{"title":"发光二极管（LED）对炎症后红斑和色素沉着的治疗和预防作用：一项初步研究。","authors":"Yanjun Dan, Li Chen, Shanglin Jin, Jingtao Zhang, Yijian Zhu, Wenjuan Ma, Ziqi Liu, Jianfeng Luo, Chengfeng Zhang, Leihong Flora Xiang","doi":"10.1111/phpp.70003","DOIUrl":null,"url":null,"abstract":"<p><p>Background/Purpose Photobiomodulation (PBM) using light-emitting diodes (LEDs) benefits tissue regeneration and wound healing. However, evidence regarding the efficacy of LED for post-inflammatory erythema (PIE) and post-inflammatory hyperpigmentation (PIH) is limited. The aim of this study was to explore the effect of medical LED (830 nm and 590 nm) in the prevention and treatment of PIE and PIH. Methods The in vivo PIE/PIH model was simplified to erythema and pigmentation reaction after acute UVB exposure. 308 nm LED light (225 or 270 mJ/cm<sup>2</sup>) was induced in vivo in the PIE/PIH model on the thigh of ten healthy subjects. Every subject received therapeutic and preventive irradiation (n = 10 in each group). 830 nm (60 J/cm<sup>2</sup>) and 590 nm LEDs (20 J/cm<sup>2</sup>) were irradiated, respectively. For therapeutic irradiation, the PIE/PIH model was induced on D1, and LEDs were irradiated on D0, 1, 3, 6 and 8. For preventive irradiation, LEDs were irradiated on D0, 1, 3, 6, and 8 and the PIE/PIH model was induced on D9. Erythema index (EI), melanin index (MI), transdermal water loss (TEWL), and C-Cube photography were measured during 10-day follow-up visits. Results For therapeutic irradiation, ΔEI and ΔMI in the 830 nm treatment group were significantly lower than in the control group (ΔEI: 9.30 vs. 11.52, p = 0.027; ΔMI: 7.79 vs. 9.25, p = 0.026). No significant difference was found between the 590 nm treatment group and the control group in ΔEI or ∆MI (p > 0.05). For preventive irradiation, ΔEI in the 830 nm prevention group and the 590 nm prevention group were both significantly lower than the control group (830 nm: 9.85 vs. 19.90, p = 0.001; 590 nm: 12.50 vs. 19.90, p = 0.008). No significant difference was found between the two prevention LED groups (p > 0.05). Conclusions Both 830 nm and 590 nm LEDs showed preventive effects for PIE, and 830 nm LEDs could effectively improve PIE and PIH.</p>","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"41 2","pages":"e70003"},"PeriodicalIF":2.5000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Therapeutic and Preventive Effects of Light-Emitting Diode (LED) for Post-Inflammatory Erythema and Hyperpigmentation: A Pilot Study.\",\"authors\":\"Yanjun Dan, Li Chen, Shanglin Jin, Jingtao Zhang, Yijian Zhu, Wenjuan Ma, Ziqi Liu, Jianfeng Luo, Chengfeng Zhang, Leihong Flora Xiang\",\"doi\":\"10.1111/phpp.70003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Background/Purpose Photobiomodulation (PBM) using light-emitting diodes (LEDs) benefits tissue regeneration and wound healing. However, evidence regarding the efficacy of LED for post-inflammatory erythema (PIE) and post-inflammatory hyperpigmentation (PIH) is limited. The aim of this study was to explore the effect of medical LED (830 nm and 590 nm) in the prevention and treatment of PIE and PIH. Methods The in vivo PIE/PIH model was simplified to erythema and pigmentation reaction after acute UVB exposure. 308 nm LED light (225 or 270 mJ/cm<sup>2</sup>) was induced in vivo in the PIE/PIH model on the thigh of ten healthy subjects. Every subject received therapeutic and preventive irradiation (n = 10 in each group). 830 nm (60 J/cm<sup>2</sup>) and 590 nm LEDs (20 J/cm<sup>2</sup>) were irradiated, respectively. For therapeutic irradiation, the PIE/PIH model was induced on D1, and LEDs were irradiated on D0, 1, 3, 6 and 8. For preventive irradiation, LEDs were irradiated on D0, 1, 3, 6, and 8 and the PIE/PIH model was induced on D9. Erythema index (EI), melanin index (MI), transdermal water loss (TEWL), and C-Cube photography were measured during 10-day follow-up visits. Results For therapeutic irradiation, ΔEI and ΔMI in the 830 nm treatment group were significantly lower than in the control group (ΔEI: 9.30 vs. 11.52, p = 0.027; ΔMI: 7.79 vs. 9.25, p = 0.026). No significant difference was found between the 590 nm treatment group and the control group in ΔEI or ∆MI (p > 0.05). For preventive irradiation, ΔEI in the 830 nm prevention group and the 590 nm prevention group were both significantly lower than the control group (830 nm: 9.85 vs. 19.90, p = 0.001; 590 nm: 12.50 vs. 19.90, p = 0.008). No significant difference was found between the two prevention LED groups (p > 0.05). Conclusions Both 830 nm and 590 nm LEDs showed preventive effects for PIE, and 830 nm LEDs could effectively improve PIE and PIH.</p>\",\"PeriodicalId\":20123,\"journal\":{\"name\":\"Photodermatology, photoimmunology & photomedicine\",\"volume\":\"41 2\",\"pages\":\"e70003\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photodermatology, photoimmunology & photomedicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/phpp.70003\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodermatology, photoimmunology & photomedicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/phpp.70003","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景/目的利用发光二极管（led）进行光生物调节（PBM）有利于组织再生和伤口愈合。然而，关于LED对炎症后红斑（PIE）和炎症后色素沉着（PIH）的疗效的证据有限。本研究旨在探讨医用LED （830 nm和590 nm）在预防和治疗PIE和PIH中的作用。方法将体内PIE/PIH模型简化为急性UVB暴露后的红斑和色素沉着反应。采用308 nm(225或270 mJ/cm2) LED光诱导10例健康受试者大腿PIE/PIH模型。每个受试者接受治疗性和预防性照射（每组n = 10）。分别照射830 nm （60 J/cm2）和590 nm （20 J/cm2）的led。治疗性照射在D1处诱导PIE/PIH模型，在D0、1、3、6、8处照射led。预防照射，在D0、1、3、6、8处照射led，在D9处诱导PIE/PIH模型。在10天的随访中测量红斑指数（EI）、黑色素指数（MI）、透皮失水（TEWL）和C-Cube摄影。结果830 nm治疗组的ΔEI和ΔMI显著低于对照组(ΔEI: 9.30 vs. 11.52, p = 0.027；ΔMI: 7.79 vs. 9.25, p = 0.026)。590 nm治疗组ΔEI、∆MI与对照组比较差异无统计学意义（p < 0.05）。对于预防性照射，830 nm预防组和590 nm预防组的ΔEI均显著低于对照组(830 nm: 9.85 vs. 19.90, p = 0.001；590 nm: 12.50 vs. 19.90, p = 0.008)。预防组与预防组间差异无统计学意义（p < 0.05）。结论830 nm和590 nm led均有预防PIE的作用，830 nm led能有效改善PIE和PIH。
The Therapeutic and Preventive Effects of Light-Emitting Diode (LED) for Post-Inflammatory Erythema and Hyperpigmentation: A Pilot Study.
Background/Purpose Photobiomodulation (PBM) using light-emitting diodes (LEDs) benefits tissue regeneration and wound healing. However, evidence regarding the efficacy of LED for post-inflammatory erythema (PIE) and post-inflammatory hyperpigmentation (PIH) is limited. The aim of this study was to explore the effect of medical LED (830 nm and 590 nm) in the prevention and treatment of PIE and PIH. Methods The in vivo PIE/PIH model was simplified to erythema and pigmentation reaction after acute UVB exposure. 308 nm LED light (225 or 270 mJ/cm2) was induced in vivo in the PIE/PIH model on the thigh of ten healthy subjects. Every subject received therapeutic and preventive irradiation (n = 10 in each group). 830 nm (60 J/cm2) and 590 nm LEDs (20 J/cm2) were irradiated, respectively. For therapeutic irradiation, the PIE/PIH model was induced on D1, and LEDs were irradiated on D0, 1, 3, 6 and 8. For preventive irradiation, LEDs were irradiated on D0, 1, 3, 6, and 8 and the PIE/PIH model was induced on D9. Erythema index (EI), melanin index (MI), transdermal water loss (TEWL), and C-Cube photography were measured during 10-day follow-up visits. Results For therapeutic irradiation, ΔEI and ΔMI in the 830 nm treatment group were significantly lower than in the control group (ΔEI: 9.30 vs. 11.52, p = 0.027; ΔMI: 7.79 vs. 9.25, p = 0.026). No significant difference was found between the 590 nm treatment group and the control group in ΔEI or ∆MI (p > 0.05). For preventive irradiation, ΔEI in the 830 nm prevention group and the 590 nm prevention group were both significantly lower than the control group (830 nm: 9.85 vs. 19.90, p = 0.001; 590 nm: 12.50 vs. 19.90, p = 0.008). No significant difference was found between the two prevention LED groups (p > 0.05). Conclusions Both 830 nm and 590 nm LEDs showed preventive effects for PIE, and 830 nm LEDs could effectively improve PIE and PIH.
期刊介绍：
The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials.
Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.
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