Photodermatology, photoimmunology & photomedicine最新文献_第8页

Frequency of skin cancer among psoriasis, vitiligo, and mycosis fungoides patients treated with narrowband ultraviolet B phototherapy. 窄带紫外线B光疗治疗银屑病、白癜风和蕈样真菌病患者皮肤癌的发生率

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2024-01-01 Epub Date: 2023-12-07 DOI: 10.1111/phpp.12936

Ilit Mimouni, Julia Shulman, Awni Abu Unes, Lev Pavlovsky, Felix Pavlotsky

{"title":"Frequency of skin cancer among psoriasis, vitiligo, and mycosis fungoides patients treated with narrowband ultraviolet B phototherapy.","authors":"Ilit Mimouni, Julia Shulman, Awni Abu Unes, Lev Pavlovsky, Felix Pavlotsky","doi":"10.1111/phpp.12936","DOIUrl":"10.1111/phpp.12936","url":null,"abstract":"Background: Narrowband ultraviolet B (NB-UVB) phototherapy is a popular and relatively contemporary treatment option. However, only a few studies to date have explored the potential risk of skin cancer following NB-UVB treatment.Objective: This study aimed to investigate the potential long-term risk of skin cancer in patients treated with NB-UVB.Methods: This cohort study included patients with psoriasis, vitiligo, and mycosis fungoides treated with NB-UVB at two university hospitals in Israel in 2000-2005. Patients were followed up for skin cancer for at least 10 years. Data were extracted from the hospital and community medical records.Results: A total of 767 patients were included in this study: 509 with psoriasis, 122 with vitiligo, and 136 with mycosis fungoides. The mean follow-up duration was 13 years. Among these patients, 4.43% developed skin cancer during the follow-up (3.93% had psoriasis, 2.46% had vitiligo, and 8.09% had mycosis fungoides). Old age and fair skin type were the only significant independent risk factors for skin cancer. There was no significant difference in the mean number of NB-UVB treatments among patients who developed skin cancer and those who did not (99.09 vs. 94.79, respectively).Conclusion: No association was observed between the number of NB-UVB treatments and carcinogenesis in any study group. Age is a significant risk factor, and older patients treated with NB-UVB should be followed up carefully.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"e12936"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138499130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Narrowband ultraviolet B phototherapy combined with intralesional injection of either latanoprost or platelet-rich plasma for stable nonsegmental vitiligo. 窄带紫外线B光疗联合局部注射拉坦前列素或富血小板血浆治疗稳定型非节段性白癜风。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2024-01-01 Epub Date: 2023-11-20 DOI: 10.1111/phpp.12929

Manal Fawzy, Sahar Al-Mokadem, Mabrokah Alshereef, Basma Elkholy

{"title":"Narrowband ultraviolet B phototherapy combined with intralesional injection of either latanoprost or platelet-rich plasma for stable nonsegmental vitiligo.","authors":"Manal Fawzy, Sahar Al-Mokadem, Mabrokah Alshereef, Basma Elkholy","doi":"10.1111/phpp.12929","DOIUrl":"10.1111/phpp.12929","url":null,"abstract":"Background: Narrowband ultraviolet B (NB-UVB) phototherapy is the cornerstone of vitiligo treatment. Its combination with other treatments usually yields a better response. Latanoprost, a prostaglandin F2α analog, and autologous platelet-rich plasma (PRP) have been reported to be effective for vitiligo.Aim: To evaluate the efficacy of NB-UVB combined with intralesional latanoprost or PRP for stable nonsegmental vitiligo (NSV).Methods: Sixty patients with stable NSV were recruited and randomly allocated to two equal groups. NB-UVB phototherapy was administered twice a week for all patients. Additionally, group A received intralesional latanoprost injections once weekly, while group B received intralesional autologous PRP injections every 2 weeks.Results: At 24 weeks, excellent repigmentation response was observed in 26.7% and 13.3% of patients in the latanoprost/NB-UVB and PRP/NB-UVB groups, respectively, with no significant difference in degrees of repigmentation between the two groups. However, the Vitiligo Extent Score for a Target Area (VESTA) score was significantly higher in the latanoprost/NB-UVB group (p = .032). Moreover, lesions located on nonacral skin responded significantly better than those on acral skin. Only erythema was significantly higher in the PRP/NB-UVB group, while the recurrence of depigmentation was significantly higher in the latanoprost/NB-UVB group.Conclusions: Both latanoprost and PRP have the potential to be effective add-on therapies to NB-UVB phototherapy for stable NSV, with latanoprost resulting in a greater repigmentation response and PRP producing a more stable response.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"e12929"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy and safety of low- versus high-fluence fractional picosecond Nd:YAG 1064-nm laser in the treatment of acne scars: A randomized split-face comparison study. 低与高通量分数皮秒Nd:YAG 1064nm激光治疗痤疮疤痕的疗效和安全性：一项随机分面比较研究。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2024-01-01 Epub Date: 2023-11-10 DOI: 10.1111/phpp.12922

Si-Hyung Lee, Dong Hyo Kim, Seong Jin Jo, Youngkyoung Lim, Ji Won Lee, Jun Hyo Lee, Tae Min Kim, Seong Rae Kim, Jeewoo Kang, Ji Young Yoon, Dae Hun Suh

{"title":"The efficacy and safety of low- versus high-fluence fractional picosecond Nd:YAG 1064-nm laser in the treatment of acne scars: A randomized split-face comparison study.","authors":"Si-Hyung Lee, Dong Hyo Kim, Seong Jin Jo, Youngkyoung Lim, Ji Won Lee, Jun Hyo Lee, Tae Min Kim, Seong Rae Kim, Jeewoo Kang, Ji Young Yoon, Dae Hun Suh","doi":"10.1111/phpp.12922","DOIUrl":"10.1111/phpp.12922","url":null,"abstract":"Background: Differences in clinical efficacy based on the fluence of fractional picosecond laser treatment for acne scars are unknown.Objective: To compare the efficacy and safety of low-fluence versus high-fluence fractional picosecond Nd:YAG 1064-nm laser treatment in acne scar patients.Methods: In this 12-week, investigator-blinded, randomized, split-face study, 25 patients with moderate-to-severe acne scars received three sessions of high-fluence laser treatment (1.0 J/cm2 ) on one side of their face and low-fluence (0.3 J/cm2 ) on the other side every 4 weeks. Patients were assessed using acne scar counts, the scar global assessment (SGA), and the ECCA scar grading scale every 4 weeks. The histological analysis compared the acne scars obtained before and 4 weeks after treatment.Results: At their last visit, 88.00% and 92.00% of the subjects achieved >30% reduction in scar counts on the low- and high-fluence sides, respectively, without a significant difference between the two sides. On both sides, the scar counts, SGA, and ECCA score significantly improved 4 weeks after the last treatment. Although the high-fluence side showed a greater reduction in scar counts (-66.73%) than the low-fluence side (-62.13%), the two sides had no significant difference in the grading scores. The high-fluence side showed significantly more severe pain and higher side-effect scores immediately and 4 weeks after treatment. Histological analysis revealed a significantly increased collagen, elastin, and vimentin expression after treatment on the low-fluence side.Conclusions: The low-fluence setting demonstrated comparable efficacy and superior safety in treating acne scars compared with the high-fluence setting.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"e12922"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71413518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Luminescence of favipiravir in skin appendages and sclera. A controlled study and literature review. 法匹拉韦在皮肤附属物和巩膜中的发光。对照研究和文献综述。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2024-01-01 Epub Date: 2023-10-26 DOI: 10.1111/phpp.12919

Deniz Demircioğlu, Emel Öztürk Durmaz

{"title":"Luminescence of favipiravir in skin appendages and sclera. A controlled study and literature review.","authors":"Deniz Demircioğlu, Emel Öztürk Durmaz","doi":"10.1111/phpp.12919","DOIUrl":"10.1111/phpp.12919","url":null,"abstract":"Background/objectives: Favipiravir is an antiviral agent, recently used for COVID-19 infections. Several reports associate favipiravir intake with Wood's lamp fluorescence of hair, nails, and sclera. The present study was designed to elucidate the positivity rates, and sites of favipiravir-related fluorescence and to unravel the site-specific changes in fluorescence positivity rates by a function of time past exposure.Methods: The study population comprised 50 patients and 50 control individuals. All patients in the patient group had received a full dose of favipiravir for COVID-19 infection. Fifty volunteers served as the control group. Wood's lamp examination was performed in a completely darkened room, and the positivity rate, extent, pattern, and distribution of fluorescence were recorded.Results: Wood's light revealed fluorescence of the fingernails, toenails, sclera, and hair in 35 (70%), 35 (70%), 22 (44%), and 8 (16%) patients, respectively. No control individual tested positive by Wood's lamp. Statistical analysis revealed significant differences between patient and control groups in terms of Wood's light luminescence in the fingernails (p = .000), toenails (p = .000), sclera (p = .000) and hair (p = .003). Although fingernail, toenail, and hair fluorescence positivity rates declined or ceased at or after 91 days of favipiravir exposure, ocular fluorescence positivity rates were prolonged up to 188 days.Conclusions: These findings confirm that favipiravir may produce fluorescence of nails, sclera, and hair, detectable by Wood's light starting from the initial month and peaking at second- and third months following exposure to the medication. Although nail and hair fluorescence tend to abate after 3 months, ocular fluorescence may persist even longer than 6 months after cessation of the medication.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"e12919"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of long-pulsed alexandrite laser therapy on facial redness and skin microbiota compositions in rosacea: A prospective, multicentre, single-arm clinical trial. 长脉冲亚历山大宝石激光治疗酒渣鼻面部发红和皮肤微生物群组成的影响：一项前瞻性、多中心、单臂临床试验。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2024-01-01 Epub Date: 2023-11-02 DOI: 10.1111/phpp.12921

Sujin Park, Hyunwoo Jang, Seol Hwa Seong, Ji Young Kim, Eun Jung Lee, Yu Jeong Bae, Yong Ju Ahn, Jihee Kim, Sang Ho Oh

{"title":"The effects of long-pulsed alexandrite laser therapy on facial redness and skin microbiota compositions in rosacea: A prospective, multicentre, single-arm clinical trial.","authors":"Sujin Park, Hyunwoo Jang, Seol Hwa Seong, Ji Young Kim, Eun Jung Lee, Yu Jeong Bae, Yong Ju Ahn, Jihee Kim, Sang Ho Oh","doi":"10.1111/phpp.12921","DOIUrl":"10.1111/phpp.12921","url":null,"abstract":"Background: Rosacea is a chronic skin disorder characterised by abnormal neurovasculature and inflammation in the central region of the face. The efficacy of pulsed-dye laser and intense pulsed light treatments for rosacea have been demonstrated in several clinical trials. However, there is currently no research on the efficacy of long-pulsed alexandrite laser (LPAL) therapy alone for rosacea-related facial redness and its effect on skin microbiota.Aim: To evaluate the efficacy of LPAL therapy on facial redness in rosacea and assess changes in skin microbiota composition.Methods: Subjects with rosacea (n = 21, mean age: 39.2 ± 11.3 years) were recruited from two medical institutions and received monthly LPAL treatments (Clarity II™, Lutronic Corp.) for 3 months. At each visit, clinical photographs were taken, and erythema was measured using a spectrometer. At the initial and final visits, the Dermatology Life Quality Index (DLQI) and Skin Sensitivity Questionnaire (SSQ) were evaluated. Skin swabs were obtained at the initial and final visit, and facial microbiome composition was analysed using 16S rRNA amplicon sequencing.Results: After three LPAL treatment sessions, the average facial erythema index, measured using Mexameter® decreased significantly from 360.0 ± 96.7 at baseline to 312.0 ± 94.5 at the final visit (p < .05). The DLQI and SSQ showed significant improvement of symptoms. Skin microbiome diversity and relative abundance were altered significantly, particularly in the genera Clostridium, Lawsonella, Bacteroides, and Lactobacillus.Conclusions: LPAL therapy alone showed favourable efficacy for the treatment of facial redness in rosacea, with some impacts on the skin microbiota composition.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61564696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment with a red-laser-based wound therapy device exerts positive effects in models of delayed keratinocyte and fibroblast wound healing. 基于红色激光的伤口治疗装置对延迟角化细胞和成纤维细胞伤口愈合模型具有积极作用。

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2024-01-01 Epub Date: 2023-11-13 DOI: 10.1111/phpp.12926

Cornelia Wiegand, Annegret Dirksen, Jörg Tittelbach

{"title":"Treatment with a red-laser-based wound therapy device exerts positive effects in models of delayed keratinocyte and fibroblast wound healing.","authors":"Cornelia Wiegand, Annegret Dirksen, Jörg Tittelbach","doi":"10.1111/phpp.12926","DOIUrl":"10.1111/phpp.12926","url":null,"abstract":"Background: Light therapy is widely used in medicine. Specifically, photobiomodulation has been shown to exert beneficial effects in wound healing disorders, which present a major challenge in health care. The study's aim was providing information on the effect of a novel, red-laser-based wound therapy device (WTD) on keratinocytes and fibroblasts during wound healing under optimal and non-optimal conditions.Methods: The scratch wound assay was employed as a wound healing model for mechanical damage with readjustment of specific cell milieus, explicitly chronic TH1 inflammation and TH2-dominant conditions. Furthermore, gene expression analysis of pro-inflammatory cytokines (IL1A, IL6, CXCL8), growth factors (TGFB1, PDGFC), transcription factors (NFKB1, TP53) and heat shock proteins (HSP90AA1, HSPA1A, HSPD1) as well as desmogleins (DSG1, DSG3) in keratinocytes and collagen (COL1A1, COL3A1) in fibroblasts was performed after WTD treatment.Results: It was shown that WTD treatment is biocompatible and supports scratch wound closure under non-optimal conditions. A distinct enhancement of desmoglein and collagen gene expression as well as induction of early growth factor gene expression was observed under chronic inflammatory conditions. Moreover, WTD increased HSPD1 transcript levels in keratinocytes and augmented collagen expression in fibroblasts during wound healing under TH2 conditions. WTD treatment also alleviated the inflammatory response in keratinocytes and induced early growth factor gene expression in fibroblasts under physiological conditions.Conclusion: Positive effects described for wound treatment with WTD could be replicated in vitro and seem to be to be conferred by a direct influence on cellular processes taking place in keratinocytes and fibroblasts during wound healing.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"e12926"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92156000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A narrative review of the impact of ultraviolet radiation and sunscreen on the skin microbiome 紫外线辐射和防晒霜对皮肤微生物群影响的叙述性综述

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-12-30 DOI: 10.1111/phpp.12943

Garett J. Grant, Indermeet Kohli, Tasneem F. Mohammad

引用次数: 0

Evaluating the factors influencing sun protection factors (SPF): Pooling data from multiple studies involving two reference ISO 24444:2019 sunscreen products (P2 and P8) 评估影响防晒系数（SPF）的因素：汇集涉及两种 ISO 24444:2019 防晒产品（P2 和 P8）的多项研究数据

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-12-29 DOI: 10.1111/phpp.12942

Corinne Granger, Carles Trullàs, Nusayha Bibi Sokeechand, Eric Jourdan, Jean Krutmann, Veronique Francois-Newton, Muzzammil Hosenally

引用次数: 0

Skin cancer survivorship and sun protection behaviors in the United States 美国的皮肤癌幸存者和防晒行为

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-12-29 DOI: 10.1111/phpp.12933

Daniela L. Domínguez Bueso, Liza M. González Ruiz, Lía I. Mondragón Márquez, Jason J. Liu

引用次数: 0

Estimation of serum and tissue level of interleukin-15 (IL-15) and IL-15 receptor alpha (IL-15Rα) in mycosis fungoides before and after phototherapy: An interventional cohort study 光疗前后真菌病患者血清和组织中白细胞介素-15（IL-15）及IL-15受体α（IL-15Rα）水平的估计：介入性队列研究

IF 2.6 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2023-12-29 DOI: 10.1111/phpp.12938

Rania M Mogawer, Randa Youssef, Kholoud Helmy, Nourhan Emad, Olfat Shaker, Sarah Orabi

引用次数: 0