Pain managementPub Date : 2025-04-03DOI: 10.1080/17581869.2025.2487408
Tania Gardner, Christine T Shiner, Alison Mahoney, Henry Loui, Marnee McKay
{"title":"Pain patterns and their association with psychological measures among people accessing an online pain management program.","authors":"Tania Gardner, Christine T Shiner, Alison Mahoney, Henry Loui, Marnee McKay","doi":"10.1080/17581869.2025.2487408","DOIUrl":"https://doi.org/10.1080/17581869.2025.2487408","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to explore the association between the distribution of pain sites and psychosocial measures at baseline of patients enrolled in an online MPMP.</p><p><strong>Patients: </strong>This study analyzed baseline data from adults (<i>N</i> = 2002) enrolled in the 'Reboot Online' pain program.</p><p><strong>Methods: </strong>Participants completed measures of Pain Self-Efficacy Questionnaire (PSEQ), Tampa Scale for Kinesiophobia (TSK), Pain Disability Index (PDI), Patient Health Questionnaire (PHQ-9), and Kessler Psychological Distress Scale (K-10). Pain was categorized by the number of body regions affected: 1, 2, 3, >3. One-way ANOVA tests examined psychosocial measure differences across these groups.</p><p><strong>Results: </strong>The majority of participants had multisite pain, with multisite pain showing significantly worse psychosocial outcome measures (<i>p</i> < .05) compared to those with a single pain site, except for kinesiophobia, which was consistently high across groups.</p><p><strong>Conclusion: </strong>Most online participants reported multisite pain, with multisite pain associated with poorer baseline psychosocial outcome measures, excluding kinesiophobia. The pattern of pain should be considered when developing and implementing online programs.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-04-01DOI: 10.1080/17581869.2025.2487413
Damiana Scuteri, Gary W Lawrence, Rosario Iannacchero, Michele Trimboli, Pierluigi Nicotera, Maria T Corasaniti, Giacinto Bagetta
{"title":"Efficacy and safety of mAbs anti-CGRP/CGRP R (eptinezumab and erenumab) or atogepant in combination with onabotulinumtoxinA in refractory chronic migraine: a clinical trial protocol.","authors":"Damiana Scuteri, Gary W Lawrence, Rosario Iannacchero, Michele Trimboli, Pierluigi Nicotera, Maria T Corasaniti, Giacinto Bagetta","doi":"10.1080/17581869.2025.2487413","DOIUrl":"https://doi.org/10.1080/17581869.2025.2487413","url":null,"abstract":"<p><p>Chronic migraine is a disabling neurovascular disorder that represents the leading cause of years lived with disability in people under 50 with a remarkable social burden due to widespread resistance to the front-line treatments used routinely in current clinical practice. The present study investigates the efficacy and safety of combination therapy using eptinezumab and erenumab, recently approved monoclonal antibodies (mAbs) directed against calcitonin gene-related peptide or its receptor, respectively, or the receptor competitive antagonist atogepant together with botulinum toxin type A in chronic migraine that has proven resistant to front-line treatments for at least 6 weeks. To this aim a retrospective and a prospective phase are designed. Furthermore, a feasible salivary biomarker of migraine is under investigation in the prospective stage of the study. Based on recent expert opinions supporting the switch to easy-to-use small molecule calcitonin gene-related peptide (CGRP)-targeting, i.e. rimegepant or atogepant in unresponsive patients, the present study may offer to clinicians a novel treatment to enhance the therapeutic preventive machinery in chronic migraine.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-5"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-03-31DOI: 10.1080/17581869.2025.2479411
Cormac F Mullins, Sarah Walsh, Joseph Fitzgerald
{"title":"Methadone in the madness: a case series and review of methadone management in hospital settings.","authors":"Cormac F Mullins, Sarah Walsh, Joseph Fitzgerald","doi":"10.1080/17581869.2025.2479411","DOIUrl":"https://doi.org/10.1080/17581869.2025.2479411","url":null,"abstract":"<p><p>The management of patients on chronic methadone therapy for opioid use disorder presents unique pharmacological and psychosocial challenges in hospital settings. This case series discusses complexities such as methadone's variable pharmacokinetics, alternatives to oral methadone and conversion ratios. Additionally, it outlines the nuances around the psychosocial considerations of methadone therapy and addressing addiction-related behaviors without compromising patient dignity. The review calls for individualized care plans with uninterrupted opioid agonist therapy to meet the baseline opioid requirements and pro-active pain management plans. Enhanced clinician education and better real-world data to guide methadone management is important to improve outcomes for this vulnerable patient cohort.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-03-02DOI: 10.1080/17581869.2025.2473871
Sanne A M Hendrickx, Ellie B M Landman, Ydo V Kleinlugtenbelt
{"title":"Post-discharge opioid utilization patterns in orthopedic patients are underestimated: an explorative study.","authors":"Sanne A M Hendrickx, Ellie B M Landman, Ydo V Kleinlugtenbelt","doi":"10.1080/17581869.2025.2473871","DOIUrl":"https://doi.org/10.1080/17581869.2025.2473871","url":null,"abstract":"<p><strong>Aim: </strong>This study explores morphine use among patients after discharge following total hip (THA) or knee arthroplasty (TKA).</p><p><strong>Method: </strong>Morphine use was monitored for 14 days post-discharge. Patients recorded their morphine intake and reported pain using a Visual Analog Scale (VAS). Incomplete reports were excluded from longitudinal analysis. Median tablet count and total morphine use in milligram equivalents (MME) were calculated. Patients were categorized as non-users (0 mmE), short-term users (<100 mmE), and consistent users (>100 mmE).</p><p><strong>Results: </strong>Of the 67 patients, six dropped out. Among the remaining, 22 (36.7%) took no morphine, while 38 (63.3%) took at least one dose, with a median VAS-score of 5. Short-term users (<i>n</i> = 19) averaged a total of 40 mmE, mainly in the first three days, while consistent users (<i>n</i> = 15) averaged in total 220 mmE during follow-up, tapering gradually. After 14 days, 3% continued usage. Four patients with incomplete data were excluded. However, for those was found that this was due to or related to the fact that they used a large amount of morphine.</p><p><strong>Conclusion: </strong>Most patients used minimal or no morphine, tapering off within two weeks.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-6"},"PeriodicalIF":1.4,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-03-01Epub Date: 2025-02-19DOI: 10.1080/17581869.2025.2467614
Mimi Mun Yee Tse, Shamay Sheung Mei Ng, Vivian Lou, Raymond S K Lo, Daphne Sze Ki Cheung, Paul H Lee, Angel Shuk Kwan Tang, Kin Pong To, Percy Poo-See Tse
{"title":"Informal caregivers' burden and chronic pain in older adults: a dyadic study unveiling the correlation and its impact.","authors":"Mimi Mun Yee Tse, Shamay Sheung Mei Ng, Vivian Lou, Raymond S K Lo, Daphne Sze Ki Cheung, Paul H Lee, Angel Shuk Kwan Tang, Kin Pong To, Percy Poo-See Tse","doi":"10.1080/17581869.2025.2467614","DOIUrl":"10.1080/17581869.2025.2467614","url":null,"abstract":"<p><strong>Background and aims: </strong>Older adults' chronic pain care includes assisting with daily activities and exercise. But the informal caregivers have stated different challenges in the caring process. This study aims to explore the chronic pain situations of older adults, the burden of their informal caregivers, and the correlation between the severity of chronic pain in older adults and the level of burden experienced by their caregivers.</p><p><strong>Methods: </strong>A total of 150 older adults (mean age: 65.44) with chronic pain and 150 informal caregivers (mean age: 41.06) were recruited for this study. Older adults completed the brief pain inventory and pain self-efficacy questionnaire. Depression, anxiety, stress, and activities of daily living were assessed. Informal caregivers also completed the caregiver burden inventory.</p><p><strong>Results: </strong>150 informal caregivers completed the questionnaire. The mean caregiver burden score was 3.73, positively associated with pain conditions and emotional tolls in older adults.</p><p><strong>Conclusion: </strong>The findings highlight the need for healthcare professionals to address the physical and emotional burdens experienced by informal caregivers. Healthcare professionals should investigate the caregiver burden. Comprehensive support strategies should be developed to enhance the well-being of both older adults and their caregivers, ultimately improving pain management and quality of life.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"123-130"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-03-01Epub Date: 2025-02-10DOI: 10.1080/17581869.2025.2464526
Aylin Ayyıldız, Burak Tayyip Dede, Mustafa Hüseyin Temel, Bülent Alyanak, Mustafa Turgut Yıldızgören, Fatih Bağcıer
{"title":"An overlooked cause of upper extremity pain: myofascial trigger points of the triceps muscle and dry needling protocol.","authors":"Aylin Ayyıldız, Burak Tayyip Dede, Mustafa Hüseyin Temel, Bülent Alyanak, Mustafa Turgut Yıldızgören, Fatih Bağcıer","doi":"10.1080/17581869.2025.2464526","DOIUrl":"10.1080/17581869.2025.2464526","url":null,"abstract":"","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"115-117"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-03-01Epub Date: 2025-02-23DOI: 10.1080/17581869.2025.2470612
Peter D Vu, Salahadin Abdi
{"title":"A unique utilization of scrambler therapy for bilateral neuropathic corneal pain: a case report.","authors":"Peter D Vu, Salahadin Abdi","doi":"10.1080/17581869.2025.2470612","DOIUrl":"10.1080/17581869.2025.2470612","url":null,"abstract":"<p><p>Management of neuropathic corneal pain (NCP) typically involves pharmacotherapy, but refractory cases may require interventions like scrambler therapy, used for various neuropathic pain conditions. We report a patient with a 15-year history of refractory NCP who underwent scrambler therapy after failed treatments. Over five consecutive days, she received 45-minute sessions with six electrodes placed around both eyes. Post-treatment, her pain resolved completely, and she reported improved screen tolerance, reduced medication use, and better quality of life. This case supports scrambler therapy's potential for NCP and discusses its underlying pathophysiology.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"119-122"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-03-01Epub Date: 2025-03-03DOI: 10.1080/17581869.2025.2470615
Albert Muñoz-Vendrell, Alba López-Bravo, Almudena Layos-Romero, Francisco J Alberola-Amores, María Obdulia Lozano Caballero, Antonio Sánchez-Soblechero, Cristian Morales-Hernández, María Victoria Castro-Sánchez, María Pilar Navarro-López, María Rocío Córdova-Infantes, Edoardo Caronna, Pablo Irimia, Alicia Gonzalez-Martinez
{"title":"Effectiveness and safety of anti-CGRP monoclonal antibodies for migraine in patients over 65 years: a systematic review.","authors":"Albert Muñoz-Vendrell, Alba López-Bravo, Almudena Layos-Romero, Francisco J Alberola-Amores, María Obdulia Lozano Caballero, Antonio Sánchez-Soblechero, Cristian Morales-Hernández, María Victoria Castro-Sánchez, María Pilar Navarro-López, María Rocío Córdova-Infantes, Edoardo Caronna, Pablo Irimia, Alicia Gonzalez-Martinez","doi":"10.1080/17581869.2025.2470615","DOIUrl":"10.1080/17581869.2025.2470615","url":null,"abstract":"<p><strong>Background: </strong>Migraine patients over 65 years have been excluded from pivotal anti-CGRP monoclonal antibody trials leaving limited real-life data on effectiveness and safety in this population. This review aims to summarize available evidence on treatment response and safety for older patients.</p><p><strong>Methods: </strong>A PubMed and Cochrane Controlled Register of Trials (CENTRAL) search identified studies on anti-CGRP monoclonal antibodies in patients with migraine over 65 up to October 2024. The review focuses on headache outcomes like reduction in monthly migraine days or monthly headache days, response rates (30%, 50%, 75%) and adverse effects of this specific population and/or against placebo, standard care, or younger patients. The quality of evidence was assessed using the GRADE tool.</p><p><strong>Results: </strong>All eligible studies were included, along with additional articles presented narratively. Data from clinical trials and post-hoc analyses show comparable efficacy and safety between older and younger patients. Similarly, early real-life studies support the use of anti-CGRP monoclonal antibodies in patients over 65 years, showing similar response rates, reductions in monthly migraine days and adverse effects.</p><p><strong>Discussion: </strong>Anti-CGRP monoclonal antibodies should likely be offered to patients over 65 although available evidence remains limited. Further studies analyzing specific data from this subgroup are necessary.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":"15 3","pages":"161-171"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}