Trends in Specific Family Refusals for Pediatric Organ and Tissue Donation: A Cross-Sectional Study.

IF 1.4 4区医学 Q3 PEDIATRICS

Pediatric Transplantation Pub Date : 2025-02-01 DOI:10.1111/petr.70028

Danton Matheus de Souza, Niflyer Costa Miranda, Rafael Rodrigo da Silva Pimentel, Edvaldo Leal de Moraes, Marcelo José Dos Santos

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引用次数: 0

Abstract

Background: When a family decides to donate the organs or tissues of their child with brain death, it is necessary to consider which organs or tissues will be donated. This phenomenon presents an ethical dilemma that is underexplored in the scientific literature, making it essential to examine this context to understand how refusals occur within donations.

Objective: To analyze the rates and trends of specific refusals for each organ and tissue from pediatric donors with brain death occurring between 2001 and 2020 in an Organ Procurement Organization in the State of São Paulo, Brazil.

Methods: This was a cross-sectional, exploratory, retrospective, quantitative study. Data were derived from a database consisting of copies of organ and tissue donation authorization forms, organized, and subjected to descriptive and inferential analyses. This study adhered to international ethical guidelines.

Results: Data from 109 real donors were analyzed. The bones, skin, and blood vessels had the highest refusal rates among tissues, as well as the pancreas and lungs for solid organs. Most organs and tissues showed a decreasing refusal trend except for the corneas, liver, and kidneys, which exhibited a stationary trend.

Conclusions: This study illustrates the refusals within real donations, with high refusal rates for tissues compared to solid organs.

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儿童器官和组织捐赠的特定家庭拒绝趋势：一项横断面研究。

背景：当一个家庭决定捐赠其脑死亡儿童的器官或组织时，有必要考虑将捐赠哪些器官或组织。这一现象提出了一个科学文献未充分探讨的伦理困境，因此有必要研究这一背景，以了解捐赠中是如何发生拒绝的。目的：分析巴西圣保罗州某器官采购组织2001年至2020年间发生的脑死亡儿童供体的每种器官和组织的特异性拒绝率和趋势。方法：采用横断面、探索性、回顾性、定量研究。数据来源于由器官和组织捐赠授权表格副本组成的数据库，经过整理，并进行描述性和推断性分析。本研究遵循国际伦理准则。结果：对109例真实供体的数据进行分析。在组织中，骨骼、皮肤和血管的拒绝率最高，在实体器官中，胰腺和肺部的拒绝率也最高。除角膜、肝脏和肾脏呈平稳趋势外，其余器官和组织均呈下降趋势。结论：本研究说明了真实捐赠中的拒绝，与实体器官相比，组织的拒绝率更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Transplantation 医学-小儿科

CiteScore

2.90

自引率

15.40%

发文量

216

审稿时长

3-8 weeks

期刊介绍： The aim of Pediatric Transplantation is to publish original articles of the highest quality on clinical experience and basic research in transplantation of tissues and solid organs in infants, children and adolescents. The journal seeks to disseminate the latest information widely to all individuals involved in kidney, liver, heart, lung, intestine and stem cell (bone-marrow) transplantation. In addition, the journal publishes focused reviews on topics relevant to pediatric transplantation as well as timely editorial comment on controversial issues.