Phosphorus, Sulfur, and Silicon and the Related Elements最新文献

{"title":"Design, synthesis, and antifungal activity of novel sulfone derivatives incorporating 1,3,4-oxadiazole and pyrimidine moieties","authors":"Tao Wang (Funding acquisition Methodology Project administration Writing – original draft Writing – review & editing) ,&nbsp;Lingling Xiao (Data curation Methodology) ,&nbsp;Yanling Ren (Data curation Methodology) ,&nbsp;Shoumei Wang (Data curation Methodology) ,&nbsp;Haiyan Wang (Data curation Methodology) ,&nbsp;Lu Yu (Conceptualization Data curation Methodology Software Writing – review & editing) ,&nbsp;Pei Li (Methodology Project administration Writing – original draft Writing – review & editing)","doi":"10.1080/10426507.2025.2517262","DOIUrl":"10.1080/10426507.2025.2517262","url":null,"abstract":"<div><div>In this study, a series of novel sulfone derivatives incorporating 1,3,4-oxadiazole and pyrimidine moieties were synthesized and confirmed their structures by ¹H NMR,¹³C NMR, and HRMS. Their <em>in vitro</em> antifungal activities of the target compounds against <em>Dothiorella gregaria</em> (<em>D. gregaria</em>), <em>Diaporthe phaseolorum</em> (<em>D. phaseolorum</em>), <em>Daldinia childiae</em> (<em>D. childiae</em>), <em>Colletotrichum godetiae</em> (<em>C. godetiae</em>), <em>Fusarium tricinctum</em> (<em>F. tricinctum</em>), <em>Neofusicoccum parvum</em> (<em>N. parvum</em>), <em>Botryosphaeria dothidea</em> (<em>B. dothidea</em>), and <em>Epicoccum sorghinum</em> (<em>E. sorghinum</em>) at 100 and 50 µg/mL were determined by the mycelium growth rate method. The bioassay results demonstrate that the target compounds exhibit comparatively lower antifungal activities against the eight plant pathogenic fungi in comparison to imazalil sulfate. To the best of our knowledge, this study presents the first report on the synthesis and antifungal activity evaluation of sulfone derivatives incorporating 1,3,4-oxadiazole and pyrimidine moieties.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 7","pages":"Pages 565-568"},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulse laser deposition prepared tin(IV) oxide thin films: effects of gamma radiation doses on their structural and optical characteristics","authors":"Noha H. Harb (Conceptualization) ,&nbsp;Hiba Al-Hameed (Investigation) ,&nbsp;Baydaa Taher Sih (Supervision) ,&nbsp;Falah A-H. Mutlak (Writing – original draft Writing – review & editing)","doi":"10.1080/10426507.2025.2519510","DOIUrl":"10.1080/10426507.2025.2519510","url":null,"abstract":"<div><div>This work studied the effects of gamma radiation on the structural and optical properties of SnO₂ thin films in a dose-dependent manner. The microstructural change was confirmed by peak shifting, peak broadening, and changes in grain size with an increase in radiation dose, as observed from X-ray diffraction analysis. Changes in the intensity of photoluminescence spectra and optical properties are due to radiation-induced defect states. The obtained results indicate that gamma irradiation can be used to tailor the characteristics of SnO₂ for various applications. In contrast to previous works, this study quantitatively connects radiation dose to structural and optical transformations, thereby addressing the fundamental mechanisms of defect formation.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 7","pages":"Pages 578-587"},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of silixol on crop productivity and soil health enhancement in black gram (Vigna mungo L.) for sustainable agriculture","authors":"P. Murali Arthanari (Conceptualization Investigation) ,&nbsp;M. Sakila (Formal analysis) ,&nbsp;K. G. Anitha (Visualization) ,&nbsp;R. Arockia Infant Paul (Methodology) ,&nbsp;R. Sathya Priya (Writing – review & editing) ,&nbsp;N. Jagathjothi (Writing – review & editing) ,&nbsp; M. Yuvaraj (Writing – original draft) ,&nbsp;P Panneerselvam (Writing – original draft) ,&nbsp;R. Sharmila (Writing – review & editing)","doi":"10.1080/10426507.2025.2523958","DOIUrl":"10.1080/10426507.2025.2523958","url":null,"abstract":"<div><div>The decline in black gram yield was primarily linked to rainfed crops, poor nutrient management, inadequate assimilate partitioning, flower dropping, poor pod setting, and physiological issues. Fertilizers with foliar spray at the reproductive stage in pulse could aid it by directly delivering the nutrients to the site of food synthesis, resulting in a faster food supply and improved crop performance. The trials were conducted to assess the efficacy of silixol on black gram growth and yield as well as soil health. Treatments including 50% RDF combined with vermicompost (VC), silixol granules soil application (SA), and silixol foliar spray (FS) are examined in the RCBD with three replications. Results revealed that 50% RDF + VC at 2.5 t/ha + silixol granules (SA) at 20 kg/ha + silixol (FS) at 1% on 40 DAS showed significant improvement in plant height (67.5 cm), DMP (1959 kg/ha), LAI (2.24), chlorophyll content (94.95 SPAD value) on 60 DAS, root nodules (667 Nos/plant) and grain yield (849 kg/ha) with 61% increase over RDF alone. Similarly, an increase in the soil microbial biomass carbon, dehydrogenase activity, and microbial population by 16.0%, 59.6% and 31.8%, respectively were by applying silixol granules with foliar spray in combination with integrated fertilization over control.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 7","pages":"Pages 596-611"},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study on early and late-stage crystallization of urea phosphate from untreated Moroccan phosphoric acid","authors":"Ayoub Cherrat (Conceptualization Data curation Formal analysis Funding acquisition Investigation Methodology Project administration Resources Software Supervision Validation Visualization Writing – original draft Writing – review & editing) ,&nbsp;Yassine Ennaciri (Formal analysis) ,&nbsp;Aziz Azifa (Formal analysis) ,&nbsp;El Mostafa Erradi (Formal analysis) ,&nbsp;Boujemaa Drif (Formal analysis) ,&nbsp;Mohamed Oubaouz (Formal analysis) ,&nbsp;Niraka Blaise (Formal analysis) ,&nbsp;Hicham El Ossmani (Formal analysis) ,&nbsp;Najoua Labjar (Methodology Resources) ,&nbsp;H. El Alaoui-Belghiti (Software) ,&nbsp;Souad El Hajjaji (Validation Visualization) ,&nbsp;Mohammed Bettach (Methodology Validation Visualization)","doi":"10.1080/10426507.2025.2517258","DOIUrl":"10.1080/10426507.2025.2517258","url":null,"abstract":"<div><div>Morocco is one of the world’s leading phosphate producers, converting its phosphate reserves into phosphoric acid, which is further used to produce urea phosphate. Urea phosphate is a valuable source of nitrogen and phosphorus for plant growth. However, phosphoric acid purification in Morocco is crucial to ensure high-quality urea phosphate production. In this study, we synthesized urea phosphate <em>via</em> an exothermic reaction of urea and phosphoric acid under optimized conditions for 90 min. Crystals began to form after 60 min, and the final sample was taken after 90 min. Elemental and morphological analyses confirmed the high purity of the synthesized urea phosphate crystals. XRD and FT-IR analyses verified the crystalline phase and elemental composition, focusing on nitrogen (N) and phosphorus (P₂O₅), important nutrients for crops. SEM and microscopy further demonstrated the excellent quality of the final product. Our results suggest that untreated Moroccan phosphoric acid can be effectively used to produce pure urea phosphate crystals, thus providing an effective solution for improving agricultural productivity.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 7","pages":"Pages 552-564"},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, X-ray crystal structure and antibacterial activity of ferulic acid derivatives bearing sulfonamide moiety","authors":"Song Bai (Conceptualization Funding acquisition Investigation Resources Supervision Writing – review & editing) ,&nbsp;Suran Wan (Conceptualization Funding acquisition Investigation Methodology Resources Writing – original draft Writing – review & editing) ,&nbsp;Rong Wu (Conceptualization Investigation Methodology Resources) ,&nbsp;Miao Li (Conceptualization Data curation Investigation Methodology) ,&nbsp;Fang Wang (Conceptualization Investigation Methodology) ,&nbsp;Shouying Tang (Conceptualization Investigation Methodology) ,&nbsp;Lijun Chen (Conceptualization Data curation Investigation Project administration) ,&nbsp;Xian Wei (Conceptualization Investigation) ,&nbsp;Shuang Feng (Conceptualization Investigation) ,&nbsp;Miaohe Zhang (Conceptualization Investigation)","doi":"10.1080/10426507.2025.2517257","DOIUrl":"10.1080/10426507.2025.2517257","url":null,"abstract":"<div><div>A total of 28 new ferulic acid derivatives bearing the sulfonamide moiety were designed and synthesized, followed by an evaluation of their antibacterial activities. The structures of the synthesized compounds (<strong>B1 − B28</strong>) were fully characterized using ¹H NMR,¹³C NMR, and HRMS techniques. Among them, the structure of compound <strong>B11</strong> was further elucidated through X-ray single-crystal diffraction analyses. Bioassay results indicated that several target compounds exhibited significant inhibitory activity against the tested plant pathogens <em>in vitro</em>. Notably, compound <strong>B28</strong> demonstrated the highest resistance to <em>Xanthomonas oryzae</em> pv. <em>oryzicola</em> (<em>Xoc</em>), with an EC₅₀ (half-maximal effective concentration) value of 28.6 <em>μ</em>g/mL, which was more than twice as effective as the control agents zinc thiazole (EC₅₀ = 74.4 <em>μ</em>g/mL) and thiodiazole copper (EC₅₀ = 97.1 <em>μ</em>g/mL). Mechanistic studies revealed that <strong>B28</strong> enhances bacterial membrane permeability and disrupts cell morphology. This work highlights promising candidates for agricultural antibacterial applications.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 7","pages":"Pages 569-577"},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of replacing SiO2 with Sb2O3, Bi2O3, and Fe2O3 on the radiation shielding properties of lead sodium aluminum silicate glass","authors":"Tarek Mohamed Fayez Ahmed ,&nbsp;Sameh Ahmed Said Negem ,&nbsp;Wesam Ahmed Mohamed Zeyara ,&nbsp;Emhemmad Jumha Emhemmad ,&nbsp;Abdelkhader Ali Abobaker Omar","doi":"10.1080/10426507.2025.2524191","DOIUrl":"10.1080/10426507.2025.2524191","url":null,"abstract":"<div><div>In this research, the radiation shielding coefficients for gamma rays were studied resulting from the addition of iron oxide (Fe₂O₃), antimony oxide (Sb₂O₃), and bismuth oxide (Bi₂O₃) to lead sodium aluminum silicate glass using the PHY-X/PSD simulation program at different energies (0.248, 0.347, 0.662, 0.826, 1.17, 1.33, 2.51 MeV) for four experimental compositions according to weight ratios: S1: 60 Pb₃O₄ − 32 SiO₂ − 3 Al₂O₃ − 5 Na₂SO₄, S2: 60 Pb₃O₄ − 29 SiO₂ − 3 Fe₂O₃ − 3 Al₂O₃ − 5 Na₂SO₄, S3: 60 Pb₃O₄ − 29 SiO₂ − 3 Sb₂O₃ − 3 Al₂O₃ −5 Na₂SO₄, S4: 60 Pb₃O₄ − 29 SiO₂ − 3 Bi₂O₃ − 3 Al₂O₃ − 5 Na₂SO₄. The results of PHY-X/PSD showed that sample S4 containing bismuth oxide had the best attenuation coefficients at all energies as compared to the other samples, followed by samples S2 and S3 containing iron oxide and antimony oxide, respectively, with approximately the same values of radiation shielding coefficients, and finally sample S1 without additives came. The X-COM results also showed that the photoelectric effect was effective at low energies, represented by the two values 0.248 and 0.347 MeV, while the Compton effect works strongly at medium energies, represented by the values of 0.662, 0.826, and 1.17 MeV, while the effect of pair production begins to appear at approximately 1.33 MeV, and its effect continues to increase as the energy value increases.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 7","pages":"Pages 588-595"},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper-catalyzed synthesis of isoindigoes and isatins from diazo(nitro)acetanilides","authors":"Xuan Ke (Data curation Formal analysis Investigation Methodology Validation Visualization Writing – original draft) ,&nbsp;Chuangchuang Xu (Data curation Formal analysis Investigation Methodology) ,&nbsp;Jiaxi Xu (Conceptualization Data curation Funding acquisition Investigation Methodology Resources Supervision Validation Visualization Writing – original draft Writing – review & editing)","doi":"10.1080/10426507.2025.2515872","DOIUrl":"10.1080/10426507.2025.2515872","url":null,"abstract":"<div><div><em>N</em>-Alkyldiazo(nitro)acetanilides generate both isoindigoes and isatins under the catalysis of Cu(MeCN)₄PF₆ in most cases and show obvious steric effect of both <em>N</em>-alkyl groups and substituents on anilines. Diazo(nitro)acetanilides with less bulky substituents generally favor formation of isoindigoes, while although those with more steric substituents generally disfavor the generation of isoindigoes, the yields of the corresponding isatins do not increase. The copper-catalyzed reaction of <em>N</em>-alkyldiazonitroacetanilides exhibits different chemoselectivity from other diazoacetanilides with α-electron-withdrawing substituents. The reactions were performed under both thermal and photo irradiation conditions, showing similar results.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 7","pages":"Pages 539-551"},"PeriodicalIF":1.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An efficient one pot synthesis of 6-(benzyloxy)-5-(2-(2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl)thiazol-4-yl)quinolin-2(1H)-ones","authors":"Manohar D. Suryawanshi (Conceptualization Resources Writing – original draft Writing – review & editing) ,&nbsp;Nitin M. Thorat (Methodology) ,&nbsp;Vilas A. Sudrik (Investigation) ,&nbsp;Ganesh D. Suryawanshi (Conceptualization Methodology) ,&nbsp;Pravin C. Mhaske (Project administration Supervision) ,&nbsp;Shamrao P. Lawande (Supervision)","doi":"10.1080/10426507.2025.2507021","DOIUrl":"10.1080/10426507.2025.2507021","url":null,"abstract":"<div><div>Synthesis of multiheterocyclic compounds enhances the bioactivity of core moieties. The number of heteroatoms present in the molecule provides good binding nature as well as lyophilic nature. New and efficient method has been developed for one-pot synthesis of 6-(benzyloxy)-5-(2-(2-((3-aryl-1-phenyl-1<em>H</em>-pyrazol-4-yl)methylene)hydrazinyl)-thiazol-4-yl)quinolin-2(1<em>H</em>)-one derivatives. The reaction between 3-aryl-1-phenyl-1<em>H</em>-pyrazole-4-carbaldehyde and thiosemicarbazide followed by cyclocondensation reaction with 6-benzyloxy-5-(2-bromo-acetyl)-1<em>H</em>-quinolin-2-one in ethanol under microwave or ultra-sonication condition affords the desired compounds. The described method of synthesis is time saving and contains efficient protocols.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 6","pages":"Pages 489-498"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response surface analyzing the leaching process and crystallization process in the preparation of phosphate concentrate and Ca(H2PO4)2 ∙ H2O from phosphate tailing","authors":"Lu Yin (Conceptualization Data curation Formal analysis Investigation Methodology Resources Software Validation Visualization Writing – original draft) ,&nbsp;Shengyang Ding (Supervision) ,&nbsp;Tao Zhang (Supervision) ,&nbsp;Li Lv (Supervision) ,&nbsp;Wenxiang Tang (Supervision) ,&nbsp;Yubao Liu (Supervision) ,&nbsp;Shengwei Tang (Funding acquisition Project administration Supervision Writing – review & editing)","doi":"10.1080/10426507.2025.2507020","DOIUrl":"10.1080/10426507.2025.2507020","url":null,"abstract":"<div><div>Phosphate tailings, a solid waste generated during phosphate processing, pose environmental pollution risks. Phosphate concentrate and dicalcium phosphate monohydrate Ca(H₂PO₄)₂ · H₂O were successfully prepared from phosphate tailings through a selective leaching of dilute H₃PO₄ solution followed by evaporation, concentration, and cooling crystallization. The process conditions were optimized using the response surface methodology (RSM). Reaction temperature was identified as the most significant factor during acid leaching. Raising temperatures increased the phosphate grade of the residue. Leaching conditions were optimized as 16 P₂O₅ wt% H₃PO₄ concentration, 75 °C, and 30 min. Under these conditions, the P₂O₅ content of the concentrate reached 27.1%. During crystallization, the seed dosage was the key factor affecting the yield. Increasing the seed dosage significantly improved crystallization yield. Under optimal conditions, the yield of Ca(H₂PO₄)₂ · H₂O was 22.7%.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 6","pages":"Pages 515-527"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel aroylthioureas against Mycobacterium tuberculosis","authors":"Emine Kutlu (Conceptualization Investigation Methodology Writing – original draft) ,&nbsp;Fatih Mehmet Emen (Conceptualization Data curation Formal analysis Funding acquisition Investigation Methodology Project administration Supervision Writing – original draft Writing – review & editing) ,&nbsp;Muhammad Asim Ali (Conceptualization Formal analysis Investigation Methodology) ,&nbsp;Ali Ihsan Karacolak (Conceptualization Formal analysis Investigation Methodology) ,&nbsp;Tuncay Yesilkaynak (Conceptualization Formal analysis Investigation Methodology Writing – original draft) ,&nbsp;Kübra Yıldırım (Conceptualization Formal analysis Investigation Methodology) ,&nbsp;Cemilenur Ataş (Conceptualization Formal analysis Investigation Methodology) ,&nbsp;Ece Şimşek (Conceptualization Formal analysis Investigation Methodology) ,&nbsp;Ahmet Yılmaz Çoban (Conceptualization Formal analysis Investigation Methodology Writing – original draft Writing – review & editing)","doi":"10.1080/10426507.2025.2509703","DOIUrl":"10.1080/10426507.2025.2509703","url":null,"abstract":"<div><div>In this study, <em>N</em>-([1,1′-biphenyl]-2-ylcarbamothioyl)-2-chlorobenzamide (L¹), <em>N</em>-([1,1′-biphenyl]-2-ylcarbamothioyl)furan-2-carboxamide (L²), <em>N</em>-((5-chloropyridin-2-yl)carbamothioyl)thiophene-2-carboxamide (L³) were synthesized and their structural characterizations were performed with FT-IR,¹H-NMR and ¹³C-NMR techniques. The crystal structure analysis of L³ was performed by single crystal X-ray diffraction method. Hirshfeld surface analyses and HOMO–LUMO energy level analyses were carried out for the L¹ and L³. The HOMO energies were calculated to be −0.21010 and −0.25281 eV, and the LUMO energies were −0.07204 and −0.17947 eV. Ionization and electron affinity values were also calculated. Newly synthesized thiourea derivatives were evaluated by nitrate reduction assay for anti-tuberculosis activity against 5 ATCC reference strains and 3 isolates of <em>Mycobacterium tuberculosis</em> with different resistance profiles. Among the synthesized derivatives, L³ did not show any anti-TB activity, while L¹ showed only low activity against ATCC 35837. Only the L² compound showed potent anti-TB activity against all <em>M. tuberculosis strains</em> tested. The L² compound has the potential to be a promising active agent against drug-resistant <em>M. tuberculosis</em>.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 6","pages":"Pages 528-537"},"PeriodicalIF":1.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}