Photodermatology, photoimmunology & photomedicine最新文献

{"title":"Ultraviolet B-induced punctate hyperkeratosis in a patient with vitiligo.","authors":"Chang-Yu Hsieh, Tsen-Fang Tsai","doi":"10.1111/phpp.12916","DOIUrl":"10.1111/phpp.12916","url":null,"abstract":"","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"681-683"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CO₂ laser combined with ALA-PDT for successful treatment of refractory acne vulgaris: A case report.","authors":"Qin Chen, Ling Li, Zhi-Qiang Song, Lan Ge","doi":"10.1111/phpp.12875","DOIUrl":"10.1111/phpp.12875","url":null,"abstract":"Dear editors, Acne vulgaris is a common skin disease of showing alteration of the keratinization process causing the progression from comedone formation to inflammatory response.1 Generally, acne vulgaris clinically responds well to the treatments such as salicylic acid, antibiotics, and/or combination with isotretinoin. However, in some individuals, acne vulgaris does not response to topical treatments or oral pharmacological interventions.2 Thus, these individuals with treatmentresistant acne vulgaris, socalled refractory acne vulgaris (RAV), require alternative options for the effective treatment. A 22yearold male patient presented to our dermatology outpatient unit with a 4year history of bilaterally facial acne vulgaris. Clinical examination showed a large number of comedones fused into one piece with inflammatory lesions on his faces (Figure 1A). The patient reported no respond to the treatment with oral isotretinoin (0.5 mg/kg/day). Therefore, the combinations of oral isotretinoin (0.5 mg/kg/day) and topical 30% salicylic acid (six times, one time per 2– 3 weeks) or alpha hydroxyl acid with adapalene gel as well as clindamycin hydrochloride and metronidazole liniments were initially used to treat the patient. After 3 months, the numbers of inflammatory lesions were slightly decreased. However, the patient reported a recurrence of superficial acne, and no alteration of the deep acne was observed (Figure 1B). Given an unsuccessful treatment with mediations, CO2 laser therapy was subsequently selected as an alternative treatment following the patient stopped taking medications for 2 weeks. The patient was treated with an ablative 10,600 nm fractional CO2 laser systems (Chongqing Jingyu Laser Technology Co., Ltd). Meanwhile, needle acupuncture was used to extrude fat plugs following CO2 laser therapy. After 2 months, the large facial acne still existed, though part of the comedones disappeared, and decreased numbers of inflammatory lesions were also observed (Figure 1C). Due to previous unsatisfactory curative effect, CO2 laser combined with 5aminolaevulinic acid photodynamic therapy (ALAPDT) were further performed. The treatment process showed as follows: CO2 laser described as above was used to vaporize the tip of comedones to form small pores, and the fat plugs were extruded by using needle acupuncture. Topical 5% ALA was immediately applied, and sterile cottons soaked with 5% ALA were covered bilaterally facial surface for 2 h. Then, Light irradiation was carried out by exposing the bilaterally facial surface to a red LED device (640 nm, Shenzhen Pumen Technology Co., Ltd) at the dose level of 72 mw/cm2 for 20 min, followed by cooling with ice for 2 h. The treatment was performed every 2 weeks. After 3 times of treatment, the facial acne was significantly improved with few inflammatory lesions and some scattered erythema and sunken acne pits (Figure 1D). The halfyear followup medical examinations showed only some sunken acne pits and no re","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"39 5","pages":"527-528"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10271266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of related factors affecting hemoporfin-mediated photodynamic therapy for port-wine stain: A retrospective study.","authors":"Jiajie Chen,&nbsp;Yu Gui,&nbsp;Sun Wang,&nbsp;Dawei Huang,&nbsp;Jiajie Lyu,&nbsp;Hui Cheng,&nbsp;Yantao Ding,&nbsp;Huabing Zhang,&nbsp;Shengxiu Liu","doi":"10.1111/phpp.12874","DOIUrl":"https://doi.org/10.1111/phpp.12874","url":null,"abstract":"<p><strong>Background: </strong>Hemoporfin-mediated photodynamic therapy (HMME-PDT) is currently considered one of the most promising therapies for port-wine stain (PWS). However, the efficacy of this is very variable and needs further studies.</p><p><strong>Methods: </strong>A total of 101 patients with PWS in the face, neck, or extremities who received at least 2 HMME-PDT sessions were included in the study, and correlations of efficacy with age, gender, locations, treatment sessions, and PDL treatment history were analyzed.</p><p><strong>Results: </strong>The efficacy of HMME-PDT in patients with different ages, locations, and different numbers of prior PDL treatment showed constantly significant differences after 1/2/last session (p < .05). The number of treatments was associated with efficacy, and patients who received more than two sessions had a better response than those who underwent two sessions only (p < .001). Ordinal logistic regression analysis confirmed the above-mentioned associations. Nevertheless, patients of different sex, subtype, and lesion size showed no significant differences.</p><p><strong>Conclusions: </strong>Our studies demonstrated that HMME-PDT is effective in the treatment of PWS. The more prior PDL treatments, older age, lips involvement, PWS on limbs were adverse factors for Hemoporfin-PDT, while multiple HMME-PDT sessions can improve effective and response rate. Besides, ambient temperature and lesions temperature should be concerned, local cooling provides some relief from pain but may influence effect.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"39 5","pages":"441-448"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response predictor for pigment reduction after one session of photo-based therapy using convolutional neural network: A proof of concept study.","authors":"Ting-Ting Yang,&nbsp;Ching-Wen Ma,&nbsp;Jyun-Wei Jhou,&nbsp;Yu-Ting Chen,&nbsp;Cheng-Che E Lan","doi":"10.1111/phpp.12891","DOIUrl":"https://doi.org/10.1111/phpp.12891","url":null,"abstract":"<p><strong>Background: </strong>Identifying treatment responders after a single session of photo-based procedure for hyperpigmentary disorders may be difficult.</p><p><strong>Objectives: </strong>We aim to train a convolutional neural network (CNN) to test the hypothesis that there exist discernible features in pretreatment photographs for identifying favorable responses after photo-based treatments for facial hyperpigmentation and develop a clinically applicable algorithm to predict treatment outcome.</p><p><strong>Methods: </strong>Two hundred and sixty-four sets of pretreatment photographs of subjects receiving photo-based treatment for esthetic enhancement were obtained using the VISIA® skin analysis system. Preprocessing was done by masking the facial features of the photographs. Each set of photographs consists of five types of images. Five independently trained CNNs based on the Resnet50 backbone were developed based on these images and the results of these CNNs were combined to obtain the final result.</p><p><strong>Results: </strong>The developed CNN algorithm has a prediction accuracy approaching 78.5% with area under the receiver operating characteristic curve being 0.839.</p><p><strong>Conclusion: </strong>The treatment efficacy of photo-based therapies on facial skin pigmentation can be predicted based on pretreatment images.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"39 5","pages":"498-505"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of pediatric indolent systemic mastocytosis: The role of UVB-NB phototherapy in the treatment of cutaneous lesions.","authors":"Valeria Brazzelli,&nbsp;Grazia Bossi,&nbsp;Alice Bonelli,&nbsp;Eugenio Isoletta,&nbsp;Martina Volontè,&nbsp;Stefania Barruscotti,&nbsp;Mara De Amici,&nbsp;Elisa Bono,&nbsp;Jacqueline Ferrari,&nbsp;Emanuela Boveri","doi":"10.1111/phpp.12894","DOIUrl":"10.1111/phpp.12894","url":null,"abstract":"Dear editor, Mastocytosis encompasses a heterogeneous group of disorders characterized by pathological expansion and accumulation of clonal mast cells within one or more organs.1 According to the latest classification, three subtypes of the disease have been recognized based on the site and extent of organ involvement and dysfunction: cutaneous mastocytosis (CM), systemic mastocytosis (SM), and mast cell sarcoma (MCS).2,3 SM has been differentiated into nonadvanced and advanced forms, while the CM is divided into maculopapular CM (MPCM), diffuse CM (DCM), and mastocytoma subtypes.2,3 In pediatric age, mastocytosis is often limited to the skin (CM) and is considered to be a myeloproliferative clonal disease with benign course, outcome, and tendency to spontaneous resolution before puberty.4 Extracutaneous involvement in pediatric mastocytosis is relatively rare, most often presenting in the form of indolent systemic mastocytosis (ISM). Virtually all children with SM present with skin lesions, usually MPCM, accompanied by increased serum tryptase levels.4 Currently, the treatment of SM in pediatric patients lacks of standard guidelines: its primary aim is to limit the release of mediators of mast cell degranulation, by avoiding potential triggering factors. The mainstay of systemic therapy is secondgeneration H1 and H2 antihistamines, useful in decreasing flushing, pruritus, and controlling wheal formation.1,5 A valuable secondline therapy, proposed as an alternative approach for the treatment of refractory cases, is phototherapy.6 UVBNB phototherapy has been shown to be effective in many dermatological pediatric diseases associated with intense itch,7,8 and UVB light has been proven to have an inhibitory effect on mast cell degranulation, likely by causing noncytotoxic damage to the membrane phospholipid metabolism.9,10 Omalizumab has been successfully used to treat severe symptoms related to mastocytosis that are recalcitrant to conventional therapies,11 including cases of CM and ISM in pediatric patients,12 while in case of aggressive SM the clinician can consider the use of imatinib (if mast cells lack the cKIT D816V mutation) or other newer tyrosinekinase inhibitors.13 We report a case of a 13yearold girl, affected by ISM, who presented with cutaneous lesions since the sixth month of life, successfully treated with UVBNB phototherapy. The patient initially received a diagnosis of MPCM, and was referred to our Dermatologic Institute due to progressive worsening of her skin lesions during adolescence. At that time, she presented with several papules and erythematous, brown macules distributed on her face, arms, and trunk, and positivity for Darier's sign. Pruritus was one of the greatest causes of discomfort for the patient. The disfiguring appearance of the skin lesions was correlated with body image concerns, deeply affecting her quality of life (Figure 1). A progressive increase in the serum tryptase values was observed (from the baseline val","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"39 5","pages":"540-542"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10272275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro-relief characterization of benign and malignant skin lesions by polarization speckle analysis in vivo.","authors":"Lioudmila Tchvialeva,&nbsp;Jamie Phillips,&nbsp;Daniel C Louie,&nbsp;Haishan Zeng,&nbsp;Harvey Lui,&nbsp;Tim K Lee","doi":"10.1111/phpp.12876","DOIUrl":"https://doi.org/10.1111/phpp.12876","url":null,"abstract":"<p><strong>Background/purpose: </strong>A recent direction in skin disease classification is to develop quantitative diagnostic techniques. Skin relief, colloquially known as roughness, is an important clinical feature. The aim of this study is to demonstrate a novel polarization speckle technique to quantitatively measure roughness on skin lesions in vivo. We then calculate the average roughness of different types of skin lesions to determine the extent to which polarization speckle roughness measurements can be used to identify skin cancer.</p><p><strong>Methods: </strong>The experimental conditions were set to target the fine relief structure on the order of ten microns within a small field of view of 3 mm. The device was tested in a clinical study on patients with malignant and benign skin lesions that resemble cancer. The cancer group includes 37 malignant melanomas (MM), 43 basal cell carcinomas (BCC), and 26 squamous cell carcinomas (SCC), all categories confirmed by gold standard biopsy. The benign group includes 109 seborrheic keratoses (SK), 79 nevi, and 11 actinic keratoses (AK). Normal skin roughness was obtained for the same patients (301 different body sites proximal to the lesion).</p><p><strong>Results: </strong>The average root mean squared (rms) roughness ± standard error of the mean for MM and nevus was equal to 19 ± 5 μm and 21 ± 3 μm, respectively. Normal skin has rms roughness of 31 ± 3 μm, other lesions have roughness of 35 ± 10 μm (AK), 35 ± 7 μm (SCC), 31 ± 4 μm (SK), and 30 ± 5 μm (BCC).</p><p><strong>Conclusion: </strong>An independent-samples Kruskal-Wallis test indicates that MM and nevus can be separated from each of the tested types of lesions, except each other. These results quantify clinical knowledge of lesion roughness and could be useful for optical cancer detection.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"39 5","pages":"449-456"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective multicentric cohort study of checkpoint inhibitors-induced pruritus with focus on management.","authors":"Chryssoula Papageorgiou,&nbsp;Elizabeth Lazaridou,&nbsp;Konstantinos Lallas,&nbsp;Kyparissos Papaioannou,&nbsp;Vasiliki Nikolaou,&nbsp;Valeria Mateeva,&nbsp;Konstantinos Efthymiadis,&nbsp;Chrysanthi Koukoutzeli,&nbsp;Konstantia Loga,&nbsp;Eleni Sogka,&nbsp;Evangelos Karamitrousis,&nbsp;George Lazaridis,&nbsp;Dimitrios Dionysopoulos,&nbsp;Aimilios Lallas,&nbsp;Christina Kemanetzi,&nbsp;Christina Fotiadou,&nbsp;Eleni Timotheadou,&nbsp;Zoe Apalla","doi":"10.1111/phpp.12892","DOIUrl":"https://doi.org/10.1111/phpp.12892","url":null,"abstract":"<p><strong>Background: </strong>Limited data on immune checkpoint inhibitor (ICI)-induced pruritus per se and efficacy of different therapeutic modalities in its management exist.</p><p><strong>Objective: </strong>To study the quantitative and qualitative characteristics of ICI-induced pruritus per se and to assess the efficacy of the therapeutic modalities usually applied.</p><p><strong>Methods: </strong>We retrospectively reviewed the records of 91 patients who were under treatment with ICIs for any kind of neoplasia and developed pruritus during treatment.</p><p><strong>Results: </strong>Twenty out of 91 individuals (22.0%) with ICI-induced pruritus had pruritus as the only symptom, while 71/91 (78.0%) presented with pruritus coexisting with an additional cutaneous toxicity. Pruritus was treated with antihistamines (18/20, 90.0%) and/or topical regimens, as first-line choice. In resistant cases, as a second therapeutic intervention, narrow-band UVB (NBUVB), oral steroids and GABA analogs were added (70.0%). Statistical analysis revealed a significant difference in mean pruritus Numerical Rating Scale (NRS) scores between baseline and sequential visits. Moreover, subgroup analysis revealed a significant reduction in mean NRS scores in those treated with phototherapy.</p><p><strong>Limitations: </strong>Retrospective design, low number of patients and survivorship bias.</p><p><strong>Conclusion: </strong>Pruritus per se was present in a substantial portion of our cohort (22.0%). Our study confirms the efficacy of current treatment strategies and suggests NBUVB as a potential steroid-sparing therapeutic alternative.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"39 5","pages":"506-511"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10627469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter case-control study comparing sun exposure habits and use of photoprotection measures in patients diagnosed with different types of skin cancer.","authors":"Alba Navarro-Bielsa,&nbsp;Tamara Gracia-Cazaña,&nbsp;Manuel Almagro,&nbsp;Sonia De la Fuente-Meira,&nbsp;Ángeles Florez,&nbsp;Oriol Yélamos,&nbsp;Trinidad Montero-Vilchez,&nbsp;Carlos González-Cruz,&nbsp;Adrián Diago,&nbsp;Isabel Abadías-Granado,&nbsp;Victoria Fuentelsaz,&nbsp;María Colmenero,&nbsp;José Bañuls,&nbsp;Salvador Arias-Santiago,&nbsp;Agustín Buendía-Eisman,&nbsp;Manuel Almenara-Blasco,&nbsp;Pedro Gil-Pallares,&nbsp;Yolanda Gilaberte","doi":"10.1111/phpp.12878","DOIUrl":"https://doi.org/10.1111/phpp.12878","url":null,"abstract":"<p><strong>Background: </strong>While skin cancer awareness programs have significantly furthered public understanding about the harmful effects of the sun, there is a disparity between photoprotection knowledge and protection practices.</p><p><strong>Objective: </strong>To compare sun exposure habits and photoprotection measures in patients diagnosed with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma versus controls.</p><p><strong>Methods: </strong>Multicentre case-control observational study carried out by 13 Spanish dermatologists between April 2020 and August 2022. Patients diagnosed with BCC, SCC, or melanoma were considered cases. The control group consisted of individuals with no history of skin cancer.</p><p><strong>Results: </strong>Of the 254 cases (56.2% female; mean age, 62.67 ± 15.65), 119 (31.2%) had BCC, 62 (16.27%) SCC, and 73 (19.1%) melanoma. The control group consisted of 127 (33.33%) individuals. Avoiding sun exposure between 12:00 and 16:00 was the most commonly used photoprotection measure (habitually/always: 63.1%), followed by the use of sunscreen (habitually/always: 58.9%). Patients with melanoma were less likely to use clothing and shade to avoid sun exposure (p < .05), whereas those with BCC and SCC reported greater use of head coverings (p = .01). BCC and SCC groups reported greater sun exposure 15 years prior, whereas controls reported greater use of sunscreen. However, at the time of this study all groups reported using SPF ≥ 21, and the majority SPF > 50. No differences were observed in photoprotection measures between people with and without a previous history of skin cancer.</p><p><strong>Conclusions: </strong>We describe differences in photoprotection measures and sun exposure patterns among patients diagnosed with different skin tumor types. Whether these differences may influence the type of tumor each developed will require further investigation.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"39 5","pages":"457-465"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10626900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of skin cancers in mycosis fungoides patients receiving PUVA therapy: A real-life experience from a single tertiary center.","authors":"Ertop Doğan Pelin,&nbsp;Bengü Nisa Akay,&nbsp;Vural Seçil,&nbsp;Arı Canan,&nbsp;Ertürk Yılmaz Tuğçe,&nbsp;Şanlı Hatice","doi":"10.1111/phpp.12872","DOIUrl":"https://doi.org/10.1111/phpp.12872","url":null,"abstract":"<p><strong>Background: </strong>Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Skin-directed therapies, including phototherapy, are the first-line treatment modalities. Psoralen plus ultraviolet A light photochemotherapy (PUVA) is quite effective in controlling the disease; however, long-term adverse effects, particularly carcinogenesis, are the cons of this treatment.</p><p><strong>Objective: </strong>There are various studies on the negative impact of PUVA on skin cancer in patients with autoimmune skin diseases. The data on the long-term effects of phototherapy on MF patients are scarce.</p><p><strong>Methods: </strong>All MF cases that received PUVA alone or combined with other treatments at a single tertiary center were analyzed. This study compared the development of non-melanoma skin cancers, melanoma, and solid organ tumors in MF patients with at least 5-year follow-up data with age- and sex-matched controls.</p><p><strong>Results: </strong>A total of 104 patients were included in the study. Ninety-two malignancies were detected in 16 (15.4%) patients, and six developed multiple malignancies. Skin cancers consisted of 56 basal cell carcinomas, 16 Bowen's disease, four squamous cell carcinomas, three melanomas, two basosquamous cell carcinomas, one Kaposi sarcoma, and one keratoacanthoma were found in nine (8.7%) patients. Eight patients developed three solid cancers and six lymphomas. The risk of developing skin cancer was associated with the total number of PUVA sessions (<250 vs ≥250 sessions; hazard ratio (HR) 4.44, 95% confidence interval (CI) 1.033-19.068; p = .045). 9 (13.2%) of 68 patients who had follow-ups for at least 5 years developed skin cancer. Compared to an age- and sex-matched cohort, the prevalence of new skin cancer was considerably greater (p = .009).</p><p><strong>Conclusions: </strong>Patients with MF are predisposed to develop secondary malignancies, and continual exposure to PUVA may potentiate this risk. Annual digital dermoscopic follow-up in MF patients treated with UVA is advised for early diagnosis and treatment of secondary cutaneous malignancies.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"39 5","pages":"428-434"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10626422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue light and the skin on social media: An analysis of posts on exposure and photoprotection strategies.","authors":"Marissa S Ceresnie,&nbsp;Jay Patel,&nbsp;Erika J Tvedten,&nbsp;Indermeet Kohli,&nbsp;Tasneem F Mohammad","doi":"10.1111/phpp.12896","DOIUrl":"10.1111/phpp.12896","url":null,"abstract":"Visible light (400– 700 nm), especially blue light, can produce erythema in all skin phototypes and longlasting changes in skin pigmentation in individuals with darker skin phototypes (SPT IVVI) when they are exposed to intensities and wavelengths similar to those from natural sun exposure.1– 5 In addition to the sun, electronic screens also emit blue light; however, they emit these wavelengths at much lower intensities— approximately three orders of magnitude lower than the corresponding intensities in sunlight. Notably, there is poor clinical evidence to substantiate adverse clinical effects from electronic blue light exposure.6,7 Despite this lack of evidence, there is public interest in the possible harmful effects of artificial blue light from electronic devices on the skin, and protection strategies against this specific source of blue light are being propagated and marketed in media outlets.8 As the public increasingly looks to social media as a source of medical information, awareness of its content is important for dermatologists to address medical misinformation. Our aim was to characterize the content contained in popular social media platforms about the sources of blue light likely to have clinical effects and blue light photoprotection strategies recommended on these platforms by different types of content creators. The top three social media platforms used for dermatologic information and product promotion were chosen based on the highest number of active users.9 Social media posts on TikTok, Instagram, and YouTube were identified using search terms or the hashtag “blue light skin damage” or “blue light skin” and were analyzed between December 2021 and January 2022. NonEnglish language, therapeutic and nondermatologic posts were excluded. Included posts were categorized into one of the following content creator categories based on the similarities of services verified on their profiles and websites: commercial industry, dermatology professional (dermatologist or dermatology physician assistant), esthetician, layperson, news source, nondermatologist physician, and selfidentified skin expert. Reported sources of blue light (sun, electronic screen, sun and screen, not mentioned) and proposed photoprotection measures (tinted, mineral, and other sunscreens; topical antioxidants; screen filter) were collected. Descriptive and chisquare tests of proportions were conducted in SAS 9.4. A total of 344 posts were identified: 70 (49.4%) from TikTok, 88 (25.6%) from Instagram, and 86 (25%) from YouTube. Most of the 344 posts were created by commercial industry (n = 102; 29.7%), followed by 71 laypeople (20.7%), 41 dermatology professionals (11.9%), 40 selfidentified skin experts (11.6%), 38 estheticians (11.0%), 35 nondermatology physicians (10.2%), and 17 news sources (4.9%). Of the 344 posts, more than half (n = 196; 57.0%) solely reported electronic screens as the source of blue light, whereas 28 (8.1%) reported sun and 87 (25.3%) reported bo","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"39 5","pages":"543-545"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10627971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}