Pediatric Transplantation最新文献_第8页

Should urinary CXCL10/creatinine be measured for kidney transplantation? 肾移植是否应测量尿 CXCL10/肌酐？

IF 1.3 4区医学

Pediatric Transplantation Pub Date : 2024-03-01 DOI: 10.1111/petr.14729

Guido Filler, Ajay P Sharma

引用次数: 0

Survival does not differ by annual center transplant volume-A Pediatric Heart Transplant Society Registry study. 存活率不因中心每年的移植量而异--儿科心脏移植协会注册研究。

IF 1.3 4区医学

Pediatric Transplantation Pub Date : 2024-03-01 DOI: 10.1111/petr.14720

A Marion Ybarra, Alicia M Kamsheh, Matthew J O'Connor, Seth A Hollander, Maria Bano, Michelle Ploutz, Gabrielle Vaughn, Andrea Lambert, Michael Wallendorf, James Kirklin, Charles E Canter

{"title":"Survival does not differ by annual center transplant volume-A Pediatric Heart Transplant Society Registry study.","authors":"A Marion Ybarra, Alicia M Kamsheh, Matthew J O'Connor, Seth A Hollander, Maria Bano, Michelle Ploutz, Gabrielle Vaughn, Andrea Lambert, Michael Wallendorf, James Kirklin, Charles E Canter","doi":"10.1111/petr.14720","DOIUrl":"10.1111/petr.14720","url":null,"abstract":"Background: There are conflicting data regarding the relationship between center volume and outcomes in pediatric heart transplantation. Previous studies have not fully accounted for differences in case mix, particularly in high-risk congenital heart disease (CHD) groups. We aimed to evaluate the relationship between center volume and outcomes using the Pediatric Heart Transplant Society (PHTS) Registry and explore how case mix may affect outcomes.Methods: A retrospective cohort study of all pediatric patients in the PHTS Registry who received a heart transplant from 2009 to 2018 was performed. Centers were divided into 5 groups based on average yearly transplant volume. The primary outcome was time to death or graft loss and outcomes were compared using Kaplan-Meier analysis.Results: There were 4583 cases among 55 centers included. There was no difference in time to death or graft loss by center volume in the entire cohort (p = .75), in patients with CHD (p = .79) or in patients with cardiomyopathy (p = .23). There was also no difference in time to death or graft loss by center size in patients undergoing transplant after Norwood, Glenn or Fontan (log rank p = .17, p = .31, and p = .10 respectively). There was a statistically significant difference in outcomes by center size in the positive crossmatch group (p < .0001), though no discernible pattern related to high or low center volume.Conclusions: Outcomes are similar among transplant centers of all sizes, including for high-risk patient groups with CHD. Future work is needed to understand how patient-specific risk factors may vary among centers of various sizes and whether this influences patient outcomes.","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"28 2","pages":"e14720"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review on clinician bias and its impact on racial and socioeconomic disparities in pediatric heart transplantation. 回顾临床医生的偏见及其对儿科心脏移植中种族和社会经济差异的影响。

IF 1.3 4区医学

Pediatric Transplantation Pub Date : 2024-03-01 DOI: 10.1111/petr.14704

Shahnawaz Amdani, Jeffrey G Gossett, Valerie Chepp, Simon Urschel, Alfred Asante-Korang, Jarrod E Dalton

引用次数: 0

Small-for-size syndrome in a 9.7 kg pediatric recipient with a whole liver graft. 一名体重 9.7 千克的小儿全肝移植受体出现 "小而全 "综合征。

IF 1.3 4区医学

Pediatric Transplantation Pub Date : 2024-03-01 DOI: 10.1111/petr.14716

Haytham Maria, Pamela L Valentino, Patrick J Healey, Yong K Kwon

{"title":"Small-for-size syndrome in a 9.7 kg pediatric recipient with a whole liver graft.","authors":"Haytham Maria, Pamela L Valentino, Patrick J Healey, Yong K Kwon","doi":"10.1111/petr.14716","DOIUrl":"10.1111/petr.14716","url":null,"abstract":"Background: Small-for-size syndrome (SFSS) in pediatric liver transplant recipients, particularly those weighing less than 10 kg, is rare. This report describes a case of a 15-month-old whole liver transplant recipient who suffered SFSS, and systematic literature review was performed to identify outcomes of such cases and potential risk factors for SFSS.Case presentation: A 15-month-old toddler with a history of biliary atresia underwent a deceased donor whole liver transplant. The graft weighed 160 g, resulting in a graft-to-recipient weight ratio (GRWR) of 1.6%. The post-operative course was complicated by SFSS, characterized by massive ascites causing hemodynamic instability and compromised hepatic artery flow. Pharmacological intervention with octreotide was initiated, and the patient eventually recovered.Conclusion: In small pediatric recipients, especially those weighing less than 10 kg, the native liver body weight ratio (LBWR) is significantly higher. When selecting an appropriately sized graft for these recipients, this higher ratio should be taken into consideration. The literature review suggests that a GRWR of less than 2% is associated with a higher incidence of small-for-size syndrome in small pediatric recipients weighing less than 10 kg.","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"28 2","pages":"e14716"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of motivational interviewing in adolescent solid organ transplant. 动机访谈法在青少年实体器官移植中的应用。

IF 1.3 4区医学

Pediatric Transplantation Pub Date : 2024-03-01 DOI: 10.1111/petr.14721

Julie M Gettings, Debra S Lefkowitz

{"title":"Applications of motivational interviewing in adolescent solid organ transplant.","authors":"Julie M Gettings, Debra S Lefkowitz","doi":"10.1111/petr.14721","DOIUrl":"10.1111/petr.14721","url":null,"abstract":"Background: Adolescence is a developmental period that is known for the highest risk of difficulties with adoption and maintenance of health behaviors for successful transplant. Motivational interviewing (MI) has been demonstrated to be an effective strategy in the management of modifiable factors impacting adherence in both adult transplant and analogous pediatric chronic illness populations.Aims: This paper describes MI and its applicability to adolescent transplant, providing examples of its potential use at each stage of the transplant journey.Materials and methods: Literature on the principles and utilization of MI are reviewed, as well as the use of MI in adult transplant and similar pediatric populations.Results: Evidence suggests high applicability of concepts of MI to pediatric transplant.Discussion: Systems-level factors influencing health behavior change are discussed, along with the importance of recognizing and managing provider bias in MI-based interactions. MI does not require a licensed behavioral health provider to use it effectively; rather, it can be used by various multidisciplinary team members throughout the course of clinical care.Conclusion: MI shows great promise as a useful intervention through all stages in the transplant journey. Though particularly well-suited to adolescents, its principles are effective across the lifespan, including with caregivers. It represents an interactional style for use by multidisciplinary team members in many patient-and caregiver-facing scenarios. As the goal is to support the patient's autonomy in decision-making, it is important for providers to recognize their own biases. Further resources for training are provided.","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"28 2","pages":"e14721"},"PeriodicalIF":1.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart disease symptoms and health-related quality of life in pediatric heart transplant recipients: A serial multiple mediator analysis. 小儿心脏移植受者的心脏病症状与健康相关生活质量：连续多重中介分析

IF 1.3 4区医学

Pediatric Transplantation Pub Date : 2024-02-01 Epub Date: 2023-12-27 DOI: 10.1111/petr.14682

James W Varni, Karen Uzark

{"title":"Heart disease symptoms and health-related quality of life in pediatric heart transplant recipients: A serial multiple mediator analysis.","authors":"James W Varni, Karen Uzark","doi":"10.1111/petr.14682","DOIUrl":"10.1111/petr.14682","url":null,"abstract":"Background: A serial multiple mediator analysis was conducted to test the predictive effects of heart disease symptoms on pediatric heart transplant recipients health-related quality of life (HRQOL) from their perspective with patient-perceived cognitive problems, patient health communication, and treatment anxiety as hypothesized mediators.Methods: One hundred and nineteen pediatric heart transplant recipients aged 8-18 completed the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales and the PedsQL Cardiac Module Heart Disease Symptoms Scale, Cognitive Problems Scale, Communication Scale and Treatment Anxiety Scale. The serial multiple mediator analysis tested the hypothesized sequential mediation of the cross-sectional association between patient-perceived heart disease symptoms and their perceived HRQOL.Results: Heart disease symptoms indirect effects on HRQOL were sequentially mediated through cognitive problems, with cognitive problems' indirect effects mediated through patient health communication and treatment anxiety. A predictive analytics analysis consisting of age, gender, and time since transplant demographic covariates, demonstrated that heart disease symptoms, cognitive problems, patient health communication, and treatment anxiety accounted for 66 percent of the variance in patient-perceived HRQOL (p < .001), representing a large effect size.Conclusions: Patient-perceived heart disease symptoms indirect effects on HRQOL in pediatric heart transplant recipients was explained by patient-perceived cognitive problems, patient health communication, and treatment anxiety. Delineating heart disease symptoms indirect effects on HRQOL from the perspective of pediatric patients may inform targeted clinical interventions to improve daily functioning in pediatric heart transplant recipients.","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":" ","pages":"e14682"},"PeriodicalIF":1.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemodynamics and urinary excretion of kidney-injury biomarkers in pediatric kidney transplantation. 儿童肾移植中肾损伤生物标志物的血流动力学和尿排泄。

IF 1.3 4区医学

Pediatric Transplantation Pub Date : 2024-02-01 Epub Date: 2023-11-20 DOI: 10.1111/petr.14637

Marieke Voet, Dirk van Lier, Joris Lemson, Alex Zarbock, Ignacio Malagon, Elisabeth Cornelissen, Peter Pickkers

引用次数: 0

Living donor liver transplantation for myocerebrohepatopathy spectrum due to POLG mutations. 活体供肝移植治疗因POLG突变引起的心肌病谱。

IF 1.3 4区医学

Pediatric Transplantation Pub Date : 2024-02-01 Epub Date: 2023-11-27 DOI: 10.1111/petr.14659

Masashi Kadohisa, Tatsuya Okamoto, Miki Yamamoto, Elena Yukie Uebayashi, Mari Sonoda, Eri Ogawa, Atsushi Yokoyama, Hidenori Kawasaki, Eitaro Hiejima, Shogo Ito, Takao Togawa, Kazuo Imagawa, Kei Murayama, Hideaki Okajima, Etsuro Hatano

{"title":"Living donor liver transplantation for myocerebrohepatopathy spectrum due to POLG mutations.","authors":"Masashi Kadohisa, Tatsuya Okamoto, Miki Yamamoto, Elena Yukie Uebayashi, Mari Sonoda, Eri Ogawa, Atsushi Yokoyama, Hidenori Kawasaki, Eitaro Hiejima, Shogo Ito, Takao Togawa, Kazuo Imagawa, Kei Murayama, Hideaki Okajima, Etsuro Hatano","doi":"10.1111/petr.14659","DOIUrl":"10.1111/petr.14659","url":null,"abstract":"Background: POLG is one of several nuclear genes associated with mitochondrial DNA maintenance defects and is a group of diseases caused by mitochondrial DNA deficiency that results in impaired adenosine triphosphate production and organ dysfunction. Myocerebrohepatopathy spectrum (MCHS) is the most severe and earliest presentation of POLG mutations, and liver transplantation (LT) for MCHS has never been reported.Case presentation: The patient was a 3-month-old boy with acute liver failure and no neurological manifestations (e.g., seizures). We performed a living donor LT using a left lateral segment graft from his father. The postoperative course was uneventful. Subsequently, a homozygous POLG mutation (c.2890C>T, p. R964C) was identified by multigene analysis of neonatal/infantile intrahepatic cholestasis. Moreover, respiratory chain complex I, II, and III enzyme activities and the ratio of mtDNA to nuclear DNA in the liver were reduced. Therefore, we considered that these clinical manifestations and examination findings met the definition for MCHS. During meticulous follow-up, the patient had shown satisfactory physical growth and mental development until the time of writing this report.Conclusion: We presumed that the absence of remarkable neurologic manifestations prior to LT in patients with MCHS is a good indication for LT and contributes to a better prognosis in the present case.","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":" ","pages":"e14659"},"PeriodicalIF":1.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138445706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Featured Cover 精选封面

IF 1.3 4区医学

Pediatric Transplantation Pub Date : 2024-02-01 DOI: 10.1111/petr.14700

Jean de Ville de Goyet, Fabrizio di Francesco, Davide Cintorino, Kejd Bici, Diletta Dona, Pasquale Bonsignore, Salvatore Gruttadauria

引用次数: 0

Recanalization of portal vein thrombosis after pediatric liver transplantation: Efficacy and safety of the transsplenic access. 小儿肝移植术后门静脉血栓再通：经脾脏入路的有效性和安全性。

IF 1.2 4区医学

Pediatric Transplantation Pub Date : 2024-02-01 Epub Date: 2023-08-07 DOI: 10.1111/petr.14537

Aline Cristine Barbosa Santos Cavalcante, Francisco César Carnevale, Charles Edouard Zurstrassen, Renata Pereira Sustovich Pugliese, Airton Mota Moreira, André Moreira Assis, João Paulo Kawaoka Matushita Junior, Vera Lucia Baggio Danesi, Marcel Albeiro Ruiz Benavides, Adriana Porta M Hirschfeld, Cristian B V Borges, Irene Kazue Miura, Gilda Porta, Eduardo Antunes Fonseca, Paulo ChapChap, João Seda Neto

{"title":"Recanalization of portal vein thrombosis after pediatric liver transplantation: Efficacy and safety of the transsplenic access.","authors":"Aline Cristine Barbosa Santos Cavalcante, Francisco César Carnevale, Charles Edouard Zurstrassen, Renata Pereira Sustovich Pugliese, Airton Mota Moreira, André Moreira Assis, João Paulo Kawaoka Matushita Junior, Vera Lucia Baggio Danesi, Marcel Albeiro Ruiz Benavides, Adriana Porta M Hirschfeld, Cristian B V Borges, Irene Kazue Miura, Gilda Porta, Eduardo Antunes Fonseca, Paulo ChapChap, João Seda Neto","doi":"10.1111/petr.14537","DOIUrl":"10.1111/petr.14537","url":null,"abstract":"Background: Endovascular management of portal vein thrombosis (PVT) is challenging. Transsplenic access (TSA) is growing as an access option to the portal system but with higher rates of bleeding complications. The aim of this article is to evaluate the efficacy and safety of transsplenic portal vein recanalization (PVR) using a metallic stent after pediatric liver transplantation.Materials and methods: This is a retrospective review of 15 patients with chronic PVT who underwent PVR via TSA between February 2016 and December 2020. Two children who had undergone catheterization of a mesenteric vein tributary by minilaparotomy were excluded from the patency analysis but included in the splenic access analysis. The technical and clinical success of PVR and complications related to the procedure via TSA were evaluated.Results: Thirteen children with PVT were treated primarily using the TSA. The mean age was 4.1 years (range, 1.5-13.7 years), and the most common clinical presentation was hypersplenism (60%). Technically successful PVR was performed in 11/13 (84.6%) children, and clinical success was achieved in 9/11 (81.8%) children. No major complications were observed, and one child presented moderate pain in the TSA (from a total of 17 TSA). The median follow-up was 48.2 months. The median primary patency was 9.9 months. Primary patency in the first 4 years was 75%, and primary assisted patency was 100% in the follow-up period.Conclusions: Transsplenic PVR is a safe and effective method for the treatment of PVT after pediatric liver transplantation.","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":" ","pages":"e14537"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0