Photodynamic Therapy With Liquid Crystal Loaded Methylene Blue in the Treatment of Verruca.

IF 2.5 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine Pub Date : 2025-05-01 DOI:10.1111/phpp.70023

Ghada F R Hassan, Yasmine S I El-Amawy, Gamal M El Maghraby, Amany M Abdel-Latif

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引用次数: 0

Abstract

Background: Verrucae (warts) are caused by human papilloma viruses. Photodynamic therapy (PDT) is a widely recommended option to treat warts.

Objectives: To assess the role of liquid crystal loaded methylene blue (MB) combined with intense pulsed light (IPL) in the treatment of verrucae.

Patients and methods: A total of 42 clinically and dermoscopically confirmed patients complaining of at least four cutaneous warts of various types were recruited in this clinical study. The lesions for the same patient were divided into 4 groups: Group (1) received topical 10% liquid crystal loaded MB, then was subjected to two passes of IPL with a 650 nm cutoff filter; Group (2) was subjected to two passes of IPL; and Group (3) received topical 10% liquid crystal loaded MB gel. They underwent four sessions at 2-week intervals. Group (4) was left with no treatment (control).

Results: Complete disappearance of warts was observed in 52.4%, 19%, and 4.8% in Group 1, 2, and 3, respectively, with no recurrence throughout the following 3 months. Regarding PDT-treated group, verruca plantaris showed the best result, followed by verruca plana, then verruca vulgaris. Comparing all groups, there was a statistically significant difference in which the PDT group showed the best result.

Conclusion: PDT using 10% liquid crystal loaded MB combined with IPL is an effective option in wart treatment with the best results in V. plantaris, followed by V. plana and V. vulgaris.

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液晶负载亚甲基蓝光动力疗法治疗疣状瘤。

背景：疣（疣）是由人乳头瘤病毒引起的。光动力疗法（PDT）是一种广泛推荐的治疗疣的选择。目的：探讨液晶负载亚甲基蓝（MB）联合强脉冲光（IPL）治疗疣状病变的疗效。患者和方法：本临床研究共招募了42例临床和皮肤镜下确诊的至少4种不同类型皮肤疣的患者。将同一患者的病变分为4组：组(1)外用10%液晶加载MB，然后用650 nm截止滤光片进行2次IPL；(2)组进行2次IPL；组(3)外用10%液晶负载MB凝胶。他们每隔两周接受四次治疗。组(4)不作任何处理（对照组）。结果：1、2、3组患者疣完全消失率分别为52.4%、19%、4.8%，术后3个月无复发。pdt治疗组以植物疣效果最好，其次为扁平疣，其次为寻常疣。各组比较，差异有统计学意义，其中PDT组效果最好。结论：10%液晶载MB PDT联合IPL是治疗疣的有效选择，以植物疣效果最好，其次为平疣和寻常疣。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodermatology, photoimmunology & photomedicine 医学-皮肤病学

CiteScore

4.40

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.