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Gepants in the acute management of migraine. Gepants在偏头痛的急性治疗中。
IF 1.7
Pain management Pub Date : 2023-11-01 Epub Date: 2023-11-09 DOI: 10.2217/pmt-2023-0106
William David Wells-Gatnik, Paolo Martelletti
{"title":"Gepants in the acute management of migraine.","authors":"William David Wells-Gatnik, Paolo Martelletti","doi":"10.2217/pmt-2023-0106","DOIUrl":"10.2217/pmt-2023-0106","url":null,"abstract":"","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"627-630"},"PeriodicalIF":1.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71522350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolongation of spinal duration by escalating doses of intrathecal epinephrine in lower limb arthroplasty. 下肢关节置换术中不断增加鞘内肾上腺素剂量延长脊柱持续时间。
IF 1.7
Pain management Pub Date : 2023-11-01 Epub Date: 2023-11-15 DOI: 10.2217/pmt-2023-0068
Christopher D Wolla, Tom I Epperson, Erick M Woltz, Bethany J Wolf, Eric D Bolin
{"title":"Prolongation of spinal duration by escalating doses of intrathecal epinephrine in lower limb arthroplasty.","authors":"Christopher D Wolla, Tom I Epperson, Erick M Woltz, Bethany J Wolf, Eric D Bolin","doi":"10.2217/pmt-2023-0068","DOIUrl":"10.2217/pmt-2023-0068","url":null,"abstract":"<p><p><b>Aim:</b> The optimal dose of low-dose intrathecal epinephrine in the absence of intrathecal opioids is unknown. <b>Materials & methods:</b> Prospective, randomized, double blind clinical trial of patients undergoing lower limb arthroplasties. The primary end point was spinal block duration measured via motor and sensory block duration. <b>Results:</b> 30 patients undergoing lower limb arthroplasty were randomized into one of six groups with varying intrathecal epinephrine doses 0-100 mcg. There was a direct linear effect between motor block duration and intrathecal epinephrine dose with higher doses being associated with longer block duration (p = 0.011). Mean motor block duration was 3.74 ± 1.13, 3.36 ± 0.47, 3.39 ± 0.60, 4.06 ± 0.98 and 5.20 ± 1.41 h for the EPI0, EPI25, EPI50, EPI75 and EPI100 groups respectively. <b>Conclusion:</b> This study reveals that low-dose intrathecal epinephrine (75-100 mcg) in the absence of intrathecal opioids can be reliably used to prolong motor block duration in lower limb arthroplasty. <b>Clinical Trial Registration</b>: NCT02619409 (ClinicalTrials.gov).</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"647-654"},"PeriodicalIF":1.7,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"107591991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crizanlizumab in sickle cell disease. Crizanlizumab治疗镰状细胞病。
IF 1.7
Pain management Pub Date : 2023-10-18 DOI: 10.2217/pmt-2023-0031
Kiranveer Kaur, Katie Kennedy, Darla Liles
{"title":"Crizanlizumab in sickle cell disease.","authors":"Kiranveer Kaur,&nbsp;Katie Kennedy,&nbsp;Darla Liles","doi":"10.2217/pmt-2023-0031","DOIUrl":"https://doi.org/10.2217/pmt-2023-0031","url":null,"abstract":"<p><p>Vaso-occlusion in sickle cell disease (SCD) leads to a myriad of manifestations driving morbidity and mortality in patients with SCD. Increased leucocyte adhesion and P-selectin expression on platelets and endothelial cells is an inciting event that leads to obstruction of microcirculation by adhesion with rigid sickled red blood cells. Crizanlizumab is a first-in-class monoclonal antibody that inhibits P-selectin and has been shown to decrease the frequency of vaso-occlusive pain crises in patients with SCD in clinical trials. The role of crizanlizumab in other manifestations of SCD still needs further investigation.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41237605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of intraoperative N-acetylcysteine on opioid consumption following spine surgery: a randomized pilot trial. 术中n -乙酰半胱氨酸对脊柱手术后阿片类药物消耗的影响:一项随机试点试验。
IF 1.4
Pain management Pub Date : 2023-10-01 Epub Date: 2023-10-25 DOI: 10.2217/pmt-2023-0061
Sylvia H Wilson, Joel M Sirianni, Kathryn H Bridges, Bethany J Wolf, Isabella E Valente, Michael D Scofield
{"title":"The impact of intraoperative N-acetylcysteine on opioid consumption following spine surgery: a randomized pilot trial.","authors":"Sylvia H Wilson, Joel M Sirianni, Kathryn H Bridges, Bethany J Wolf, Isabella E Valente, Michael D Scofield","doi":"10.2217/pmt-2023-0061","DOIUrl":"10.2217/pmt-2023-0061","url":null,"abstract":"<p><p><b>Aim:</b> N-acetylcysteine (NAC) decreases inflammation and could augment perioperative analgesia. <b>Materials & methods:</b> This prospective pilot trial examined postoperative opioid consumption at 12 h following intraoperative NAC. In phase I, 20 adults scheduled for posterior spine surgery were randomized to NAC (0, 50, 100 and 150 mg/kg) to determine the optimal dose. In phase II, 30 patients were randomized to placebo or NAC (150 mg/kg). Opioid consumption, pain ratings and time to opioid rescue were recorded. <b>Results:</b> Postoperative opioid consumption was reduced in the NAC group 19.3% at 12 h and 20% at 18 and 36 h. Opioid consumption was reduced 22-24% in the NAC group at all times after adjusting for intraoperative opioid administration. NAC subjects reported lower pain scores relative to placebo. <b>Conclusion:</b> Subjects randomized to NAC consumed less postoperative opioids and reported less pain versus placebo. Larger randomized controlled trials are needed to further evaluate NAC for analgesia. <b>Clinical Trial Registration</b>: NCT04562597 (ClinicalTrials.gov).</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"593-602"},"PeriodicalIF":1.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Painful diabetic peripheral neuropathy of the feet: integrating prescription-strength capsaicin into office procedures. 疼痛性糖尿病足周围神经病变：将处方强度的辣椒素纳入办公程序。
IF 1.7
Pain management Pub Date : 2023-10-01 Epub Date: 2023-09-26 DOI: 10.2217/pmt-2023-0028
Orlando Landrum, Lizandra Marcondes, Toni Egharevba, Karina Gritsenko
{"title":"Painful diabetic peripheral neuropathy of the feet: integrating prescription-strength capsaicin into office procedures.","authors":"Orlando Landrum, Lizandra Marcondes, Toni Egharevba, Karina Gritsenko","doi":"10.2217/pmt-2023-0028","DOIUrl":"10.2217/pmt-2023-0028","url":null,"abstract":"<p><p>Prescription-strength (8%) capsaicin topical system is a US FDA-approved treatment for painful diabetic peripheral neuropathy of the feet. A 30 min application of the capsaicin 8% topical system can provide sustained (up to 3 months) local pain relief by desensitizing and reducing TRPV1-expressing cutaneous fibers. Capsaicin is not absorbed systemically; despite associated application-site discomfort, capsaicin 8% topical system is well tolerated, with no known drug interactions or contraindications, and could offer clinical advantages over oral options. Capsaicin 8% topical system are not for patient self-administration and require incorporation into office procedures, with the added benefit of treatment compliance. This article reviews existing literature and provides comprehensive, practical information regarding the integration of capsaicin 8% topical systems into office procedures.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"613-626"},"PeriodicalIF":1.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treating bone metastases with local therapy in a breast cancer patient resulted in decreased pain and prevented fracture. 一位癌症患者采用局部治疗的方法治疗骨转移，减轻了疼痛，防止了骨折。
IF 1.7
Pain management Pub Date : 2023-10-01 Epub Date: 2023-10-05 DOI: 10.2217/pmt-2023-0069
David Palma, Nikhil Thakur, Joe C Loy, Bryan S Margulies
{"title":"Treating bone metastases with local therapy in a breast cancer patient resulted in decreased pain and prevented fracture.","authors":"David Palma, Nikhil Thakur, Joe C Loy, Bryan S Margulies","doi":"10.2217/pmt-2023-0069","DOIUrl":"10.2217/pmt-2023-0069","url":null,"abstract":"<p><p>Lytic lesions from bone metastases from breast, lung and prostate carcinomas, are associated with a poor prognosis and significant morbidities that include fracture and debilitating pain. Chemotherapeutics, palliative radiation therapy and surgical intervention are routinely used to treat these lesions. The ZetaMet™ Bone Graft is a novel antitumorigenic and osteoinductive graft that offers a potential alternative treatment option. ZetaMet is composed of calcium phosphate salts, type-I collagen and the small molecule N-allyl noroxymorphone dihydrate. Here, we report the case of a stage IV breast cancer patient with multiple lytic metastatic lesions to the spine that were successfully treated, which led to a significant reduction in pain and increased quality of life. This outcome demonstrates that a locally administered therapeutic intervention may represent an important alternative for patients with bone metastases that warrants further study.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"569-577"},"PeriodicalIF":1.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41146600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The clinical impact of pectoral nerve block in an 'enhanced recovery after surgery' program in breast surgery. 胸神经阻滞在乳腺外科“术后恢复增强”计划中的临床影响。
IF 1.7
Pain management Pub Date : 2023-10-01 Epub Date: 2023-11-08 DOI: 10.2217/pmt-2023-0063
Duccio Conti, Juri Valoriani, Piercarlo Ballo, Maddalena Pazzi, Lara Gianesello, Veronica Mengoni, Valentina Criscenti, Eleonora Gemmi, Caterina Stera, Federica Zoppi, Lorenzo Galli, Vittorio Pavoni
{"title":"The clinical impact of pectoral nerve block in an 'enhanced recovery after surgery' program in breast surgery.","authors":"Duccio Conti, Juri Valoriani, Piercarlo Ballo, Maddalena Pazzi, Lara Gianesello, Veronica Mengoni, Valentina Criscenti, Eleonora Gemmi, Caterina Stera, Federica Zoppi, Lorenzo Galli, Vittorio Pavoni","doi":"10.2217/pmt-2023-0063","DOIUrl":"10.2217/pmt-2023-0063","url":null,"abstract":"<p><p><b>Background:</b> Pectoral nerve block (PECS) is increasingly performed in breast surgery. <b>Aim:</b> The study evaluated the clinical impact of these blocks in the postoperative course. <b>Patients & methods:</b> In this case-control study, patients undergoing breast surgery with 'enhanced recovery after surgery' pathways were divided into group 1 (57 patients) in whom PECS was performed before general anesthesia, and group 2 (57 patients) in whom only general anesthesia was effected. <b>Results:</b> Postoperative opioid consumption (p < 0.002), pain at 32 h after surgery (p < 0.005) and the length of stay (p < 0.003) were significantly lower in group 1. <b>Conclusion:</b> Reducing opioid consumption and pain after surgery, PECS could favor a faster recovery with a reduction in length of stay, ensuring a higher turnover of patients undergoing breast surgery.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"585-592"},"PeriodicalIF":1.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71484920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lancinating lumbar facet syndrome: a congenitally absent facet joint. Lancinating腰椎小关节综合征：先天性小关节缺失。
IF 1.7
Pain management Pub Date : 2023-10-01 Epub Date: 2023-09-29 DOI: 10.2217/pmt-2023-0065
Peter D Vu, Vishal Bansal, Aila Malik, Alexa Ryder, Jason W Chen
{"title":"Lancinating lumbar facet syndrome: a congenitally absent facet joint.","authors":"Peter D Vu, Vishal Bansal, Aila Malik, Alexa Ryder, Jason W Chen","doi":"10.2217/pmt-2023-0065","DOIUrl":"10.2217/pmt-2023-0065","url":null,"abstract":"<p><p>Congenitally absent or hypoplastic L5-S1 facet (zygapophyseal) joints are an aberrated rarity, with less than 30 reported cases. This absence of facet joint and contralateral hypertrophic facet provides a continuum of presentations that can complicate low back pain diagnoses and management. A broad differential including lumbar facet syndrome, disc degeneration, spinal stenosis, herniated radiculopathy, spondyloarthropathies and sacroiliac joint pain should be considered initially, with the flexibility for other diagnoses. Understanding the effects of different anatomical, biomechanical and physiological changes on spinal health is essential for patient care. We report a progression of lumbar radiculopathy complicated by the presence of a congenitally absent left L5-S1 facet joint and hypertrophic right L5-S1 facet joint. Furthermore, our discussion concentrates on pathophysiology, differential diagnoses and management of congenitally absent facet joints and the impact they can have on low back pain and spinal health.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"579-583"},"PeriodicalIF":1.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41130569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of telerehabilitation exercise in patients with chronic neck pain: a protocol for a non-inferiority randomized controlled trial. 远程康复运动对慢性颈部疼痛患者的疗效：一项非劣效性随机对照试验的方案。
IF 1.7
Pain management Pub Date : 2023-09-01 Epub Date: 2023-10-18 DOI: 10.2217/pmt-2023-0070
Giovanna Laura Neves Antonio, Mariana Quixabeira Almeida, Mariana Arias Avila, Marcos Amaral de Noronha, Luiz Fernando Approbato Selistre
{"title":"Efficacy of telerehabilitation exercise in patients with chronic neck pain: a protocol for a non-inferiority randomized controlled trial.","authors":"Giovanna Laura Neves Antonio,&nbsp;Mariana Quixabeira Almeida,&nbsp;Mariana Arias Avila,&nbsp;Marcos Amaral de Noronha,&nbsp;Luiz Fernando Approbato Selistre","doi":"10.2217/pmt-2023-0070","DOIUrl":"10.2217/pmt-2023-0070","url":null,"abstract":"<p><p>The aim of this study is to investigate if telerehabilitation is just as effective as the same face-to-face exercise program in patients with chronic neck pain (NP). 140 participants will participate in this non-inferiority randomized controlled trial. Primary outcomes will be pain intensity and disability, and secondary outcomes will be kinesiophobia, catastrophizing, fear avoidance beliefs, anxiety and depression symptoms, self-efficacy for pain and global perceived effect. It will be collected at baseline, 6 weeks and 6 months after intervention. The analysis of non-inferiority will be calculated by mixed linear models considering the non-inferiority margin. The results of this clinical trial will be able to overcome the barriers that physiotherapists face for the success of their therapies. In addition, it may reduce the high demands and public health costs with NP. Brazilian Clinical Trials Registry (RBR-6VBSMB). <b>Clinical Trial Registration:</b> REBEC (Brazilian Registry of Clinical Trials) RBR-6VBSMB (ClinicalTrials.gov).</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"497-507"},"PeriodicalIF":1.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41237522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quadratus lumborum block and transversus abdominis plane block in laparoscopic nephrectomy: a meta-analysis. 腹腔镜肾切除术中腰方肌阻滞和腹横面阻滞:一项荟萃分析。
IF 1.7
Pain management Pub Date : 2023-09-01 Epub Date: 2023-09-18 DOI: 10.2217/pmt-2023-0033
Abdul S Alvi, Jamal A Nasir, Muhammad A Nizam, Muhammad M Hamdani, Nabeel A Bhangar, Syed A Sibtain, Ali S Lalani, Michiel C Warlé
{"title":"Quadratus lumborum block and transversus abdominis plane block in laparoscopic nephrectomy: a meta-analysis.","authors":"Abdul S Alvi,&nbsp;Jamal A Nasir,&nbsp;Muhammad A Nizam,&nbsp;Muhammad M Hamdani,&nbsp;Nabeel A Bhangar,&nbsp;Syed A Sibtain,&nbsp;Ali S Lalani,&nbsp;Michiel C Warlé","doi":"10.2217/pmt-2023-0033","DOIUrl":"10.2217/pmt-2023-0033","url":null,"abstract":"<p><p><b>Aim:</b> To study the efficacy of quadratus lumborum block (QLB) and transversus abdominis plane (TAP) in laparoscopic nephrectomy patients. <b>Materials & methods:</b> We conducted a meta-analysis of randomized controlled trials for QLB and/or TAP technique compared with each other or a control. <b>Results:</b> Direct analysis of 24 h post-op pain score at rest for each compared with control showed significant reduction, QLB (mean differences [MD] [95% CI]: -1.12 [-1.87,-0.36]; p = 0.004) and TAP (MD [95% CI]: -0.36 [-0.59, -0.12]; p = 0.003). With movement both were respectively lower than control QLB (MD [95% CI]: -1.12 [-1.51, -0.72]; p = <0.0001) and TAP (MD [95% CI]: -0.50 [-0.95, -0.05]; p = 0.03). Moreover, QLB demonstrated less risk 24 h of post-op nausea vomiting (PONV) versus control (PONV; risk ratios [RR] [95% CI]: 0.64 [0.45,0.90]; p = 0.01). <b>Conclusion:</b> TAP and QLB reduce pain scores compared with control, whereas only QLB reduces PONV compared with control.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"555-567"},"PeriodicalIF":1.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10286033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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