Photodermatology, photoimmunology & photomedicine最新文献

{"title":"Omalizumab Therapy Results in Defined Behavioural Changes and Improvements in Quality of Life in Solar Urticaria.","authors":"Donna Parkin, Elizabeth J Marjanovic, Mark D Farrar, Lesley E Rhodes, Kirsty J Rutter","doi":"10.1111/phpp.70088","DOIUrl":"10.1111/phpp.70088","url":null,"abstract":"<p><strong>Background: </strong>Solar urticaria is a rare photodermatosis in which exquisite photosensitivity can require extreme behavioural adaptations, resulting in a substantial impact on quality of life (QoL). Omalizumab therapy has been demonstrated to improve several clinical outcome measures, but the impact on behavioural measures is poorly understood. Our objectives were to examine daylight exposure behaviours and QoL measures pre- and post-omalizumab therapy.</p><p><strong>Methods: </strong>Daylight exposure diaries were completed by n = 5 patients with solar urticaria and n = 7 healthy participants during different seasons in England, UK (51.1-53.5^oN). These incorporated a range of measures, including time spent outdoors and clothing worn, and Dermatology Life Quality Index (DLQI) data were also collected.</p><p><strong>Results: </strong>Prior to omalizumab, patients spent less time outdoors in sunny vs. non-sunny conditions in spring (mean 10 vs. 29 min/day, p < 0.05) and less than healthy volunteers (44 min in sunny conditions/day). On omalizumab, patients increased their time outdoors in sunny conditions, reaching similar levels to healthy volunteers in spring (45 min/day) and further increasing to 85 min/day in summer. This was accompanied by fewer days with symptoms (symptoms on 75% days in spring pre-omalizumab vs. 26% days in summer on omalizumab), an apparent doubling of skin surface area exposure and substantial improvement in patients' QoL (mean past-year DLQI pre-omalizumab vs. past-week summer on omalizumab 22 vs. 5, p < 0.001).</p><p><strong>Conclusion: </strong>Omalizumab therapy was associated with behavioural changes that increase daylight exposure, accompanied by improved QoL. This study highlights the importance of considering a range of outcome measures in assessing response to therapy.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70088"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13068439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroa Vacciniforme Lymphoproliferative Disorder With a Truncating KLF2 Variant Presenting as Benign Photodermatoses.","authors":"John Warner-Levy, Angelia Ong, Nina Farquharson, Jean Ayer","doi":"10.1111/phpp.70096","DOIUrl":"10.1111/phpp.70096","url":null,"abstract":"","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70096"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Are the Histological Changes Corresponding to Clinical Effacement of Atrophic Acne Scars After Fractional Carbon Dioxide Laser Intervention-A Prospective Interventional Study in Skin of Color.","authors":"Abhinav Bansal, Kabir Sardana, Purnima Paliwal, Ananta Khurana, Savitha Sharath, Prisha Paliwal","doi":"10.1111/phpp.70086","DOIUrl":"10.1111/phpp.70086","url":null,"abstract":"<p><strong>Background: </strong>Pre-defined dose parameters of fractional carbon dioxide (Fr:CO₂) laser used for acne scars are not aligned with the histological depth achieved by the laser, which predicts scar improvement.</p><p><strong>Objectives: </strong>To evaluate the baseline histological depth and architecture of different acne scars and compare the histological changes and clinical improvement after Fr:CO₂ laser.</p><p><strong>Methods: </strong>We conducted a prospective study of atrophic acne scars-ice-pick, boxcar, or rolling. The patients were treated with three sessions of Fr:CO₂ laser with pre-determined dosimetry at 3-month intervals. Clinical evaluation was done at every visit using Echelle d'Evaluation clinique des Cicatrices d'acné (ECCA) scoring and individual atrophic acne scars count. Punch biopsy of predominant scars was taken pre- and 1-month post-treatment. The vertical depth of the scars was measured and histological changes in collagen and elastin were noted.</p><p><strong>Results: </strong>Forty-three patients with atrophic acne scars were included (27 boxcar, 9 ice-pick, and 7 rolling). Median histological depth of ice-pick, rolling and boxcar scars in pre-laser biopsies was 1606, 1546 and 1172 μm respectively, which significantly reduced to 1024 (p = 0.008), 858 (p = 0.018) and 746.5 μm (p < 0.0001) after the final laser session. Significant correlations were noted between acne scar reduction efficiency (ASRE%) and histological parameters at 7 months [ASRE% boxcar, increase in collagen grading (p < 0.05); ASRE% rolling, increased scar vascularization (p = 0.03) and ASRE% ice-pick, increased surrounding dermal elastin (p ≤ 0.05)].</p><p><strong>Conclusion: </strong>Fr:CO₂ laser intervention should be guided by scar-specific depth assessment, enabling optimal dosing and correlating this with histological changes would determine clinical improvement in acne scars.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70086"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of 590 Nm and 590/630 Nm Light-Emitting Diode Therapy for Sensitive Skin: A Prospective Randomized Controlled Trial.","authors":"Xuanxuan He, Muyang He, Xuchao Wang, Chengfeng Zhang, Shanglin Jin","doi":"10.1111/phpp.70090","DOIUrl":"10.1111/phpp.70090","url":null,"abstract":"<p><strong>Objectives: </strong>Sensitive skin (SS) is a prevalent condition characterized by exaggerated sensory responses to environmental stimuli. Emerging evidence suggests that light-emitting diode (LED) therapy may alleviate SS symptoms by modulating inflammation and enhancing skin barrier function. This study aimed to evaluate the efficacy and safety of 590 nm yellow LED monotherapy versus the combination of 590 nm and 630 nm red-yellow LED therapy in SS patients.</p><p><strong>Methods: </strong>A single-center, prospective, randomized controlled trial was conducted on 30 volunteers diagnosed with SS. Participants were randomized into three groups: Group A (control, emollient only), Group B (590 nm yellow light, 10 mW/cm², 11 min, thrice weekly), and Group C (590/630 nm dual light, 30 mW/cm², 10 min, thrice weekly). Outcomes were assessed using the Laurent Misery sensitive scale-10 (SS-10) questionnaire, Thinkview imaging, transepidermal water loss (TEWL), pH value, erythema index (EI), melanin index (MI), and lactic acid sting test (LAST). Participants were evaluated at baseline and at follow-up visits during Weeks 2, 4, and 8.</p><p><strong>Results: </strong>Both LED treatment groups showed significant improvements in SS-10 scores compared to the control (p = 0.0025 and p < 0.0001). The 590 nm LED yellow light treatment markedly reduced EI (p = 0.0282), MI (p = 0.0109), TEWL (p = 0.0479) and showed superior improvements in LAST (p = 0.0013) compared with control, while 590/630 nm LED irradiation reduced lactic acid sting scores significantly compared with control (p = 0.0239). No adverse events were reported.</p><p><strong>Conclusions: </strong>LED light therapy, particularly 590 nm yellow light, is a safe and effective modality for alleviating SS symptoms, with dual-wavelength therapy showing complementary benefits.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70090"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay of Skin Aging: Mitochondrial Stress and Ultraviolet Exposure.","authors":"Wanxing Liao, Yihao Wang, Yiping Wang, Junlin Liao, Nian Chen, Chiyu Jia, Li Zeng","doi":"10.1111/phpp.70089","DOIUrl":"10.1111/phpp.70089","url":null,"abstract":"<p><strong>Background: </strong>Skin photoaging, clinically characterized by wrinkles and hyperpigmentation, accounts for 80% of extrinsic aging. Chronic UV exposure drives this process via oxidative damage. However, its synergistic axis with mitochondrial dysfunction remains mechanistically elusive. This study aims to elucidate the mechanistic link between mitochondrial oxidative stress and UV-induced photoaging, focusing on reactive oxygen species overproduction as a central driver of cellular decline.</p><p><strong>Methods: </strong>Through integrative analysis of molecular pathways and experimental validation, we investigated mitochondrial dysfunction, ROS accumulation, and UV-induced damage in skin cells. Therapeutic interventions, including mitochondrial-targeted antioxidants (e.g., MitoQ) and protective agents, were tested to assess their efficacy in restoring mitochondrial integrity and mitigating oxidative stress.</p><p><strong>Results: </strong>UV radiation exacerbates mitochondrial dysfunction by inducing ROS overproduction, mtDNA mutations and membrane permeability alterations, creating a vicious cycle that accelerates skin aging. Conversely, mitochondrial oxidative stress amplifies UV-induced damage, promoting collagen degradation and apoptosis. Interventions targeting mitochondrial function, such as MitoQ and mesenchymal stem cell-derived exosomes, significantly reduced ROS levels, preserved membrane potential, and enhanced skin resilience. Notably, PINK1/Parkin-mediated mitophagy and STAT3/p53 pathways were identified as critical regulators of mitochondrial homeostasis during photoaging.</p><p><strong>Conclusion: </strong>This study clarifies the bidirectional relationship between mitochondrial stress and photoaging, highlighting ROS as a pivotal mediator. Restoring mitochondrial function via antioxidants or mitophagy enhancers offers actionable strategies to delay skin aging. These findings provide a foundation for novel anti-aging therapies with potential clinical and cosmetic applications.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70089"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Treatment Response in Granuloma Annulare.","authors":"Shir Toubiana, Ela Glazer Michael, Alina Lozinski, Felix Pavlotsky, Aviv Barzilai, Sharon Baum","doi":"10.1111/phpp.70093","DOIUrl":"10.1111/phpp.70093","url":null,"abstract":"<p><strong>Background/purpose: </strong>Granuloma annulare (GA) is a chronic inflammatory dermatosis with limited effective treatments and inconsistent response rates across modalities. The Goeckerman protocol, consisting of coal tar, phototherapy, and topical corticosteroids (TCS), has demonstrated robust efficacy in other inflammatory dermatoses but has not been systematically evaluated in GA. This study aimed to characterize treatment outcomes across multiple therapeutic approaches, including the Goeckerman protocol, and to explore clinical factors associated with treatment response.</p><p><strong>Methods: </strong>A retrospective cohort study was performed at Sheba Medical Center (2010-2024) including 240 patients with biopsy-confirmed GA. Treatment modalities included TCS, phototherapy, combination therapy, the Goeckerman protocol, and observation. Responses were dermatologist-assessed as complete, partial, or none. Multivariate logistic regression was used to examine factors associated with treatment response.</p><p><strong>Results: </strong>Among 240 patients (mean age 55.4 years; 77.5% female), 184 had follow-up data (median 3.0 months). The overall response rate was 58.2% (107/184). Response differed significantly by modality: Goeckerman protocol 93.5% (29/31), TCS + phototherapy 69.6% (16/23), TCS alone 56.3% (49/87), no active treatment 32.4% (12/37), and phototherapy alone 16.7% (1/6). In multivariate analysis, the Goeckerman protocol was the strongest factor associated with treatment response (odds ratio [OR] 32.52; 95% CI 7.45-233.64; p < 0.001), followed by combination therapy (OR 5.79; p = 0.006) and TCS (OR 2.82; p = 0.015). Hyperlipidemia was associated with response in univariate analysis but did not remain significant in the multivariable model.</p><p><strong>Conclusions: </strong>Treatment modality was the factor most strongly associated with treatment response in this cohort. The Goeckerman protocol demonstrated a notably high response rate compared with other commonly used therapies. Although these findings should be interpreted in the context of a retrospective design and potential selection bias, they suggest that intensive multimodal anti-inflammatory therapy may represent a promising treatment strategy for this challenging condition.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70093"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sunscreen Efficacy Against UVA1- And Visible Light-Induced Skin Pigmentation Is Influenced by Ancestry.","authors":"Florian Dimmers, Niklas Lück, Yimeng Wang, Christian Staerk, Tao Zhang, Jean Krutmann","doi":"10.1111/phpp.70094","DOIUrl":"10.1111/phpp.70094","url":null,"abstract":"<p><strong>Background: </strong>There is growing evidence that individuals with different skin phototypes require tailored approaches to achieve optimal photoprotection. Individuals with darker skin phototypes are more prone to UVA1- and visible light-induced pigmentation, whereas lighter phototypes are more susceptible to shorter wavelengths such as UVB and UVA2. Thus, skin phototype is an important determinant of sunscreen efficacy. In the present study, we have asked if ancestry-independent of phototype-is another factor affecting sunscreen efficacy.</p><p><strong>Objectives: </strong>(i) To determine the overall photoprotective effects of two sunscreen formulations against UVA1, visible light (VL), and combined visible light plus UVA1, and (ii) to compare the photoprotective efficacy of both products between Han Chinese participants and participants of European ancestry.</p><p><strong>Methods: </strong>Forty healthy volunteers (N = 20 Han Chinese; N = 20 of European ancestry), matched for phototype, constitutive pigmentation, gender, and age, were exposed to VL, UVA1, and combined VL plus UVA1 to induce pigmentation responses following standardized irradiation protocols. Skin responses across treated and untreated sites were analyzed using linear mixed-effects models.</p><p><strong>Results: </strong>Across all participants, both sunscreen formulations provided significant protection against VL, UVA1, and combined VL plus UVA1. Notably, photoprotective efficacy against UVA1-induced immediate (IPD) and persistent pigment darkening (PPD) differed significantly between individuals of different ancestries, with one formulation showing stronger protection in Han Chinese.</p><p><strong>Conclusion: </strong>This exploratory study indicates that sunscreen efficacy may differ across ancestries. Thus, sunscreens should not only be tailored to different phototypes but also need to consider ancestry-related factors.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70094"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Ultraviolet to Visible Light: Emerging Concepts in Comprehensive Photoprotection.","authors":"Hiba Mohammed, Indermeet Kohli, Henry W Lim","doi":"10.1111/phpp.70098","DOIUrl":"10.1111/phpp.70098","url":null,"abstract":"<p><strong>Background: </strong>Photoprotection has traditionally focused on ultraviolet (UV) radiation, particularly UVB and UVA. Recent evidence highlights the significant role of long-wavelength UVA1 (LW-UVA1, 370-400 nm) and visible light (VL; 400-700 nm) in inducing pigmentation, erythema, and photoaging. This review study summarizes recent advances in LW-UVA1 and VL photoprotection and discusses emerging UV-filter formulations, non-filtering protective ingredients (PINGs), personalized photoprotection, skin microbiome, and environmental considerations.</p><p><strong>Methods: </strong>A literature review was conducted using PubMed and Google Scholar online databases to identify recent studies on LW-UVA1 and VL-related photoprotection. Studies were screened for direct relevance to VL and LW-UVA1 and excluded if not available in English, lacked relevance, or had insufficient methodological detail. This review represents a narrative synthesis without formal systematic quality assessment. Results are summarized.</p><p><strong>Results: </strong>LW-UVA1 and VL exert synergistic effects on the skin, resulting in erythema and sustained pigmentation. Advances include tinted mineral sunscreens with expanding shade ranges, newer UV filters with broader coverage (e.g., Mexoryl 400, TriAsorB), and oral and topical PINGs to be used as potential adjuncts. Environmental concerns for currently used UV filters persist, however. Skin microbiome has also emerged as a target and potential source for novel photoprotective agents. Personalized photoprotection recommendations now provide an individualized approach, taking skin phototype, lifestyle, and risk profile into consideration.</p><p><strong>Conclusion: </strong>Photoprotection is expanding to include a broader-spectrum coverage, including LW-UVA1 and VL with new filters, formulations, and adjuncts. These innovations enhance UV protection, but environmental and long-term safety concerns highlight the need for continued research to ensure safe, effective, and inclusive photoprotection.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70098"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Measurement of UVA Protection Factor (ISO 24442:2011) Across 38 Different SPF 50 and SPF 50+ Sunscreens Reveals High Heterogeneity and Limitations in the Level of Protection.","authors":"Antony Young, Caroline Tricaud, Françoise Bernerd, Yipin Yuan, Pascale Renoux, Marion Sensenbrenner, Ann-Laure Demessant, Caroline Le Floc'h, Martin Josso, Philippe Andres","doi":"10.1111/phpp.70092","DOIUrl":"10.1111/phpp.70092","url":null,"abstract":"<p><strong>Background/purpose: </strong>The UVB and UVA components of terrestrial solar ultraviolet radiation (UVR) cause acute and chronic damage to skin. These adverse effects can be reduced by sunscreen application. The sun protection factor (SPF) is primarily a measure of UVB protection against erythema and does not quantify protection from UVA, which is the major component of solar UVR. The study aim was to assess UVA protection in relation to labelled SPF and to determine if this met the EU recommendation for a SPF/UVA-PF ratio of ≤ 3, as recommended by the EU. Unlike SPF assessment, there is no universal consensus for the determination and labelling of UVA-PF.</p><p><strong>Methods: </strong>Thirty-eight sunscreens with SPF ≥ 50 were selected from Europe, Latin America, Oceania, and Asia. UVA-PF was determined with the ISO 24442:2011 in vivo method, which assesses the ability of a sunscreen to inhibit persistent pigment darkening induced by UVA radiation in a laboratory environment.</p><p><strong>Results: </strong>There was variation of UVA-PF ranging from 3.6 to 46.6. Sixty-eight percent (26/38) of sunscreens complied with EU recommendations. Thus, about one third failed these standards, with SPF/UVA-PF ratios varying from 3.1 (borderline failure) to 16.7 (major failure). Failure to comply was observed in several products sold in Europe.</p><p><strong>Conclusion: </strong>The study demonstrates the limitations of many commercial sunscreens to reach EU standards, with significant variations in UVA protection and a lack of relationship between SPF and UVA-PF values. This highlights the importance of improving labelling standards to ensure consumers receive consistent and adequate UVA protection, especially for those with UVA-dependent photodermatoses.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT06068010.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70092"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultraviolet Radiations Impact on the Skin-Brain Axis: A Literature Review of our Current Knowledge.","authors":"Mariam Deriouich, Anne Dompmartin, Jean Matthieu L'Orphelin","doi":"10.1111/phpp.70097","DOIUrl":"10.1111/phpp.70097","url":null,"abstract":"<p><strong>Background: </strong>Sunlight is essential for vitamin D synthesis and contributes to mood regulation, but it is also a major risk factor for skin aging and carcinogenesis. While the cutaneous and immune effects of ultraviolet radiation are well documented, its potential impact on brain function remains poorly understood. This review aims to synthesize current evidence on the effects of ultraviolet exposure on the central nervous system, with a particular focus on photoimmunological mechanisms and skin-derived signaling pathways.</p><p><strong>Methods: </strong>We conducted a narrative review of experimental and clinical studies investigating the systemic and neurological consequences of UV exposure. Findings from photodermatology, immunology, neuroscience, and microbiome research were integrated to examine potential skin-brain interactions.</p><p><strong>Results: </strong>UV exposure induces systemic inflammatory responses and immunosuppression, alters the skin microbiome, and modulates circulating neuroactive mediators. These processes are associated with changes in neurotransmitter systems, neuroplasticity, and brain structure in both animal models and human studies. Emerging evidence supports the existence of indirect pathways linking UV-induced skin and immune responses to central nervous system function, including immune and microbiota-related mechanisms.</p><p><strong>Conclusion: </strong>Collectively, available data suggest that UV radiation may influence brain function indirectly through interconnected skin, immune, and microbiota pathways. As interest in balanced and \"healthy\" sun exposure increases, further interdisciplinary research is needed to clarify the neurological consequences of UV exposure and to assess its potential implications in photodermatology and photomedicine.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"42 3","pages":"e70097"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}