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Perioperative N-acetylcysteine: evidence and indications. 围手术期 N-乙酰半胱氨酸：证据和适应症。
IF 1.4
Pain management Pub Date : 2024-08-21 DOI: 10.1080/17581869.2024.2388504
Phillip Ryan Wilson, Kathryn H Bridges, Michael Scofield, Sylvia H Wilson
{"title":"Perioperative N-acetylcysteine: evidence and indications.","authors":"Phillip Ryan Wilson, Kathryn H Bridges, Michael Scofield, Sylvia H Wilson","doi":"10.1080/17581869.2024.2388504","DOIUrl":"https://doi.org/10.1080/17581869.2024.2388504","url":null,"abstract":"<p><p>Nonopioid analgesics serve to improve analgesia and limit side effects and risks of perioperative opioids. N-acetylcysteine (NAC), the primary treatment of acetaminophen toxicity, may have perioperative indications, including analgesia. NAC impacts glutathione synthesis, oxidant scavenging, glutamate receptor modulation and neuroinflammation. Potential perioperative benefits include arrhythmia prevention after cardiac surgery, decreased contrast-induced nephropathy, improved post-transplant liver function and superior pulmonary outcomes with general anesthesia. NAC may improve perioperative analgesia, with some studies displaying a reduction in postoperative opioid use. NAC is generally well tolerated with an established safety profile. NAC administration may predispose to gastrointestinal effects, while parenteral administration may carry a risk of anaphylactoid reactions, including bronchospasm. Larger randomized trials may clarify the impact of NAC on perioperative analgesic outcomes.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-world evidence of durable multi-dimensional improvement after 60-day peripheral nerve stimulation treatment used for shoulder pain. 经过 60 天的外周神经刺激治疗后，肩部疼痛得到持久、多维度改善的真实证据。
IF 1.4
Pain management Pub Date : 2024-07-23 DOI: 10.1080/17581869.2024.2371779
Ali Valimahomed, David Dickerson, Henry Vucetic, Joseph Rutledge, Claire A Zurn, Nathan D Crosby, Joseph W Boggs
{"title":"Real-world evidence of durable multi-dimensional improvement after 60-day peripheral nerve stimulation treatment used for shoulder pain.","authors":"Ali Valimahomed, David Dickerson, Henry Vucetic, Joseph Rutledge, Claire A Zurn, Nathan D Crosby, Joseph W Boggs","doi":"10.1080/17581869.2024.2371779","DOIUrl":"https://doi.org/10.1080/17581869.2024.2371779","url":null,"abstract":"<p><p><b>Aim:</b> This real-world analysis aims to quantify improvements in multiple health domains in patients who received 60-day peripheral nerve stimulation (PNS) for shoulder pain. <b>Materials & methods:</b> Patients reported percent pain relief and Patient Global Impression of Change in quality of life, physical function and sleep at the end of treatment (EOT), 3 months, and 6 months. <b>Results:</b> Of 768 patients, 80.7% were responders in at least one domain at EOT. In a subset who were followed up, a cumulative 75% continued to respond in at least one domain through 6 months (85% [n = 140/165] at 3 months and 88% [n = 53/60] at 6 months). <b>Conclusion:</b> 60-day PNS used for shoulder pain produced multi-dimensional improvements across health domains at EOT and through 6 months.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PPARγ and AKt gene modulation following pregabalin and duloxetine combination for painful diabetic polyneuropathy. 普瑞巴林和度洛西汀联合治疗糖尿病疼痛性多发性神经病变后的 PPARγ 和 AKt 基因调节作用
IF 1.4
Pain management Pub Date : 2024-07-01 DOI: 10.1080/17581869.2024.2370758
Ashok K Saxena, Nimisha Thanikkal, G. Chilkoti, P. Gondode, Tusha Sharma, B. D. Banerjee
{"title":"PPARγ and AKt gene modulation following pregabalin and duloxetine combination for painful diabetic polyneuropathy.","authors":"Ashok K Saxena, Nimisha Thanikkal, G. Chilkoti, P. Gondode, Tusha Sharma, B. D. Banerjee","doi":"10.1080/17581869.2024.2370758","DOIUrl":"https://doi.org/10.1080/17581869.2024.2370758","url":null,"abstract":"Aim: Diabetic peripheral neuropathy (DPN) induces chronic neuropathic pain in diabetic patients. Current treatments like pregabalin and duloxetine offer limited efficacy. This study evaluates combining pregabalin and duloxetine versus pregabalin alone for DPN pain relief, and explores gene modulation (PPARγ and Akt) to understand neuropathic pain's molecular basis. Materials & methods: Diabetic patients with DPN were randomized into groups receiving combination therapy or pregabalin alone for 4 weeks. Pain intensity, gene expression and quality of life were assessed. Results: Combination therapy significantly reduced pain, improved quality of life and upregulated PPARγ and Akt genes compared with monotherapy. Conclusion: Pregabalin and duloxetine combination therapy in DPN led to PPARγ mRNA upregulation and negative correlation of Akt gene expression with pain scores. This combination therapy effectively reduced pain and improved quality of life.Clinical Trial Registration: CTRI/2021/02/031068.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analgesic utility of automatic lancing device for heel prick in neonates: a systematic review and meta-analysis. 新生儿足跟刺穿自动穿刺器的镇痛效用：系统综述和荟萃分析。
IF 1.4
Pain management Pub Date : 2024-06-28 DOI: 10.1080/17581869.2024.2368451
Rajendra Prasad Anne, Emine A Rahiman
{"title":"Analgesic utility of automatic lancing device for heel prick in neonates: a systematic review and meta-analysis.","authors":"Rajendra Prasad Anne, Emine A Rahiman","doi":"10.1080/17581869.2024.2368451","DOIUrl":"10.1080/17581869.2024.2368451","url":null,"abstract":"<p><p><b>Background:</b> This systematic review and meta-analysis assessed the benefits of an automatic lancing device compared with a manual lancet or a hypodermic needle in neonates. <b>Materials & methods:</b> We followed the Cochrane Handbook methodology, used the RoB-2 tool for risk of bias assessment, RevMan 4.1 for meta-analysis and GRADE framework for certainty assessment. We searched the databases and gray literature on 15 November 2023. <b>Results:</b> Six eligible studies enrolling 539 neonates were included. An automatic lancing device reduced pain scores during and after heel prick, sampling time and the need for repeat puncture. The certainty of evidence was very low to moderate. <b>Conclusion:</b> An automatic lancing device is preferred for heel pricks in neonates, given less pain and higher efficiency.<b>PROSPERO registration number:</b> CRD42023483189.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of prospective studies regarding percutaneous peripheral nerve stimulation treatment in the management of chronic pain 经皮外周神经刺激治疗慢性疼痛的前瞻性研究综述
IF 1.7
Pain management Pub Date : 2024-06-10 DOI: 10.1080/17581869.2024.2352398
Scott G Pritzlaff, Usman Latif, J. Rosenow, John Chae, Richard D Wilson, William J Huffman, Nathan D. Crosby, J. Boggs
{"title":"A review of prospective studies regarding percutaneous peripheral nerve stimulation treatment in the management of chronic pain","authors":"Scott G Pritzlaff, Usman Latif, J. Rosenow, John Chae, Richard D Wilson, William J Huffman, Nathan D. Crosby, J. Boggs","doi":"10.1080/17581869.2024.2352398","DOIUrl":"https://doi.org/10.1080/17581869.2024.2352398","url":null,"abstract":"","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141363799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidural spread of surgical site infection from spinal cord stimulation trial. 脊髓刺激试验引起的手术部位感染的硬膜外扩散。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-08 DOI: 10.1080/17581869.2024.2373044
Taif Mukhdomi, Bennett Andrassy, Semih Gungor
{"title":"Epidural spread of surgical site infection from spinal cord stimulation trial.","authors":"Taif Mukhdomi, Bennett Andrassy, Semih Gungor","doi":"10.1080/17581869.2024.2373044","DOIUrl":"10.1080/17581869.2024.2373044","url":null,"abstract":"<p><p>We present a case of deep surgical site infection (SSI) at a spinal cord stimulator (SCS) trial implantation site, resulting from an allergic reaction to an unknown agent. A 38-year-old female with complex regional pain syndrome began an SCS trial, noting 100% pain relief for 5 days. Fluid drainage from the surgical site was reported on POD6 and trial leads were removed the following day. The patient was hospitalized with sepsis. Blood cultures revealed <i>Staphylococcus aureus</i>. MRIs showed skin breakdown and cellulitis of the paraspinal musculature extending into the epidural space. The patient was maintained with antibiotics and rigorous wound care for 9 days and the surgical site infection resolved. The patient proceeded to SCS implantation, and reported good pain relief with the implanted device.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-management of primary dysmenorrhea-related pain: cross-sectional study on non-pharmacological interventions. 原发性痛经相关疼痛的自我管理：非药物干预横断面研究。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-23 DOI: 10.1080/17581869.2024.2376519
Jéssica Cordeiro Rodrigues, Guilherme Tavares de Arruda, Pâmela Calixto de Moraes, Caren Beatriz Firão, Mariana Arias Avila, Patricia Driusso
{"title":"Self-management of primary dysmenorrhea-related pain: cross-sectional study on non-pharmacological interventions.","authors":"Jéssica Cordeiro Rodrigues, Guilherme Tavares de Arruda, Pâmela Calixto de Moraes, Caren Beatriz Firão, Mariana Arias Avila, Patricia Driusso","doi":"10.1080/17581869.2024.2376519","DOIUrl":"10.1080/17581869.2024.2376519","url":null,"abstract":"<p><p><b>Aim:</b> Different nonpharmacological strategies are adopted to decrease primary dysmenorrhea (PD)-related pain. The present study aimed to verify women's use of nonpharmacological methods for pain and compare them with evidence from the literature.<b>Materials & methods:</b> A two-step study was conducted, comprising an online survey with 9144 women to assess nonpharmacological strategies for relieving PD-related pain, and a literature review on PubMed of verify the evidence of nonpharmacological methods.<b>Results:</b> Many women reported using heat therapy (61.5%), tea (42.4%) and massage (30.9%) to alleviate menstrual pain. However, the literature on these methods is limited.<b>Conclusion:</b> Several nonpharmacological methods are used by women to relieve PD-related pain and studies with low bias risk are needed to prove their effectiveness.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burn pain management in a female patient with severe burn injuries in Nepal: a case study and review. 尼泊尔重度烧伤女患者的烧伤疼痛管理：病例研究与综述。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-08-05 DOI: 10.1080/17581869.2024.2382072
Sundar Adhikari, Roshani Gurung, Suresh Bastakoti, Alian A Alrasheedy, Bhuvan Kc
{"title":"Burn pain management in a female patient with severe burn injuries in Nepal: a case study and review.","authors":"Sundar Adhikari, Roshani Gurung, Suresh Bastakoti, Alian A Alrasheedy, Bhuvan Kc","doi":"10.1080/17581869.2024.2382072","DOIUrl":"10.1080/17581869.2024.2382072","url":null,"abstract":"<p><p>Burn injuries in low-resource settings like Nepal present significant public health challenges, leading to substantial morbidity, mortality and severe pain. This paper assesses burn pain management in Nepal, emphasizing the need for enhanced strategies. A case study of a female patient with severe burn injuries from a rural village in Western Nepal illustrates current challenges. Reviewing studies on burn pain management in Nepal shows limited access to specialized facilities, inadequate palliative care, medication shortages and insufficient healthcare professionals. Pharmacological interventions are impacted by financial constraints and a lack of protocols, while nonpharmacological approaches have not been explored and contextualized for the Nepalese context due to similar financial issues. Comprehensive burn pain management requires addressing resource constraints through collaborative health-aid partnerships.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and predictors of pain among women who underwent cesarean section in Fiji. 斐济剖腹产妇女疼痛的特征和预测因素。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-09 DOI: 10.1080/17581869.2024.2370757
Ravneel Narayan, Masoud Mohammadnezhad, Nikansha Kumar, Sabiha Khan
{"title":"Characteristics and predictors of pain among women who underwent cesarean section in Fiji.","authors":"Ravneel Narayan, Masoud Mohammadnezhad, Nikansha Kumar, Sabiha Khan","doi":"10.1080/17581869.2024.2370757","DOIUrl":"10.1080/17581869.2024.2370757","url":null,"abstract":"<p><p><b>Aim:</b> To identify the characteristics and predictors of post cesarean section (CS) pain among women.<b>Materials & methods:</b> This quantitative study was conducted at Labasa hospital in Fiji over a 6-month period. A total of 312 mothers who received spinal, epidural and general anesthesia were included. Their pain score was assessed using the visual analogue scale 24 h postoperatively.<b>Results:</b> 70.8% women had either moderate or severe pain on the visual analogue scale. About 41.3% women expressed dissatisfaction with their pain management and 70.5% women had difficulties in performing activities due to pain. Lower parity was noted to be a positive predictor of pain among women undergoing CS.<b>Conclusion:</b> Adequate pain management for post-CS patient at Labasa hospital is lacking.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temperature difference between the affected and unaffected limbs in complex regional pain syndrome. 复杂性区域疼痛综合征患肢与非患肢之间的温差。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-08-08 DOI: 10.1080/17581869.2024.2377950
Burcu Candan, Semih Gungor
{"title":"Temperature difference between the affected and unaffected limbs in complex regional pain syndrome.","authors":"Burcu Candan, Semih Gungor","doi":"10.1080/17581869.2024.2377950","DOIUrl":"10.1080/17581869.2024.2377950","url":null,"abstract":"<p><p><b>Background:</b> Complex regional pain syndrome (CRPS) is classified into two subtypes based on clinical presentation: warm or cold.<b>Methods:</b> We examined the distribution of warm and cold subtypes in CRPS patients before they received lumbar sympathetic block. We retrospectively analyzed 81 prelumbar sympathetic block Forward Looking InfraRed images obtained from 30 patients to study temperature asymmetry between affected and unaffected limbs.<b>Results:</b> In 23 of the 30 patients (77%), the temperature difference between the affected and affected limbs was within the normal range (<0.6°C difference). Of the remaining seven cases, six (20%) were diagnosed with cold-CRPS and one (3%) with warm-CRPS. During subsequent interventions, 74% of the patients maintained a temperature difference within the normal range (<0.6°C difference).<b>Conclusion:</b> Retrospective analysis of Forward Looking InfraRed thermal camera images in CRPS patients showed that 77% of patients did not exhibit significant temperature asymmetry (<0.6°C difference) between affected and unaffected limbs.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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