Pain management最新文献_第7页

Neuroinflammatory pathways linking pain and rehabilitation outcomes in schizophrenia: a narrative review. 神经炎症通路连接疼痛和康复结果在精神分裂症：叙述性回顾。

IF 1.7

Pain management Pub Date : 2026-08-03 DOI: 10.1080/17581869.2026.2713532

Sanaz Sedghi Esfahani, Elmira Mahdinia, Setareh Dehkhodaei, Nadia Abedi Oumali, Soroush Taherkhani, Raheleh Rafaiee

{"title":"Neuroinflammatory pathways linking pain and rehabilitation outcomes in schizophrenia: a narrative review.","authors":"Sanaz Sedghi Esfahani, Elmira Mahdinia, Setareh Dehkhodaei, Nadia Abedi Oumali, Soroush Taherkhani, Raheleh Rafaiee","doi":"10.1080/17581869.2026.2713532","DOIUrl":"https://doi.org/10.1080/17581869.2026.2713532","url":null,"abstract":"Introduction: Schizophrenia is a chronic and disabling neuropsychiatric disorder traditionally defined by psychotic and cognitive symptoms. Increasing evidence suggests that neuroinflammatory mechanisms contribute to its pathophysiology and may also underlie common but underrecognized somatic manifestations. These include altered pain perception, characterized by both diminished sensitivity and chronic pain, with important implications for functional outcomes and rehabilitation.Areas covered: This narrative review examines clinical, preclinical, and translational studies addressing the role of neuroinflammation in schizophrenia, with a specific focus on microglial and astrocytic activation, cytokine signaling, oxidative stress pathways, and their interactions with central pain processing circuits. The review was informed by targeted searches of PubMed, Scopus, Web of Science, and Google Scholar, covering articles published from database inception to January 2026, with emphasis on studies relevant to pain modulation, symptom expression, and neurobiological heterogeneity in schizophrenia.Expert opinion: Neuroinflammation represents a biologically plausible link between core schizophrenia pathology and altered pain perception. Recognition of pain as an integrated component of disease biology, rather than a secondary complaint, may improve clinical assessment and treatment planning. Investigating and targeting neuroinflammatory pathways holds promise for personalized interventions that address neuropsychiatric symptoms and pain, potentially enhancing rehabilitation outcomes and quality of life.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-19"},"PeriodicalIF":1.7,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hidden impact of pain in Parkinson's disease: exploring the role of pain interference in gait performance. 疼痛在帕金森病中的隐性影响：探索疼痛干扰在步态表现中的作用。

IF 1.7

Pain management Pub Date : 2026-08-01 Epub Date: 2026-06-15 DOI: 10.1080/17581869.2026.2672489

Beatriz Menezes DeJesus, Annanda Oliveira Santos, Leylane Oliveira, Heitor Franco Santos, Josimari Melo DeSantana

{"title":"The hidden impact of pain in Parkinson's disease: exploring the role of pain interference in gait performance.","authors":"Beatriz Menezes DeJesus, Annanda Oliveira Santos, Leylane Oliveira, Heitor Franco Santos, Josimari Melo DeSantana","doi":"10.1080/17581869.2026.2672489","DOIUrl":"10.1080/17581869.2026.2672489","url":null,"abstract":"Objective: To investigate the relationship between clinical pain and functional mobility, especially gait performance, in individuals with Parkinson's Disease (PD).Method: Pain was evaluated using the Brief Pain Inventory (BPI), while functional mobility was measured through the Timed Up and Go (TUG), Six-Minute Walk Test (6MWT) distance and Freezing of Gait Questionnaire (FOGQ) total score.Results: Thirty-four individuals with PD were assessed during the \"ON\" medication state. While reported pain intensity was low, pain interference was moderate and significantly correlated with reduced walking performance and greater freezing of gait severity (p < 0.05, ρ=0.37). Notably, higher pain interference, but not intensity, was associated with shorter 6MWT distances (p < 0.01, ρ=-0.48) and more frequent freezing episodes (p < 0.001, ρ=0.64). Another test, the TUG was not affected by pain.Conclusion: Assessing pain interference, rather than pain intensity alone, is essential when addressing functional mobility in PD. Pain interference is significantly related to reduced gait performance and increased freezing, highlighting the importance of rehabilitation strategies that focus on minimizing disruptive impact of pain on movement.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"877-885"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporomandibular disorders in children and adolescents: an underexplored condition in need of developmentally informed diagnostic guidance. 儿童和青少年颞下颌关节疾病：需要发育知情诊断指导的未充分探索的条件。

IF 1.7

Pain management Pub Date : 2026-08-01 Epub Date: 2026-05-22 DOI: 10.1080/17581869.2026.2676726

Caroline M Sawicki, Linda Sangalli

{"title":"Temporomandibular disorders in children and adolescents: an underexplored condition in need of developmentally informed diagnostic guidance.","authors":"Caroline M Sawicki, Linda Sangalli","doi":"10.1080/17581869.2026.2676726","DOIUrl":"10.1080/17581869.2026.2676726","url":null,"abstract":"Introduction: Temporomandibular disorders (TMD) are increasingly recognized in children and adolescents, yet their diagnosis and clinical management remain less clearly defined than in adult populations. Despite evidence that TMD symptoms often emerge during critical periods of craniofacial growth and that TMD-related pain in adolescence substantially increases the risk of persistence into adulthood, pediatric TMD remains underrepresented in research, clinical guidelines, and professional education.Areas covered: The review synthesizes emerging consensus on age-appropriate screening tools and diagnostic frameworks based on adaptations of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for children and adolescents; highlights the importance of interdisciplinary, biopsychosocial approaches for early identification, prognosis, and management of pediatric TMD; and identifies key gaps in epidemiology, diagnostic validation, and longitudinal outcomes. When pediatric-specific evidence is available, this review summarizes practical approaches to screening, clinical examination, and psychosocial assessment that are feasible in primary care and pediatric dental settings. Gaps in the validation of diagnostic tools and thresholds across developmental stages are identified as pressing research priorities, as they directly influence epidemiological estimates, clinical decision-making, and care pathways.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"929-946"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13419674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can large language models help in the assessment of people with pain? 大型语言模型能帮助评估疼痛患者吗？

IF 1.7

Pain management Pub Date : 2026-08-01 DOI: 10.1080/17581869.2026.2710351

Jacopo Amidei, Andreas Kaltenbrunner, Jose Gregorio Ferreira de Sa, Ruben Nieto

{"title":"Can large language models help in the assessment of people with pain?","authors":"Jacopo Amidei, Andreas Kaltenbrunner, Jose Gregorio Ferreira de Sa, Ruben Nieto","doi":"10.1080/17581869.2026.2710351","DOIUrl":"https://doi.org/10.1080/17581869.2026.2710351","url":null,"abstract":"Chronic pain (CP) affects an important proportion of the global population, imposing a significant socio-economic burden and serving as a leading cause of disability. While the biopsychosocial approach is the gold standard for treatment, many patients fail to receive adequate care due to healthcare resource constraints. Effective management requires a comprehensive assessment. However, traditional questionnaires often miss the subjective and multidimensional depth of the pain experience. Differently, written narratives (WNs) empower patients to describe their pain in their own words. Nevertheless, qualitative analysis, such as WN, is often time-consuming for clinicians.This paper explores how Large Language Models (LLMs) can facilitate clinicians in analyzing WNs. Evidence from the AINarratives project and other emerging studies indicates that LLMs can evaluate pain narratives with accuracy and utility comparable to human experts, identifying biopsychosocial themes that correlate with standardized clinical scores.We conclude that LLMs should serve as clinical companions rather than substitutes, streamlining qualitative data processing to enhance the clinician-patient interaction and facilitate personalized care.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement in vestibular symptoms following cervical medial branch radiofrequency neurotomy: a case report suggesting cervicogenic mechanisms. 颈椎内侧支射频神经切开术后前庭症状的改善：一个提示颈源性机制的病例报告。

IF 1.7

Pain management Pub Date : 2026-08-01 Epub Date: 2026-05-11 DOI: 10.1080/17581869.2026.2672490

Kristina Organista, Semih Gungor

引用次数: 0

Determining the efficacy of self-myofascial release technique versus muscle energy technique in sacroiliac pain management: a clinical trial protocol. 确定自我肌筋膜释放技术与肌肉能量技术在骶髂疼痛治疗中的疗效：一项临床试验方案。

IF 1.7

Pain management Pub Date : 2026-08-01 Epub Date: 2026-04-28 DOI: 10.1080/17581869.2026.2664769

Rama Taneja, Amita Aggarwal

{"title":"Determining the efficacy of self-myofascial release technique versus muscle energy technique in sacroiliac pain management: a clinical trial protocol.","authors":"Rama Taneja, Amita Aggarwal","doi":"10.1080/17581869.2026.2664769","DOIUrl":"10.1080/17581869.2026.2664769","url":null,"abstract":"Aim: This study aims to compare self-myofascial release with the muscle energy technique for sacroiliac pain.Methodology: Forty patients with sacroiliac pain who fulfil the eligibility criteria and provide written informed consent will be recruited from a tertiary care hospital for a two-group pre-post experimental study design. After noting the demographic details, subjects will be randomized using a computerized randomization method. Group A will receive the self-myofascial release technique, and Group B will receive the Muscle Energy Technique. Conventional treatment will also be given in both groups. Both interventions will be administered for a period of 2 weeks. Primary Outcome measures will include pain (Visual Analog scale), pressure-pain threshold (Pressure Algometer), and Function. The Secondary Outcome includes Leg Length Discrepancy and Quality of life (EuroQol-5 Dimension). All outcomes will be recorded at baseline, at the end of 2 weeks and after 4 weeks.Conclusion and relevance: This trial will expand our understanding of the use of the self-myofascial release technique and Muscle Energy Technique in treating patients with sacroiliac pain, and inform the development of a tailored protocol for manual therapy interventions in these patient care settings.Clinical trial registration: The www.ctri.nic.in/Clinicaltrials identifier is CTRI/2025/07/090693 (Version 1.0-10 July 2025).","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"835-844"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond joint damage: mechanistic insights into osteoarthritis pain. 超越关节损伤：对骨关节炎疼痛的机械洞察。

IF 1.7

Pain management Pub Date : 2026-08-01 Epub Date: 2026-04-14 DOI: 10.1080/17581869.2026.2659824

Giacomo Rossettini, Chad E Cook, Jorge Hugo Villafañe

引用次数: 0

Exploring the link between anxiety, depression and somatization with pain severity in chronic low back pain patients: a survey at a tertiary care hospital. 探讨慢性腰痛患者的焦虑、抑郁和躯体化与疼痛严重程度之间的联系：一项在三级保健医院的调查。

IF 1.7

Pain management Pub Date : 2026-08-01 Epub Date: 2026-05-16 DOI: 10.1080/17581869.2026.2674766

Mehar Zaka, Umaimah Batool Mirza, Mariam Bibi, Ayesha Bibi, Ayesha Sheikh, Javed Akbar Dars, Ahmed Asad Raza

{"title":"Exploring the link between anxiety, depression and somatization with pain severity in chronic low back pain patients: a survey at a tertiary care hospital.","authors":"Mehar Zaka, Umaimah Batool Mirza, Mariam Bibi, Ayesha Bibi, Ayesha Sheikh, Javed Akbar Dars, Ahmed Asad Raza","doi":"10.1080/17581869.2026.2674766","DOIUrl":"10.1080/17581869.2026.2674766","url":null,"abstract":"Background: Chronic low back pain (CLBP) is a major cause of disability worldwide and is strongly associated with anxiety, depression, and somatization. This study assessed the prevalence of these psychopathologies and their relationship with pain severity in Pakistani CLBP patients.Objective: To determine the prevalence of anxiety, depression, and somatization and evaluate their predictive value for pain severity in CLBP.Methodology: A cross-sectional study was conducted from April to October 2024 at Jinnah Postgraduate Medical Center, Karachi. Fifty-eight CLBP patients and 58 healthy controls completed PHQ-9, GAD-7, and PHQ-15 questionnaires. Statistical analyses included Chi-square, Mann-Whitney U, and ordinal logistic regression.Results: CLBP patients showed significantly higher rates of anxiety (86.2%), depression (86.2%), and somatization (96.5%) than controls (p < 0.001). Depression was the only significant predictor of pain severity (β = -1.957, p = 0.009, OR = 0.141, 95% CI: 0.033-0.607), unexpectedly associating higher depression with lower reported pain severity. Anxiety and somatization were not significant predictors.Conclusion: Psychological distress is highly prevalent in CLBP, supporting its biopsychosocial nature. The inverse relationship between depression and pain severity warrants further investigation, while routine psychological screening and multidisciplinary care remain essential.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"887-895"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13432827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of thermal radiofrequency ablation versus corticosteroid injections for pain reduction in facet-mediated chronic low back pain: a systematic review and meta-analysis. 热射频消融与皮质类固醇注射减轻关节面介导的慢性腰痛的有效性：一项系统回顾和荟萃分析。

IF 1.7

Pain management Pub Date : 2026-08-01 Epub Date: 2026-05-18 DOI: 10.1080/17581869.2026.2675483

Justin Le, Han Jie Liu, Andrew Atschinow, Lisa Huang, Jason Tran, Anish Rana, Brandon Lazar, Gilbert Siu

{"title":"Effectiveness of thermal radiofrequency ablation versus corticosteroid injections for pain reduction in facet-mediated chronic low back pain: a systematic review and meta-analysis.","authors":"Justin Le, Han Jie Liu, Andrew Atschinow, Lisa Huang, Jason Tran, Anish Rana, Brandon Lazar, Gilbert Siu","doi":"10.1080/17581869.2026.2675483","DOIUrl":"10.1080/17581869.2026.2675483","url":null,"abstract":"Background: Facet joint syndrome (FJS) is a prevalent cause of chronic low back pain (CLBP), resulting in reduced quality of life. Radiofrequency ablation (RFA) and corticosteroid injections are commonly utilized; however, direct comparative evidence specific to lumbar FJS remains limited.Methods: A comprehensive search of PubMed, Embase, Web of Science, Cochrane Library, and Scopus (from inception to November 2025) was conducted to identify randomized controlled trials (RCTs) evaluating thermal RFA versus corticosteroid injections. The primary outcome measured was the Visual Analog Scale (VAS) at 3- and 6-months. Review Manager 5.4 was used to evaluate mean differences (MD) across outcomes using a random-effects model.Result: Three RCTs with a total of 146 patients were included. Pooled analysis demonstrated significantly greater pain reduction with RFA at both 3-months (MD = -1.27; 95% CI, -1.96 to -0.58; p = 0.0003) and 6-months (MD = -0.86; 95% CI, -1.18 to -0.54; p < 0.00001), favoring RFA. Heterogeneity was moderate to low across timepoints. Although significant, these results fell underneath the minimally important clinical difference (MCID).Conclusion: In our study, thermal RFA provided greater pain reduction than corticosteroid injections for FJS causing CLBP, suggesting a modest short-term advantage in pain reduction.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"921-928"},"PeriodicalIF":1.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

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Pain management Pub Date : 2026-08-01 Epub Date: 2026-01-26 DOI: 10.1080/17581869.2026.2621584

引用次数: 0