Phosphorus, Sulfur, and Silicon and the Related Elements最新文献_第8页

Novel 4H-pyrimido[2,1-b]benzothiazoles derivatives: Camphorsulphonic acid catalyzed enantioselective synthesis, optimization, and biological study 新型4H-嘧啶并[2,1-b]苯并噻唑衍生物：樟脑磺酸催化对映选择性合成、优化和生物学研究

IF 1.3 4区化学

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI: 10.1080/10426507.2023.2199994

Manoj N. Bhoi , Mayuri A. Borad , Ankita P. Solanki , Hitesh D. Patel

{"title":"Novel 4H-pyrimido[2,1-b]benzothiazoles derivatives: Camphorsulphonic acid catalyzed enantioselective synthesis, optimization, and biological study","authors":"Manoj N. Bhoi , Mayuri A. Borad , Ankita P. Solanki , Hitesh D. Patel","doi":"10.1080/10426507.2023.2199994","DOIUrl":"https://doi.org/10.1080/10426507.2023.2199994","url":null,"abstract":"<div>An efficient, highly convergent route for the synthesis of novel fourteen single isomer derivatives of ethyl-2-methyl-4-(pyridin-2-yl)-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxylate have been developed by one-pot, three-component reaction between pyridine 2-aldehyde, β-ketoester and various derivatives of 2-amino benzothiazole in the presence of D-(+)-10-camphorsulphonic acid (D-(+)-10-CSA) as an effective chiral acid catalyst. Under the optimized conditions with 20 mol% catalyst loading, a wide range of optically active 4H-pyrimido[2,1-b]benzothiazole derivatives were obtained in good yields (up to 82%) with good to excellent enantioselectivities (84-99%ee). Their structures were elucidated by various spectroscopic methods such as 1H-NMR, 13C-NMR, Chiral HPLC, mass and elemental analysis. The attractive feature of this approach is one-pot synthesis, good yield, environment benign, mild reaction condition, simple, efficient, excellent stereoselectivity, water soluble catalyst and easy workup. All the final scaffolds have been screened for antibacterial activity. Among them, 4a’, 4c’, 4d’, 4e’, 4f’, 4g’, 4j’,4m’ and 4n’ were proven to possess enhanced antibacterial properties as compared to the standard drug.</div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"198 10","pages":"Pages 822-835"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49729622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-pot synthesis of a new class of alkynyl anionic synthons: the 4-(2',2-trimethylsilylethynylphenoxymethyl)-2H-chromen-2-ones 一类新的炔基阴离子合成物:4-(2′，2-三甲基硅乙基苯氧甲基)- 2h -2-酮

IF 1.3 4区化学

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI: 10.1080/10426507.2022.2150851

G.B. Venkatesh , S. HariPrasad , A.S. Jeevan Chakravarthy

引用次数: 0

Synthesis, characterization, and quantum chemistry local chemical reactivity description of new phosphorylated derivatives of piperazine 新型哌嗪磷酸化衍生物的合成、表征和量子化学局部化学反应性描述

IF 1.3 4区化学

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI: 10.1080/10426507.2023.2193404

Stephany González-González , Marco Franco-Pérez , Christiaan Jardínez , Jorge Jairo Cariño-Moreno , María Guadalupe Ramírez-Sotelo , Angel Zamudio-Medina

{"title":"Synthesis, characterization, and quantum chemistry local chemical reactivity description of new phosphorylated derivatives of piperazine","authors":"Stephany González-González , Marco Franco-Pérez , Christiaan Jardínez , Jorge Jairo Cariño-Moreno , María Guadalupe Ramírez-Sotelo , Angel Zamudio-Medina","doi":"10.1080/10426507.2023.2193404","DOIUrl":"https://doi.org/10.1080/10426507.2023.2193404","url":null,"abstract":"<div>We report a fast, safe, and efficient procedure for the synthesis of phosphorylated derivatives of piperazines through a multicomponent reaction (MCR) strategy. Our key reagents were the piperazines 1-(2-methoxyphenyl) piperazine and 3-(4- (2-methoxyphenyl) piperazin-1-yl) propan-1-amine which reacted with five different phosphorous chlorides. A total of ten new derivatives were obtained, all confirmed by NMR spectroscopy (1H, 13C, and 31P) and mass spectrometry. Then, the reactivity profile of our new compounds was characterized through the new theoretical framework of the Local Electronic Temperature of Atoms in Molecules (LT-AIMs), from which we identified the most reactive sites of each of our derivatives. Furthermore, some of the quantities defined within this context were used to reproduce trends observed in our NMR records. A brief discussion about the advantages of performing a combined experimental and theoretical chemical characterization of recently synthesized compounds is also presented, particularly for those compounds with potential therapeutic features.</div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"198 8","pages":"Pages 693-703"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49712604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aromatic metamorphosis of thiophenes: replacing endocyclic sulfur with a different atom or group of atoms 噻吩的芳香变态:用不同的原子或原子团取代内环硫

IF 1.3 4区化学

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI: 10.1080/10426507.2023.2190978

Hideki Yorimitsu

引用次数: 0

Synthesis of aza-S(VI) motifs aza-S(VI)基序的合成

IF 1.3 4区化学

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI: 10.1080/10426507.2023.2175827

James A. Bull

引用次数: 0

Basal application of different sources of silicon fertilizers to enhance biochemical factors in sugarcane (Saccharum officinarum L.) 不同来源硅肥的基础施用提高甘蔗生化因子的研究

IF 1.3 4区化学

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI: 10.1080/10426507.2022.2145607

Veeran Sivakumar Indhumathi , Periyakaman Chandramani , Peyandi Paraman Mahendran , Jayachandran Jayaraj

{"title":"Basal application of different sources of silicon fertilizers to enhance biochemical factors in sugarcane (Saccharum officinarum L.)","authors":"Veeran Sivakumar Indhumathi , Periyakaman Chandramani , Peyandi Paraman Mahendran , Jayachandran Jayaraj","doi":"10.1080/10426507.2022.2145607","DOIUrl":"https://doi.org/10.1080/10426507.2022.2145607","url":null,"abstract":"<div>Four silicon sources viz., rice husk ash, bagasse ash, calcium silicate, sodium metasilicate each at the rate of 500 and 1000 kg/ha were incorporated as basal application in two sugarcane fields of Poovanthi and Silaiman village of Sivagangai and Madurai district respectively. Leaves from the silicon treated plants were collected at 90,180 and 270 d after planting for analysis of biochemical factors which revealed that the silicon content in the Poovanthi village was ranged from 1.18 to 1.77% and that of Silaiman village was 1.28 to 1.78%. Similarly phenol content ranged from 7.68 to 10.33 mg/g and 10.49 to 12.85 mg/g, tannin content ranged from 4.21 to 6.32 and 4.70 to 7.03 mg/g, peroxidase activity ranged from 32.18 to 38.60 and 38.07 to 44.38 Δ460/min/mg and phenylalanine ammonia lyase activity ranged from 29.93 to 36.85 and 36.31 to 44.48 Δ290/µmol m−1mL−1g−1 in the fields of Poovanthi and Silaiman village respectively. Among the four sources of silicon fertilizers tested, basal application of calcium silicate at 500 kg/ha was found effective in facilitating the maximum accumulation of silicon content along with phenol, tannin content, peroxidase and phenylalanine ammonia lyase activity.</div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"198 4","pages":"Pages 311-320"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49700535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ratiometric H2S probe that can be recognized by the naked eye and its application in cell imaging 肉眼可识别的比率H2S探针及其在细胞成像中的应用

IF 1.3 4区化学

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI: 10.1080/10426507.2023.2199995

Fangfang Luo , Le Wang , Xiao Zhang , Ping Xu , Xiao Wang , Yi Qu

引用次数: 0

Direct synthesis of γ,γ-diketophosphonates from pentacovalent 1,2λ5-oxaphosphorane 由五价1,2λ5-磷烷直接合成γ，γ-二酮膦酸盐

IF 1.3 4区化学

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI: 10.1080/10426507.2023.2198713

Tae Woo Kim , Chung-Min Park , Kang-Yeoun Jung

引用次数: 0

Synthesis and antiproliferative evaluation of novel 1,3,4-thiadiazole-S-alkyl derivatives based on quinazolinone 新型喹唑啉酮类1,3,4-噻二唑- s -烷基衍生物的合成及抗增殖性评价

IF 1.3 4区化学

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI: 10.1080/10426507.2023.2176500

Yanle Men , Zijian Li , Hongying Wang , Yuming Liu , Xuguang Liu , Baoquan Chen

{"title":"Synthesis and antiproliferative evaluation of novel 1,3,4-thiadiazole-S-alkyl derivatives based on quinazolinone","authors":"Yanle Men , Zijian Li , Hongying Wang , Yuming Liu , Xuguang Liu , Baoquan Chen","doi":"10.1080/10426507.2023.2176500","DOIUrl":"https://doi.org/10.1080/10426507.2023.2176500","url":null,"abstract":"<div>Thirty-five novel 1,3,4-thiadiazole-S-alkyl derivatives based on quinazolinone have been designed and synthesized. The structures of the target compounds 5a − 5p and 6a − 6s were confirmed by their IR, 1H NMR, 13C NMR, HR-ESI-MS spectroscopic data. This study detected their cytotoxicity for mouse fibroblast (normal cells, L929) and their in vitro antiproliferative activities against human cancer cell lines (Hela, MCF-7 and A549) by using CCK-8 assay. The results of all the tested compounds 5a − 5p and 6a − 6s showed that the growth and reproduction of cells were impeded to a certain extent. Compared with the reference drug 5-FU, some compounds even showed better proliferation inhibition against various cancer cells. Among these, most of the compounds had relatively less cytotoxicity to L929 cells. 6-Chloro-2-(2-(benzylthio)-1,3,4-thiadiazol-5-yl)-quinazolin-4(3H)-one (6a) gave expression to the strongest inhibitory activity on Hela cells with IC50 value of 1.40 µM. 6-Chloro-2-[2-(4-trifluoromethylbenzylthio)-1,3,4-thiadiazol-5-yl]-quinazolin-4(3H)-one (6s) displayed high antitumor activities against MCF-7 cells with IC50 values of 3.01 µM. 2-[2-(Benzylthio)-1,3,4-thiadiazol-5-yl]-quinazolin-4(3H)-one (5a) revealed excellent antitumor activities against A549 cells with IC50 values of 2.21 µM.</div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"198 7","pages":"Pages 591-601"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49728039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfur chemistry in action. New perspectives for organic synthesis 硫化学的作用。有机合成的新前景

IF 1.3 4区化学

Phosphorus, Sulfur, and Silicon and the Related Elements Pub Date : 2023-01-01 DOI: 10.1080/10426507.2023.2173755

Samir Z. Zard

引用次数: 0