controlling wheal formation.1,5 A valuable secondline therapy, proposed as an alternative approach for the treatment of refractory cases, is phototherapy.6 UVBNB phototherapy has been shown to be effective in many dermatological pediatric diseases associated with intense itch,7,8 and UVB light has been proven to have an inhibitory effect on mast cell degranulation, likely by causing noncytotoxic damage to the membrane phospholipid metabolism.9,10 Omalizumab has been successfully used to treat severe symptoms related to mastocytosis that are recalcitrant to conventional therapies,11 including cases of CM and ISM in pediatric patients,12 while in case of aggressive SM the clinician can consider the use of imatinib (if mast cells lack the cKIT D816V mutation) or other newer tyrosinekinase inhibitors.13 We report a case of a 13yearold girl, affected by ISM, who presented with cutaneous lesions since the sixth month of life, successfully treated with UVBNB phototherapy. The patient initially received a diagnosis of MPCM, and was referred to our Dermatologic Institute due to progressive worsening of her skin lesions during adolescence. At that time, she presented with several papules and erythematous, brown macules distributed on her face, arms, and trunk, and positivity for Darier's sign. Pruritus was one of the greatest causes of discomfort for the patient. The disfiguring appearance of the skin lesions was correlated with body image concerns, deeply affecting her quality of life (Figure 1). A progressive increase in the serum tryptase values was observed (from the baseline val","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10272275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro-relief characterization of benign and malignant skin lesions by polarization speckle analysis in vivo.","authors":"Lioudmila Tchvialeva,&nbsp;Jamie Phillips,&nbsp;Daniel C Louie,&nbsp;Haishan Zeng,&nbsp;Harvey Lui,&nbsp;Tim K Lee","doi":"10.1111/phpp.12876","DOIUrl":"https://doi.org/10.1111/phpp.12876","url":null,"abstract":"<p><strong>Background/purpose: </strong>A recent direction in skin disease classification is to develop quantitative diagnostic techniques. Skin relief, colloquially known as roughness, is an important clinical feature. The aim of this study is to demonstrate a novel polarization speckle technique to quantitatively measure roughness on skin lesions in vivo. We then calculate the average roughness of different types of skin lesions to determine the extent to which polarization speckle roughness measurements can be used to identify skin cancer.</p><p><strong>Methods: </strong>The experimental conditions were set to target the fine relief structure on the order of ten microns within a small field of view of 3 mm. The device was tested in a clinical study on patients with malignant and benign skin lesions that resemble cancer. The cancer group includes 37 malignant melanomas (MM), 43 basal cell carcinomas (BCC), and 26 squamous cell carcinomas (SCC), all categories confirmed by gold standard biopsy. The benign group includes 109 seborrheic keratoses (SK), 79 nevi, and 11 actinic keratoses (AK). Normal skin roughness was obtained for the same patients (301 different body sites proximal to the lesion).</p><p><strong>Results: </strong>The average root mean squared (rms) roughness ± standard error of the mean for MM and nevus was equal to 19 ± 5 μm and 21 ± 3 μm, respectively. Normal skin has rms roughness of 31 ± 3 μm, other lesions have roughness of 35 ± 10 μm (AK), 35 ± 7 μm (SCC), 31 ± 4 μm (SK), and 30 ± 5 μm (BCC).</p><p><strong>Conclusion: </strong>An independent-samples Kruskal-Wallis test indicates that MM and nevus can be separated from each of the tested types of lesions, except each other. These results quantify clinical knowledge of lesion roughness and could be useful for optical cancer detection.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective multicentric cohort study of checkpoint inhibitors-induced pruritus with focus on management.","authors":"Chryssoula Papageorgiou,&nbsp;Elizabeth Lazaridou,&nbsp;Konstantinos Lallas,&nbsp;Kyparissos Papaioannou,&nbsp;Vasiliki Nikolaou,&nbsp;Valeria Mateeva,&nbsp;Konstantinos Efthymiadis,&nbsp;Chrysanthi Koukoutzeli,&nbsp;Konstantia Loga,&nbsp;Eleni Sogka,&nbsp;Evangelos Karamitrousis,&nbsp;George Lazaridis,&nbsp;Dimitrios Dionysopoulos,&nbsp;Aimilios Lallas,&nbsp;Christina Kemanetzi,&nbsp;Christina Fotiadou,&nbsp;Eleni Timotheadou,&nbsp;Zoe Apalla","doi":"10.1111/phpp.12892","DOIUrl":"https://doi.org/10.1111/phpp.12892","url":null,"abstract":"<p><strong>Background: </strong>Limited data on immune checkpoint inhibitor (ICI)-induced pruritus per se and efficacy of different therapeutic modalities in its management exist.</p><p><strong>Objective: </strong>To study the quantitative and qualitative characteristics of ICI-induced pruritus per se and to assess the efficacy of the therapeutic modalities usually applied.</p><p><strong>Methods: </strong>We retrospectively reviewed the records of 91 patients who were under treatment with ICIs for any kind of neoplasia and developed pruritus during treatment.</p><p><strong>Results: </strong>Twenty out of 91 individuals (22.0%) with ICI-induced pruritus had pruritus as the only symptom, while 71/91 (78.0%) presented with pruritus coexisting with an additional cutaneous toxicity. Pruritus was treated with antihistamines (18/20, 90.0%) and/or topical regimens, as first-line choice. In resistant cases, as a second therapeutic intervention, narrow-band UVB (NBUVB), oral steroids and GABA analogs were added (70.0%). Statistical analysis revealed a significant difference in mean pruritus Numerical Rating Scale (NRS) scores between baseline and sequential visits. Moreover, subgroup analysis revealed a significant reduction in mean NRS scores in those treated with phototherapy.</p><p><strong>Limitations: </strong>Retrospective design, low number of patients and survivorship bias.</p><p><strong>Conclusion: </strong>Pruritus per se was present in a substantial portion of our cohort (22.0%). Our study confirms the efficacy of current treatment strategies and suggests NBUVB as a potential steroid-sparing therapeutic alternative.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10627469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter case-control study comparing sun exposure habits and use of photoprotection measures in patients diagnosed with different types of skin cancer.","authors":"Alba Navarro-Bielsa,&nbsp;Tamara Gracia-Cazaña,&nbsp;Manuel Almagro,&nbsp;Sonia De la Fuente-Meira,&nbsp;Ángeles Florez,&nbsp;Oriol Yélamos,&nbsp;Trinidad Montero-Vilchez,&nbsp;Carlos González-Cruz,&nbsp;Adrián Diago,&nbsp;Isabel Abadías-Granado,&nbsp;Victoria Fuentelsaz,&nbsp;María Colmenero,&nbsp;José Bañuls,&nbsp;Salvador Arias-Santiago,&nbsp;Agustín Buendía-Eisman,&nbsp;Manuel Almenara-Blasco,&nbsp;Pedro Gil-Pallares,&nbsp;Yolanda Gilaberte","doi":"10.1111/phpp.12878","DOIUrl":"https://doi.org/10.1111/phpp.12878","url":null,"abstract":"<p><strong>Background: </strong>While skin cancer awareness programs have significantly furthered public understanding about the harmful effects of the sun, there is a disparity between photoprotection knowledge and protection practices.</p><p><strong>Objective: </strong>To compare sun exposure habits and photoprotection measures in patients diagnosed with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma versus controls.</p><p><strong>Methods: </strong>Multicentre case-control observational study carried out by 13 Spanish dermatologists between April 2020 and August 2022. Patients diagnosed with BCC, SCC, or melanoma were considered cases. The control group consisted of individuals with no history of skin cancer.</p><p><strong>Results: </strong>Of the 254 cases (56.2% female; mean age, 62.67 ± 15.65), 119 (31.2%) had BCC, 62 (16.27%) SCC, and 73 (19.1%) melanoma. The control group consisted of 127 (33.33%) individuals. Avoiding sun exposure between 12:00 and 16:00 was the most commonly used photoprotection measure (habitually/always: 63.1%), followed by the use of sunscreen (habitually/always: 58.9%). Patients with melanoma were less likely to use clothing and shade to avoid sun exposure (p < .05), whereas those with BCC and SCC reported greater use of head coverings (p = .01). BCC and SCC groups reported greater sun exposure 15 years prior, whereas controls reported greater use of sunscreen. However, at the time of this study all groups reported using SPF ≥ 21, and the majority SPF > 50. No differences were observed in photoprotection measures between people with and without a previous history of skin cancer.</p><p><strong>Conclusions: </strong>We describe differences in photoprotection measures and sun exposure patterns among patients diagnosed with different skin tumor types. Whether these differences may influence the type of tumor each developed will require further investigation.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10626900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular protection in congenital erythropoietic porphyria: A potential role for gaming glasses.","authors":"A Fityan,&nbsp;G A Aneju,&nbsp;A M S Morley,&nbsp;R Sarkany","doi":"10.1111/phpp.12889","DOIUrl":"10.1111/phpp.12889","url":null,"abstract":"Congenital erythropoietic porphyria (CEP) or Günthers disease is a rare hematological porphyria, which occurs due to an inherited reduction in activity of the uroporphyrinogen III synthase enzyme (UROS). This results in the accumulation of water soluble, type I isomer porphyrins in the skin.1 Exposure to violet light in the Soret waveband (roughly 400– 410 nm) leads to the development of blisters on exposed skin, scar formation and subsequent disfigurement. Uroporphyrins are also deposited in other body tissues including the eye. Exposure of the ocular surface to violet light leads to vesicle formation, scarring, and symblephara. Scleral damage includes both acute scleritis and slowly progressive scleral necrosis, and may be accompanied by corneal thinning, perforation, visual loss and significant morbidity.2,3 Early education regarding the importance of photoprotection for patients with CEP is vital to limit the development of irreversible ocular damage. Many sunglasses offer a high level of protection against UVA and UVB helping to prevent against chronic UV exposurerelated cataract and pterygium formation. However, the protection afforded by standard sunglasses is only guaranteed up to 380 nm in Europe (BS EN ISO 123121:2013) and thus offers patients with CEP little or no protection against ocular damage caused by porphyrinrelated, short wavelength, visible light.4 Despite this, patients with CEP rely on standard sunglasses or, in some instances, nothing at all, given that the orangetinted lenses that provide protection against short wavelength visible light are often considered cosmetically unacceptable. Such behavior puts patients at risk of exposure to potentially damaging levels of visible light. In recent years, there has been increasing public awareness of the negative impact of exposure to artificial blue light on sleep.5,6 This has led to the manufacture and marketing of blue light protecting glasses to protect the eyes against blue light from computer and mobile device screens (gaming glasses). In view of these potentially useful properties for patients with porphyria, we undertook a small study to assess the wavelength of light blocked by these lenses to determine whether the protection might be sufficient to recommend their use in CEP. Seven different pairs of gaming spectacles were randomly selected and purchased online via Amazon UK marketplace (Table 1). The optical transmission characteristics of all lenses were measured using a DMC150 Bentham spectroradiometer (Bentham Instruments) in a radiation beam from an Abet 2000 Solar Simulator (Abet Technologies, Inc) in the ultraviolet and near visible region from 250 to 500 nm. Comparison of the transmitted spectrum of each lens with that of the unfiltered monochromator was used to derive the lens transmission.7 Of the seven spectacles (G1– G7) tested, five reduced transmission within the CEP spectral band (400– 415 nm) by more than 94% and six by more than 87%. Two pairs of glasses, ","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10332135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of skin cancers in mycosis fungoides patients receiving PUVA therapy: A real-life experience from a single tertiary center.","authors":"Ertop Doğan Pelin,&nbsp;Bengü Nisa Akay,&nbsp;Vural Seçil,&nbsp;Arı Canan,&nbsp;Ertürk Yılmaz Tuğçe,&nbsp;Şanlı Hatice","doi":"10.1111/phpp.12872","DOIUrl":"https://doi.org/10.1111/phpp.12872","url":null,"abstract":"<p><strong>Background: </strong>Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Skin-directed therapies, including phototherapy, are the first-line treatment modalities. Psoralen plus ultraviolet A light photochemotherapy (PUVA) is quite effective in controlling the disease; however, long-term adverse effects, particularly carcinogenesis, are the cons of this treatment.</p><p><strong>Objective: </strong>There are various studies on the negative impact of PUVA on skin cancer in patients with autoimmune skin diseases. The data on the long-term effects of phototherapy on MF patients are scarce.</p><p><strong>Methods: </strong>All MF cases that received PUVA alone or combined with other treatments at a single tertiary center were analyzed. This study compared the development of non-melanoma skin cancers, melanoma, and solid organ tumors in MF patients with at least 5-year follow-up data with age- and sex-matched controls.</p><p><strong>Results: </strong>A total of 104 patients were included in the study. Ninety-two malignancies were detected in 16 (15.4%) patients, and six developed multiple malignancies. Skin cancers consisted of 56 basal cell carcinomas, 16 Bowen's disease, four squamous cell carcinomas, three melanomas, two basosquamous cell carcinomas, one Kaposi sarcoma, and one keratoacanthoma were found in nine (8.7%) patients. Eight patients developed three solid cancers and six lymphomas. The risk of developing skin cancer was associated with the total number of PUVA sessions (<250 vs ≥250 sessions; hazard ratio (HR) 4.44, 95% confidence interval (CI) 1.033-19.068; p = .045). 9 (13.2%) of 68 patients who had follow-ups for at least 5 years developed skin cancer. Compared to an age- and sex-matched cohort, the prevalence of new skin cancer was considerably greater (p = .009).</p><p><strong>Conclusions: </strong>Patients with MF are predisposed to develop secondary malignancies, and continual exposure to PUVA may potentiate this risk. Annual digital dermoscopic follow-up in MF patients treated with UVA is advised for early diagnosis and treatment of secondary cutaneous malignancies.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10626422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue light and the skin on social media: An analysis of posts on exposure and photoprotection strategies.","authors":"Marissa S Ceresnie,&nbsp;Jay Patel,&nbsp;Erika J Tvedten,&nbsp;Indermeet Kohli,&nbsp;Tasneem F Mohammad","doi":"10.1111/phpp.12896","DOIUrl":"10.1111/phpp.12896","url":null,"abstract":"Visible light (400– 700 nm), especially blue light, can produce erythema in all skin phototypes and longlasting changes in skin pigmentation in individuals with darker skin phototypes (SPT IVVI) when they are exposed to intensities and wavelengths similar to those from natural sun exposure.1– 5 In addition to the sun, electronic screens also emit blue light; however, they emit these wavelengths at much lower intensities— approximately three orders of magnitude lower than the corresponding intensities in sunlight. Notably, there is poor clinical evidence to substantiate adverse clinical effects from electronic blue light exposure.6,7 Despite this lack of evidence, there is public interest in the possible harmful effects of artificial blue light from electronic devices on the skin, and protection strategies against this specific source of blue light are being propagated and marketed in media outlets.8 As the public increasingly looks to social media as a source of medical information, awareness of its content is important for dermatologists to address medical misinformation. Our aim was to characterize the content contained in popular social media platforms about the sources of blue light likely to have clinical effects and blue light photoprotection strategies recommended on these platforms by different types of content creators. The top three social media platforms used for dermatologic information and product promotion were chosen based on the highest number of active users.9 Social media posts on TikTok, Instagram, and YouTube were identified using search terms or the hashtag “blue light skin damage” or “blue light skin” and were analyzed between December 2021 and January 2022. NonEnglish language, therapeutic and nondermatologic posts were excluded. Included posts were categorized into one of the following content creator categories based on the similarities of services verified on their profiles and websites: commercial industry, dermatology professional (dermatologist or dermatology physician assistant), esthetician, layperson, news source, nondermatologist physician, and selfidentified skin expert. Reported sources of blue light (sun, electronic screen, sun and screen, not mentioned) and proposed photoprotection measures (tinted, mineral, and other sunscreens; topical antioxidants; screen filter) were collected. Descriptive and chisquare tests of proportions were conducted in SAS 9.4. A total of 344 posts were identified: 70 (49.4%) from TikTok, 88 (25.6%) from Instagram, and 86 (25%) from YouTube. Most of the 344 posts were created by commercial industry (n = 102; 29.7%), followed by 71 laypeople (20.7%), 41 dermatology professionals (11.9%), 40 selfidentified skin experts (11.6%), 38 estheticians (11.0%), 35 nondermatology physicians (10.2%), and 17 news sources (4.9%). Of the 344 posts, more than half (n = 196; 57.0%) solely reported electronic screens as the source of blue light, whereas 28 (8.1%) reported sun and 87 (25.3%) reported bo","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10627971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrowband ultraviolet B phototherapy for pityriasis lichenoides: A real-life experience.","authors":"Esra Agaoglu,&nbsp;Hilal Kaya Erdogan,&nbsp;Ersoy Acer,&nbsp;Zeynep Nurhan Saracoglu,&nbsp;Muzaffer Bilgin","doi":"10.1111/phpp.12895","DOIUrl":"https://doi.org/10.1111/phpp.12895","url":null,"abstract":"<p><strong>Introduction: </strong>Pityriasis lichenoides (PL) is a papulosquamous disease affecting both children and adults, for which narrowband-UVB (NB-UVB) phototherapy is regarded as a commonly used treatment option. The aim of this study was to investigate the efficacy of NB-UVB phototherapy in the management of PL and to compare response rates in pediatric and adult age groups.</p><p><strong>Materials and methods: </strong>This observational, retrospective study included 20 PL patients (12 pityriasis lichenoides chronica; PLC, 8 pityriasis lichenoides et varioliformis acuta; PLEVA) who failed to respond to other treatment modalities. The data for this study were collected retrospectively from patient follow-up forms in the phototherapy unit.</p><p><strong>Results: </strong>A complete response (CR) was obtained in all pediatric patients with PL, while 53.8% of adult patients had achieved CR. The mean cumulative dose required to achieve the CR was higher in pediatric patients than adult patients with PL (p < .05). The CR was achieved in 6 (75%) of 8 PLEVA patients, while 8 (66.7%) of 12 PLC patients had reached to CR. The mean number of exposures for patients with PLC to achieve a CR was higher than patients with PLEVA (p < .05). Erythema was the most common adverse effect during phototherapy particularly in 5 (35.7%) of the patients with PL who had achieved CR.</p><p><strong>Conclusions: </strong>NB-UVB is an effective and well-tolerated treatment option for PL especially in diffuse types. A higher response can be obtained in children with higher cumulative dose. Patients with PLC may require more exposures for CR than patients with PLEVA.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10279940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircRNA-406918 enhances the degradation of advanced glycation end products in photoaged human dermal fibroblasts via targeting cathepsin D.","authors":"Yingying Qu,&nbsp;Mengyao Wang,&nbsp;Jingjing Lan,&nbsp;Xianyin Huang,&nbsp;Jingxi Huang,&nbsp;Hongpeng Li,&nbsp;Yue Zheng,&nbsp;Qingfang Xu","doi":"10.1111/phpp.12887","DOIUrl":"10.1111/phpp.12887","url":null,"abstract":"<p><strong>Background: </strong>Lysosomal cathepsin D (CTSD) can degrade internalized advanced glycation end products (AGEs) in dermal fibroblasts. CTSD expression is decreased in photoaged fibroblasts, which contributes to intracellular AGEs deposition and further plays a role in AGEs accumulation of photoaged skin. The mechanism under downregulated CTSD expression is unclear.</p><p><strong>Objective: </strong>To explore possible mechanism of regulating CTSD expression in photoaged fibroblasts.</p><p><strong>Methods: </strong>Dermal fibroblasts were induced into photoaging with repetitive ultraviolet A (UVA) irradiation. The competing endogenous RNA (ceRNA) networks were constructed to predict candidate circRNAs or miRNAs related with CTSD expression. AGEs-BSA degradation by fibroblasts was studied with flow cytometry, ELISA, and confocal microscopy. Effects of overexpressing circRNA-406918 via lentiviral transduction on CTSD expression, autophagy, AGE-BSA degradation were analyzed in photoaged fibroblasts. The correlation between circRNA-406918 and CTSD expression or AGEs accumulation in sun-exposed and sun-protected skin was studied.</p><p><strong>Results: </strong>CTSD expression, autophagy, and AGEs-BSA degradation were significantly decreased in photoaged fibroblasts. CircRNA-406918 was identified to regulate CTSD expression, autophagy, and senescence in photoaged fibroblasts. Overexpressing circRNA-406918 potently decreased senescence and increased CTSD expression, autophagic flux, and AGEs-BSA degradation in photoaged fibroblasts. Moreover, circRNA-406918 level was positively correlated with CTSD mRNA expression and negatively associated with AGEs accumulation in photodamaged skin. Further, circRNA-406918 was predicted to mediate CTSD expression through sponging eight miRNAs.</p><p><strong>Conclusion: </strong>These findings suggest that circRNA-406918 regulates CTSD expression and AGEs degradation in UVA-induced photoaged fibroblasts and might exert a role in AGEs accumulation in photoaged skin.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10281692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specnuezhenide ameliorates ultraviolet-induced skin photoaging in mice by regulating the Sirtuin 3/8-Oxoguanine DNA glycosylase signal.","authors":"Nan Tang,&nbsp;Ying-Yun Ren,&nbsp;Hao-Tian Wu,&nbsp;Xi-Ting Lv,&nbsp;Xiao-Ting Liu,&nbsp;Qi-Lin Li,&nbsp;Guo-En Wang,&nbsp;Yan-Hua Wu","doi":"10.1111/phpp.12880","DOIUrl":"https://doi.org/10.1111/phpp.12880","url":null,"abstract":"<p><strong>Purpose: </strong>Ultraviolet-induced skin photoaging was involved in DNA oxidative damage. Specnuezhenide, one of the secoiridoids extracted from Ligustri Lucidi Fructus, possesses antioxidant and anti-inflammatory effects. Whether specnuezhenide ameliorates skin photoaging remains unclear. This study aimed to investigate the effect of specnuezhenide on skin photoaging induced by ultraviolet and explore the underlying mechanism.</p><p><strong>Methods: </strong>Mice were employed to treat with ultraviolet to induce skin photoaging, then administrated 10 and 20 mg/kg of specnuezhenide. Histological analysis, protein expression, network pharmacology, and autodock analysis were conducted.</p><p><strong>Results: </strong>Specnuezhenide ameliorated ultraviolet-induced skin photoaging in mice via the increase in collagen contents, and decrease in epidermal thickness, malondialdehyde content, and β-galactosidase expression in the skin. Specnuezhenide reduced cutaneous apoptosis and inflammation in mice with skin photoaging. In addition, network pharmacology data indicated that specnuezhenide possessed potential targets on the NOD-like receptor signaling pathway. Validation experiment found that specnuezhenide inhibited the expression of NOD-like receptor family pyrin domain-containing 3, gasdermin D-C1, and Caspase 1. Furthermore, the expression of 8-Oxoguanine DNA glycosylase (OGG1), sirtuin 3 (SIRT3), and superoxide dismutase 2 was increased in specnuezhenide-treated mice with photoaging.</p><p><strong>Conclusion: </strong>Specnuezhenide protected against ultraviolet-induced skin photoaging in mice via a probable activation of SIRT3/OGG1 signal.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10644426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}