Chenghao Tang (Conceptualization Funding acquisition Writing – original draft Writing – review & editing) , Liang Chen (Data curation) , Qian Wang (Investigation) , Xiaoli Huang (Investigation) , Lanlan Wang (Data curation) , Wenting Yang (Validation) , Yue Zhou (Investigation) , Pei Li (Writing – original draft) , Xiang Wang (Writing – original draft)
{"title":"含有1,3,4-恶二唑硫醚的吲哚C2衍生物的设计、合成及抗菌性能评价","authors":"Chenghao Tang (Conceptualization Funding acquisition Writing – original draft Writing – review & editing) , Liang Chen (Data curation) , Qian Wang (Investigation) , Xiaoli Huang (Investigation) , Lanlan Wang (Data curation) , Wenting Yang (Validation) , Yue Zhou (Investigation) , Pei Li (Writing – original draft) , Xiang Wang (Writing – original draft)","doi":"10.1080/10426507.2025.2546581","DOIUrl":null,"url":null,"abstract":"<div><div>A series of novel indole C2 derivatives containing 1,3,4-oxadiazole thioether moiety were designed and synthesized <em>via</em> natural compound indole-2-carboxylic acid as start material, and their biological activities were tested for <em>Pseudomonas syringae pv actinidiae</em> (<em>Psa</em>), <em>Xanthomonas axonopodis</em> pv <em>citri</em> (<em>Xac</em>), and <em>Xanthomonas oryzae</em> pv <em>oryzae</em> (<em>Xoo</em>). Bioassay findings revealed that a subset of the target compounds demonstrated robust antibacterial activities against <em>Psa</em>, <em>Xoo</em> and <em>Xac</em> at concentrations of both 100 and 50 μg/mL. Ongoing research is focused on exploring their bioactive applications, aiming to identify novel indole C2 derivatives and investigate their broad applicability.</div></div>","PeriodicalId":20056,"journal":{"name":"Phosphorus, Sulfur, and Silicon and the Related Elements","volume":"200 10","pages":"Pages 805-813"},"PeriodicalIF":1.6000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design, synthesis and antibacterial evaluation of indole C2 derivatives containing 1,3,4-oxadiazole thioether moiety\",\"authors\":\"Chenghao Tang (Conceptualization Funding acquisition Writing – original draft Writing – review & editing) , Liang Chen (Data curation) , Qian Wang (Investigation) , Xiaoli Huang (Investigation) , Lanlan Wang (Data curation) , Wenting Yang (Validation) , Yue Zhou (Investigation) , Pei Li (Writing – original draft) , Xiang Wang (Writing – original draft)\",\"doi\":\"10.1080/10426507.2025.2546581\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A series of novel indole C2 derivatives containing 1,3,4-oxadiazole thioether moiety were designed and synthesized <em>via</em> natural compound indole-2-carboxylic acid as start material, and their biological activities were tested for <em>Pseudomonas syringae pv actinidiae</em> (<em>Psa</em>), <em>Xanthomonas axonopodis</em> pv <em>citri</em> (<em>Xac</em>), and <em>Xanthomonas oryzae</em> pv <em>oryzae</em> (<em>Xoo</em>). Bioassay findings revealed that a subset of the target compounds demonstrated robust antibacterial activities against <em>Psa</em>, <em>Xoo</em> and <em>Xac</em> at concentrations of both 100 and 50 μg/mL. Ongoing research is focused on exploring their bioactive applications, aiming to identify novel indole C2 derivatives and investigate their broad applicability.</div></div>\",\"PeriodicalId\":20056,\"journal\":{\"name\":\"Phosphorus, Sulfur, and Silicon and the Related Elements\",\"volume\":\"200 10\",\"pages\":\"Pages 805-813\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-08-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phosphorus, Sulfur, and Silicon and the Related Elements\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1042650725000796\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phosphorus, Sulfur, and Silicon and the Related Elements","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1042650725000796","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Design, synthesis and antibacterial evaluation of indole C2 derivatives containing 1,3,4-oxadiazole thioether moiety
A series of novel indole C2 derivatives containing 1,3,4-oxadiazole thioether moiety were designed and synthesized via natural compound indole-2-carboxylic acid as start material, and their biological activities were tested for Pseudomonas syringae pv actinidiae (Psa), Xanthomonas axonopodis pv citri (Xac), and Xanthomonas oryzae pv oryzae (Xoo). Bioassay findings revealed that a subset of the target compounds demonstrated robust antibacterial activities against Psa, Xoo and Xac at concentrations of both 100 and 50 μg/mL. Ongoing research is focused on exploring their bioactive applications, aiming to identify novel indole C2 derivatives and investigate their broad applicability.
期刊介绍:
Phosphorus, Sulfur, and Silicon and the Related Elements is a monthly publication intended to disseminate current trends and novel methods to those working in the broad and interdisciplinary field of heteroatom chemistry.