Pain management最新文献

{"title":"Fibromyalgia, more than \"just pain\".","authors":"M Elena González-Álvarez, Giacomo Rossettini, Jorge Hugo Villafañe","doi":"10.1080/17581869.2025.2513216","DOIUrl":"10.1080/17581869.2025.2513216","url":null,"abstract":"","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"359-361"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of memantine and vitamin C in postoperative pain management: a randomized clinical trial.","authors":"Masoud Saadat Fakhr, Amirhasan Mohajeri, Bahar Amini, Reza Shah Hosseini, Fatemeh Rafizadeh, Elham Esmaeili, Mahnaz Narimani Zamanabadi","doi":"10.1080/17581869.2025.2516415","DOIUrl":"10.1080/17581869.2025.2516415","url":null,"abstract":"<p><strong>Aim: </strong>Acute postoperative pain affects most surgical patients, often delaying recovery. Memantine (Namenda®), an N-methyl-D-aspartate (NMDA) receptor antagonist, offers potential for effective pain relief with minimal adverse effects. This study examines memantine's effectiveness in reducing acute postoperative pain and opioid consumption compared to vitamin C, which served as an active comparator.</p><p><strong>Patients and methods: </strong>This double-blind randomized clinical trial was conducted in 2021 at a single tertiary-care hospital (Boali, Amirul Mominin, and Farhikhtegan Hospital). Patients aged 15-75 undergoing elective abdominal surgery were randomized to receive either memantine (<i>n</i> = 17) or vitamin C (<i>n</i> = 17). Pain was assessed using the visual analogue scale (VAS) at 0, 6, 12, and 24 hours postoperatively, with pethidine rescue analgesia (VAS >V). Statistical analyses included the Mann-Whitney test (non-normally distributed data), repeated-measures ANOVA (time effects), and Fisher's exact test (categorical variables).</p><p><strong>Results: </strong>Memantine significantly reduced postoperative pain at all intervals compared to vitamin C (<i>p</i> < 0.05), with the largest difference at 24 hours (3.2 ± 0.2 vs. 4.7 ± 0.1, <i>p</i> < 0.001). Narcotic use was lower in the memantine group (31.7 ± 2.5 mg vs. 42.9 ± 4.1 mg, <i>p</i> = 0.81). Pain intensity declined over time in both groups, but the reduction was greater with memantine (group-by-time interaction, <i>p</i> = 0.034).</p><p><strong>Conclusions: </strong>Memantine was more effective than vitamin C (active comparator) in reducing acute postoperative pain and opioid requirements following elective abdominal surgery. These findings support memantine's potential as a non-opioid adjunct for pain management in this population. However, limitations include a small sample size, single-center design, and short follow-up period. Further multicenter trials with larger cohorts and extended observation are warranted to confirm these results and optimize dosing strategies.</p><p><strong>Clinicaltrialregistration: </strong>https://irct.behdasht.gov.ir/trial/80349 is: IRCTID: IRCT20240120060739N1).</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"379-385"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid deprescribing: rethinking policies to facilitate better patient outcomes.","authors":"Aili V Langford, Kellia Chiu","doi":"10.1080/17581869.2025.2516409","DOIUrl":"10.1080/17581869.2025.2516409","url":null,"abstract":"<p><p>Deprescribing, the patient-centered process of reducing or stopping a medication when the potential harms outweigh the likely benefits, has emerged as a promising strategy to mitigate opioid-related harm. Typically, opioid deprescribing occurs at the individual level, however, adopting a policy-driven approach could expand its reach and impact. To date, prescription opioid control policies that have been implemented with the intention of reducing opioid use and harm have often resulted in unintended consequences. In this article we discuss whether and how the concept of opioid deprescribing can be operationalized at a policy level. We review the goals, challenges and consequences of opioid control policies, explore how they intersect with system-level factors, and propose pathways for developing and implementing future opioid deprescribing policies. We argue that the development and implementation of patient-centered opioid deprescribing policies are both essential and feasible, if key challenges such as structural stigma and the complex interplay between pain and opioid use disorder are recognized and addressed. Robust evaluation frameworks will also be critical for monitoring outcomes and refining interventions. By prioritizing patient and provider needs, and carefully considering pertinent system-level factors, policymakers may be able to foster more effective and compassionate opioid management and reduce opioid-related harm.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"413-423"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rimegepant orally disintegrating tablet for acute treatment of migraine: a plain language summary of a clinical study.","authors":"Robert Croop, Peter J Goadsby, David A Stock, Charles M Conway, Micaela Forshaw, Elyse G Stock, Richard B Lipton","doi":"10.1080/17581869.2025.2487406","DOIUrl":"10.1080/17581869.2025.2487406","url":null,"abstract":"","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"301-309"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case series of CT-fusion and real-time US-guidance in percutaneous RF thermocoagulation for trigeminal rhizotomy.","authors":"Chia-Hong Guo, Yung-Chi Hsu, Wei-Chen Liao, Hao-Lun Kao, Wei-Chou Chang, Yi-Chih Hsu","doi":"10.1080/17581869.2025.2508683","DOIUrl":"10.1080/17581869.2025.2508683","url":null,"abstract":"<p><p>This case series evaluates the feasibility, safety, and efficacy of real-time computed tomography fusion with ultrasound guidance (CTF-USG) in percutaneous radiofrequency thermocoagulation (RFT) for trigeminal rhizotomy. Traditional imaging modalities such as CT and fluoroscopy lack real-time visualization, increasing the risk of vascular injury and reducing procedural precision. The CTF-USG technique integrates CT imaging with real-time ultrasound via electromagnetic tracking, enabling accurate needle navigation and anatomical confirmation. Six patients with refractory trigeminal neuralgia affecting the V2 or V3 divisions underwent RFT guided by CTF-USG. All procedures achieved first-attempt needle placement success with no immediate complications. Postoperative assessments demonstrated significant reductions in pain scores at one and three months. The real-time imaging capability facilitated avoidance of critical structures, enhanced procedural safety. In conclusion, CTF-USG offers real-time imaging superior to C-arm fluoroscopy or standard CT, reducing complications and improving procedural accuracy. Primary technique efficacy was 100%. These advantages support its adoption in treating refractory trigeminal neuralgia.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"317-323"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-acute sequelae SARS-CoV-2 infection and neuropathic pain: a narrative review of the literature and future directions.","authors":"Peter D Vu, Salahadin Abdi","doi":"10.1080/17581869.2025.2501521","DOIUrl":"10.1080/17581869.2025.2501521","url":null,"abstract":"<p><strong>Purpose of review: </strong>Neuropathic pain is a recognized and debilitating symptom of SARS-CoV-2 infection across acute, post-acute, and long-COVID phases. Initially emerging as acute or subacute symptoms, these neuropathic manifestations can evolve into chronic conditions, with approximately 10% of all SARS-CoV-2 cases (estimated 65 million individuals globally) developing post-acute SARS-CoV-2 (PASC) neuropathic sequalae. Given the limited literature specifically addressing neuropathic pain related to PASC, a deeper understanding is needed to improve management and reduce patient burden.</p><p><strong>Recent findings: </strong>PASC symptoms are associated with disease severity, elevated body mass indexes, preexisting psychological conditions, and addiction history. Sex differences appear to influence prevalence, and the multisystem nature of PASC complicates symptom presentation, with mood disorders, fatigue, and cognitive dysfunction contributing to altered pain perception. Proposed mechanisms include immune dysregulation, persistent viral protein effects, and neuroanatomical changes. Management typically involves a multimodal approach.</p><p><strong>Summary: </strong>This review examines SARS-CoV-2 neuropathic pain across the illness trajectory, examining its pathophysiology, prevalence, and treatment. It highlights the potential for subacute neuropathic symptoms to become chronic and calls for future research to refine long-term management strategies and assess broader healthcare implications.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"333-343"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baastrup's disease in a patient with multifactorial back pain: a case report.","authors":"Komal Luthra, Melissa Schwartz, Darsha Krishnamurthi, Pranamya Suri, Scott Benkovic, Akhil Chhatre","doi":"10.1080/17581869.2025.2507559","DOIUrl":"10.1080/17581869.2025.2507559","url":null,"abstract":"<p><p>Lower back pain is a common yet often misdiagnosed condition due to its multifactorial nature and presence of other underlying pathologies. Baastrup's disease is an underdiagnosed cause of lower back pain. We present a case of a 67-year-old female who initially presented with lower back pain and associated radiation to bilateral lower extremities. The patient's imaging revealed moderate spinal canal stenosis at L4-L5 due to grade 1 anterolisthesis, severe right L5-S1 neural foraminal stenosis, and a dorsal epidural cyst with interspinous bursitis possibly related to Baastrup's disease. The patient underwent L4-L5 interlaminar epidural steroid injection with cyst aspiration under fluoroscopic guidance and had temporary relief. Given the multifactorial nature of her pain, she subsequently underwent greater trochanter bursa steroid injections and bilateral L3-L5 medial branch blocks, resulting in significant pain relief. Our case demonstrates the multifactorial nature of lower back pain, where treatment of each underlying aspect, including identification of Baastrup's Disease with associated epidural cyst, resulted in pain relief. It also underscored the importance of considering the patient's history when using steroid injections in interventional procedures and determining when a patient is more appropriate for surgery.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"311-315"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of intra-arterial lidocaine administration for pain control in uterine artery embolization for cesarean scar pregnancy.","authors":"Tianhong Cai, Rong Zhang, Kai Chen, Ting Deng, Tenghui Zhan","doi":"10.1080/17581869.2025.2511464","DOIUrl":"10.1080/17581869.2025.2511464","url":null,"abstract":"<p><strong>Background: </strong>Uterine artery embolization (UAE) for cesarean scar pregnancy (CSP) can cause significant pain.</p><p><strong>Objectives: </strong>To evaluate safety and efficacy of intra-arterial lidocaine during UAE for CSP.</p><p><strong>Methods: </strong>Retrospective study of 255 CSP patients: Control Group (184) without lidocaine; Study Group I (39) with unilateral lidocaine; Study Group II (32) with bilateral lidocaine. Outcomes included VAS pain scores and morphine usage.</p><p><strong>Results: </strong>Early postoperative VAS scores (0-2 hours) were significantly lower in study groups (<i>p</i> < 0.001). No differences in later VAS scores (4-24 hours), maximal VAS scores, morphine dosage, or safety indicators.</p><p><strong>Conclusion: </strong>Intra-arterial lidocaine during UAE for CSP provides effective analgesia immediately post-procedure but only for the first 2-4 hours, without reducing overall opioid requirements.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"325-332"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological therapies to treat musculoskeletal pain.","authors":"Giacomo Farì, Silvia Fiore, Giustino Varrassi, Andrea Bernetti","doi":"10.1080/17581869.2025.2509475","DOIUrl":"10.1080/17581869.2025.2509475","url":null,"abstract":"","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"297-299"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese acupoint therapies in cancer pain management: research advances and future perspectives.","authors":"Zhengqin Shi, Hong Sun, Junlei Wu, Yude Jin, Sujie Cao, Jianli Cai","doi":"10.1080/17581869.2025.2510191","DOIUrl":"10.1080/17581869.2025.2510191","url":null,"abstract":"<p><p>Cancer pain management (CPM) is crucial in oncology care, with current approaches including pharmacotherapy, radiotherapy, chemotherapy, nerve blocks, and psychological support. However, long-term drug use risks adverse effects and addiction, while physiotherapies often lack sustained efficacy. Therefore, identifying safer adjuvant analgesic therapies has become an urgent issue. Traditional Chinese Medicine (TCM) acupoint therapies (acupuncture, moxibustion, and acupoint injection) offer safer adjuvant analgesia with growing clinical validation. This narrative review aims to introduce the research progress of acupoint therapy in alleviating cancer pain and the role of emerging technologies in advancing acupoint therapy. All literature selections were sourced exclusively from PubMed and CNKI databases. First, we briefly introduce the mechanisms of cancer pain, outline relevant evaluation methods, and summarize the limitations of existing CPM strategies. Additionally, we discuss the therapeutic effects, underlying mechanisms, and potential improvements of acupoint therapies in CPM. Notably, recent advancements in information technology, artificial intelligence, and materials science, along with the development of noninvasive stimulation methods and innovative devices, have significantly advanced the understanding of acupoint treatment mechanisms and expanded their clinical applications. Finally, we highlight the challenges and future directions for TCM acupoint therapies. This study provides clinical insights and recommendations for CPM.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"345-358"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}