Photodermatology, photoimmunology & photomedicine最新文献

Hydroa Vacciniforme Lymphoproliferative Disorder With a Truncating KLF2 Variant Presenting as Benign Photodermatoses. 带有截断型KLF2变异的疫苗样水疱性淋巴细胞增生性疾病表现为良性光性皮肤病。

IF 2.2 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-05-01 DOI: 10.1111/phpp.70096

John Warner-Levy, Angelia Ong, Nina Farquharson, Jean Ayer

引用次数: 0

Sunscreen Efficacy Against UVA1- And Visible Light-Induced Skin Pigmentation Is Influenced by Ancestry. 防晒霜对UVA1和可见光诱导的皮肤色素沉着的功效受血统的影响。

IF 2.2 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-05-01 DOI: 10.1111/phpp.70094

Florian Dimmers, Niklas Lück, Yimeng Wang, Christian Staerk, Tao Zhang, Jean Krutmann

{"title":"Sunscreen Efficacy Against UVA1- And Visible Light-Induced Skin Pigmentation Is Influenced by Ancestry.","authors":"Florian Dimmers, Niklas Lück, Yimeng Wang, Christian Staerk, Tao Zhang, Jean Krutmann","doi":"10.1111/phpp.70094","DOIUrl":"https://doi.org/10.1111/phpp.70094","url":null,"abstract":"Background: There is growing evidence that individuals with different skin phototypes require tailored approaches to achieve optimal photoprotection. Individuals with darker skin phototypes are more prone to UVA1- and visible light-induced pigmentation, whereas lighter phototypes are more susceptible to shorter wavelengths such as UVB and UVA2. Thus, skin phototype is an important determinant of sunscreen efficacy. In the present study, we have asked if ancestry-independent of phototype-is another factor affecting sunscreen efficacy.Objectives: (i) To determine the overall photoprotective effects of two sunscreen formulations against UVA1, visible light (VL), and combined visible light plus UVA1, and (ii) to compare the photoprotective efficacy of both products between Han Chinese participants and participants of European ancestry.Methods: Forty healthy volunteers (N = 20 Han Chinese; N = 20 of European ancestry), matched for phototype, constitutive pigmentation, gender, and age, were exposed to VL, UVA1, and combined VL plus UVA1 to induce pigmentation responses following standardized irradiation protocols. Skin responses across treated and untreated sites were analyzed using linear mixed-effects models.Results: Across all participants, both sunscreen formulations provided significant protection against VL, UVA1, and combined VL plus UVA1. Notably, photoprotective efficacy against UVA1-induced immediate (IPD) and persistent pigment darkening (PPD) differed significantly between individuals of different ancestries, with one formulation showing stronger protection in Han Chinese.Conclusion: This exploratory study indicates that sunscreen efficacy may differ across ancestries. Thus, sunscreens should not only be tailored to different phototypes but also need to consider ancestry-related factors.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70094"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Window Tinting: An Underutilized Resource for Photoprotection for Photosensitive and High-Risk Skin Cancer Patients. 窗口着色：光敏性和高风险皮肤癌患者的光保护未充分利用的资源。

IF 2.2 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-05-01 DOI: 10.1111/phpp.70095

Nada Hentati, Chandler W Rundle, Bryan T Carroll

引用次数: 0

The Utilization of Optical Coherence Tomography in the Assessment of Melasma Activity and Differential Diagnosis. 光学相干层析成像在黄褐斑活动评估和鉴别诊断中的应用。

IF 2.2 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-03-01 DOI: 10.1111/phpp.70082

Xiao Ma, Zhe Li, Jie Liu

{"title":"The Utilization of Optical Coherence Tomography in the Assessment of Melasma Activity and Differential Diagnosis.","authors":"Xiao Ma, Zhe Li, Jie Liu","doi":"10.1111/phpp.70082","DOIUrl":"10.1111/phpp.70082","url":null,"abstract":"Background and objectives: Melasma represents a prevalent facial hyperpigmentation disorder that predominantly affects Asian females. This study aims to assess the applicability of Optical Coherence Tomography (OCT) in the cases of melasma, Hori's nevus, and freckles and to summarize the features of OCT images.Patients and methods: This single-center, evaluator-blinded, observational study was carried out at the Department of Dermatology, Peking Union Medical College Hospital from October 2024 to June 2025. All participants underwent noninvasive dermoscopy, reflectance confocal microscopy, and OCT examinations of lesional and perilesional areas.Results: 47 patients with melasma, 6 patients with Hori's nevus, and 13 patients with freckles were included. 18 patients with melasma (38.3%) were categorized into the active stage, whereas 29 patients with melasma (61.7%) were classified into the stable stage. A disruption of the basement membrane zone exceeding 50% and blood vessel dilation were more frequently observed in the active stage (p < 0.05). In the context of differential diagnosis, a disruption of the basement membrane zone exceeding 50% can be regarded as a differentiating factor among melasma, Hori's nevus, and freckles (p < 0.05).Conclusion: OCT can unveil the characteristic features of different melasma stages and offer crucial information for melasma staging and differential diagnosis.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 2","pages":"e70082"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effectiveness of Home-Based Phototherapy in Vitiligo: A Systematic Review and Meta-Analysis. 家庭光疗治疗白癜风的有效性：一项系统综述和meta分析。

IF 2.2 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-03-01 DOI: 10.1111/phpp.70079

Firdavis Xireaili, Hieu Ha, Zhao Feng Liu, Lawrence Lin, Michelle Min Hsiao, Adrian Mar, Christopher Chew

{"title":"The Effectiveness of Home-Based Phototherapy in Vitiligo: A Systematic Review and Meta-Analysis.","authors":"Firdavis Xireaili, Hieu Ha, Zhao Feng Liu, Lawrence Lin, Michelle Min Hsiao, Adrian Mar, Christopher Chew","doi":"10.1111/phpp.70079","DOIUrl":"10.1111/phpp.70079","url":null,"abstract":"Background: Phototherapy with narrowband ultraviolet B (UVB) is an effective treatment for vitiligo. However, it requires frequent in-office visits. Self-administered home-based UVB (HBUVB) therapy with a handheld or panel device is an alternative that has received limited research attention. The purpose of this systematic review and meta-analysis is to evaluate the effectiveness and safety of HBUVB in the treatment of vitiligo compared to in-office UVB (IOUVB).Methods: Searches were conducted on Medline, Cochrane and Embase from inception until 4th of August, 2024. Studies with primary data of patients being treated with a hand-held UVB device were included in this study. Efficacy as measured in number of patients achieving > 50% or > 75% repigmentation was the primary study outcome. Secondary outcomes analyzed were cost, adverse events and adherence.Results: Eighteen studies were included with a total of 1341 vitiligo patients. Of these, four studies (148 HBUVB and 143 IOUVB) could be used for the meta-analysis. HBUVB was not inferior to IOUVB at achieving > 50% (OR 1.04, 95% CI 0.58-1.87) and > 75% repigmentation (OR 1.26, 95% CI 0.65-2.42). Home-based UVB was not associated with an increase in risk for either erythema or burning sensations when compared to IOUVB. There was a 14% lower rate of discontinuation amongst patients using HBUVB.Conclusions and significance/impact: Home-based UVB therapy is not inferior to in-office UVB therapy in efficacy or rate of adverse events and demonstrates favourable treatment adherence. This meta-analysis provides evidence supporting HBUVB as a safe and effective alternative to IOUVB in patients with vitiligo.Trial registration: PROSPERO registration number: (CRD42023478123).","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 2","pages":"e70079"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12972856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Efficacy of Local and Whole-Body Phototherapy for the Treatment of Various Types of Alopecia Areata". 评“局部与全身光疗治疗不同类型斑秃的疗效”。

IF 2.2 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-03-01 DOI: 10.1111/phpp.70074

Sijia Li, Liming Wu

引用次数: 0

Correction to "The Efficacy of UVA1 Phototherapy in Psoriasis: Clinical and Histological Aspects". 修正“UVA1光疗对银屑病的疗效：临床和组织学方面”。

IF 2.2 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-03-01 DOI: 10.1111/phpp.70083

引用次数: 0

Pulsed Dye Laser Versus Carboxytherapy for the Treatment of Stria Rubra: A Randomized Clinical and Histopathological Study. 脉冲染料激光与羧基疗法治疗红纹：一项随机临床和组织病理学研究。

IF 2.2 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-03-01 DOI: 10.1111/phpp.70080

Rana F Hilal, Aya Fahim, Amira Elbendary, Rawan Abumayyala

{"title":"Pulsed Dye Laser Versus Carboxytherapy for the Treatment of Stria Rubra: A Randomized Clinical and Histopathological Study.","authors":"Rana F Hilal, Aya Fahim, Amira Elbendary, Rawan Abumayyala","doi":"10.1111/phpp.70080","DOIUrl":"https://doi.org/10.1111/phpp.70080","url":null,"abstract":"Background: Pulsed Dye Laser (PDL) and carboxytherapy target the vascular component of Stria Rubra (SR), followed by a secondary rejuvenating effect.Objective: To compare the efficacy and safety of PDL and carboxytherapy for the treatment of SR.Materials & methods: Twenty patients with SR were included in this study. Each patient received PDL to one randomly selected SR side and carboxytherapy to the other randomly selected SR side. Clinical outcome assessment was done using number of striae and maximum stria width, Vancouver Scar scale (VSS), Erythema index (EI), and histopathological evaluation.Results: Significant improvement in VSS, EI, and histopathological scoring was found after treatment with each modality, whether PDL or carboxytherapy. Comparison between both modalities revealed a non-significant difference between PDL and carboxytherapy as regards VSS, EI, and histopathological scoring change. Histopathological analysis showed a significant increase of collagen and elastic fibres following PDL. Collagen fibres and perpendicular blood vessels increased significantly with carboxytherapy. PIH was encountered following PDL.Conclusion: Both PDL and carboxytherapy are effective for the treatment of SR. PDL is proposed to produce a better outcome as regards improving the texture of SR skin. The risk of pigmentation can be avoided by proper PDL dosage.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 2","pages":"e70080"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Tinted Sunscreens Protection Against Blue Light Using Transmittance Spectroscopy In Vitro Technique. 利用体外透射光谱技术评价有色防晒霜对蓝光的防护作用。

IF 2.2 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-03-01 DOI: 10.1111/phpp.70075

Hawasatu Dumbuya, Katharine Podimatis, Pearl Grimes

{"title":"Evaluation of Tinted Sunscreens Protection Against Blue Light Using Transmittance Spectroscopy In Vitro Technique.","authors":"Hawasatu Dumbuya, Katharine Podimatis, Pearl Grimes","doi":"10.1111/phpp.70075","DOIUrl":"https://doi.org/10.1111/phpp.70075","url":null,"abstract":"Background/purpose: Blue light component of visible light spectrum, between the wavelengths of 400-500 nm, specifically from 415 to 455 nm, known as high energy visible (HEV) light, has the greatest photobiological capability, including biological and cutaneous effects. Currently, there are no regulatory guidelines for assessing sunscreens protection against HEV. In this study, we evaluated the HEV-blocking potential of various tinted sunscreens after blue light irradiation using transmittance spectroscopy in vitro technique.Methods: We compared various commercialized tinted sunscreen formulations with SPF levels ranging from 30 to 50, varying UV filter systems, antioxidant types, and iron oxide (FeO) concentrations to account for different shades. HEV (415-455 nm) transmittance for each sunscreen applied on PMMA plates was measured using an OL756 spectroradiometer, before and after blue light irradiation (200 J/cm2) with solar simulator. The HEV-blocking potential percentage of each formulation was calculated before and after irradiation.Results: Overall, sunscreens formulated with FeO and both inorganic filters, zinc oxide and titanium dioxide, demonstrated higher HEV absorbance profiles and blocking potential than darker-tinted organic sunscreens or hybrid, where one inorganic UV filter was present. Consistent with prior reports, the HEV absorbance and blocking potential also correlated with the FeO levels.Conclusion: This study's findings suggest that depending on their formulations, commercialized tinted sunscreens exhibit different levels of blue light protection. Given the relative newness of tinted sunscreens, plus a lack of regulatory standards, there is a need for more research developing methods to measure protection efficacy of products against visible/blue light exposure.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 2","pages":"e70075"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Efficacy Study of 755 nm Picosecond Laser Combined With 595 nm Pulsed Dye Laser in the Treatment of Port-Wine Stain. 755 nm皮秒激光联合595 nm脉冲染料激光治疗葡萄色斑的临床疗效研究。

IF 2.2 4区医学

Photodermatology, photoimmunology & photomedicine Pub Date : 2026-03-01 DOI: 10.1111/phpp.70077

Jian Huang, Yu Zhang, Zhen Tang, Binping Luo, Lina Tan, Jianyun Lu, Yaping Xiang, Lihua Gao

{"title":"Clinical Efficacy Study of 755 nm Picosecond Laser Combined With 595 nm Pulsed Dye Laser in the Treatment of Port-Wine Stain.","authors":"Jian Huang, Yu Zhang, Zhen Tang, Binping Luo, Lina Tan, Jianyun Lu, Yaping Xiang, Lihua Gao","doi":"10.1111/phpp.70077","DOIUrl":"10.1111/phpp.70077","url":null,"abstract":"Background: Port-wine stain (PWS) is a disfiguring vascular anomaly characterized by persistent cutaneous erythema and progressive tissue hyperplasia. Although pulsed dye laser (PDL) is the first-line treatment and alleviates certain clinical manifestations, incomplete lesion clearance and high recurrence rates persist in some patients, posing significant therapeutic challenges.Objective: To evaluate the efficacy and safety of sequential therapy with a 755 nm picosecond laser (PSL) combined with 595 nm PDL versus 595 nm PDL alone in treating PWS.Methods: Thirty-four patients with PWS were enrolled. Lesions were randomly divided into paired subregions (PDL and PDL + PSL) using a subregional control design. Efficacy was assessed through objective and subjective measures: standardized clinical and dermoscopic images were used to quantify visual scores and clearance rates; reflectance confocal microscopy (RCM) quantitatively analyzed changes in vascular density and diameter; patient satisfaction and adverse reactions were also evaluated.Results: The PSL + PDL group showed significantly greater improvement in visual assessment scores, lesion area clearance, vascular density, vascular diameter, and patient satisfaction compared to the PDL group (all p < 0.05). While no statistically significant difference was observed in adverse event incidence rates between the two treatment modalities (p > 0.05), both regimens exhibited favorable safety profiles.Conclusion: The PSL + PDL regimen shows significantly superior efficacy over PDL alone, thus presenting a promising and advanced therapeutic alternative for PWS treatment.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 2","pages":"e70077"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0