Pain management最新文献

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A plain language summary describing changes in pain associated with uterine fibroids among women receiving relugolix combination therapy. 以通俗易懂的语言概述了接受瑞格列奈联合疗法的妇女在子宫肌瘤相关疼痛方面的变化。
IF 1.4
Pain management Pub Date : 2024-10-28 DOI: 10.1080/17581869.2024.2408114
Elizabeth A Stewart, Andrea S Lukes, Roberta Venturella, Juan-Camilo Arjona Ferreira, Yulan Li, Elke Hunsche, Rachel B Wagman, Ayman Al-Hendy
{"title":"A plain language summary describing changes in pain associated with uterine fibroids among women receiving relugolix combination therapy.","authors":"Elizabeth A Stewart, Andrea S Lukes, Roberta Venturella, Juan-Camilo Arjona Ferreira, Yulan Li, Elke Hunsche, Rachel B Wagman, Ayman Al-Hendy","doi":"10.1080/17581869.2024.2408114","DOIUrl":"https://doi.org/10.1080/17581869.2024.2408114","url":null,"abstract":"<p><strong>What is this summary about?: </strong>This is a summary of two research studies (known as clinical trials) called LIBERTY 1 and LIBERTY 2. These studies compared how well a medicine called relugolix combination therapy and placebo worked in reducing heavy menstrual bleeding (periods) in women with uterine fibroids (published in a separate article referenced in the section: Where can readers find more information on these studies?). Researchers also looked at whether women with moderate to severe pain from uterine fibroids saw improvement in their worst pain symptoms after 24 weeks of treatment (results described in the present summary).</p><p><strong>What are the key takeaways?: </strong>Women with moderate to severe pain from uterine fibroids (menstrual or nonmenstrual pain) took either relugolix combination therapy or placebo (once daily by mouth) for 24 weeks. During the last 5 weeks of treatment, 65% of women taking relugolix combination therapy and 19% of women taking placebo reported having minimal or no menstrual pain. Similarly, 45% of women taking relugolix combination therapy and 22% of women taking placebo reported having minimal or no non-menstrual pain. During the same time period, 71% of the women taking relugolix combination therapy and 40% of women taking placebo reported their worst pain was reduced by about one third compared with the start of the study.</p><p><strong>What were the main conclusions reported by the researchers?: </strong>Women with moderate to severe pain from uterine fibroids taking relugolix combination therapy were more likely to have minimal or no pain from uterine fibroids after treatment compared with women taking placebo.<b>Clinical Trial Registration:</b> NCT03049735 (LIBERTY 1), NCT03103087 (LIBERTY 2) (ClinicalTrials.gov).</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combatting opioid misuse, overuse and abuse: a systematic review of pharmacists' services and outcomes. 打击阿片类药物的误用、过量使用和滥用:药剂师服务和成果系统回顾。
IF 1.4
Pain management Pub Date : 2024-10-22 DOI: 10.1080/17581869.2024.2411930
Bhuvan Kc, Alian A Alrasheedy, Mohamed Izham Mohamed Ibrahim, Vibhu Paudyal, Christina Malini Christopher, Sunil Shrestha, Shakti Shrestha
{"title":"Combatting opioid misuse, overuse and abuse: a systematic review of pharmacists' services and outcomes.","authors":"Bhuvan Kc, Alian A Alrasheedy, Mohamed Izham Mohamed Ibrahim, Vibhu Paudyal, Christina Malini Christopher, Sunil Shrestha, Shakti Shrestha","doi":"10.1080/17581869.2024.2411930","DOIUrl":"https://doi.org/10.1080/17581869.2024.2411930","url":null,"abstract":"<p><p><b>Aim:</b> To examine the range of services pharmacists provide and their impact on patient outcomes, harm reduction, and appropriate opioid use.<b>Methods:</b> Six databases were searched (MEDLINE, EMBASE, Scopus, PsycINFO, CENTRAL and Cochrane Methodology Register) from inception to March 2023. The protocol was registered in PROSPERO (CRD42023401895).<b>Results:</b> Twenty-nine studies identified five key areas of pharmacist interventions in opioid management-naloxone programs and opioid de-escalation, patient and primary healthcare providers' education and motivational interview, prescription monitoring and opioid risk screening, clinical pharmacy interventions (pharmacotherapy, medication review, prescribing, adherence monitoring), and collaborative healthcare approaches to promote optimal opioid use. Outcomes assessment indicated harm reduction, improved safety, increased non-opioid analgesic use, decreased opioid consumption, and enhanced pain management.<b>Conclusion:</b> This review underscores pharmacists' vital role in tackling opioid misuse, overuse and abuse, providing a foundation for evidence-based policies to minimize harm and promote optimal opioid use.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustained relief with spinal cord stimulator despite anterior lead migration: a case report. 脊髓刺激器在前导联线移位的情况下仍能持续缓解症状:病例报告。
IF 1.4
Pain management Pub Date : 2024-10-04 DOI: 10.1080/17581869.2024.2407283
Soun Sheen, Kent Nouri
{"title":"Sustained relief with spinal cord stimulator despite anterior lead migration: a case report.","authors":"Soun Sheen, Kent Nouri","doi":"10.1080/17581869.2024.2407283","DOIUrl":"https://doi.org/10.1080/17581869.2024.2407283","url":null,"abstract":"<p><p>Lead migration is a common complication of spinal cord stimulation, although anterior migration is rare. While early studies suggested that anterior stimulation may produce analgesic effects, it is thought to be poorly tolerated due to abnormal paresthesia and muscle contractions due to its proximity to the corticospinal tract. This case report presents a unique case of sustained pain relief despite anterior lead migration, which suggests that anterior column stimulation may hold clinical significance for pain management. Further studies are needed to explore its analgesic mechanisms and potential therapeutic application. Strategies to prevent lead migration, particularly in the early postoperative period, are also crucial for optimizing outcomes.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Trying to explain the unexplainable": why research on contextual factors in musculoskeletal pain is needed. "试图解释无法解释的问题":为什么需要对肌肉骨骼疼痛的环境因素进行研究?
IF 1.4
Pain management Pub Date : 2024-09-27 DOI: 10.1080/17581869.2024.2406224
Giacomo Rossettini, Alvisa Palese, Chad Cook
{"title":"\"Trying to explain the unexplainable\": why research on contextual factors in musculoskeletal pain is needed.","authors":"Giacomo Rossettini, Alvisa Palese, Chad Cook","doi":"10.1080/17581869.2024.2406224","DOIUrl":"https://doi.org/10.1080/17581869.2024.2406224","url":null,"abstract":"","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PPARγ and AKt gene modulation following pregabalin and duloxetine combination for painful diabetic polyneuropathy. 普瑞巴林和度洛西汀联合治疗糖尿病疼痛性多发性神经病变后的 PPARγ 和 AKt 基因调节作用
IF 1.4
Pain management Pub Date : 2024-07-01 DOI: 10.1080/17581869.2024.2370758
Ashok K Saxena, Nimisha Thanikkal, G. Chilkoti, P. Gondode, Tusha Sharma, B. D. Banerjee
{"title":"PPARγ and AKt gene modulation following pregabalin and duloxetine combination for painful diabetic polyneuropathy.","authors":"Ashok K Saxena, Nimisha Thanikkal, G. Chilkoti, P. Gondode, Tusha Sharma, B. D. Banerjee","doi":"10.1080/17581869.2024.2370758","DOIUrl":"https://doi.org/10.1080/17581869.2024.2370758","url":null,"abstract":"Aim: Diabetic peripheral neuropathy (DPN) induces chronic neuropathic pain in diabetic patients. Current treatments like pregabalin and duloxetine offer limited efficacy. This study evaluates combining pregabalin and duloxetine versus pregabalin alone for DPN pain relief, and explores gene modulation (PPARγ and Akt) to understand neuropathic pain's molecular basis. Materials & methods: Diabetic patients with DPN were randomized into groups receiving combination therapy or pregabalin alone for 4 weeks. Pain intensity, gene expression and quality of life were assessed. Results: Combination therapy significantly reduced pain, improved quality of life and upregulated PPARγ and Akt genes compared with monotherapy. Conclusion: Pregabalin and duloxetine combination therapy in DPN led to PPARγ mRNA upregulation and negative correlation of Akt gene expression with pain scores. This combination therapy effectively reduced pain and improved quality of life.Clinical Trial Registration: CTRI/2021/02/031068.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of prospective studies regarding percutaneous peripheral nerve stimulation treatment in the management of chronic pain 经皮外周神经刺激治疗慢性疼痛的前瞻性研究综述
IF 1.7
Pain management Pub Date : 2024-06-10 DOI: 10.1080/17581869.2024.2352398
Scott G Pritzlaff, Usman Latif, J. Rosenow, John Chae, Richard D Wilson, William J Huffman, Nathan D. Crosby, J. Boggs
{"title":"A review of prospective studies regarding percutaneous peripheral nerve stimulation treatment in the management of chronic pain","authors":"Scott G Pritzlaff, Usman Latif, J. Rosenow, John Chae, Richard D Wilson, William J Huffman, Nathan D. Crosby, J. Boggs","doi":"10.1080/17581869.2024.2352398","DOIUrl":"https://doi.org/10.1080/17581869.2024.2352398","url":null,"abstract":"","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141363799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidural spread of surgical site infection from spinal cord stimulation trial. 脊髓刺激试验引起的手术部位感染的硬膜外扩散。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-08 DOI: 10.1080/17581869.2024.2373044
Taif Mukhdomi, Bennett Andrassy, Semih Gungor
{"title":"Epidural spread of surgical site infection from spinal cord stimulation trial.","authors":"Taif Mukhdomi, Bennett Andrassy, Semih Gungor","doi":"10.1080/17581869.2024.2373044","DOIUrl":"10.1080/17581869.2024.2373044","url":null,"abstract":"<p><p>We present a case of deep surgical site infection (SSI) at a spinal cord stimulator (SCS) trial implantation site, resulting from an allergic reaction to an unknown agent. A 38-year-old female with complex regional pain syndrome began an SCS trial, noting 100% pain relief for 5 days. Fluid drainage from the surgical site was reported on POD6 and trial leads were removed the following day. The patient was hospitalized with sepsis. Blood cultures revealed <i>Staphylococcus aureus</i>. MRIs showed skin breakdown and cellulitis of the paraspinal musculature extending into the epidural space. The patient was maintained with antibiotics and rigorous wound care for 9 days and the surgical site infection resolved. The patient proceeded to SCS implantation, and reported good pain relief with the implanted device.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-management of primary dysmenorrhea-related pain: cross-sectional study on non-pharmacological interventions. 原发性痛经相关疼痛的自我管理:非药物干预横断面研究。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-23 DOI: 10.1080/17581869.2024.2376519
Jéssica Cordeiro Rodrigues, Guilherme Tavares de Arruda, Pâmela Calixto de Moraes, Caren Beatriz Firão, Mariana Arias Avila, Patricia Driusso
{"title":"Self-management of primary dysmenorrhea-related pain: cross-sectional study on non-pharmacological interventions.","authors":"Jéssica Cordeiro Rodrigues, Guilherme Tavares de Arruda, Pâmela Calixto de Moraes, Caren Beatriz Firão, Mariana Arias Avila, Patricia Driusso","doi":"10.1080/17581869.2024.2376519","DOIUrl":"10.1080/17581869.2024.2376519","url":null,"abstract":"<p><p><b>Aim:</b> Different nonpharmacological strategies are adopted to decrease primary dysmenorrhea (PD)-related pain. The present study aimed to verify women's use of nonpharmacological methods for pain and compare them with evidence from the literature.<b>Materials & methods:</b> A two-step study was conducted, comprising an online survey with 9144 women to assess nonpharmacological strategies for relieving PD-related pain, and a literature review on PubMed of verify the evidence of nonpharmacological methods.<b>Results:</b> Many women reported using heat therapy (61.5%), tea (42.4%) and massage (30.9%) to alleviate menstrual pain. However, the literature on these methods is limited.<b>Conclusion:</b> Several nonpharmacological methods are used by women to relieve PD-related pain and studies with low bias risk are needed to prove their effectiveness.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burn pain management in a female patient with severe burn injuries in Nepal: a case study and review. 尼泊尔重度烧伤女患者的烧伤疼痛管理:病例研究与综述。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-08-05 DOI: 10.1080/17581869.2024.2382072
Sundar Adhikari, Roshani Gurung, Suresh Bastakoti, Alian A Alrasheedy, Bhuvan Kc
{"title":"Burn pain management in a female patient with severe burn injuries in Nepal: a case study and review.","authors":"Sundar Adhikari, Roshani Gurung, Suresh Bastakoti, Alian A Alrasheedy, Bhuvan Kc","doi":"10.1080/17581869.2024.2382072","DOIUrl":"10.1080/17581869.2024.2382072","url":null,"abstract":"<p><p>Burn injuries in low-resource settings like Nepal present significant public health challenges, leading to substantial morbidity, mortality and severe pain. This paper assesses burn pain management in Nepal, emphasizing the need for enhanced strategies. A case study of a female patient with severe burn injuries from a rural village in Western Nepal illustrates current challenges. Reviewing studies on burn pain management in Nepal shows limited access to specialized facilities, inadequate palliative care, medication shortages and insufficient healthcare professionals. Pharmacological interventions are impacted by financial constraints and a lack of protocols, while nonpharmacological approaches have not been explored and contextualized for the Nepalese context due to similar financial issues. Comprehensive burn pain management requires addressing resource constraints through collaborative health-aid partnerships.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and predictors of pain among women who underwent cesarean section in Fiji. 斐济剖腹产妇女疼痛的特征和预测因素。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-09 DOI: 10.1080/17581869.2024.2370757
Ravneel Narayan, Masoud Mohammadnezhad, Nikansha Kumar, Sabiha Khan
{"title":"Characteristics and predictors of pain among women who underwent cesarean section in Fiji.","authors":"Ravneel Narayan, Masoud Mohammadnezhad, Nikansha Kumar, Sabiha Khan","doi":"10.1080/17581869.2024.2370757","DOIUrl":"10.1080/17581869.2024.2370757","url":null,"abstract":"<p><p><b>Aim:</b> To identify the characteristics and predictors of post cesarean section (CS) pain among women.<b>Materials & methods:</b> This quantitative study was conducted at Labasa hospital in Fiji over a 6-month period. A total of 312 mothers who received spinal, epidural and general anesthesia were included. Their pain score was assessed using the visual analogue scale 24 h postoperatively.<b>Results:</b> 70.8% women had either moderate or severe pain on the visual analogue scale. About 41.3% women expressed dissatisfaction with their pain management and 70.5% women had difficulties in performing activities due to pain. Lower parity was noted to be a positive predictor of pain among women undergoing CS.<b>Conclusion:</b> Adequate pain management for post-CS patient at Labasa hospital is lacking.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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