Photodermatology, photoimmunology & photomedicine最新文献

{"title":"German Cohort Observational Study to Investigate the Short- and Long-Term Safety and Clinical Effectiveness of Afamelanotide 16 mg (SCENESSE) in Patients With Erythropoietic Protoporphyria (EPP).","authors":"Bernhard Homey, Kathrin Schelonke, Carla Marie Schlegel, Daniela Bruch-Gerharz, Karsten Weller, Lea Kiefer, Ulrich Stölzel, Petra Staubach-Renz, Joanna Wegner, Regine Keller-Melchior, Gillian Walker, Malgorzata Bochno, Pilar Bilbao","doi":"10.1111/phpp.13012","DOIUrl":"10.1111/phpp.13012","url":null,"abstract":"<p><strong>Background: </strong>Afamelanotide 16 mg (SCENESSE) is the first approved treatment for erythropoietic protoporphyria (EPP). EPP is a rare autosomal recessive inherited disorder of the haem biosynthesis pathway, where patients experience severe and debilitating acute phototoxicity. It affects at least one in 140,000 of the European population. A postauthorisation safety study (PASS) and a disease registry were imposed as conditions of the European marketing authorisation.</p><p><strong>Objectives: </strong>Evaluate the short- and long-term safety and clinical effectiveness of afamelanotide 16 mg in EPP patients enrolled in the PASS in Germany.</p><p><strong>Methods: </strong>The PASS (EUPAS13004) is an ongoing observational study collecting safety and effectiveness variables from treated and untreated EPP patients in the European EPP Disease Registry. Patients (n = 200, none untreated) received afamelanotide according to the summary of product characteristics. Treatment-emergent adverse events were collected as safety variables. Clinical effectiveness was assessed with the EPP-QoL tool and through treatment continuity.</p><p><strong>Results: </strong>The short- and long-term safety and benefit-risk profile of afamelanotide under real-world conditions is consistent with the positive safety profile seen in clinical trials. EPP patients reported a significant increase in QoL compared with baseline values (p < 0.0001) and 91.0% of patients who started treatment continue being treated. The safety profile of afamelanotide in patients over 70 years of age is consistent with the overall patient population.</p><p><strong>Conclusions: </strong>Afamelanotide treatment was highly effective and associated with a higher QoL in EPP patients. The study shows a positive safety profile of afamelanotide, with the treatment providing an ongoing clinical benefit.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 2","pages":"e13012"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Methyl Aminolevulinate-Based Photodynamic Therapy and Antibiotics in the Treatment of Mycobacterium gordonae Scalp Infection: A Case Report.","authors":"Beatriz Clemente-Hernández, Marcial Álvarez-Salafranca, Tamara Gracia-Cazaña, Itziar Muelas-Rives, Lucía Ferrando-Lamana, Jesús Viñuelas-Bayón, Yolanda Gilaberte","doi":"10.1111/phpp.70012","DOIUrl":"https://doi.org/10.1111/phpp.70012","url":null,"abstract":"","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 2","pages":"e70012"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photosensitizing Drugs and Risk of Skin Cancer in Women-A Prospective Population-Based Study.","authors":"Gustav Boelsgaard Christensen, Johan Kappelin, Jenny Sandgren, Kari Nielsen, Åsa Ingvar","doi":"10.1111/phpp.70013","DOIUrl":"10.1111/phpp.70013","url":null,"abstract":"<p><strong>Background: </strong>Several widely used drugs have photosensitizing properties, and much research has been conducted to find associations between their use and the risk of developing cutaneous malignant melanoma (cM), basal cell carcinoma (BCC) or cutaneous squamous cell carcinoma (cSCC), often with conflicting results.</p><p><strong>Objective: </strong>To assess whether the use of commonly prescribed photosensitizing drugs increases skin cancer risk.</p><p><strong>Methods: </strong>Analyses were performed using a large cohort of women, with prospectively collected information on phenotypic traits and sun exposure. Comprehensive information on pharmaceutical treatments and skin cancer occurrence was obtained through national registries. Drugs with photosensitizing properties were grouped according to the Anatomical Therapeutic Chemical system in nine groups, and associations between the use of such drugs were investigated using multivariable Cox regression analysis. The number of retrieved daily doses was analyzed to test the dose-response relationship.</p><p><strong>Results: </strong>Hormone replacement therapy significantly increased the risk of BCC (hazard ratio [HR] 1.24; 95% confidence interval [CI]: 1.11-1.39), cSCC (HR 1.23; 95% CI: 1.03-1.47) and cM (HR 1.31; 95% CI: 1.01-1.69), with estrogen driving this risk. There was a trend of increased risk of BCC and cM with higher doses of estrogen treatment. Subgroup analysis among those using diuretics showed that loop diuretics were associated with increased cSCC risk (HR 1.6; 95% CI: 1.3-2.0), including a positive association between risk and dose. Furthermore, increased risks of BCC (HR 1.25; 95% CI: 1.09-1.44) and cM (HR 1.41; 95% CI: 1.03-1.93) were associated with thiazide use. NSAIDs showed a possible curvilinear association to BCC and cSCC.</p><p><strong>Conclusions: </strong>Estrogen treatment increased the risk of all investigated skin cancers. Among those using diuretics, loop diuretics increased the risk of cSCC, and thiazide use increased the risk of BCC. We suggest that physicians should advise female patients prescribed estrogen, thiazides, or loop diuretics to limit their sun exposure.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 2","pages":"e70013"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Minimal Erythema Dose Between Affected and Unaffected Skin in Vitiligo Patients With Fitzpatrick Skin Phototypes III, IV, and V.","authors":"Hui Wenn Chin, Adawiyah Jamil, Madiha Muhamad Sarkan, Jyh Jong Tang","doi":"10.1111/phpp.70015","DOIUrl":"https://doi.org/10.1111/phpp.70015","url":null,"abstract":"<p><strong>Introduction: </strong>Vitiligo is a depigmenting autoimmune disease. This study aimed to determine the minimal erythema dose (MED) of vitiligo-affected skin and normal skin among patients with skin phototype III, IV, and V.</p><p><strong>Methods: </strong>A cross-sectional study was performed. MED was determined using a handheld device with wavelength of 311 nm. Vitiligo severity was measured using the Vitiligo Area Scoring Index (VASI) while disease activity was assessed by the Vitiligo Disease Activity (VIDA). Sun exposure was quantified by the Sun Exposure Index (SEI).</p><p><strong>Results: </strong>A total of 36 patients (mean age of 49.06 ± 21.29 years old) participated with 12 patients from each skin phototype. MEDs of skin affected by vitiligo were 255 ± 120.3, 280 ± 93.4, and 525 ± 226.1 mJ/cm² for phototypes III, IV, and V respectively. The MEDs of unaffected skin were 465 ± 120.3, 580 ± 123.6, and 1150 ± 116.8 mJ/cm² for phototypes III, IV, and V respectively. The MEDs for skin affected by vitiligo were 45%, 52%, and 54% less than the MEDs of unaffected skin for phototypes III, IV, and V respectively. The differences in MEDs between vitiligo-affected skin and unaffected skin were significant for all skin phototypes (p < 0.001). MED of skin with vitiligo negatively correlated with vitiligo severity, r = -0.426, p = 0.01. There were no significant correlations between MED and VIDA, disease duration, or SEI.</p><p><strong>Conclusion: </strong>MED of skin with vitiligo was much lower than unaffected skin, and MEDs between skin phototypes III, IV, and V differed despite similar depigmentation. MED was not influenced by vitiligo disease activity, duration, or sun exposure.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 2","pages":"e70015"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Dose UVA-1 Phototherapy Treatment for Hand Eczema: A Safety and Effective Treatment.","authors":"María Dolores Pegalajar-García, Francisco J Navarro-Triviño, Ángela Ayén-Rodríguez, Francisco J De la Torre-Gomar","doi":"10.1111/phpp.13018","DOIUrl":"https://doi.org/10.1111/phpp.13018","url":null,"abstract":"","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 1","pages":"e13018"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Photo-Induced Urticarial Vasculitis.","authors":"Anna Wolinska, Luke Oonan, Eoin Storan","doi":"10.1111/phpp.70002","DOIUrl":"https://doi.org/10.1111/phpp.70002","url":null,"abstract":"","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 1","pages":"e70002"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effect of Exosomes From Adipose Derived Stem Cells on Changes in GSH/ROS Levels During Skin Photoaging.","authors":"Yiping Wang, Xu Shen, Shenghua Song, Nian Chen, Yihao Wang, Wanxing Liao, Chiyu Jia, Li Zeng","doi":"10.1111/phpp.70009","DOIUrl":"https://doi.org/10.1111/phpp.70009","url":null,"abstract":"<p><strong>Objective: </strong>Exosomes (Exos) from adipose derived stem cells (ADSCs) can delay skin photoaging, but their effects on reactive oxygen species (ROS) remains unclear. This study aimed to investigate the relationship between adipose derived stem cell exosomes (ADSCs-Exos) in anti-photoaging of skin and glutathione (GSH)/ ROS expression in human fibroblasts.</p><p><strong>Methods: </strong>A skin photoaging model was established by irradiating human fibroblasts with ultraviolet B (UVB) light in vitro. Next, exosomes from ADSCs were isolated for treating the photoaged fibroblasts. Afterwards, the alterations in photoaged fibroblasts were analyzed by a series of assays including senescence-associated β-galactosidase (SA-β-Gal) staining, p16 expression, ROS staining, and GSH content.</p><p><strong>Results: </strong>After a human fibroblast photoaging model was subjected to ADSCs-Exos treatment, we found that the high concentration exosome group had the highest GSH content. Cellular staining showed that levels of SA-β-Gal, p16, and ROS of the high concentration-treated group were lower than other groups.</p><p><strong>Conclusions: </strong>ADSCs-Exos can protect skin fibroblasts from photoaging via increasing the ratio of GSH/ROS.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 1","pages":"e70009"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized Photoprotection: Expert Consensus and Recommendations From a Delphi Study Among Dermatologists.","authors":"Magdalena de Troya-Martín, Alba Rodríguez-Martínez, Francisco Rivas-Ruiz, Andras Subert, Maria-Ivonne Arellano-Mendoza, Piergiacomo Calzavara-Pinton, Maria Victoria de Gálvez, Yolanda Gilaberte, Chee-Leok Goh, Henry W Lim, Sergio Schalka, Peter Wolf, Salvador González","doi":"10.1111/phpp.70001","DOIUrl":"10.1111/phpp.70001","url":null,"abstract":"<p><strong>Background: </strong>Recommending comprehensive personalized photoprotection requires an accurate assessment of the patient's skin, including phototype, lifestyle, exposure conditions, environmental factors, and concomitant cutaneous conditions as well as deep knowledge of the available options: sunscreen ingredients (type of filters, spectrum coverage, sun protection factor, enhanced active ingredients), oral photoprotection, and other methods of sun protection and avoidance.</p><p><strong>Objectives: </strong>To establish consensus-based recommendations endorsed by an international panel of experts for personalized medical photoprotection recommendations that are applicable globally.</p><p><strong>Methods: </strong>A two-round Delphi study was designed to determine the degree of agreement and relevance of aspects related to personalized medical photoprotection. Items with ≥ 80% agreement and relevance were considered approved.</p><p><strong>Results: </strong>A list of 28 recommendations for personalized medical photoprotection was approved by a panel of dermatology professionals from seven different countries. Recommendations were categorized as: (1) updated perspectives in photoprotection, (2) clinical management, (3) skin cancer prevention, (4) dark skin phototypes and skin prone to hyperpigmentation, and (5) age and lifestyle.</p><p><strong>Conclusion: </strong>This study established recommendations for the implementation of personalized medical photoprotection worldwide, highlighting areas needing further scientific and clinical evidence.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 1","pages":"e70001"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Light and Laser Therapies on the Microecosystem of Sebaceous Glands in Acne Treatment.","authors":"Jiaoxiong Xu, Shengbo Huang, Zhengzheng Fu, Wen Zheng, Wanting Luo, Niangqiao Zhuang, Liuhong Liu, Renliang He, Fang Yang","doi":"10.1111/phpp.70005","DOIUrl":"10.1111/phpp.70005","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris (acne) is one of the most common skin diseases with complex pathogenesis. Numerous studies have shown that the microecosystem of sebaceous glands and Cutibacterium acnes play key roles in its pathogenesis. Antibiotics targeting C. acnes have been widely used in acne treatment, but the growing prevalence of antibiotic resistance has become alarming. Further research into the microecosystem of sebaceous glands and the role of specific C. acnes phylotypes in acne pathogenesis has led to a paradigm shift in acne treatment. Currently, non-antibiotic therapies such as light therapy and laser therapy are becoming increasingly popular, opening up new opportunities in acne management.</p><p><strong>Methods: </strong>Studies on the microecosystem of sebaceous glands associated with acne and the effects of light and laser therapies on the microecosystem in acne treatment were retrieved from the PubMed database.</p><p><strong>Results: </strong>Dysbiosis of the microecosystem of the pilosebaceous unit is closely related to the pathogenesis of acne. Light and laser therapies have an impact on the microecosystem of the pilosebaceous unit in acne treatment.</p><p><strong>Conclusions: </strong>Light and laser therapies are the popular alternative options in acne treatment. The mechanisms of their effect on the microecosystem of sebaceous glands are not completely clear and require further research, especially for laser therapy.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 1","pages":"e70005"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing in the Role of Low-Dose UV-A1 Phototherapy in the Treatment of Scleredema. Report on Three Cases and Literature Review.","authors":"Carlos Llamas-Segura, Francisco Javier De La Torre-Gomar, Marta Cebolla-Verdugo, Laura Linares-González, Ricardo Ruiz-Villaverde","doi":"10.1111/phpp.70004","DOIUrl":"https://doi.org/10.1111/phpp.70004","url":null,"abstract":"","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 1","pages":"e70004"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}