Garett J. Grant, Indermeet Kohli, Tasneem F. Mohammad
{"title":"A narrative review of the impact of ultraviolet radiation and sunscreen on the skin microbiome","authors":"Garett J. Grant, Indermeet Kohli, Tasneem F. Mohammad","doi":"10.1111/phpp.12943","DOIUrl":"https://doi.org/10.1111/phpp.12943","url":null,"abstract":"The human skin microbiome is a dynamic ecosystem that plays an important role in skin health. The skin microbiome has been implicated in numerous diseases, and our knowledge surrounding it continues to evolve. A better understanding of the interactions between the environment and the skin microbiome will lead to improvements in skin health.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"18 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139069647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Corinne Granger, Carles Trullàs, Nusayha Bibi Sokeechand, Eric Jourdan, Jean Krutmann, Veronique Francois-Newton, Muzzammil Hosenally
{"title":"Evaluating the factors influencing sun protection factors (SPF): Pooling data from multiple studies involving two reference ISO 24444:2019 sunscreen products (P2 and P8)","authors":"Corinne Granger, Carles Trullàs, Nusayha Bibi Sokeechand, Eric Jourdan, Jean Krutmann, Veronique Francois-Newton, Muzzammil Hosenally","doi":"10.1111/phpp.12942","DOIUrl":"https://doi.org/10.1111/phpp.12942","url":null,"abstract":"Standardized methods for sun protection factor (SPF) testing are still beset with endpoint and method-driven issues, and can be influenced by multiple factors. The purpose of this analysis is to explore the factors influencing the results of sun protection factor (SPF) testing in human subjects according to the ISO 24444:2019 standard. Intrinsic factors, such as baseline skin color, age and gender, the minimal erythemal dose on an unprotected area (MED<i>u</i>), as well as environmental factors such as season/weather influences, are considered for analysis.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"243 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139069141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniela L. Domínguez Bueso, Liza M. González Ruiz, Lía I. Mondragón Márquez, Jason J. Liu
{"title":"Skin cancer survivorship and sun protection behaviors in the United States","authors":"Daniela L. Domínguez Bueso, Liza M. González Ruiz, Lía I. Mondragón Márquez, Jason J. Liu","doi":"10.1111/phpp.12933","DOIUrl":"https://doi.org/10.1111/phpp.12933","url":null,"abstract":"Skin cancer survivors are more vulnerable to subsequent skin cancers and other malignancies, but previous studies have not examined in detail their sun protection behavior prevalence by sociodemographic factors. We aimed to understand the sociodemographic disparities in the prevalence of three important types of sun protection behaviors: using sunscreen, seeking shade, and wearing protective clothing, among skin cancer survivors and those without skin cancer history.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"1 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139069140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rania M Mogawer, Randa Youssef, Kholoud Helmy, Nourhan Emad, Olfat Shaker, Sarah Orabi
{"title":"Estimation of serum and tissue level of interleukin-15 (IL-15) and IL-15 receptor alpha (IL-15Rα) in mycosis fungoides before and after phototherapy: An interventional cohort study","authors":"Rania M Mogawer, Randa Youssef, Kholoud Helmy, Nourhan Emad, Olfat Shaker, Sarah Orabi","doi":"10.1111/phpp.12938","DOIUrl":"https://doi.org/10.1111/phpp.12938","url":null,"abstract":"Mycosis fungoides (MF) is a chronic, highly recurrent cutaneous T-cell lymphoma, whose pathogenesis has not yet been fully elucidated. Interleukin-15 was previously highlighted as a viability factor for cutaneous T-cell lymphoma with previous studies shedding light on its role in pathogenesis of MF and its plausibility as a potential therapeutic target.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"5 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139069345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alba Rodríguez Martínez, Carmen Vaz Pardal, José Aguilera Arjona, Francisco Rivas Ruiz, Diego Doncel Molinero, Manuel Ruiz Paulano, Andras Subert, Jose Vicente Gutiérrez Manzanedo, Jacobo Cambil Martín, Maria Victoria de Gálvez Aranda, Leocricia Jiménez López, Nuria Blázquez Sánchez, Magdalena de Troya Martín
{"title":"Skin cancer prevention in extreme sports: Intervention in a 24-h race","authors":"Alba Rodríguez Martínez, Carmen Vaz Pardal, José Aguilera Arjona, Francisco Rivas Ruiz, Diego Doncel Molinero, Manuel Ruiz Paulano, Andras Subert, Jose Vicente Gutiérrez Manzanedo, Jacobo Cambil Martín, Maria Victoria de Gálvez Aranda, Leocricia Jiménez López, Nuria Blázquez Sánchez, Magdalena de Troya Martín","doi":"10.1111/phpp.12940","DOIUrl":"https://doi.org/10.1111/phpp.12940","url":null,"abstract":"Excessive sun exposure and sunburns are the main preventable causes of skin cancer. The growing popularity of outdoor sports in developed countries has motivated the objective of this work to study the risk of photoexposure and the skin cancer prevention needs of athletes in an extreme race and evaluate an intervention targeted at this population.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"44 9 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139069470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nneamaka Ezekwe, Aunna Pourang, Alexis B. Lyons, Shanthi Narla, Amruth Atyam, Shereen Zia, Ben J. Friedman, Iltefat H. Hamzavi, Henry W. Lim, Indermeet Kohli
{"title":"Evaluation of the protection of sunscreen products against long wavelength ultraviolet A1 and visible light-induced biological effects","authors":"Nneamaka Ezekwe, Aunna Pourang, Alexis B. Lyons, Shanthi Narla, Amruth Atyam, Shereen Zia, Ben J. Friedman, Iltefat H. Hamzavi, Henry W. Lim, Indermeet Kohli","doi":"10.1111/phpp.12937","DOIUrl":"https://doi.org/10.1111/phpp.12937","url":null,"abstract":"Long wavelength ultraviolet-A1 in combination with visible light induces hyperpigmentation, particularly in dark-skin phototypes. This study evaluated the efficacy of four sunscreen formulations in protecting against VL + UVA1 (370–700 nm).","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"5 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138563857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tatiana Görig, Christian Apfelbacher, Karl Philipp Drewitz, Anne Kerstin Reimers, Eckhard W Breitbart, Katharina Diehl
{"title":"Sunburn and sun protection during recreational outdoor sport in summer: Findings from the German general population aged 16-65 years.","authors":"Tatiana Görig, Christian Apfelbacher, Karl Philipp Drewitz, Anne Kerstin Reimers, Eckhard W Breitbart, Katharina Diehl","doi":"10.1111/phpp.12898","DOIUrl":"10.1111/phpp.12898","url":null,"abstract":"<p><strong>Background: </strong>Sunburn can increase one's risk of developing skin cancer. We aimed to quantify the prevalence of sunburn during recreational outdoor sport (ROS) in summer, to explore the use of different sun protection measures, and to examine factors associated with sunburn during ROS using a population-based sample from Germany.</p><p><strong>Methods: </strong>For this cross-sectional study, 2081 individuals aged 16-65 years who reported being engaged in ROS in summer were surveyed via standardized telephone interviews in 2020 (National Cancer Aid Monitoring, NCAM).</p><p><strong>Results: </strong>Overall, 16.7% reported experiencing at least one sunburn during ROS in the past twelve months. Sunburn occurrence was negatively associated with the age of the participants (e.g. OR = 0.49 in 56-65 year-olds, p < .001), and positively associated with skin type I/II (OR = 1.55, p < .001) and with having a higher number of nevi (OR = 1.42, p = .005). While wearing sleeved shirts was the most frequently-used sun protection measure during ROS (74.9%), wearing headgear was least common in our sample (29.0%). In multivariate analyses, sunburn was positively associated with the use of sun protection measures (e.g. OR = 1.32 for wearing sleeved shirts, p = .02).</p><p><strong>Conclusions: </strong>Our nationwide data show that ROS is one of the settings where sun protection should play a greater role. Especially in organized sports, particular attention should be devoted to organizational (e.g. exercise outside peak hours) or contextual measures (e.g. shade by the natural or built environment) to prevent skin cancer in later life.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"589-597"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9758890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qing-Ling Quan, Kyeong-No Yoon, Ji Su Lee, Eun Ju Kim, Dong Hun Lee
{"title":"Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D.","authors":"Qing-Ling Quan, Kyeong-No Yoon, Ji Su Lee, Eun Ju Kim, Dong Hun Lee","doi":"10.1111/phpp.12914","DOIUrl":"10.1111/phpp.12914","url":null,"abstract":"<p><strong>Background/purpose: </strong>Ultraviolet (UV) radiation has both harmful and beneficial effects on human skin and health. It causes skin damage, aging, and cancer; however, it is also a primary source of vitamin D. Additionally, UV radiation can impact energy metabolism and has protective effects on several cardiovascular and metabolic disorders in mice and humans. However, the mechanisms of UV protection against these diseases have not been clearly identified.</p><p><strong>Methods: </strong>This review summarizes the systemic effects of UV radiation on hypertension and several metabolic diseases such as obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD) in mice, and we also consider the mechanisms of action of the related regulators nitric oxide (NO) and vitamin D.</p><p><strong>Results: </strong>UV exposure can lower blood pressure and prevent the development of cardiovascular diseases and metabolic disorders, such as metabolic syndrome, obesity, and type 2 diabetes, primarily through mechanisms that depend on UV-induced NO. UV radiation may also effectively delay the onset of type 1 diabetes through mechanisms that rely on UV-induced vitamin D. UV-induced NO and vitamin D play roles in preventing and slowing the progression of NAFLD.</p><p><strong>Conclusion: </strong>UV exposure is a promising nonpharmacological intervention for cardiovascular and metabolic disorders. NO and vitamin D may play a crucial role in mediating these effects. However, further investigations are required to elucidate the exact mechanisms and determine the optimal dosage and exposure duration of UV radiation.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"573-581"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yomna Mazid El-Hamd Neinaa, Bassant Sherif El-Sayed Awara, Osama El-Said Shalaby, Naeim Mohammed Abd El-Naby
{"title":"Clinical and dermoscopic assessment of ablative carbon dioxide laser versus intradermal heparin sodium in xanthelasma.","authors":"Yomna Mazid El-Hamd Neinaa, Bassant Sherif El-Sayed Awara, Osama El-Said Shalaby, Naeim Mohammed Abd El-Naby","doi":"10.1111/phpp.12915","DOIUrl":"10.1111/phpp.12915","url":null,"abstract":"<p><strong>Background: </strong>Ablative carbon dioxide (CO<sub>2</sub> ) laser is still a cornerstone in the management of xanthelasma. However, post-laser complications such as post-inflammatory hyperpigmentation or scarring have to be considered. Heparin sodium was recently suggested as an effective therapeutic modality for xanthelasma.</p><p><strong>Objective: </strong>The aim of this work was to compare the therapeutic value of ablative CO<sub>2</sub> laser versus intradermal heparin sodium in xanthelasma.</p><p><strong>Methods: </strong>This study was piloted on 30 xanthelasma patients, whose lesions were randomly categorized into two groups. Group A was managed with CO<sub>2</sub> laser ablation (2 sessions scheduled every 4 weeks), whereas Group B was managed with intradermal heparin sodium injections (10 sessions scheduled every week). Pre- and post-treatments evaluations were done both clinically and dermoscopically.</p><p><strong>Results: </strong>Significant reduction of xanthelasma lesions was reported in response to both therapeutic interventions. However, the ablative CO<sub>2</sub> laser was more significantly effective than intradermal heparin sodium. Interestingly, intradermal injection of heparin sodium was nearly as effective as ablative CO<sub>2</sub> laser in early (<2 years duration) grade I and II xanthelasma, with a lower incidence of post-therapy side effects.</p><p><strong>Conclusions: </strong>Intradermal injection of heparin sodium could be suggested as a safe and cost-effective therapeutic technique for early mild grade I and II xanthelasma. Moreover, it could be recommended as a pre-operative management of grade III and IV xanthelasma to reduce the lesions to be easily ablated with CO<sub>2</sub> laser.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"648-656"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41140746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M El Mansouri, S Essaddouki, M Mouradi, A Oukerroum, F Z El Fatoiki, M T Truchuelo, M A Vitale, S González, S Chiheb
{"title":"Evaluation of the effectiveness and safety of combined oral and topical photoprotection with a standardized extract of Polypodium leucotomos (Fernblock®) in a Moroccan population with xeroderma pigmentosum.","authors":"M El Mansouri, S Essaddouki, M Mouradi, A Oukerroum, F Z El Fatoiki, M T Truchuelo, M A Vitale, S González, S Chiheb","doi":"10.1111/phpp.12904","DOIUrl":"10.1111/phpp.12904","url":null,"abstract":"<p><strong>Background: </strong>Xeroderma pigmentosum (XP) is a rare autosomal-recessive genodermatosis resulting from a DNA-repair defect syndrome. The purpose was to evaluate the prevention on new malignant lesions in patients taking a supplement with Fernblock® (Polypodium leucotomos extract [PLE]) and secondarily correlation with the photoprotective behavior.</p><p><strong>Methods: </strong>A prospective, single-center and open cohort study was conducted over a 12-month period. The study was performed in Morocco. Optimal photoprotection behavior was recommended. Patients were instructed to take one capsule containing 480 mg of Fernblock® and 5 mcg vitamin D and to apply sunscreen with a SPF50+ and Fernblock® every 2 h during sun exposure. The demographic, clinical, and dermatoscopic patient data were collected at baseline (T0) and following visits at 3 months (T3), 6 months (T6), and 12 months (T12) when it was assessed: Investigator Global Assessment (IGA), Patient/Guardian Global Assessment (PGA), Patient/Guardian Satisfaction Questionnaire, and Photographic and Adverse Events Registration. Pertinent statistical study was performed.</p><p><strong>Results: </strong>Eighteen patients completed the study. Eleven patients (61%) finished the study without new lesions. Seven patients developed new lesions by the end of the study. Among them, only 30% showed an ideal photoprotective behavior. The lack of an optimal photoprotective behavior increased the probability of developing lesions by 2.5 times with 95% confidence interval.</p><p><strong>Conclusions: </strong>In our study, more than 60% of patients taking a supplement with Fernblock® did not develop new lesions, and furthermore, we detected that patients following almost ideal photoprotection were 2.5 times less likely to develop NMSC lesions.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":" ","pages":"607-612"},"PeriodicalIF":2.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9997791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}