Photodermatology, photoimmunology & photomedicine最新文献_第10页

Mesenchymal stem cell-derived exosomes and skin photoaging: From basic research to practical application. 间充质干细胞衍生外泌体与皮肤光老化:从基础研究到实际应用。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-08-21 DOI: 10.1111/phpp.12910

Yihao Wang, Xu Shen, Shenghua Song, Yan Chen, Yiping Wang, Junlin Liao, Nian Chen, Li Zeng

{"title":"Mesenchymal stem cell-derived exosomes and skin photoaging: From basic research to practical application.","authors":"Yihao Wang, Xu Shen, Shenghua Song, Yan Chen, Yiping Wang, Junlin Liao, Nian Chen, Li Zeng","doi":"10.1111/phpp.12910","DOIUrl":"10.1111/phpp.12910","url":null,"abstract":"Background: Skin photoaging is a condition caused by long-term exposure to ultraviolet irradiation, resulting in a variety of changes in the skin, such as capillary dilation, increased or absent pigmentation, dryness, sagging, and wrinkles. Stem cells possess a remarkable antioxidant capacity and the ability to proliferate, differentiate, and migrate, and their main mode of action is through paracrine secretion, with exosomes being the primary form of secretion. Stem cell-derived exosomes contain a variety of growth factors and cytokines and may have great potential to promote skin repair and delay skin ageing.Methods: This review focuses on the mechanisms of UV-induced skin photoaging, the research progress of stem cell exosomes against skin photoaging, emerging application approaches and limitations in the application of exosome therapy.Result: Exosomes derived from various stem cells have the potential to prevent skin photoaging.Conclusion: The combination with novel materials may be a key step for their practical application, which could be an important direction for future basic research and practical applications.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"556-566"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10037241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of low-level light therapy in management of central centrifugal cicatricial alopecia: A case series of four patients. 应用低强度光治疗中央离心性瘢痕性脱发:附4例病例。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-08-23 DOI: 10.1111/phpp.12905

Madison K Cook, Brittany N Feaster, Jacob J Subash, Jorge Larrondo, Amy J McMichael

引用次数: 0

Properties and safety of topical dihydroxyacetone in sunless tanning products: A review. 外用二羟基丙酮在日晒产品中的性能和安全性综述。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-09-12 DOI: 10.1111/phpp.12913

Shayan Owji, Fayven Teklehaimanot, Jalal Maghfour, Henry W Lim

{"title":"Properties and safety of topical dihydroxyacetone in sunless tanning products: A review.","authors":"Shayan Owji, Fayven Teklehaimanot, Jalal Maghfour, Henry W Lim","doi":"10.1111/phpp.12913","DOIUrl":"10.1111/phpp.12913","url":null,"abstract":"Sunless tanning products have risen in popularity as the desire for a tanned appearance continues alongside growing concerns about the deleterious effects of ultraviolet radiation exposure from the sun. Dihydroxyacetone (DHA) is a simple carbohydrate found nearly universally in sunless tanning products that serves to impart color to the skin. The Food and Drug Administration (FDA), which regulates sunless tanning products as cosmetics, allows DHA for external use while maintaining that its ingestion, inhalation, or contact with mucosal surfaces should be avoided. Given its widespread use and a paucity of reviews on its safety, we aim to review the literature on the topical properties and safety profile of DHA. Available data indicate that DHA possesses only minimal to no observable photoprotective properties. In vitro studies suggest that, while DHA concentrations much higher than those in sunless tanning products are needed to induce significant cytotoxicity, even low millimolar, nonlethal concentrations can alter the function of keratinocytes, tracheobronchial cells, and other cell types on a cellular and molecular level. Instances of irritant and allergic contact dermatitis triggered by DHA exposures have also been reported. While no other side effects in humans have been observed, additional studies on the safety and toxicity of DHA in humans are warranted, with a focus on concentrations and frequencies of DHA exposure typically encountered by consumers.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"567-572"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10211159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of interleukin-36γ induced by ultraviolet radiation in chronic actinic dermatitis. 紫外线诱导的白细胞介素-36γ在慢性光化性皮炎中的作用。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-08-06 DOI: 10.1111/phpp.12903

Li Wang, Yunhua Tu, Wenjuan Wu, Ying Tu, Zhenghui Yang, Yanjie Chai, Xinwang Yang, Li He

{"title":"Role of interleukin-36γ induced by ultraviolet radiation in chronic actinic dermatitis.","authors":"Li Wang, Yunhua Tu, Wenjuan Wu, Ying Tu, Zhenghui Yang, Yanjie Chai, Xinwang Yang, Li He","doi":"10.1111/phpp.12903","DOIUrl":"10.1111/phpp.12903","url":null,"abstract":"Background: Chronic actinic dermatitis (CAD) is an immune-mediated photodermatosis characterized by a high eosinophil count and total immunoglobulin E (IgE) in the peripheral blood of patients. At present, however, the reasons for their elevation remain unclear.Objective: The current study aimed to detect changes in inflammatory cytokines in CAD and explore their role in this disease.Methods: Enzyme-linked immunosorbent assay and Luminex assay were conducted to measure inflammatory factor levels. Immunohistochemical analysis and quantitative real-time polymerase chain reaction were performed to evaluate the expression levels of interleukin-36γ (IL-36γ), IL-8, chemokine (C-C motif) ligand 17 (CCL17), and CCL18. CCK8 kits were used to assess cell proliferation. Immunofluorescence was used to detect nuclear factor κB (NF-κB) p65 nuclear translocation. Western blot analysis was performed to detect the protein expression level of phosphorylated NF-κB (p-NF-κB) p65. Hematoxylin and eosin and Masson trichrome staining were applied to observe histological changes in a chronic photo-damaged mouse model.Results: Eosinophils, total IgE, IL-36γ, IL-8, tumor necrosis factor α, CCL17, and CCL18 were elevated in CAD. Of note, IL-36γ promoted the proliferation of eosinophilic cells (EOL-1) and the production of IgE in peripheral blood mononuclear cells. IL-36γ also promoted the production of IL-8 and CCL18 in immortalized human keratinocytes (HaCaT cells), while ultraviolet radiation (UVR)-induced IL-36γ via activation of the NF-κB signaling pathway.Conclusions: IL-36γ was involved in the pathogenesis of CAD and UVR contributed to the production of IL-36γ, which may provide a novel therapeutic target for CAD.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"598-606"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10302834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progressive nonsegmental vitiligo successfully treated with oral tofacitinib and narrow-band UVB: A case report of 2-year follow-up. 口服托法替尼联合窄带UVB治疗进展性非节段性白癜风2年随访1例。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-07-06 DOI: 10.1111/phpp.12900

Zhongyi Xu, Xiaoxue Xing, Yijie Xuan, Leihong Flora Xiang, Chengfeng Zhang

引用次数: 0

Chronic actinic dermatitis and fragrance sensitization: Case report with good response to dupilumab. 慢性光化性皮炎和芳香致敏:dupilumab反应良好的病例报告。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-07-23 DOI: 10.1111/phpp.12902

Laura Taboada Paz, Verónica Sánchez García, Ángela María García Miñarro, Juan Manuel Ramos Rincón, Pedro Gil Pallares, Elena Vicente Basanta, Juan Francisco Silvestre Salvador

引用次数: 0

Proteomics analysis to investigate the potential mechanism of theacrine against UV-induced skin photodamage. 蛋白质组学分析探讨抗紫外线皮肤光损伤的潜在机制。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-08-29 DOI: 10.1111/phpp.12908

Yong He, Xinkai Zheng, Yunfeng Hu, Liehua Deng, Jin Xu, Shi Wu

{"title":"Proteomics analysis to investigate the potential mechanism of theacrine against UV-induced skin photodamage.","authors":"Yong He, Xinkai Zheng, Yunfeng Hu, Liehua Deng, Jin Xu, Shi Wu","doi":"10.1111/phpp.12908","DOIUrl":"10.1111/phpp.12908","url":null,"abstract":"Aim: This study aimed to explore the underlying mechanism of theacrine treatment of UV-induced skin photodamage.Materials and methods: Tandem Mass Tag (TMT) relative quantitative proteomics analysis was used to characterize the proteins and pathways associated with the ability of theacrine to combat photodamage in mouse skin by modeling UV irradiation of the backs of ICR mice.Results: Apoptosis-related proteins and signaling pathways play a key role in the ability of theacrine to protect against skin photodamage, according to proteomic and bioinformatics analysis; molecular docking and Western blotting further revealed that theacrine was associated with apoptosis-related proteins (p53, Bcl-2, Bax, caspase-3, and cleaved-caspase-3) with strong binding affinity, which can significantly reduce skin cell apoptosis induced by UV exposure.Conclusion: The findings revealed that theacrine can reduce UVB-induced epidermal damage by controlling the apoptosis signaling pathway, implying that theacrine could be a useful anti-UVB damage agent.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"620-632"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10114176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photopatch testing in Singapore: A 10-year retrospective study. 新加坡的Photopatch测试：一项为期10年的回顾性研究。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-09-25 DOI: 10.1111/phpp.12912

Shi Yu Derek Lim, Anthony Teik-Jin Goon, Yung Hian Leow, Tricia Yi Rui Chong, Eugene Sern-Ting Tan, Wei Na Suzanne Cheng

{"title":"Photopatch testing in Singapore: A 10-year retrospective study.","authors":"Shi Yu Derek Lim, Anthony Teik-Jin Goon, Yung Hian Leow, Tricia Yi Rui Chong, Eugene Sern-Ting Tan, Wei Na Suzanne Cheng","doi":"10.1111/phpp.12912","DOIUrl":"10.1111/phpp.12912","url":null,"abstract":"Background: Photopatch testing represents the gold standard for the diagnosis of photoallergic contact dermatitis (PACD). We aimed to identify common photoallergens in our tertiary dermatological referral centre from 2012 to 2021, to compare this to the preceding period studied, and data from other communities.Methods: We conducted a retrospective review of all 90 patients who underwent photopatch testing at the National Skin Centre, Singapore, between 2012 and 2021.Results: Of 90 patients, 19 (21.1%) were male, and the mean age was 41.6 years. Eighty-four (93.3%) underwent testing to our standard sunscreen series, 10 (11.1%) to our extended series, and 73 (81.1%) to their own items. Seventeen (18.9%) were diagnosed with PACD (i.e., photocontact allergy with present or past relevance), 12 (13.3%) with ACD, and 4 (4.4%) with photoaugmented ACD. Relevant reactions were commonest to oxybenzone (8, 9.5%) and mexenone (3, 3.6%). Eleven (15.1%) had PACD to their own items, with 3 of 4 (75%) tested to ketoprofen diagnosed with PACD and the remaining 1 (25%) with photoaugmented ACD. Age, race, sex, atopy, and site of involvement were not associated with photocontact allergy. Compared to the preceding time period, the overall frequency of photocontact allergy and PACD decreased, but rates of photoallergic reactions to individual photoallergens were not significantly different.Conclusion: Organic ultraviolet absorbers such as oxybenzone and mexenone remained the most relevant photoallergens. Personal item testing was valuable, and testing to ketoprofen should be considered.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"642-647"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41140345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel treatment for Riehl's melanosis targeting both dermal melanin and vessels. 一种针对皮肤黑色素和血管的里尔黑素病的新治疗方法。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-08-23 DOI: 10.1111/phpp.12907

Yul Hee Kim, Young Joon Park, Du Jin Baek, Ji Eun Kwon, Hee Young Kang

{"title":"A novel treatment for Riehl's melanosis targeting both dermal melanin and vessels.","authors":"Yul Hee Kim, Young Joon Park, Du Jin Baek, Ji Eun Kwon, Hee Young Kang","doi":"10.1111/phpp.12907","DOIUrl":"10.1111/phpp.12907","url":null,"abstract":"Background/purpose: Riehl's melanosis is a difficult-to-treat condition characterized by persisting dermal hyperpigmentation. This study aimed to evaluate the efficacy of a histology-specific targeted therapy for Riehl's melanosis.Methods: Skin biopsy samples of Riehl's melanosis were assessed to identify histology-specific targets for treatment. Subsequently, the efficacy of a combination involving a fractional picosecond laser and a pulsed dye laser (PDL) targeting the dermal melanin and vessels, respectively, was evaluated. Clinical improvement was assessed using the dermal pigmentation area and severity index (DPASI). The treatment outcomes were compared to those of a control, in this case a single laser treatment solely targeting pigmentation.Results: Histological and immunohistochemical analyses identified dermal melanin pigment and dilated vessels as treatment targets for Riehl's melanosis. The combined treatment of the fractional picosecond laser and PDL showed a significant reduction of the DPASI scores, which was significantly better than the control group. Patients who underwent the combined laser treatment indicated high levels of satisfaction with no adverse events except of transient erythema and oedema.Conclusion: The combined treatment of a fractional picosecond laser and a PDL was more effective for Riehl's melanosis compared to single laser treatment. The treatment targets both dermal pigmentation and dilated vessels, offering promising results for those working to manage Riehl's melanosis.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"613-619"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10049800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of offline extracorporeal photopheresis in cutaneous T-cell lymphomas: A retrospective study. 体外脱机光疗治疗皮肤t细胞淋巴瘤的疗效和安全性:一项回顾性研究。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-11-01 Epub Date: 2023-07-19 DOI: 10.1111/phpp.12901

Carlos Moreno-Vílchez, Cristina Muniesa, Eva González-Barca, Nadia García-Muñoz, Sandra Ortega-Sánchez, Octavio Servitje

引用次数: 0