Pediatric Transplantation最新文献

{"title":"Central Nervous System Infections in Pediatric Solid Organ Transplant Recipients.","authors":"Amna AlSaihati, Kathleen E Hosek, Cristina Otero, Brandon H Tran, Carrie A Mohila, David Moreno McNeill, Mini Michael, Krupa R Mysore, Joseph A Spinner, Claire E Bocchini, Kristen G Valencia Deray","doi":"10.1111/petr.70432","DOIUrl":"10.1111/petr.70432","url":null,"abstract":"<p><strong>Background: </strong>Solid organ transplant (SOT) recipients face an increased risk of central nervous system (CNS) infections due to immunosuppression. The incidence of CNS infections in adult SOT recipients ranges from 0.4% to 10%, while it remains unknown in pediatric SOT recipients. Herein, we describe the incidence, clinical presentation, and outcomes of CNS infections in pediatric SOT recipients.</p><p><strong>Methods: </strong>We conducted a single-center retrospective cohort study that included 1628 first-time SOT recipients ≤ 21 years of age from 2003 to 2023.</p><p><strong>Results: </strong>We identified 23 patients with CNS infection representing an incidence of 2.3 per 1000 patient-years. They occurred in 8/400 (2%) heart; 7/570 (1.2%) liver; 5/220 (2.3%) lung; 2/400 (0.5%) kidney, and 1/38 (2.6%) multi-organ transplant recipients. Documented symptoms included fever in 15/23 (65%), altered mental status in 7/23 (30%), nausea and emesis in 6/23 (26%), and headache in 6/23 (26%). Neuroimaging was performed in 15/23 (65%) patients with CNS infection; 10/15 (67%) had abnormal findings. Bacterial and fungal infections predominated, each accounting for 8/23 (35%) cases, followed by viral infections in 7/23 (30%) cases. Among patients with CNS infection, all-cause mortality was observed in 9/23 (39%), while it was 263/1605 (16%) in those without a CNS infection (p < 0.01).</p><p><strong>Conclusions: </strong>CNS infections in SOT recipients are rare and presentation can be non-specific, though associated with a high mortality. These findings highlight the importance of maintaining clinical awareness of CNS infection in SOT recipients.</p>","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"30 8","pages":"e70432"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Perfusion and Mitigating Risk Factors for Delayed Graft Function in Pediatric Kidney Transplant Recipients.","authors":"Kyle A Merrill, Cassie Kirby, Teresa Ambrosino, Charles D Varnell, Alexander Bondoc, Lakhmir Chawla, Stuart L Goldstein, David K Hooper","doi":"10.1111/petr.70429","DOIUrl":"10.1111/petr.70429","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplantation confers prolonged and improved quality of life versus dialysis for patients with end-stage kidney disease (ESKD). Delayed graft function (DGF) increases the risk of allograft rejection and decreases allograft survival. In adults, prolonged warm (WIT) and cold ischemia time (CIT) increase risk of DGF, and machine perfusion (MP) during organ transportation reduces this risk. However, there is a paucity of data regarding risk factors for DGF in children.</p><p><strong>Methods: </strong>We retrospectively evaluated risk and protective factors for DGF in patients aged 18 months to 21 years who underwent kidney transplantation at Cincinnati Children's Hospital Medical Center between 11/1/2017 and 11/30/2021. DGF was defined as receiving dialysis within 7 days post-transplant.</p><p><strong>Results: </strong>Nine of 89 (10%) patients developed DGF. Patients with DGF had longer median WIT (49 IQR: 44-57 vs. 37 min IQR: 30-43; p = 0.002) and were more likely to have received a deceased donor (DD) allograft (p = 0.04, RR1.7 (95% CI: 1.2-2.4)). There was no difference in CIT between those who did and did not experience DGF (464 IQR:329-788 vs. 271 min. IQR:271-788; p = 0.16). No patients who received DD-MP kidneys developed DGF. DGF in recipients of DD-non-MP kidneys had longer WIT (53 IQR: 43-57 vs. 36 min. IQR: 30-44; p < 0.009).</p><p><strong>Conclusion: </strong>Increased WIT increases the risk of DGF in pediatric kidney transplant recipients, whereas MP appears to be protective against DGF and may ameliorate the adverse effect of CIT. DGF was rare in the cohort and further studies are necessary due to the low incidence of DGF.</p>","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"30 8","pages":"e70429"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Perioperative Surgical Factors Affect Early Graft Function in Pediatric Kidney Transplantation?","authors":"Muhammet Irfan Donmez, Hakan Bahadir Haberal, Mehmet Tasdemir, Alper Varman, Huseyin Bakkaloglu, Ayhan Dinckan, Muhammed Emin Polat, Alicia López-Abad, Alessio Pecoraro, Benoît Mesnard, Julien Branchereau, Thomas Loubersac, Beatriz Bañuelos Marco, Thomas Prudhomme, Alberto Piana, Alberto Costa Silva, Angelo Territo","doi":"10.1111/petr.70414","DOIUrl":"10.1111/petr.70414","url":null,"abstract":"<p><strong>Background: </strong>Early graft function after pediatric kidney transplantation (KT) may be influenced by perioperative hemodynamic and fluid management variables. However, previous studies have yielded conflicting results. This study aimed to evaluate the impact of perioperative factors on early graft function in pediatric KT recipients.</p><p><strong>Methods: </strong>This retrospective multicenter study included pediatric KT recipients from four academic centers in Turkiye and France. Early graft function was assessed using estimated glomerular filtration rate (eGFR) at postoperative day 7 and day 30. Delayed graft function (DGF) was defined as the need for dialysis within the first 7 days post-transplant. Mean arterial pressure (MAP) was calculated where reperfusion blood pressure data were available, and a sensitivity analysis accounting for transplant center was performed. Associations between perioperative variables and outcomes were evaluated using univariate and multivariate regression analyses.</p><p><strong>Results: </strong>Ninety-seven patients were included (median age 154 months; 45.4% female). DGF occurred in 11.3% of recipients. In multivariate analysis, no perioperative variable was independently associated with DGF. Longer cold ischemia time was independently associated with lower 7-day eGFR (B = -0.05; 95% CI -0.10 to -0.01; p = 0.014). At 30 days, preemptive transplantation (B = -15.99; 95% CI -27.02 to -4.96; p = 0.005) and DGF (B = -36.94; 95% CI -58.39 to -15.50; p = 0.001) were independently associated with lower eGFR; the preemptive association was attenuated after accounting for transplant center.</p><p><strong>Conclusion: </strong>Intraoperative hemodynamic parameters were not independently associated with DGF or early graft function. At day 7, early graft function was primarily associated with cold ischemia time, whereas at day 30 it was mainly associated with preemptive transplantation status and DGF.</p>","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"30 8","pages":"e70414"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Response to Dr. Imamura.","authors":"Waldemar F Carlo, David L S Morales","doi":"10.1111/petr.70418","DOIUrl":"10.1111/petr.70418","url":null,"abstract":"","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"30 8","pages":"e70418"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Living Donor Liver Transplantation in Children With Alagille Syndrome: Results From Vanguard Multicenter Study of International Living Donor Liver Transplantation Group.","authors":"Yusuke Yanagi, Sinya Okumura, Taiichi Wakiya, Yuta Hirata, Jiyoung Kim, Masaki Honda, Kazuya Hirukawa, Tonguc Utku Yilmaz, Takanobu Hara, Toru Ikegami, Mureo Kasahara","doi":"10.1111/petr.70426","DOIUrl":"10.1111/petr.70426","url":null,"abstract":"<p><strong>Background: </strong>The morbidity and mortality after living donor liver transplantation (LDLT) in children with Alagille syndrome (AGS) are complex because of the multisystem involvement of the disease. Evidence on long-term outcomes and donor selection remains limited.</p><p><strong>Methods: </strong>This multicenter retrospective study included 49 pediatric patients with AGS who underwent LDLT between 2001 and 2020 at eight institutions in Japan, Korea, and Turkey. Clinical characteristics, transplant indications, donor selection, posttransplant growth, renal function, and complications were analyzed.</p><p><strong>Results: </strong>The median age at LDLT was 1.1 years. Major indications for transplantation were severe growth failure (91.8%) and advanced liver disease with hepatic dysfunction. Based on donor evaluations, 11% of candidates were excluded due to genetic or anatomical concerns. The 5-year patient and graft survival rates were 93.7% and 91.5%, respectively. LDLT before 2 years of age was associated with significantly greater catch-up in height and weight. Long-term renal deterioration was observed, particularly beyond 15 years after transplantation, and older age at LDLT was an independent predictor of lower long-term estimated glomerular filtration rate. Cardiac anomalies were manageable with appropriate preoperative evaluation, whereas vasculopathies were observed after adolescence. A history of Kasai portoenterostomy did not significantly affect posttransplant outcomes.</p><p><strong>Conclusions: </strong>LDLT provides excellent short- and long-term outcomes in pediatric AGS. Timely LT may improve growth and preserve renal function before progressive multisystem complications become established. Long-term surveillance and comprehensive donor evaluation remain essential.</p>","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"30 8","pages":"e70426"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Rate of Urological Complications in Pediatric Kidney Transplantation Using a Stentless Ureteral Anastomosis.","authors":"Gaetano Ciancio, Jeffrey J Gaynor, Mahmoud Morsi, Henry Ocando Nava, Matthew Gaynor, Marissa Defreitas, Jayanthi Chandar","doi":"10.1111/petr.70431","DOIUrl":"https://doi.org/10.1111/petr.70431","url":null,"abstract":"<p><strong>Background: </strong>Pediatric kidney transplant recipients are susceptible to a range of complications that may compromise allograft function and are associated with significant morbidity. Urologic complications represent an important subset that may necessitate multiple radiological and/or surgical interventions.</p><p><strong>Methods: </strong>Our previously reported modified extravesical ureteroneocystostomy technique was designed to avoid routine stent placement at the time of transplant as well as to reduce postoperative urologic complications. Here, we reviewed 107 consecutive pediatric kidney transplant recipients transplanted at our center since 2014 who received no stent placement at the time of transplant.</p><p><strong>Results: </strong>The observed percentage who developed a urologic complication during the first 12 months post-transplant was 3.7% (4/107), and only 2.8% (3/107) required surgical intervention. Ureteral obstruction/stricture was observed in 2.8% (3/107), with two being due to UPJ obstruction, and one being due to the occurrence of multiple kidney stones that occluded the distal ureter/ureterovesical junction (UVJ). No urinary leaks, 0.0% (0/107), were observed during the first 12 months post-transplant. Additionally, poor bladder compliance along with Grade 4 vesicoureteral reflux occurred in one patient. One patient (who developed a UPJ obstruction) was successfully managed with interventional radiology alone. The other three patients required surgical intervention: ureteral reimplantation for the patient having UVJ obstruction due to multiple kidney stones, pyeloureterostomy in one patient with a UPJ obstruction, and bladder augmentation along with (ureter, ileum, and ileal) Monti Mitrofanoff in the patient having poor bladder compliance.</p><p><strong>Conclusions: </strong>In pediatric kidney transplantation, our extravesical ureteroneocystostomy technique without routine ureteral stent placement was associated with a low incidence of post-transplant urological complications.</p>","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"30 8","pages":"e70431"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Transplant: Chronic Kidney Disease in Pediatric Hematopoietic Stem Cell Transplant Survivors-A 20-Year Single-Center Cohort Study.","authors":"Alcotzer Inbar, Talgam-Horshi Efrat, Sidlik Muskatel Rakefet, Kraus Aviva, Yanir Assaf, Yahel Anat, Stein Jerry, Levy-Erez Daniella","doi":"10.1111/petr.70417","DOIUrl":"10.1111/petr.70417","url":null,"abstract":"<p><strong>Background: </strong>Pediatric hematopoietic stem cell transplantation (HSCT) is curative for malignant and non-malignant diseases, yet survivors remain at substantial risk for late renal complications. Data on chronic kidney disease (CKD) incidence and its determinants in pediatric HSCT recipients are limited.</p><p><strong>Methods: </strong>We conducted a single-center retrospective cohort study of 261 pediatric patients (aged 0-21 years) who underwent HSCT at Schneider Children's Medical Center, Israel, between 2000 and 2020. Acute kidney injury (AKI) was defined per KDIGO creatinine criteria. CKD was defined as eGFR < 90 mL/min/1.73 m² sustained ≥ 3 months and/or proteinuria or hypertension. Given the limited number of CKD events, multivariable logistic regression identifying factors associated with CKD was treated as exploratory. Overall survival was analyzed using Kaplan-Meier methodology.</p><p><strong>Results: </strong>AKI episodes occurred in 20.5% of patients during the first three months post-HSCT. CKD incidence increased progressively: 6.0% at one year, 8.6% at three years, and 16.5% at five years-substantially exceeding the ~5% background prevalence reported in the general Israeli pediatric population. Older age at transplantation was the only variable significantly associated with CKD in this exploratory model (mean 11.96 vs. 7.12 years in the CKD and non-CKD groups, respectively; p = 0.008). A higher proportion of patients who developed CKD had undergone four or more transplantations compared with those who did not (31.6% vs. 3.7%), though this difference did not reach statistical significance (p = 0.22) and should be regarded as hypothesis-generating. Patients with a borderline baseline creatinine in the early post-transplant period had lower overall survival than those with a normal baseline creatinine (log-rank p = 0.05), an association whose biological basis requires further study.</p><p><strong>Conclusions: </strong>CKD affects a substantial and growing proportion of pediatric HSCT survivors in this cohort, particularly those transplanted at older ages. These findings are associative rather than causal, given the retrospective, single-center design and limited number of CKD events. They nonetheless support systematic long-term renal surveillance and nephrology referral as part of post-HSCT survivorship care, with prospective, adequately powered studies needed to confirm risk factors and clarify mechanisms.</p>","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"30 8","pages":"e70417"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aligning Words With What Matters: Evaluation of a Nationwide Sample of Pediatric Kidney Transplant Educational Materials.","authors":"Taylor R House, Makayla A Thomas, Aaron Wightman, Kelly Helm, Ryan J Coller, Ari Pollack, Susan P Y Wong","doi":"10.1111/petr.70421","DOIUrl":"10.1111/petr.70421","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplant education promotes early partnership between children, caregivers, and clinicians by sharing information and fostering engagement to maximize outcomes. We evaluated educational materials' accessibility, alignment with shared priorities, and portrayal of life participation.</p><p><strong>Methods: </strong>We performed a content analysis of pediatric kidney transplant centers' educational materials to assess how they addressed 4 key priorities: kidney function, infection, survival, and life participation. We assessed printed materials' readability using Simple Measures of Gobbledygook and Flesch-Kincaid tools and audiovisual materials' understandability and actionability using the Patient Education Materials Assessment Tool.</p><p><strong>Results: </strong>Of 73 centers approached, 23 (32% response) provided educational packets. Only 6 packets (26%) included materials targeted to children. Average reading grade level was high (SMOG 8.9 ± 1.7; Flesch-Kincaid 9.5 ± 1.8), with only 1 packet written at sixth-grade level. Audiovisual materials were not highly understandable or actionable. Among key priorities shared by children, caregivers, and clinicians, packets most frequently addressed infection, followed by kidney function, life participation, and survival. We identified 3 themes reflecting portrayal of the key priority of life participation: hope and caution-a proactive, optimistic tone about certain aspects of life participation and cautious tempering of expectations for others; maximizing physical transplant benefits-detailed guidance on physical activity, but limited attention to psychosocial well-being; and being \"normal\"-a focus on restoring physical health while framing mental and emotional distress as potential threats to normalcy.</p><p><strong>Conclusions: </strong>There are important opportunities to enhance transplant educational materials by tailoring content to children, increasing accessibility, and more consistently and comprehensively addressing concerns about life participation after transplant.</p>","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"30 8","pages":"e70421"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing, Phenotype, and Reversibility of Neurological Complications After Pediatric Liver Transplantation.","authors":"Teruhiko Imamura","doi":"10.1111/petr.70437","DOIUrl":"https://doi.org/10.1111/petr.70437","url":null,"abstract":"","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"30 8","pages":"e70437"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza Disease Burden and Vaccine Effectiveness in Children and Adolescents With Solid Organ Transplant: 2018-2024.","authors":"Daniela Barisano, Justin K Chen, Hillary Kuzaro, Anastacia Serluco, Mark D Gonzalez, Gwen Nance, Keyner Rojas, Precious Nchekwube, Elizabeth Cohen, Inci Yildirim","doi":"10.1111/petr.70433","DOIUrl":"10.1111/petr.70433","url":null,"abstract":"<p><strong>Background: </strong>Solid organ transplant (SOT) recipients have an increased risk of influenza infection. Annual vaccination is the primary strategy to reduce the burden of influenza disease, but vaccine effectiveness (VE) varies annually for influenza. There is limited data published demonstrating influenza VE in pediatric SOT over time.</p><p><strong>Methods: </strong>We conducted a retrospective, case-control study using a test-negative design to estimate influenza VE against laboratory-confirmed influenza infections among pediatric SOT recipients aged 6 months to 21 years at two large pediatric transplant centers, spanning the six influenza seasons from fall 2018 through spring 2024. Logistic regression models were used to compare odds ratios (ORs) of vaccination in cases to controls. VE was calculated as [100% × (1 - adjusted OR)], and 95% confidence intervals (CIs) were computed around the estimates.</p><p><strong>Results: </strong>Across all 6 seasons, there were 4 585 patient encounters, of which 961 had an influenza test and were included in the study. Overall, 750 (78.0%) patients received the seasonal influenza vaccine, and 94 (9.9%) tested positive for influenza. Among vaccinated patients, the prevalence of influenza diagnosis was lower (6.8%) than among unvaccinated patients (20.4%) (OR 0.28, 95% CI 0.18-0.43). The adjusted VE against laboratory-confirmed influenza infection was 72.0% (95% CI 57.0-82.0) and varied by season. VE was similar between organ groups: Kidney (65.9%, 95% CI 29.7-83.4), heart (86.4%, 95% CI 59.0-95.5), and liver (71.7%, 95% CI 41.6-86.3).</p><p><strong>Conclusions: </strong>Influenza vaccination decreased the risk of influenza infection among pediatric SOT recipients for the 2018-2024 influenza seasons.</p>","PeriodicalId":20038,"journal":{"name":"Pediatric Transplantation","volume":"30 8","pages":"e70433"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13491261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}