Photodermatology, photoimmunology & photomedicine最新文献

{"title":"A decrease of mitochondrial ubiquitin ligase increases the secretion of matrix metalloproteinase-1 by dermal fibroblasts through the induction of ER stress.","authors":"Yushi Katsuyama, Yuri Okano, Hitoshi Masaki","doi":"10.1111/phpp.12897","DOIUrl":"10.1111/phpp.12897","url":null,"abstract":"<p><strong>Background: </strong>We previously reported that the level of mitochondrial ubiquitin ligase (MITOL) protein in fibroblasts was decreased by UVA and that the knock-down (KD) of MITOL increased the secretion of matrix metalloprotease-1 (MMP-1) by fibroblasts. A recent study reported that MITOL suppresses endoplasmic reticulum (ER) stress by stabilizing the interaction between ER and mitochondria (MT) through the ubiquitination of mitofusin 2. These facts suggest that a decrease of MITOL would increase the secretion of MMP-1 through ER stress, but the detailed mechanism of that process in dermal fibroblasts remains unclear. Thus, this study was conducted to clarify the involvement of ER stress in the oversecretion of MMP-1 induced by the decreased MT quality caused by MITOL-KD.</p><p><strong>Methods: </strong>MITOL-KD normal human dermal fibroblast (NHDFs) were prepared by treating them with MITOL-small interfering RNA, after which their MMP-1 protein levels were measured. ER stress in NHDFs was evaluated by measuring the mRNA levels of spliced X-box binding protein 1 (sXBP1) and the protein levels of inositol-requiring enzyme 1α (IRE1α).</p><p><strong>Results: </strong>MITOL-KD NHDFs enhanced the secretion of MMP-1 via interleukin-6 (IL-6) elicited by the activation of nuclear factor-kappa B (NF-κB). The secretion of MMP-1 could be abrogated by a neutralizing IL-6 antibody and by JSH23, which is an inhibitor of NF-κB activation. Furthermore, MITOL-KD NHDFs as well as UVA-irradiated NHDFs showed increased ER stress levels. In addition, tunicamycin, which is an inducer of ER stress, also increased MMP-1 secretion.</p><p><strong>Conclusion: </strong>These results suggested that the decrease of MITOL caused the oversecretion of MMP-1 via NF-κB-IL-6 signaling through the activation of ER stress in fibroblasts.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9664264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel treatment for Riehl's melanosis targeting both dermal melanin and vessels.","authors":"Yul Hee Kim, Young Joon Park, Du Jin Baek, Ji Eun Kwon, Hee Young Kang","doi":"10.1111/phpp.12907","DOIUrl":"10.1111/phpp.12907","url":null,"abstract":"<p><strong>Background/purpose: </strong>Riehl's melanosis is a difficult-to-treat condition characterized by persisting dermal hyperpigmentation. This study aimed to evaluate the efficacy of a histology-specific targeted therapy for Riehl's melanosis.</p><p><strong>Methods: </strong>Skin biopsy samples of Riehl's melanosis were assessed to identify histology-specific targets for treatment. Subsequently, the efficacy of a combination involving a fractional picosecond laser and a pulsed dye laser (PDL) targeting the dermal melanin and vessels, respectively, was evaluated. Clinical improvement was assessed using the dermal pigmentation area and severity index (DPASI). The treatment outcomes were compared to those of a control, in this case a single laser treatment solely targeting pigmentation.</p><p><strong>Results: </strong>Histological and immunohistochemical analyses identified dermal melanin pigment and dilated vessels as treatment targets for Riehl's melanosis. The combined treatment of the fractional picosecond laser and PDL showed a significant reduction of the DPASI scores, which was significantly better than the control group. Patients who underwent the combined laser treatment indicated high levels of satisfaction with no adverse events except of transient erythema and oedema.</p><p><strong>Conclusion: </strong>The combined treatment of a fractional picosecond laser and a PDL was more effective for Riehl's melanosis compared to single laser treatment. The treatment targets both dermal pigmentation and dilated vessels, offering promising results for those working to manage Riehl's melanosis.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10049800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of offline extracorporeal photopheresis in cutaneous T-cell lymphomas: A retrospective study.","authors":"Carlos Moreno-Vílchez, Cristina Muniesa, Eva González-Barca, Nadia García-Muñoz, Sandra Ortega-Sánchez, Octavio Servitje","doi":"10.1111/phpp.12901","DOIUrl":"10.1111/phpp.12901","url":null,"abstract":"","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9834750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photopatch testing in Singapore: A 10-year retrospective study.","authors":"Shi Yu Derek Lim, Anthony Teik-Jin Goon, Yung Hian Leow, Tricia Yi Rui Chong, Eugene Sern-Ting Tan, Wei Na Suzanne Cheng","doi":"10.1111/phpp.12912","DOIUrl":"10.1111/phpp.12912","url":null,"abstract":"<p><strong>Background: </strong>Photopatch testing represents the gold standard for the diagnosis of photoallergic contact dermatitis (PACD). We aimed to identify common photoallergens in our tertiary dermatological referral centre from 2012 to 2021, to compare this to the preceding period studied, and data from other communities.</p><p><strong>Methods: </strong>We conducted a retrospective review of all 90 patients who underwent photopatch testing at the National Skin Centre, Singapore, between 2012 and 2021.</p><p><strong>Results: </strong>Of 90 patients, 19 (21.1%) were male, and the mean age was 41.6 years. Eighty-four (93.3%) underwent testing to our standard sunscreen series, 10 (11.1%) to our extended series, and 73 (81.1%) to their own items. Seventeen (18.9%) were diagnosed with PACD (i.e., photocontact allergy with present or past relevance), 12 (13.3%) with ACD, and 4 (4.4%) with photoaugmented ACD. Relevant reactions were commonest to oxybenzone (8, 9.5%) and mexenone (3, 3.6%). Eleven (15.1%) had PACD to their own items, with 3 of 4 (75%) tested to ketoprofen diagnosed with PACD and the remaining 1 (25%) with photoaugmented ACD. Age, race, sex, atopy, and site of involvement were not associated with photocontact allergy. Compared to the preceding time period, the overall frequency of photocontact allergy and PACD decreased, but rates of photoallergic reactions to individual photoallergens were not significantly different.</p><p><strong>Conclusion: </strong>Organic ultraviolet absorbers such as oxybenzone and mexenone remained the most relevant photoallergens. Personal item testing was valuable, and testing to ketoprofen should be considered.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41140345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized lichen sclerosus responding to UVA1 phototherapy and methotrexate treatment: A case report.","authors":"Yusuf Can Edek, Sheyda Gharadaeghi, Esra Adışen","doi":"10.1111/phpp.12917","DOIUrl":"10.1111/phpp.12917","url":null,"abstract":"","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49681071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of infrared radiation on the human skin.","authors":"Luke Horton, Joshua Brady, Colin M Kincaid, Angeli Eloise Torres, Henry W Lim","doi":"10.1111/phpp.12899","DOIUrl":"10.1111/phpp.12899","url":null,"abstract":"<p><strong>Background: </strong>Infrared radiation (IR) is the portion of the electromagnetic spectrum between visible light (VL) and microwaves, with wavelengths between 700 nm and 1 mm. Humans are mainly exposed to ultraviolet (UV) radiation (UVR) and IR through the sun. Unlike UVR which is well known for its carcinogenic properties, the relationship between IR and skin health has not been as extensively studied; as such, we gather the available published evidence here to better elucidate this relationship.</p><p><strong>Methods: </strong>Several databases including Pubmed, Google Scholar, and Embase were searched for articles relating to infrared radiation and the skin. Articles were selected for their relevance and novelty.</p><p><strong>Results: </strong>Detrimental effects such as thermal burns, photocarcinogenesis, and photoaging have been reported, though evidence suggests that these may be due to the thermal effects produced secondary to IR exposure rather than the isolated effect of IR. There are currently no chemical or physical filters specifically available for protection against IR, and existing compounds are not known to have IR-filtering capacity. Interestingly, IR may have some photoprotective properties against the carcinogenic effects of UVR. Furthermore, IR has been used with encouraging results in skin rejuvenation, wound healing, and hair restoration when given at an appropriate therapeutic dose.</p><p><strong>Conclusion: </strong>A better understanding of the current landscape of research surrounding IR can help illuminate its effects on the skin and highlight areas for further research. Here, we review relevant data on IR to assess its deleterious and beneficial effects on human skin, along with possible means for IR photoprotection.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9764396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultraviolet B-induced punctate hyperkeratosis in a patient with vitiligo.","authors":"Chang-Yu Hsieh, Tsen-Fang Tsai","doi":"10.1111/phpp.12916","DOIUrl":"10.1111/phpp.12916","url":null,"abstract":"","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CO₂ laser combined with ALA-PDT for successful treatment of refractory acne vulgaris: A case report.","authors":"Qin Chen,&nbsp;Ling Li,&nbsp;Zhi-Qiang Song,&nbsp;Lan Ge","doi":"10.1111/phpp.12875","DOIUrl":"10.1111/phpp.12875","url":null,"abstract":"Dear editors, Acne vulgaris is a common skin disease of showing alteration of the keratinization process causing the progression from comedone formation to inflammatory response.1 Generally, acne vulgaris clinically responds well to the treatments such as salicylic acid, antibiotics, and/or combination with isotretinoin. However, in some individuals, acne vulgaris does not response to topical treatments or oral pharmacological interventions.2 Thus, these individuals with treatmentresistant acne vulgaris, socalled refractory acne vulgaris (RAV), require alternative options for the effective treatment. A 22yearold male patient presented to our dermatology outpatient unit with a 4year history of bilaterally facial acne vulgaris. Clinical examination showed a large number of comedones fused into one piece with inflammatory lesions on his faces (Figure 1A). The patient reported no respond to the treatment with oral isotretinoin (0.5 mg/kg/day). Therefore, the combinations of oral isotretinoin (0.5 mg/kg/day) and topical 30% salicylic acid (six times, one time per 2– 3 weeks) or alpha hydroxyl acid with adapalene gel as well as clindamycin hydrochloride and metronidazole liniments were initially used to treat the patient. After 3 months, the numbers of inflammatory lesions were slightly decreased. However, the patient reported a recurrence of superficial acne, and no alteration of the deep acne was observed (Figure 1B). Given an unsuccessful treatment with mediations, CO2 laser therapy was subsequently selected as an alternative treatment following the patient stopped taking medications for 2 weeks. The patient was treated with an ablative 10,600 nm fractional CO2 laser systems (Chongqing Jingyu Laser Technology Co., Ltd). Meanwhile, needle acupuncture was used to extrude fat plugs following CO2 laser therapy. After 2 months, the large facial acne still existed, though part of the comedones disappeared, and decreased numbers of inflammatory lesions were also observed (Figure 1C). Due to previous unsatisfactory curative effect, CO2 laser combined with 5aminolaevulinic acid photodynamic therapy (ALAPDT) were further performed. The treatment process showed as follows: CO2 laser described as above was used to vaporize the tip of comedones to form small pores, and the fat plugs were extruded by using needle acupuncture. Topical 5% ALA was immediately applied, and sterile cottons soaked with 5% ALA were covered bilaterally facial surface for 2 h. Then, Light irradiation was carried out by exposing the bilaterally facial surface to a red LED device (640 nm, Shenzhen Pumen Technology Co., Ltd) at the dose level of 72 mw/cm2 for 20 min, followed by cooling with ice for 2 h. The treatment was performed every 2 weeks. After 3 times of treatment, the facial acne was significantly improved with few inflammatory lesions and some scattered erythema and sunken acne pits (Figure 1D). The halfyear followup medical examinations showed only some sunken acne pits and no re","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10271266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of related factors affecting hemoporfin-mediated photodynamic therapy for port-wine stain: A retrospective study.","authors":"Jiajie Chen,&nbsp;Yu Gui,&nbsp;Sun Wang,&nbsp;Dawei Huang,&nbsp;Jiajie Lyu,&nbsp;Hui Cheng,&nbsp;Yantao Ding,&nbsp;Huabing Zhang,&nbsp;Shengxiu Liu","doi":"10.1111/phpp.12874","DOIUrl":"https://doi.org/10.1111/phpp.12874","url":null,"abstract":"<p><strong>Background: </strong>Hemoporfin-mediated photodynamic therapy (HMME-PDT) is currently considered one of the most promising therapies for port-wine stain (PWS). However, the efficacy of this is very variable and needs further studies.</p><p><strong>Methods: </strong>A total of 101 patients with PWS in the face, neck, or extremities who received at least 2 HMME-PDT sessions were included in the study, and correlations of efficacy with age, gender, locations, treatment sessions, and PDL treatment history were analyzed.</p><p><strong>Results: </strong>The efficacy of HMME-PDT in patients with different ages, locations, and different numbers of prior PDL treatment showed constantly significant differences after 1/2/last session (p < .05). The number of treatments was associated with efficacy, and patients who received more than two sessions had a better response than those who underwent two sessions only (p < .001). Ordinal logistic regression analysis confirmed the above-mentioned associations. Nevertheless, patients of different sex, subtype, and lesion size showed no significant differences.</p><p><strong>Conclusions: </strong>Our studies demonstrated that HMME-PDT is effective in the treatment of PWS. The more prior PDL treatments, older age, lips involvement, PWS on limbs were adverse factors for Hemoporfin-PDT, while multiple HMME-PDT sessions can improve effective and response rate. Besides, ambient temperature and lesions temperature should be concerned, local cooling provides some relief from pain but may influence effect.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response predictor for pigment reduction after one session of photo-based therapy using convolutional neural network: A proof of concept study.","authors":"Ting-Ting Yang,&nbsp;Ching-Wen Ma,&nbsp;Jyun-Wei Jhou,&nbsp;Yu-Ting Chen,&nbsp;Cheng-Che E Lan","doi":"10.1111/phpp.12891","DOIUrl":"https://doi.org/10.1111/phpp.12891","url":null,"abstract":"<p><strong>Background: </strong>Identifying treatment responders after a single session of photo-based procedure for hyperpigmentary disorders may be difficult.</p><p><strong>Objectives: </strong>We aim to train a convolutional neural network (CNN) to test the hypothesis that there exist discernible features in pretreatment photographs for identifying favorable responses after photo-based treatments for facial hyperpigmentation and develop a clinically applicable algorithm to predict treatment outcome.</p><p><strong>Methods: </strong>Two hundred and sixty-four sets of pretreatment photographs of subjects receiving photo-based treatment for esthetic enhancement were obtained using the VISIA® skin analysis system. Preprocessing was done by masking the facial features of the photographs. Each set of photographs consists of five types of images. Five independently trained CNNs based on the Resnet50 backbone were developed based on these images and the results of these CNNs were combined to obtain the final result.</p><p><strong>Results: </strong>The developed CNN algorithm has a prediction accuracy approaching 78.5% with area under the receiver operating characteristic curve being 0.839.</p><p><strong>Conclusion: </strong>The treatment efficacy of photo-based therapies on facial skin pigmentation can be predicted based on pretreatment images.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10331645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}