Design, synthesis and antibacterial evaluation of indole C2 derivatives containing 1,3,4-oxadiazole thioether moiety

IF 1.6 4区 化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR
Chenghao Tang (Conceptualization Funding acquisition Writing – original draft Writing – review & editing) , Liang Chen (Data curation) , Qian Wang (Investigation) , Xiaoli Huang (Investigation) , Lanlan Wang (Data curation) , Wenting Yang (Validation) , Yue Zhou (Investigation) , Pei Li (Writing – original draft) , Xiang Wang (Writing – original draft)
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引用次数: 0

Abstract

A series of novel indole C2 derivatives containing 1,3,4-oxadiazole thioether moiety were designed and synthesized via natural compound indole-2-carboxylic acid as start material, and their biological activities were tested for Pseudomonas syringae pv actinidiae (Psa), Xanthomonas axonopodis pv citri (Xac), and Xanthomonas oryzae pv oryzae (Xoo). Bioassay findings revealed that a subset of the target compounds demonstrated robust antibacterial activities against Psa, Xoo and Xac at concentrations of both 100 and 50 μg/mL. Ongoing research is focused on exploring their bioactive applications, aiming to identify novel indole C2 derivatives and investigate their broad applicability.
含有1,3,4-恶二唑硫醚的吲哚C2衍生物的设计、合成及抗菌性能评价
以天然化合物吲哚-2-羧酸为原料,设计合成了一系列含有1,3,4-恶二唑硫醚的新型吲哚C2衍生物,并对其对丁香假单胞菌pv actinidiae (Psa)、柑橘黄单胞菌pv citri (Xac)和米黄单胞菌pv oryzae (Xoo)的生物活性进行了测试。生物测定结果显示,在浓度为100和50 μg/mL时,部分目标化合物对Psa、Xoo和Xac均表现出较强的抗菌活性。正在进行的研究重点是探索其生物活性应用,旨在鉴定新的吲哚C2衍生物并研究其广泛的适用性。
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来源期刊
CiteScore
2.60
自引率
7.70%
发文量
103
审稿时长
2.1 months
期刊介绍: Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.
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