Pain managementPub Date : 2023-07-01Epub Date: 2023-07-17DOI: 10.2217/pmt-2023-0027
Ristiawan M Laksono, Taufiq A Siswagama, Aswoco A Asmoro, Hasan Sjahrir, Andi Mt Musba, Willy Halim, Walter van der Weegen, Kris Vissers
{"title":"Identifying pain problems, healthcare professional perceptions, expectations and challenges in multidisciplinary pain center establishment.","authors":"Ristiawan M Laksono, Taufiq A Siswagama, Aswoco A Asmoro, Hasan Sjahrir, Andi Mt Musba, Willy Halim, Walter van der Weegen, Kris Vissers","doi":"10.2217/pmt-2023-0027","DOIUrl":"10.2217/pmt-2023-0027","url":null,"abstract":"<p><p><b>Aim:</b> Before establishing a multidisciplinary pain center (MPC), the pain problem, healthcare professionals (HCP) perceptions, expectations and the potential challenges of MPC establishment need to be identified. <b>Methods:</b> A quantitative survey study of 1058 Indonesian HCPs. The study uses a national inquiry sent by the International Association for the Study of Pain (IASP) chapter for pain. <b>Results:</b> 99.0% of respondents had met patients with pain as the primary complaint and acute pain as the most common complaint. Insufficient pain management in Indonesian healthcare, insufficient pain epidemiological data and unaware HCP about MPC become problems of pain management in Indonesia. However, most HCP agreed that health facilities should have MPC. Financial issues (insufficient patient insurance) were considered the most important barrier for referring patients to MPC. <b>Conclusion:</b> The identified core problem, HCP perceptions, expectations and challenges of MPC establishment should become a consideration in the strategic planning of MPC establishment.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9824160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2023-07-01Epub Date: 2023-07-17DOI: 10.2217/pmt-2022-0104
Clarence Kong, Irvan J Bubic, Audrey A Tran, Gary Tan, Anthony J Medak, Jessica Oswald
{"title":"Genicular nerve block for emergency department patient: a successful management of subacute osteoarthritic knee pain.","authors":"Clarence Kong, Irvan J Bubic, Audrey A Tran, Gary Tan, Anthony J Medak, Jessica Oswald","doi":"10.2217/pmt-2022-0104","DOIUrl":"10.2217/pmt-2022-0104","url":null,"abstract":"<p><p>The genicular nerve block (GNB) performed under ultrasound is a common procedure in the perioperative and outpatient setting for the treatment of surgical knee pain and osteoarthritis. It provides motor-sparing analgesia to the knee, making it a potential alternative to other modes of pain management in the emergency department (ED). We present an elderly woman with acute-on-chronic osteoarthritic knee pain which was relieved for a week after a GNB during her ED visit. In patients with knee pain, the ultrasound guided GNB has the potential to provide short-term analgesia for patients with pain refractory to other modes of analgesia. The GNB shows promise as a reliable contribution to a multimodal approach to pain management in the ED setting.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9826639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2023-07-01Epub Date: 2023-07-28DOI: 10.2217/pmt-2023-0051
Eliana Ege, Daniel Briggi, Saba Javed, Albert Huh, Billy K Huh
{"title":"Risk factors for surgical site infection in advanced neuromodulation pain procedures: a retrospective study.","authors":"Eliana Ege, Daniel Briggi, Saba Javed, Albert Huh, Billy K Huh","doi":"10.2217/pmt-2023-0051","DOIUrl":"10.2217/pmt-2023-0051","url":null,"abstract":"<p><p><b>Aim:</b> To assess the effects of diabetes mellitus (DM) and related variables on surgical site infection (SSI) risk in neuromodulation. <b>Methods:</b> This retrospective study followed patients who underwent neuromodulation procedures for at least 9 months to identify postoperative infections. Demographics, clinical characteristics and surgical outcomes were compared. <b>Results:</b> Of 195 cases included, 5 (2.6%) resulted in SSIs. Median HbA1c was significantly higher for the cases with SSIs (8.2 vs 5.6%; p = 0.0044). The rate of SSI was significantly higher among patients with DM (17.9 vs 0%; p = 0.0005), HbA1c≥7% (37.5 vs 0%; p = 0.0009), and perioperative glucose ≥200 mg/dl (40 vs 2.3%; p = 0.0101). <b>Conclusion:</b> DM, elevated HbA1c and perioperative hyperglycemia may all contribute to increased risk of SSIs with neuromodulation procedures.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9883825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2023-07-01Epub Date: 2023-08-16DOI: 10.2217/pmt-2023-0008
German William Rangel, Karina Ortega Agón, Daniela Rangel Santos, Juan Pablo Duran, Karol Nathalia Cabeza Diaz
{"title":"Ultrasound-guided bilateral pulsed radiofrequency of the phrenic nerve for prolonged hiccups: a case report.","authors":"German William Rangel, Karina Ortega Agón, Daniela Rangel Santos, Juan Pablo Duran, Karol Nathalia Cabeza Diaz","doi":"10.2217/pmt-2023-0008","DOIUrl":"10.2217/pmt-2023-0008","url":null,"abstract":"<p><p>Singultus is the sudden onset of erratic diaphragmatic and intercostal muscle contraction immediately followed by laryngeal closure. Pathophysiology involves afferent, central and efferent components. Bilateral phrenic nerve block was performed to a 46-year-old woman with a brain tumor with persistent hiccups, with initially positive response but later symptom recurrence. Bilateral pulsed radiofrequency of the phrenic nerve was performed guided by ultrasonography (US). In the follow-up, absence of hiccups was confirmed. The patient was discharged 24 h later. Persistent or untreatable singultus is an infrequent condition that should not be dismissed. This approach is a safe, accurate and effective therapeutic approach for patient's refractory to conservative treatment. Further studies are needed to establish safety and effectiveness of the treatment.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10007283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2023-07-01Epub Date: 2023-08-11DOI: 10.2217/pmt-2023-0034
Elizabeth Khusid, Briana Lui, Andrea Ibarra, Kristine Villegas, Robert S White
{"title":"Review of racial/ethnic disparities in obstetrics-related anesthesia administration and pain management.","authors":"Elizabeth Khusid, Briana Lui, Andrea Ibarra, Kristine Villegas, Robert S White","doi":"10.2217/pmt-2023-0034","DOIUrl":"10.2217/pmt-2023-0034","url":null,"abstract":"<p><p>While racial/ethnic disparities in maternal outcomes including mortality and severe maternal morbidity are well documented, there is limited information on disparities in obstetric anesthesia practices. This paper reviews literature on racial/ethnic disparities in peripartum anesthesia administration and postpartum pain management. Current literature demonstrates racial/ethnic disparities in several aspects of obstetric anesthesia care including neuraxial administration for vaginal labor pain, neuraxial versus general anesthesia for cesarean delivery, post neuraxial anesthesia complications, postpartum pain management and postdural puncture headache treatment practices. However, many studies are dated or have limited data from single institutions or states. More research on nation-wide racial/ethnic disparities in obstetric anesthesia is needed to understand its broader practice and management in the USA.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9965233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2023-07-01Epub Date: 2023-08-24DOI: 10.2217/pmt-2023-0043
Loren Francis, Jackson Condrey, Christopher Wolla, Tara Kelly, Bethany Wolf, Ryan McFadden, Adam Brown, Sanford Zeigler, Sylvia H Wilson
{"title":"Parasternal intercostal plane block catheters for cardiac surgery: a retrospective, propensity weighted, cohort study.","authors":"Loren Francis, Jackson Condrey, Christopher Wolla, Tara Kelly, Bethany Wolf, Ryan McFadden, Adam Brown, Sanford Zeigler, Sylvia H Wilson","doi":"10.2217/pmt-2023-0043","DOIUrl":"10.2217/pmt-2023-0043","url":null,"abstract":"<p><p><b>Aim:</b> Anesthesia for cardiac surgery has evolved toward fast-track recovery strategies incorporating non opioid analgesics and regional anesthesia. <b>Materials & methods:</b> This retrospective cohort study compared opioid consumption, pain scores and length of stay in patients who underwent cardiac surgery via median sternotomy and did or did not receive preoperative parasternal intercostal plane block catheters with postoperative ropivacaine infusions. <b>Results:</b> Postoperative opioid consumption and postoperative pain scores did not differ. Blocks were associated with decreased intraoperative opioids and reduced length of stay in the intensive care unit and hospital. <b>Conclusion:</b> Parasternal intercostal plane block catheters were not associated with decreased postoperative opioid consumption or pain scores, but were associated with reduced intraoperative opioids and length of stay.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10435105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2023-06-01DOI: 10.2217/pmt-2023-0044
Vishal Bansal, Mayank Aranke, Peter Vu, Saba Javed
{"title":"Serotonin syndrome from combination hydrocodone and cyclobenzaprine in a patient with cerebral palsy.","authors":"Vishal Bansal, Mayank Aranke, Peter Vu, Saba Javed","doi":"10.2217/pmt-2023-0044","DOIUrl":"https://doi.org/10.2217/pmt-2023-0044","url":null,"abstract":"<p><p><b>Aim:</b> Serotonin syndrome (SS) is a life-threatening syndrome that occurs with the use of serotonergic drugs, most commonly due to two or more agents. Cerebral palsy is associated with mood disorders, and more commonly pain, with a prevalence of up to 50-80%. <b>Case presentation:</b> A 58-year-old female with cerebral palsy, metastatic malignancy and mood disorder who presented to the emergency department with acute-on-chronic pain, and signs of SS. She was initiated on iv. dilaudid, titrated off oral medications and scheduled for a left-sided sacroiliac joint injection. <b>Results:</b> It was suspected that due to additional doses of hydrocodone and cyclobenzaprine, she developed moderate-SS. <b>Conclusion:</b> Physicians need to be cognizant of comorbidities and uncommon pain medications that can predispose patients to SS.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10037950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2023-06-01DOI: 10.2217/pmt-2023-0047
Amaal J Starling, Melissa Kolbet, Roger Cady, Thomas Brevig
{"title":"Treatment with eptinezumab for migraine prevention in people with chronic migraine and medication-overuse headache: a plain language summary.","authors":"Amaal J Starling, Melissa Kolbet, Roger Cady, Thomas Brevig","doi":"10.2217/pmt-2023-0047","DOIUrl":"https://doi.org/10.2217/pmt-2023-0047","url":null,"abstract":"<p><strong>What is this summary about?: </strong>This is a summary of three articles describing preventive treatment of migraine in participants with a diagnosis of both chronic migraine and medication-overuse headache in a study called PROMISE-2 (PRevention Of Migraine via Intravenous ALD403 Safety and Efficacy-2). People living with chronic migraine and medication-overuse headache have one of the most disabling, costly, and difficult-to-treat headache disorders.</p><p><strong>What were the results?: </strong>After preventive migraine treatment with eptinezumab (trade name Vyepti), participants with chronic migraine and medication-overuse headache experienced fewer migraine days, a reduced severity of migraine attacks, and a reduced use of acute medication. More participants receiving eptinezumab treatment no longer met the definition of either chronic migraine or medication-overuse headache throughout the study when compared with those receiving placebo.</p><p><strong>What do the results mean?: </strong>Eptinezumab is beneficial for people who often use acute medication(s) due to frequent headache episodes or migraine attacks.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10034522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2023-06-01DOI: 10.2217/pmt-2023-0040
Ramesh Boinpally, Matthew Butler, Jonathan Rojo, Lisa Borbridge, Veronica Wangsadipura, Anna Papinska
{"title":"Evaluation of the pharmacokinetic interactions and safety of atogepant coadministered with esomeprazole.","authors":"Ramesh Boinpally, Matthew Butler, Jonathan Rojo, Lisa Borbridge, Veronica Wangsadipura, Anna Papinska","doi":"10.2217/pmt-2023-0040","DOIUrl":"https://doi.org/10.2217/pmt-2023-0040","url":null,"abstract":"<p><p><b>Aim:</b> To investigate potential pharmacokinetic interactions between atogepant and esomeprazole. <b>Methods:</b> Atogepant, esomeprazole, or both were administered to 32 healthy adults in an open-label, nonrandomized, crossover study. Systemic exposure (area under the plasma concentration-time curve [AUC] and peak plasma concentration [C<sub>max</sub>]) for atogepant administered in combination versus alone were compared using a linear mixed effects model. <b>Results:</b> Coadministration with esomeprazole delayed atogepant time to C<sub>max</sub> by ∼1.5 h and reduced C<sub>max</sub> by ∼23% with no statistically significant change in AUC compared with atogepant alone. Administration of atogepant 60 mg alone or in combination with esomeprazole 40 mg was well tolerated in healthy adults. <b>Conclusion:</b> Esomeprazole had no clinically meaningful effect on atogepant pharmacokinetics. <b>Clinical Trial Registration</b>: unregistered phase I study.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10412044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2023-06-01DOI: 10.2217/pmt-2023-0005
Jeimylo C de Castro, Daniel Wang, Jeffrey Strakowski, Dessy R Emril, George C Chang Chien
{"title":"Alpha-2 macroglobulin for the treatment of neuroma pain in the stump of a below-knee amputee patient.","authors":"Jeimylo C de Castro, Daniel Wang, Jeffrey Strakowski, Dessy R Emril, George C Chang Chien","doi":"10.2217/pmt-2023-0005","DOIUrl":"https://doi.org/10.2217/pmt-2023-0005","url":null,"abstract":"<p><p>This case report describes the successful treatment of neuroma pain in the setting of below knee amputations using alpha-2-macroglobulin (A2M). A 34-year-old female patient presented with 9 months of stump pain despite conservative treatment. The exam revealed persistent pain through rest periods and weight-bearing status during therapy. Ultrasound showed neuroma formation with neovascularization. The patient underwent two A2M hydrodissection treatments, 2 weeks apart. The patient reported significant pain relief. Ultrasound showed decreases in neovascularization and cross-sectional area of the neuroma. The patient was able to ambulate pain-free for 2 years and reported no pain since. A2M may be a treatment for patients with neuroma pain in the setting of amputations.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10040926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}