Optimizing pediatric liver transplantation: Evaluating the impact of donor age and graft type on patient survival outcome

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-04 DOI:10.1111/petr.14771

Yong K. Kwon, Pamela L. Valentino, Patrick J. Healey, Andre A. S. Dick, Evelyn K. Hsu, James D. Perkins, Mark L. Sturdevant

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引用次数: 0

Abstract

BackgroundWe examined the combined effects of donor age and graft type on pediatric liver transplantation outcomes with an aim to offer insights into the strategic utilization of these donor and graft options.MethodsA retrospective analysis was conducted using a national database on 0–2‐year‐old (N = 2714) and 3–17‐year‐old (N = 2263) pediatric recipients. These recipients were categorized based on donor age (≥40 vs <40 years) and graft type. Survival outcomes were analyzed using the Kaplan–Meier and Cox proportional hazards models, followed by an intention‐to‐treat (ITT) analysis to examine overall patient survival.ResultsLiving and younger donors generally resulted in better outcomes compared to deceased and older donors, respectively. This difference was more significant among younger recipients (0–2 years compared to 3–17 years). Despite this finding, ITT survival analysis showed that donor age and graft type did not impact survival with the exception of 0–2‐year‐old recipients who had an improved survival with a younger living donor graft.ConclusionsTimely transplantation has the largest impact on survival in pediatric recipients. Improving waitlist mortality requires uniform surgical expertise at many transplant centers to provide technical variant graft (TVG) options and shed the conservative mindset of seeking only the “best” graft for pediatric recipients.

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优化小儿肝移植手术：评估供体年龄和移植物类型对患者存活结果的影响

背景我们研究了供体年龄和移植物类型对小儿肝移植结果的综合影响，旨在为战略性地利用这些供体和移植物选择提供见解。方法我们利用一个全国性数据库对0-2岁（N = 2714）和3-17岁（N = 2263）的小儿受者进行了回顾性分析。这些受者根据供体年龄（≥40 岁 vs <40 岁）和移植物类型进行分类。采用 Kaplan-Meier 模型和 Cox 比例危险模型对生存结果进行分析，然后进行意向治疗 (ITT) 分析，以检查患者的总体生存情况。这种差异在年轻受者（0-2 岁与 3-17 岁）中更为明显。尽管有这一发现，但 ITT 存活率分析表明，供体年龄和移植物类型对存活率并无影响，但 0-2 岁受者的存活率因年轻的活体供体移植物而有所提高。要改善等待名单上的死亡率，需要许多移植中心具备统一的外科专业知识，提供技术变异移植物（TVG）选择，并摆脱只为儿科受者寻求 "最佳 "移植物的保守心态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.