Phosphorus, Sulfur, and Silicon and the Related Elements最新文献

{"title":"Exploring the anticancer potential of thienoquinoline derivatives: a comprehensive review","authors":"Bhargav B. Dave (Conceptualization Investigation Software Visualization Writing – original draft) ,&nbsp;Tarun P. Patel (Software) ,&nbsp;Megha A. Patel (Software Writing – review & editing) ,&nbsp;Paresh S. Patel (Writing – original draft Writing – review & editing)","doi":"10.1080/10426507.2025.2611022","DOIUrl":"10.1080/10426507.2025.2611022","url":null,"abstract":"<div><div>Heterocyclic scaffolds represent crucial frameworks in modern drug development owing to their wide range of biological effects. Among these, quinoline derivatives exhibit notable antibacterial, anti-inflammatory, antimalarial, and anticancer activities. Thienoquinoline, a fused analogue of quinoline, has recently emerged as a promising structure with significant <em>antiproliferative</em> potential. Research findings suggest that these compounds can modulate vital molecular pathways responsible for cancer progression and cell survival. This review highlights current insights into the biological evaluation and significance of thienoquinoline derivatives, emphasizing their prospective utility as <em>antiproliferative</em> agents.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"201 4","pages":"Pages 349-360"},"PeriodicalIF":1.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An efficient and biodegradable Natural Deep Eutectic Solvents (NADES) for synthesis and antimicrobial activity of some novel 5-arylidene-2-thiazolidine-4-ones","authors":"Alireza Khajeh-Amiri (Project administration Supervision Writing – review & editing) ,&nbsp;Naser Foroughifar (Project administration) ,&nbsp;Masoumeh Sadeghi Nik (Investigation Writing – original draft) ,&nbsp;Fatemeh Zahra Abbasian (Investigation)","doi":"10.1080/10426507.2025.2599285","DOIUrl":"10.1080/10426507.2025.2599285","url":null,"abstract":"<div><div>The choice of solvent in organic synthesis is one of the strategies, according to the framework of green chemistry. Natural deep eutectic solvents (NADESs), as a new generation of ionic liquids (ILs), are known as environmentally benign alternatives to the conventional organic solvents to increase the efficiency of organic transformations. In the present work, we reported an efficient reaction to prepare novel thiazolidine-4-one derivatives in the presence of NADES as a catalyst. This NADES based on Choline Chloride (ChCl)/urea was prepared easily with high purity and has several advantages, such as being environmentally friendly, using a simple workup procedure, having a shorter reaction time, and affording good yields. Thiazolidine-4-ones are an important class of heterocyclic compounds with useful applications in various fields. The structures of synthesized compounds 4a–j were characterized by IR,¹H NMR, ¹³C NMR spectroscopy, and elemental analysis and assayed <em>in vitro</em> for their antimicrobial activity.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"201 4","pages":"Pages 416-423"},"PeriodicalIF":1.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinidine and hydroquinidine in the synthesis of chiral salts of dithiophosphonic acids with antimicrobial activity","authors":"Ilyas S. Nizamov (Conceptualization Writing – original draft Writing – review & editing) ,&nbsp;Vladimir Yu. Yakimov (Investigation) ,&nbsp;Ilnar D. Nizamov (Investigation) ,&nbsp;Elena V. Kuznetsova (Investigation) ,&nbsp;Ivan I. Kalekulin (Investigation) ,&nbsp;Denis Yu. Grishaev (Investigation) ,&nbsp;Elvira S. Batyeva (Methodology)","doi":"10.1080/10426507.2025.2606131","DOIUrl":"10.1080/10426507.2025.2606131","url":null,"abstract":"<div><div>The reaction of (8 <em>R</em>,9<em>S</em>)-quinidine with 4-methoxyphenyl dithiophosphonic acids in racemic 2-butanol, 2-ethylhexanol and diethyl malate afforded optically active quinuclidinium 4-methoxyphenyl dithiophosphonates. <em>О</em>-(2-Ethylhexyl)-4-phenoxyphenyl dithiophosphonate was prepared from (8 <em>R</em>,9<em>S</em>)-quinidine and <em>О</em>-(2-ethylhexyl)-4-phenoxyphenyl dithiophosphonic acid in racemic 2-ethylhexanol. The reaction of (8 <em>R</em>,9<em>S</em>)-hydroquinidine with <em>О</em>-(2-ethylhexyl)-4-methoxyphenyl dithiophosphonic acid resulted in optically active quinuclidinium <em>О</em>-(2-ethylhexyl)-4-methoxyphenyl dithiophosphonate. The <em>О</em>-2-butyl-4-methoxyphenyl dithiophosphonic acid showed almost the same antifungal activity against <em>Candida albicans</em> (growth inhibition zone was 20 mm) as that of fungicide triticonazole (growth inhibition zone was 22 mm). Quinuclidinium <em>О</em>-2-butyl-4-methoxyphenyl dithiophosphonate on the basis of (8 <em>R</em>,9<em>S</em>)-quinidine (<strong>3a</strong>) and quinuclidinium <em>О</em>-(2-ethylhexyl)-4-methoxyphenyl dithiophosphonate on the basis of (8 <em>R</em>,9<em>S</em>)-quinidine (<strong>3b</strong>) showed the highest antibacterial activity against <em>Bacillus cereus</em> and <em>Staphylococcus aureus</em> with growth inhibition zones in the range 18–19 and 16–18 mm, respectively.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"201 4","pages":"Pages 448-456"},"PeriodicalIF":1.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A computational investigation of structural and spectroscopic properties of [MoCp2(6-mercaptopurine)]+ complexes","authors":"Maryam Azari (Investigation Methodology Writing – original draft Writing – review & editing) ,&nbsp;Reza Ghiasi (Conceptualization Investigation Methodology Supervision Validation Writing – original draft Writing – review & editing) ,&nbsp;Behrooz Mirza (Investigation Methodology Writing – original draft Writing – review & editing)","doi":"10.1080/10426507.2025.2612549","DOIUrl":"10.1080/10426507.2025.2612549","url":null,"abstract":"<div><div>A computational investigation was reported to illustrate the structure, bonding, and spectroscopic properties of two isomers of [MoCp₂(6-mercaptopurine)]⁺ complex. Quantum chemistry computations were considered with mPW1PW91 functional, 6–311 G(d,p) (for main group atoms) and the Def2-TZVPPD (for Mo) basis sets. Two possible isomers were considered by the interaction of interactions of MoCp₂ with N5 atom (<strong>A</strong>) and MoCp₂ with N3 atom (<strong>B</strong>). Energetic stability and polarity of the two isomers were explored. Energetic stability was found for B-complex than A-complex. Energy decomposition analysis (EDA), the natural bond orbital (NBO) approach, and the electron localization function (ELF) provided a significant understanding of the nature and strength of the molybdenocene and 6-mercaptopurine binding. Charge decomposition analysis (CDA) was used to illustrate the charge transfer between two fragments. CDA results revealed larger charge transfer was occurred from 6-mercaptopurine ligand to MoCp₂ fragment for two complexes. Additionally, the ¹⁴N NQR parameters of two complexes of [MoCp₂(6-mercaptopurine)]⁺ were calculated.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"201 4","pages":"Pages 464-475"},"PeriodicalIF":1.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of nitrile functionality: FDA-approved small molecules from 2021 to 2024","authors":"Davide Benedetto Tiz (Conceptualization Data curation Visualization Writing – original draft Writing – review & editing) ,&nbsp;Francesca Mangiavacchi (Resources Writing – review & editing) ,&nbsp;Luca Sancineto (Data curation Writing – review & editing)","doi":"10.1080/10426507.2025.2611024","DOIUrl":"10.1080/10426507.2025.2611024","url":null,"abstract":"<div><div>Nitrile-containing drugs represent an important class of natural and pharmaceutical compounds, exhibiting diverse biological activities across multiple therapeutic areas. The incorporation of a nitrile functional group in drug molecules influences their pharmacokinetic properties, bioavailability, and metabolic stability. This review provides a comprehensive analysis of the role of nitrile groups in drug design, their pharmacological significance, and the key synthetic strategies used for the development of the eleven FDA-approved nitrile-containing drugs from 2021 to 2024.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"201 4","pages":"Pages 376-394"},"PeriodicalIF":1.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imidazoles in medicine: a review of its pharmacological and therapeutic applications","authors":"Narasimman K. (Conceptualization Data curation Formal analysis Funding acquisition Investigation Methodology Writing – original draft) ,&nbsp;K. Jayamoorthy (Project administration Resources Software Supervision Validation Visualization Writing – review & editing)","doi":"10.1080/10426507.2025.2611018","DOIUrl":"10.1080/10426507.2025.2611018","url":null,"abstract":"<div><div>Imidazole and its derivatives constitute a versatile class of heterocyclic compounds with wide-ranging pharmacological and therapeutic potential. This review highlights their biological significance, emphasizing key activities such as anti-cancer, anti-mycobacterial, anti-hypertensive, anti-thrombin, kinase inhibition, anti-diarrheal, and anti-platelet effects. Clinically approved drugs containing the imidazole moiety such as Nirogacestat, Pretomanid, Eprosartan, Dabigatran etexilate, Acalabrutinib, Eluxadoline, and Cangrelor are discussed concerning their mechanisms of action, synthesis pathways, and therapeutic roles. Despite their broad potential, variations in structure, safety concerns, and regulatory challenges remain critical considerations. This review underscores the imidazole scaffold’s pharmacological significance and its expanding prospects in drug discovery and medicinal chemistry.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"201 4","pages":"Pages 361-375"},"PeriodicalIF":1.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gold nanoparticles functionalization with 1-(2-furoyl)-3-phenylthiourea","authors":"M. Muñoz-Arias (Conceptualization Investigation Methodology Visualization Writing – review & editing) ,&nbsp;K. Téllez-Silva (Investigation) ,&nbsp;I. Gil de Muro (Investigation Methodology Writing – review & editing) ,&nbsp;O. Estévez-Hernández (Conceptualization Formal analysis Investigation Methodology Supervision Writing – original draft Writing – review & editing)","doi":"10.1080/10426507.2026.2613645","DOIUrl":"10.1080/10426507.2026.2613645","url":null,"abstract":"<div><div>Understanding the impact of functionalizing gold nanoparticles with thiourea derivatives is essential for optimizing their physicochemical properties and developing platforms based on the integration of these systems for specific applications. Gold nanoparticles functionalization with acylthioureas is a novel approach due to the lack of prior literature on this class of compounds. In this work, gold nanoparticles were obtained by the Turkevich method using a gold precursor/reducing agent ratio of 1/10.5. The nanoparticles were characterized using UV-Vis spectroscopy, electrophoretic light scattering, and transmission electron microscopy. The surface plasmon resonance band of the nanoparticles was used to evaluate the impact of their interaction with thiourea and 1-(2-furoyl)-3-phenylthiourea in aqueous media, and the electrochemical response of the thiourea derivative was previously evaluated on an Au(111) electrode. Finally, solid-phase diffuse reflectance spectra of the samples involved in this system were obtained as direct evidence of the functionalization of the gold nanoparticles. This multi-technique characterization provided robust evidence of successful surface modification and colloidal stability. Crucially, this study provides the first evidence of a key advantage: 1-(2-furoyl)-3-phenylthiourea effectively modifies the nanoparticle surface without inducing significant aggregation, a common limitation with simple thiourea. Additionally, an insightful discussion on tautomerism and substituent effects in explaining the differences in aggregation behavior between both compounds is addressed.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"201 4","pages":"Pages 493-504"},"PeriodicalIF":1.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifaceted study of a pyrimidine sulfonamide derivative: structure, reactivity, optoelectronics, and bioactivity","authors":"Krishna Murthy Potla (Project administration Software Supervision Writing – original draft Writing – review & editing) ,&nbsp;Suneetha Vankayalapati (Conceptualization Data curation Methodology Writing – original draft) ,&nbsp;J. N. Cheerlin Mishma (Investigation Methodology Resources Software) ,&nbsp;S. Janani (Formal analysis Investigation Methodology Resources) ,&nbsp;Sanja J. Armaković (Formal analysis Investigation Methodology Validation) ,&nbsp;Stevan Armaković (Data curation Formal analysis Investigation Methodology Software Validation)","doi":"10.1080/10426507.2026.2636149","DOIUrl":"10.1080/10426507.2026.2636149","url":null,"abstract":"<div><div>Pyrimidinesulfonamide derivatives have garnered significant interest owing to their broad spectrum of applications in pharmaceutical development and optoelectronic device engineering. However, despite their potential, comprehensive studies elucidating the structural stability, electronic properties, and reactivity of these compounds remain scarce, limiting the rational design of functional materials in these fields. In this work, we address this critical knowledge gap by synthesizing and characterizing <em>N</em>-(5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-<em>N</em>-methylmethanesulfonamide (NMMS), integrating both experimental and advanced computational approaches. Single-crystal X-ray diffraction revealed a monoclinic Pbca space group stabilized by intramolecular C–H···Br interactions. Density functional theory (DFT) analyses of molecular electrostatic potential (MEP), average local ionization energies, Fukui functions, and non-covalent interactions (RDG), topological analysis (ELF, LOL) provided detailed insight into electronic distribution and reactive sites previously unreported for the title compound. Additionally, we computed bond dissociation energies, and nonlinear optical (NLO) properties demonstrating NMMS’s chemical stability and optoelectronic potential. Excited-state calculations (ADC(2)) revealed a small singlet–triplet energy gap (<span><math><mo>Δ</mo><mrow><msub><mrow><mi>E</mi></mrow><mrow><mrow><msub><mrow><mi>S</mi></mrow><mrow><mn>1</mn></mrow></msub></mrow><mo>−</mo><mrow><msub><mrow><mi>T</mi></mrow><mrow><mn>1</mn></mrow></msub></mrow></mrow></msub></mrow><mo>&lt;</mo><mn>0.37</mn><mi></mi><mtext>eV</mtext></math></span>), suggesting promise for thermally activated delayed fluorescence (TADF) applications. Molecular docking and dynamics simulations further indicated stable interactions with biological targets, pointing to potential pharmaceutical relevance. This work represents the first integrated structural, electronic, and functional study of NMMS, advancing understanding in the design of multifunctional materials at the interface of pharmaceutical chemistry and optoelectronics.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"201 4","pages":"Pages 395-408"},"PeriodicalIF":1.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New pyrazole-thiadiazole Schiff derivatives: synthesis, characterization and pharmacological evaluation","authors":"Manjunatha C. Ramegowda (Conceptualization Methodology) ,&nbsp;Vrushabendra Basavanna (Software Writing – review & editing) ,&nbsp;Manasa Chandramouli (Writing – review & editing) ,&nbsp;Srikantamurthy Ningaiah (Methodology) ,&nbsp;Nanjundaswamy G. Siddamallappa (Investigation) ,&nbsp;Kavitha C. Vijendra (Investigation) ,&nbsp;Raghavendra M. Puttaswamy (Investigation) ,&nbsp;Umesha K. Bhadraiah (Supervision)","doi":"10.1080/10426507.2025.2606126","DOIUrl":"10.1080/10426507.2025.2606126","url":null,"abstract":"<div><div>This study reports the synthesis, characterization and pharmacological evaluation of novel series of 1,3,4-thiadiazole containing pyrazole Schiff base heterocycles. The structural elucidation of the synthesized compounds was performed using ¹H and ¹³C NMR spectroscopy, mass spectrometry (MS) analysis, Fourier Transform Infrared spectroscopy (FT-IR) analysis. The antibacterial activity, antioxidant potential and cytotoxicity studies of newly synthesized compounds were assessed. The compound <strong>8a</strong> exhibiting most potent inhibitory effect against <em>S. aureus</em> and <em>E. coli</em> with inhibition zones of 20 and 18 mm, respectively, at 50 µg/mL. The antioxidant potential of the compounds was evaluated using DPPH radical scavenging assay and FRAP assay which envisioned that the compounds <strong>8a</strong>, <strong>8c,</strong> and <strong>8d</strong> showed highest potency. Cytotoxicity studies conducted on triple-negative breast cancer (MDA-MB-231) and estrogen receptor-positive breast cancer (MCF-7) cell lines showed that compound <strong>8c</strong> exhibited the strongest anticancer activity with 65.29% inhibition against MDA-MB-231 and 54.36% of inhibition against MCF-7 cell line at 1000 µM concentration. These findings suggest that these hybrid heterocycles hold significant promise as potential candidates for antimicrobial, antioxidant and anticancer applications.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"201 4","pages":"Pages 435-447"},"PeriodicalIF":1.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical investigation on the reaction mechanism between cyclic phosphenium cations and oxirane","authors":"Xiaojun Tan (Writing – original draft)","doi":"10.1080/10426507.2025.2603995","DOIUrl":"10.1080/10426507.2025.2603995","url":null,"abstract":"<div><div>The insertion reaction mechanism between cyclic phosphenium cations and oxirane has been systematically investigated at the M06-2X/6-311++G** level of theory, aiming to gain a deeper understanding of their reactivity as valence isoelectronic analogs of cyclic carbenes. In the initial step, the cyclic phosphenium cation functions as an electrophilic reagent, accepting the <em>σ</em> electrons of oxirane to form a complex. Both isolated double bonds and conjugated systems are capable of reducing the positive charge on the phosphorus atom, thereby stabilizing the cyclic phosphenium cation. Designing viable and stable cyclic phosphenium cations by introducing isolated double bonds and conjugated systems is expected to broaden their applications in coordination chemistry and catalytic systems. The second step involves the conversion of the complex into a spiro-heterocyclic product through a transition state, with the resulting products exhibiting greater stability than the initial complexes.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"201 4","pages":"Pages 424-434"},"PeriodicalIF":1.6,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}